Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development / E. RUBENSTEIN in Autism, 23-2 (February 2019)  

Public ISBD [article]  inAutism > 23-2 (February 2019) . - p.436-448 Titre : Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : E. RUBENSTEIN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; C. BRADLEY, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; E. MOODY, Auteur ; J. PANDEY, Auteur ; R. E. PRETZEL, Auteur ; A. G. HOWARD, Auteur ; A. F. OLSHAN, Auteur ; B. W. PENCE, Auteur ; J. DANIELS, Auteur Article en page(s) : p.436-448 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  broader autism phenotype  endophenotypes  subgrouping Index. décimale : PER Périodiques Résumé : The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype-a set of sub-clinical characteristics of autism spectrum disorder-on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: Mild Language Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation (e.g. anxiety/depression), General Developmental Delay, and Significant Developmental Delay with Repetitive Motor Behaviors. Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research. En ligne : http://dx.doi.org/10.1177/1362361317753563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development [Texte imprimé et/ou numérique] / E. RUBENSTEIN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; C. BRADLEY, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; E. MOODY, Auteur ; J. PANDEY, Auteur ; R. E. PRETZEL, Auteur ; A. G. HOWARD, Auteur ; A. F. OLSHAN, Auteur ; B. W. PENCE, Auteur ; J. DANIELS, Auteur . - p.436-448. Langues : Anglais (eng) in Autism > 23-2 (February 2019) . - p.436-448 Mots-clés : autism spectrum disorder  broader autism phenotype  endophenotypes  subgrouping Index. décimale : PER Périodiques Résumé : The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype-a set of sub-clinical characteristics of autism spectrum disorder-on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: Mild Language Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation (e.g. anxiety/depression), General Developmental Delay, and Significant Developmental Delay with Repetitive Motor Behaviors. Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research. En ligne : http://dx.doi.org/10.1177/1362361317753563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

A Distinct Three-Factor Structure of Restricted and Repetitive Behaviors in an Epidemiologically Sound Sample of Preschool-Age Children with Autism Spectrum Disorder / L. HIRUMA in Journal of Autism and Developmental Disorders, 51-10 (October 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3456-3468 Titre : A Distinct Three-Factor Structure of Restricted and Repetitive Behaviors in an Epidemiologically Sound Sample of Preschool-Age Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : L. HIRUMA, Auteur ; R. E. PRETZEL, Auteur ; A. L. TAPIA, Auteur ; James W. BODFISH, Auteur ; C. BRADLEY, Auteur ; Lisa D. WIGGINS, Auteur ; M. HSU, Auteur ; L. C. LEE, Auteur ; S. E. LEVY, Auteur ; J. DANIELS, Auteur Article en page(s) : p.3456-3468 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Child  Child, Preschool  Cognition  Factor Analysis, Statistical  Humans  Stereotyped Behavior  Autism spectrum disorder (ASD)  Exploratory factor analysis  Preschool children  Restricted and repetitive behaviors (RRB) Index. décimale : PER Périodiques Résumé : Prior studies investigating restricted and repetitive behavior (RRB) subtypes within autism spectrum disorder (ASD) have found varied factor structures for symptom groupings, in part, due to variation in symptom measurement and broad sample age ranges. This study examined RRBs among 827 preschool-age children, ages 35 to 71 months, through an exploratory factor analysis of RRB items from the Autism Diagnostic Interview-Revised (ADI-R) collected through the Study to Explore Early Development. The factor structures of RRBs among children with confirmed ASD versus those with non-autism developmental concerns were qualitatively compared. Correlations between RRB factors and participant characteristics were examined in the ASD group. Three conceptually well-defined factors characterized as repetitive sensorimotor behaviors (RSMB), insistence on sameness (IS), and a novel stereotyped speech (SPEECH) factor emerged for the ASD group only. Distinct factors were supported by different clinical correlates. Findings have implications for improving differential diagnosis and understanding of ASD symptomatology in this age range. En ligne : http://dx.doi.org/10.1007/s10803-020-04776-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] A Distinct Three-Factor Structure of Restricted and Repetitive Behaviors in an Epidemiologically Sound Sample of Preschool-Age Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / L. HIRUMA, Auteur ; R. E. PRETZEL, Auteur ; A. L. TAPIA, Auteur ; James W. BODFISH, Auteur ; C. BRADLEY, Auteur ; Lisa D. WIGGINS, Auteur ; M. HSU, Auteur ; L. C. LEE, Auteur ; S. E. LEVY, Auteur ; J. DANIELS, Auteur . - p.3456-3468. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3456-3468 Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Child  Child, Preschool  Cognition  Factor Analysis, Statistical  Humans  Stereotyped Behavior  Autism spectrum disorder (ASD)  Exploratory factor analysis  Preschool children  Restricted and repetitive behaviors (RRB) Index. décimale : PER Périodiques Résumé : Prior studies investigating restricted and repetitive behavior (RRB) subtypes within autism spectrum disorder (ASD) have found varied factor structures for symptom groupings, in part, due to variation in symptom measurement and broad sample age ranges. This study examined RRBs among 827 preschool-age children, ages 35 to 71 months, through an exploratory factor analysis of RRB items from the Autism Diagnostic Interview-Revised (ADI-R) collected through the Study to Explore Early Development. The factor structures of RRBs among children with confirmed ASD versus those with non-autism developmental concerns were qualitatively compared. Correlations between RRB factors and participant characteristics were examined in the ASD group. Three conceptually well-defined factors characterized as repetitive sensorimotor behaviors (RSMB), insistence on sameness (IS), and a novel stereotyped speech (SPEECH) factor emerged for the ASD group only. Distinct factors were supported by different clinical correlates. Findings have implications for improving differential diagnosis and understanding of ASD symptomatology in this age range. En ligne : http://dx.doi.org/10.1007/s10803-020-04776-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

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