Comparison of three different eye-tracking tasks for distinguishing autistic from typically developing children and autistic symptom severity / Juan KOU in Autism Research, 12-10 (October 2019)  

Public ISBD [article]  inAutism Research > 12-10 (October 2019) . - p.1529-1540 Titre : Comparison of three different eye-tracking tasks for distinguishing autistic from typically developing children and autistic symptom severity Type de document : texte imprimé Auteurs : Juan KOU, Auteur ; Jiao LE, Auteur ; Meina FU, Auteur ; Chunmei LAN, Auteur ; Zhuo CHEN, Auteur ; Qiang LI, Auteur ; Weihua ZHAO, Auteur ; Lei XU, Auteur ; Benjamin BECKER, Auteur ; Keith M. KENDRICK, Auteur Article en page(s) : p.1529-1540 Langues : Anglais (eng) Mots-clés : Chinese children  attentional preference bias  autism spectrum disorder  dynamic social stimuli  eye-tracking Index. décimale : PER Périodiques Résumé : Altered patterns of visual social attention preference detected using eye-tracking and a variety of different paradigms are increasingly proposed as sensitive biomarkers for autism spectrum disorder. However, few eye-tracking studies have compared the relative efficacy of different paradigms to discriminate between autistic compared with typically developing children and their sensitivity to specific symptoms. To target this issue, the current study used three common eye-tracking protocols contrasting social versus nonsocial stimuli in young (2-7 years old) Chinese autistic (n = 35) and typically developing (n = 34) children matched for age and gender. Protocols included dancing people versus dynamic geometrical images, biological motion (dynamic light point walking human or cat) versus nonbiological motion (scrambled controls), and child playing with toy versus toy alone. Although all three paradigms differentiated autistic and typically developing children, the dancing people versus dynamic geometry pattern paradigm was the most effective, with autistic children showing marked reductions in visual preference for dancing people and correspondingly increased one for geometric patterns. Furthermore, this altered visual preference in autistic children was correlated with the Autism Diagnostic Observation Schedule social affect score and had the highest discrimination accuracy. Our results therefore indicate that decreased visual preference for dynamic social stimuli may be the most effective visual attention-based paradigm for use as a biomarker for autism in Chinese children. Clinical trial ID: NCT03286621 (clinicaltrials.gov); Clinical trial name: Development of Eye-tracking Based Markers for Autism in Young Children. Autism Res 2019, 12: 1529-1540. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Eye-tracking measures may be useful in aiding diagnosis and treatment of autism, although it is unclear which specific tasks are optimal. Here we compare the ability of three different social eye-gaze tasks to discriminate between autistic and typically developing young Chinese children and their sensitivity to specific autistic symptoms. Our results show that a dynamic task comparing visual preference for social (individuals dancing) versus geometric patterns is the most effective both for diagnosing autism and sensitivity to its social affect symptoms. En ligne : http://dx.doi.org/10.1002/aur.2174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Comparison of three different eye-tracking tasks for distinguishing autistic from typically developing children and autistic symptom severity [texte imprimé] / Juan KOU, Auteur ; Jiao LE, Auteur ; Meina FU, Auteur ; Chunmei LAN, Auteur ; Zhuo CHEN, Auteur ; Qiang LI, Auteur ; Weihua ZHAO, Auteur ; Lei XU, Auteur ; Benjamin BECKER, Auteur ; Keith M. KENDRICK, Auteur . - p.1529-1540. Langues : Anglais (eng) in Autism Research > 12-10 (October 2019) . - p.1529-1540 Mots-clés : Chinese children  attentional preference bias  autism spectrum disorder  dynamic social stimuli  eye-tracking Index. décimale : PER Périodiques Résumé : Altered patterns of visual social attention preference detected using eye-tracking and a variety of different paradigms are increasingly proposed as sensitive biomarkers for autism spectrum disorder. However, few eye-tracking studies have compared the relative efficacy of different paradigms to discriminate between autistic compared with typically developing children and their sensitivity to specific symptoms. To target this issue, the current study used three common eye-tracking protocols contrasting social versus nonsocial stimuli in young (2-7 years old) Chinese autistic (n = 35) and typically developing (n = 34) children matched for age and gender. Protocols included dancing people versus dynamic geometrical images, biological motion (dynamic light point walking human or cat) versus nonbiological motion (scrambled controls), and child playing with toy versus toy alone. Although all three paradigms differentiated autistic and typically developing children, the dancing people versus dynamic geometry pattern paradigm was the most effective, with autistic children showing marked reductions in visual preference for dancing people and correspondingly increased one for geometric patterns. Furthermore, this altered visual preference in autistic children was correlated with the Autism Diagnostic Observation Schedule social affect score and had the highest discrimination accuracy. Our results therefore indicate that decreased visual preference for dynamic social stimuli may be the most effective visual attention-based paradigm for use as a biomarker for autism in Chinese children. Clinical trial ID: NCT03286621 (clinicaltrials.gov); Clinical trial name: Development of Eye-tracking Based Markers for Autism in Young Children. Autism Res 2019, 12: 1529-1540. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Eye-tracking measures may be useful in aiding diagnosis and treatment of autism, although it is unclear which specific tasks are optimal. Here we compare the ability of three different social eye-gaze tasks to discriminate between autistic and typically developing young Chinese children and their sensitivity to specific autistic symptoms. Our results show that a dynamic task comparing visual preference for social (individuals dancing) versus geometric patterns is the most effective both for diagnosing autism and sensitivity to its social affect symptoms. En ligne : http://dx.doi.org/10.1002/aur.2174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Large-scale neural network compensation associated with camouflaging in trait autism and its potential mental health costs / Han GUO in Molecular Autism, 17 (2026)  

Public ISBD [article]  inMolecular Autism > 17 (2026) Titre : Large-scale neural network compensation associated with camouflaging in trait autism and its potential mental health costs Type de document : texte imprimé Auteurs : Han GUO, Auteur ; Xiaobing CHEN, Auteur ; Aihua ZHOU, Auteur ; Juan KOU, Auteur ; Yi LEI, Auteur ; Keith M. KENDRICK, Auteur ; Lei XU, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Social camouflaging refers to strategies to hide or compensate for social difficulties, often at significant mental health costs, and is particularly prevalent in autism. The large-scale neural network associated with this adaptation remains poorly understood. This study aimed to identify these neural network patterns and their link to potential mental health issues. En ligne : https://doi.org/10.1186/s13229-026-00710-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584 [article] Large-scale neural network compensation associated with camouflaging in trait autism and its potential mental health costs [texte imprimé] / Han GUO, Auteur ; Xiaobing CHEN, Auteur ; Aihua ZHOU, Auteur ; Juan KOU, Auteur ; Yi LEI, Auteur ; Keith M. KENDRICK, Auteur ; Lei XU, Auteur. Langues : Anglais (eng) in Molecular Autism > 17 (2026) Index. décimale : PER Périodiques Résumé : Social camouflaging refers to strategies to hide or compensate for social difficulties, often at significant mental health costs, and is particularly prevalent in autism. The large-scale neural network associated with this adaptation remains poorly understood. This study aimed to identify these neural network patterns and their link to potential mental health issues. En ligne : https://doi.org/10.1186/s13229-026-00710-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=584

The Cost of Social Integration: Distinct Neural Inefficiency in Autistic Children Underlies Symptom Severity / Juan KOU in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70289 Titre : The Cost of Social Integration: Distinct Neural Inefficiency in Autistic Children Underlies Symptom Severity Type de document : texte imprimé Auteurs : Juan KOU, Auteur ; Mengyuan YANG, Auteur ; Lan ZHANG, Auteur ; Jiao LE, Auteur ; Lihui HUANG, Auteur ; Yi LEI, Auteur Article en page(s) : p.e70289 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is characterized by difficulties in social interaction, as individuals with ASD process social cues like gestures and facial expressions in a unique way. Despite this knowledge, the exact neurophysiological mechanisms driving these differences and their direct impact on clinical symptoms remain unclear.?This study delves deeper into understanding the neurophysiological mechanisms involved in social cue integration, moving beyond mere behavioral observations. Specifically, we investigated how autistic children and typically developing (TD) peers process congruent and incongruent social signals in everyday situations.?We compared 34 male autistic (2.5?6?years) versus 34 TD children via eye-tracking and functional near-infrared spectroscopy to measure gaze, pupil dilation, and frontal activation during gesture-face integration. TD children exhibited heightened attention to happy faces while maintaining equal attention to neutral faces and gestures when reward gestures were paired. The ASD group did not demonstrate an effective processing strategy. ASD children exhibited heightened pupil dilation and anterior prefrontal cortex (aPFC) activation in all conditions. Crucially, their gaze patterns and aPFC activation significantly correlated with poorer adaptive functioning and positively predicted autism severity. Autistic children go through a distinct, neurologically demanding, and inefficient process to integrate multimodal social cues. This inefficient compensatory attempt results in a metabolically costly physiological state, which is directly connected to the core challenges of ASD. The identified features provide a preliminary proof-of-concept for objective biomarkers, offering quantifiable, physiological indices of severity, thus enabling the development of targeted neurocognitive interventions. En ligne : https://doi.org/10.1002/aur.70289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] The Cost of Social Integration: Distinct Neural Inefficiency in Autistic Children Underlies Symptom Severity [texte imprimé] / Juan KOU, Auteur ; Mengyuan YANG, Auteur ; Lan ZHANG, Auteur ; Jiao LE, Auteur ; Lihui HUANG, Auteur ; Yi LEI, Auteur . - p.e70289. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70289 Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is characterized by difficulties in social interaction, as individuals with ASD process social cues like gestures and facial expressions in a unique way. Despite this knowledge, the exact neurophysiological mechanisms driving these differences and their direct impact on clinical symptoms remain unclear.?This study delves deeper into understanding the neurophysiological mechanisms involved in social cue integration, moving beyond mere behavioral observations. Specifically, we investigated how autistic children and typically developing (TD) peers process congruent and incongruent social signals in everyday situations.?We compared 34 male autistic (2.5?6?years) versus 34 TD children via eye-tracking and functional near-infrared spectroscopy to measure gaze, pupil dilation, and frontal activation during gesture-face integration. TD children exhibited heightened attention to happy faces while maintaining equal attention to neutral faces and gestures when reward gestures were paired. The ASD group did not demonstrate an effective processing strategy. ASD children exhibited heightened pupil dilation and anterior prefrontal cortex (aPFC) activation in all conditions. Crucially, their gaze patterns and aPFC activation significantly correlated with poorer adaptive functioning and positively predicted autism severity. Autistic children go through a distinct, neurologically demanding, and inefficient process to integrate multimodal social cues. This inefficient compensatory attempt results in a metabolically costly physiological state, which is directly connected to the core challenges of ASD. The identified features provide a preliminary proof-of-concept for objective biomarkers, offering quantifiable, physiological indices of severity, thus enabling the development of targeted neurocognitive interventions. En ligne : https://doi.org/10.1002/aur.70289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

---

1 (1 - 3 / 3) Par page : 25 50 100 200