All-cause and cause-specific mortality in people with autism spectrum disorder: A systematic review / Laurence FORSYTH in Research in Autism Spectrum Disorders, 105 (July 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 105 (July 2023) . - 102165 Titre : All-cause and cause-specific mortality in people with autism spectrum disorder: A systematic review Type de document : texte imprimé Auteurs : Laurence FORSYTH, Auteur ; Marc MCSORLEY, Auteur ; Ewelina RYDZEWSKA, Auteur Article en page(s) : 102165 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  All-cause mortality  Cause-specific mortality  Systematic review Index. décimale : PER Périodiques Résumé : Background The aim of this systematic review was to synthesise the current literature on all-cause and cause-specific mortality in individuals with autism spectrum disorders (ASD) to identify whether they experience an increased risk of mortality compared to the general population and to establish which specific causes of death are most prevalent in people with ASD. Method Medline, Embase, CINAHL and PsycINFO databases were searched. The review was registered with PROSPERO (CRD42021219582). Results 26 of the 8505 retrieved papers were included. 25 studies reported an increased risk of mortality for people with ASD. Out of 21 studies reporting the relevant statistics, 15 found autistic individuals to have at least a two times higher risk of dying when compared to the general population. 11 studies suggested that females with ASD were at an even greater risk of death when compared to their male counterparts. The most common causes of deaths were from external causes (particularly suicide) and neurological disorders. Conclusions Recognising the increased mortality experienced by people with ASD is an important factor in how clinicians, support workers and healthcare systems in general should plan and approach care for this population. Although a significant portion of deaths in this group occurs due to intentional or unintentional external causes, the reviewed literature also indicates that many people with ASD die from underlying health conditions. As the increased mortality risk seems to be partially mediated by the co-occurrence of other conditions, it is of great importance to provide an increased level of support and care for this population. En ligne : https://doi.org/10.1016/j.rasd.2023.102165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] All-cause and cause-specific mortality in people with autism spectrum disorder: A systematic review [texte imprimé] / Laurence FORSYTH, Auteur ; Marc MCSORLEY, Auteur ; Ewelina RYDZEWSKA, Auteur . - 102165. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 105 (July 2023) . - 102165 Mots-clés : Autism spectrum disorders  All-cause mortality  Cause-specific mortality  Systematic review Index. décimale : PER Périodiques Résumé : Background The aim of this systematic review was to synthesise the current literature on all-cause and cause-specific mortality in individuals with autism spectrum disorders (ASD) to identify whether they experience an increased risk of mortality compared to the general population and to establish which specific causes of death are most prevalent in people with ASD. Method Medline, Embase, CINAHL and PsycINFO databases were searched. The review was registered with PROSPERO (CRD42021219582). Results 26 of the 8505 retrieved papers were included. 25 studies reported an increased risk of mortality for people with ASD. Out of 21 studies reporting the relevant statistics, 15 found autistic individuals to have at least a two times higher risk of dying when compared to the general population. 11 studies suggested that females with ASD were at an even greater risk of death when compared to their male counterparts. The most common causes of deaths were from external causes (particularly suicide) and neurological disorders. Conclusions Recognising the increased mortality experienced by people with ASD is an important factor in how clinicians, support workers and healthcare systems in general should plan and approach care for this population. Although a significant portion of deaths in this group occurs due to intentional or unintentional external causes, the reviewed literature also indicates that many people with ASD die from underlying health conditions. As the increased mortality risk seems to be partially mediated by the co-occurrence of other conditions, it is of great importance to provide an increased level of support and care for this population. En ligne : https://doi.org/10.1016/j.rasd.2023.102165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

General health of adults with autism spectrum disorders – A whole country population cross-sectional study / Ewelina RYDZEWSKA in Research in Autism Spectrum Disorders, 60 (April 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 60 (April 2019) . - p.59-66 Titre : General health of adults with autism spectrum disorders – A whole country population cross-sectional study Type de document : texte imprimé Auteurs : Ewelina RYDZEWSKA, Auteur ; Laura A. HUGHES-MCCORMACK, Auteur ; Christopher GILLBERG, Auteur ; Angela HENDERSON, Auteur ; Cecilia MACINTYRE, Auteur ; Julie RINTOUL, Auteur ; Sally-Ann COOPER, Auteur Article en page(s) : p.59-66 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Adults  General health status  Health inequalities  Observational study Index. décimale : PER Périodiques Résumé : Background General health status in adult populations with autism spectrum disorders has been little studied. We aimed to investigate general health status and predictors of poor health in adults with autism spectrum disorders compared with other adults. Method Whole country data were drawn from Scotland’s Census, 2011. We calculated and compared the frequencies of health status in adults with and without autism spectrum disorders. We then used logistic regressions to calculate odds ratios (OR) with 95% confidence intervals (95% CI) of autism predicting poor general health in the whole population, adjusted for age and gender, and OR (95% CI) of age and gender predicting poor general health within the autism spectrum disorders population. Results Autism spectrum disorders were reported for 6649/3,746,584 (0.2%) adults aged 25+years, of whom 46.8% (N = 3111) had poor general health, compared with 23.7% (N = 887,878) of other people. Poor health was common across the entire lifecourse for adults with autism spectrum disorders. Autism had OR = 5.1 (4.9–5.4, 95% CI) for predicting poor general health, or OR = 7.5 (6.9–8.2, 95% CI) when the interaction with age was included. Poorer health was more common at older age, and for women. Conclusions Poor general health merits attention across the full lifecourse for adults with autism. Health practitioners need to be alert to the burden of potential health problems to seek them out to be addressed, and so the health agenda can turn towards potential mechanisms for prevention and better support for adults who may call upon services for people with autism. En ligne : https://doi.org/10.1016/j.rasd.2019.01.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387 [article] General health of adults with autism spectrum disorders – A whole country population cross-sectional study [texte imprimé] / Ewelina RYDZEWSKA, Auteur ; Laura A. HUGHES-MCCORMACK, Auteur ; Christopher GILLBERG, Auteur ; Angela HENDERSON, Auteur ; Cecilia MACINTYRE, Auteur ; Julie RINTOUL, Auteur ; Sally-Ann COOPER, Auteur . - p.59-66. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 60 (April 2019) . - p.59-66 Mots-clés : Autism spectrum disorder  Adults  General health status  Health inequalities  Observational study Index. décimale : PER Périodiques Résumé : Background General health status in adult populations with autism spectrum disorders has been little studied. We aimed to investigate general health status and predictors of poor health in adults with autism spectrum disorders compared with other adults. Method Whole country data were drawn from Scotland’s Census, 2011. We calculated and compared the frequencies of health status in adults with and without autism spectrum disorders. We then used logistic regressions to calculate odds ratios (OR) with 95% confidence intervals (95% CI) of autism predicting poor general health in the whole population, adjusted for age and gender, and OR (95% CI) of age and gender predicting poor general health within the autism spectrum disorders population. Results Autism spectrum disorders were reported for 6649/3,746,584 (0.2%) adults aged 25+years, of whom 46.8% (N = 3111) had poor general health, compared with 23.7% (N = 887,878) of other people. Poor health was common across the entire lifecourse for adults with autism spectrum disorders. Autism had OR = 5.1 (4.9–5.4, 95% CI) for predicting poor general health, or OR = 7.5 (6.9–8.2, 95% CI) when the interaction with age was included. Poorer health was more common at older age, and for women. Conclusions Poor general health merits attention across the full lifecourse for adults with autism. Health practitioners need to be alert to the burden of potential health problems to seek them out to be addressed, and so the health agenda can turn towards potential mechanisms for prevention and better support for adults who may call upon services for people with autism. En ligne : https://doi.org/10.1016/j.rasd.2019.01.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=387

Making a Case for an Autism-Specific Multimorbidity Index: A Comparative Cohort Study / Dewy NIJHOF in Journal of Autism and Developmental Disorders, 56-11 (November 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-11 (November 2026) . - p.4429-4437 Titre : Making a Case for an Autism-Specific Multimorbidity Index: A Comparative Cohort Study Type de document : texte imprimé Auteurs : Dewy NIJHOF, Auteur ; Filip SOSENKO, Auteur ; Laura McKernan WARD, Auteur ; Deborah CAIRNS, Auteur ; Laura HUGHES, Auteur ; Ewelina RYDZEWSKA, Auteur Article en page(s) : p.4429-4437 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autistic people experience challenges in healthcare, including disparities in health outcomes and multimorbidity patterns distinct from the general population. This study investigated the efficacy of existing multimorbidity indices in predicting COVID- 19 mortality among autistic adults and proposes a bespoke index, the ASD-MI, tailored to their specific health profile. Using data from the CVD-COVID-UK/COVID-IMPACT Consortium, encompassing England’s entire population, we identified 1,027 autistic adults hospitalized for COVID- 19, among whom 62 died due to the virus. Predictors were selected using logistic regression with fivefold cross-validation, comparing AUCs amongst multimorbidity indices. Diabetes, coronary heart disease, and thyroid disorders were selected as predictors for the ASD-MI, outperforming the Quan Index, a general population-based measure, with an AUC of 0.872 versus 0.828, respectively. Notably, the ASD-MI exhibited better model fit (pseudo-R2 0.25) compared to the Quan Index (pseudo-R2 0.20). These findings underscore the need for tailored indices in predicting mortality risks among autistic individuals. However, caution is warranted in interpreting results, given the limited understanding of morbidity burden in this population. Further research is needed to refine autism-specific indices and elucidate the complex interplay between long-term conditions and mortality risk, informing targeted interventions to address health disparities in autistic adults. This study highlights the importance of developing healthcare tools tailored to the unique needs of neurodivergent populations to improve health outcomes and reduce disparities. En ligne : https://doi.org/10.1007/s10803-025-06823-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=595 [article] Making a Case for an Autism-Specific Multimorbidity Index: A Comparative Cohort Study [texte imprimé] / Dewy NIJHOF, Auteur ; Filip SOSENKO, Auteur ; Laura McKernan WARD, Auteur ; Deborah CAIRNS, Auteur ; Laura HUGHES, Auteur ; Ewelina RYDZEWSKA, Auteur . - p.4429-4437. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-11 (November 2026) . - p.4429-4437 Index. décimale : PER Périodiques Résumé : Autistic people experience challenges in healthcare, including disparities in health outcomes and multimorbidity patterns distinct from the general population. This study investigated the efficacy of existing multimorbidity indices in predicting COVID- 19 mortality among autistic adults and proposes a bespoke index, the ASD-MI, tailored to their specific health profile. Using data from the CVD-COVID-UK/COVID-IMPACT Consortium, encompassing England’s entire population, we identified 1,027 autistic adults hospitalized for COVID- 19, among whom 62 died due to the virus. Predictors were selected using logistic regression with fivefold cross-validation, comparing AUCs amongst multimorbidity indices. Diabetes, coronary heart disease, and thyroid disorders were selected as predictors for the ASD-MI, outperforming the Quan Index, a general population-based measure, with an AUC of 0.872 versus 0.828, respectively. Notably, the ASD-MI exhibited better model fit (pseudo-R2 0.25) compared to the Quan Index (pseudo-R2 0.20). These findings underscore the need for tailored indices in predicting mortality risks among autistic individuals. However, caution is warranted in interpreting results, given the limited understanding of morbidity burden in this population. Further research is needed to refine autism-specific indices and elucidate the complex interplay between long-term conditions and mortality risk, informing targeted interventions to address health disparities in autistic adults. This study highlights the importance of developing healthcare tools tailored to the unique needs of neurodivergent populations to improve health outcomes and reduce disparities. En ligne : https://doi.org/10.1007/s10803-025-06823-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=595

A Population-Based Cross-Sectional Investigation of COVID-19 Hospitalizations and Mortality Among Autistic People / Dewy NIJHOF in Journal of Autism and Developmental Disorders, 56-11 (November 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-11 (November 2026) . - p.4451-4462 Titre : A Population-Based Cross-Sectional Investigation of COVID-19 Hospitalizations and Mortality Among Autistic People Type de document : texte imprimé Auteurs : Dewy NIJHOF, Auteur ; Filip SOSENKO, Auteur ; Daniel MACKAY, Auteur ; Michael FLEMING, Auteur ; Bhautesh D. JANI, Auteur ; Jill P. PELL, Auteur ; Chris HATTON, Auteur ; Deborah CAIRNS, Auteur ; Angela HENDERSON, Auteur ; Laura McKernan WARD, Auteur ; Ewelina RYDZEWSKA, Auteur ; Maria GARDANI, Auteur ; Elliot MILLINGTON, Auteur ; Craig MELVILLE, Auteur ; C. V. D. Covid- U. K. Covid-Impact Consortium THE, Auteur Article en page(s) : p.4451-4462 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Current evidence suggests the possibility that autistic people may be at more risk of COVID-19 infection, hospitalisation, and mortality than the general population. Previous studies, however, are either limited in scale or do not investigate potential risk factors. Research into risk factors focused on general population samples. The current study aims to investigate these risk factors in the autistic population. Using data-linkage and a whole-country population, this study modelled associations between autism and COVID-19 hospitalisation and mortality risk in adults, investigating a multitude of clinical and demographic risk factors. Autistic adults had higher rates of hospitalisation, Standardised Incident Ratio 1.6 in 2020 and 1.3 in 2021, and mortality, Standardised Mortality Ratio 1.52 in 2020 and 1.34 in 2021, due to COVID-19 than the general population. In both populations, age, complex multimorbidity and vaccination status were the most significant predictors of COVID-19 hospitalisation and mortality. Effects of psychotropic medication varied by class. Although similar factors exhibited a positive association with heightened risk of severe COVID-19 in both the autistic and general populations, with comparable effect sizes, mortality rates were elevated among the autistic population compared to the general population. Specifically, complex multimorbidity and classification of prescribed medications may emerge as particularly significant predictors of severe COVID-19 among individuals within the autistic population due to higher prevalence of complex multimorbidity in the autistic population and variability in the association between medication classes and severe COVID-19 between both populations, though further research is needed. En ligne : https://doi.org/10.1007/s10803-025-06844-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=595 [article] A Population-Based Cross-Sectional Investigation of COVID-19 Hospitalizations and Mortality Among Autistic People [texte imprimé] / Dewy NIJHOF, Auteur ; Filip SOSENKO, Auteur ; Daniel MACKAY, Auteur ; Michael FLEMING, Auteur ; Bhautesh D. JANI, Auteur ; Jill P. PELL, Auteur ; Chris HATTON, Auteur ; Deborah CAIRNS, Auteur ; Angela HENDERSON, Auteur ; Laura McKernan WARD, Auteur ; Ewelina RYDZEWSKA, Auteur ; Maria GARDANI, Auteur ; Elliot MILLINGTON, Auteur ; Craig MELVILLE, Auteur ; C. V. D. Covid- U. K. Covid-Impact Consortium THE, Auteur . - p.4451-4462. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-11 (November 2026) . - p.4451-4462 Index. décimale : PER Périodiques Résumé : Current evidence suggests the possibility that autistic people may be at more risk of COVID-19 infection, hospitalisation, and mortality than the general population. Previous studies, however, are either limited in scale or do not investigate potential risk factors. Research into risk factors focused on general population samples. The current study aims to investigate these risk factors in the autistic population. Using data-linkage and a whole-country population, this study modelled associations between autism and COVID-19 hospitalisation and mortality risk in adults, investigating a multitude of clinical and demographic risk factors. Autistic adults had higher rates of hospitalisation, Standardised Incident Ratio 1.6 in 2020 and 1.3 in 2021, and mortality, Standardised Mortality Ratio 1.52 in 2020 and 1.34 in 2021, due to COVID-19 than the general population. In both populations, age, complex multimorbidity and vaccination status were the most significant predictors of COVID-19 hospitalisation and mortality. Effects of psychotropic medication varied by class. Although similar factors exhibited a positive association with heightened risk of severe COVID-19 in both the autistic and general populations, with comparable effect sizes, mortality rates were elevated among the autistic population compared to the general population. Specifically, complex multimorbidity and classification of prescribed medications may emerge as particularly significant predictors of severe COVID-19 among individuals within the autistic population due to higher prevalence of complex multimorbidity in the autistic population and variability in the association between medication classes and severe COVID-19 between both populations, though further research is needed. En ligne : https://doi.org/10.1007/s10803-025-06844-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=595

Prevalence of sensory impairments, physical and intellectual disabilities, and mental health in children and young people with self/proxy-reported autism: Observational study of a whole country population / Ewelina RYDZEWSKA in Autism, 23-5 (July 2019)  

Public ISBD [article]  inAutism > 23-5 (July 2019) . - p.1201-1209 Titre : Prevalence of sensory impairments, physical and intellectual disabilities, and mental health in children and young people with self/proxy-reported autism: Observational study of a whole country population Type de document : texte imprimé Auteurs : Ewelina RYDZEWSKA, Auteur ; Laura A. HUGHES-MCCORMACK, Auteur ; Christopher GILLBERG, Auteur ; Angela HENDERSON, Auteur ; Cecilia MACINTYRE, Auteur ; Julie RINTOUL, Auteur ; Sally-Ann COOPER, Auteur Article en page(s) : p.1201-1209 Langues : Anglais (eng) Mots-clés : autism  children  comorbidities  hearing  mental health  physical disability  vision  young people Index. décimale : PER Périodiques Résumé : This study investigated the comorbid conditions in a whole country population of children/young people aged 0-24 years with and without autism. Data were drawn from Scotland's Census 2011. We calculated the percentage with autism, their extent of comorbid conditions, odds ratio (with 95% confidence intervals) of autism predicting comorbidities, adjusted for age and gender, and odds ratio for age and gender predicting comorbidities within the cohort with autism. A total of 25,063/1,548,819 (1.6%) had autism: 19,880 (79.3%) males and 5183 (20.7%) females. Autism had an odds ratio of 5.4 (5.1-5.6) for predicting deafness/partial hearing loss, odds ratio of 8.9 (8.1-9.7) for blindness/partial sight loss, odds ratio of 49.7 (38.1-64.9) for intellectual disabilities, odds ratio of 15.7 (13.4-18.5) for mental health conditions, odds ratio of 15.8 (14.1-17.8) for physical disability and odds ratio of 3.9 (3.8-4.0) for other conditions. Females with autism were more likely to have each additional condition than males, including intellectual disabilities, suggesting they may have more severe autism than males and adding evidence that autism may be currently underdiagnosed in more intellectually able females. These conditions are disabling and have a significant impact on long-term quality of life; their coexistence with autism adds extra complexity. It is important to raise clinicians' awareness of this extent of comorbidity, and to have accurate prevalence data to plan prevention and intervention measures, and to follow health inequality trends. En ligne : http://dx.doi.org/10.1177/1362361318791279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] Prevalence of sensory impairments, physical and intellectual disabilities, and mental health in children and young people with self/proxy-reported autism: Observational study of a whole country population [texte imprimé] / Ewelina RYDZEWSKA, Auteur ; Laura A. HUGHES-MCCORMACK, Auteur ; Christopher GILLBERG, Auteur ; Angela HENDERSON, Auteur ; Cecilia MACINTYRE, Auteur ; Julie RINTOUL, Auteur ; Sally-Ann COOPER, Auteur . - p.1201-1209. Langues : Anglais (eng) in Autism > 23-5 (July 2019) . - p.1201-1209 Mots-clés : autism  children  comorbidities  hearing  mental health  physical disability  vision  young people Index. décimale : PER Périodiques Résumé : This study investigated the comorbid conditions in a whole country population of children/young people aged 0-24 years with and without autism. Data were drawn from Scotland's Census 2011. We calculated the percentage with autism, their extent of comorbid conditions, odds ratio (with 95% confidence intervals) of autism predicting comorbidities, adjusted for age and gender, and odds ratio for age and gender predicting comorbidities within the cohort with autism. A total of 25,063/1,548,819 (1.6%) had autism: 19,880 (79.3%) males and 5183 (20.7%) females. Autism had an odds ratio of 5.4 (5.1-5.6) for predicting deafness/partial hearing loss, odds ratio of 8.9 (8.1-9.7) for blindness/partial sight loss, odds ratio of 49.7 (38.1-64.9) for intellectual disabilities, odds ratio of 15.7 (13.4-18.5) for mental health conditions, odds ratio of 15.8 (14.1-17.8) for physical disability and odds ratio of 3.9 (3.8-4.0) for other conditions. Females with autism were more likely to have each additional condition than males, including intellectual disabilities, suggesting they may have more severe autism than males and adding evidence that autism may be currently underdiagnosed in more intellectually able females. These conditions are disabling and have a significant impact on long-term quality of life; their coexistence with autism adds extra complexity. It is important to raise clinicians' awareness of this extent of comorbidity, and to have accurate prevalence data to plan prevention and intervention measures, and to follow health inequality trends. En ligne : http://dx.doi.org/10.1177/1362361318791279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

The prevalence of coexisting mental health conditions in gender diverse autistic people: A systematic review / Mikayla VAN RENSBURG ; Ling DING ; Ewelina RYDZEWSKA in Research in Autism Spectrum Disorders, 116 (August 2024)  

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