Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 / Allen J. ROSENSPIRE in Autism Research, 4-4 (August 2011)  

Public ISBD [article]  inAutism Research > 4-4 (August 2011) . - p.242-249 Titre : Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 Type de document : texte imprimé Auteurs : Allen J. ROSENSPIRE, Auteur ; Wonsuk YOO, Auteur ; Sherri MENARD, Auteur ; Anthony R. TORRES, Auteur Année de publication : 2011 Article en page(s) : p.242-249 Langues : Anglais (eng) Mots-clés : immunology  anti-transglutaminase antibody  pediatrics Index. décimale : PER Périodiques Résumé : We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. En ligne : http://dx.doi.org/10.1002/aur.194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141 [article] Autism spectrum disorders are associated with an elevated autoantibody response to tissue transglutaminase-2 [texte imprimé] / Allen J. ROSENSPIRE, Auteur ; Wonsuk YOO, Auteur ; Sherri MENARD, Auteur ; Anthony R. TORRES, Auteur . - 2011 . - p.242-249. Langues : Anglais (eng) in Autism Research > 4-4 (August 2011) . - p.242-249 Mots-clés : immunology  anti-transglutaminase antibody  pediatrics Index. décimale : PER Périodiques Résumé : We report that a significant number of autistic children have serum levels of IgA antibodies above normal to the enzyme tissue transglutaminase II (TG2), and that expression of these antibodies to TG2 is linked to the (HLA)-DR3, DQ2 and DR7, DQ2 haplotypes. TG2 is expressed in the brain, where it has been shown to be important in cell adhesion and synaptic stabilization. Thus, these children appear to constitute a subpopulation of autistic children who fall within the autism disease spectrum, and for whom autoimmunity may represent a significant etiological component of their autism. En ligne : http://dx.doi.org/10.1002/aur.194 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=141

Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls / Thayne L. SWEETEN in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.410-414 Titre : Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls Type de document : texte imprimé Auteurs : Thayne L. SWEETEN, Auteur ; Lisa A. CROEN, Auteur ; Gayle C. WINDHAM, Auteur ; J. Dennis ODELL, Auteur ; E. Gene STUBBS, Auteur ; Anthony R. TORRES, Auteur Article en page(s) : p.410-414 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  Hhv-6  Herpesvirus Index. décimale : PER Périodiques Résumé : Previous research indicates that infection, especially from viruses in the family Herpesviridae, may play a role in the etiology of some cases of autism spectrum disorder (ASD). Using a case-control design and the polymerase chain reaction with site-specific primers, we screened newborn and childhood blood samples for the presence of eight human herpesviruses. Herpesvirus DNA was detected in 4 of 225 ASD individuals and 2 of 235 controls, with the most frequently detected virus being HHV-6B. Although this study does not detect a significant ASD-Herpesviridae association, it is limited by the use of site-specific primers. We suggest that new techniques using bioinformatics to search next-generation sequencing databases will be more revealing of possible ASD-virus associations. En ligne : http://dx.doi.org/10.1007/s10803-018-3691-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls [texte imprimé] / Thayne L. SWEETEN, Auteur ; Lisa A. CROEN, Auteur ; Gayle C. WINDHAM, Auteur ; J. Dennis ODELL, Auteur ; E. Gene STUBBS, Auteur ; Anthony R. TORRES, Auteur . - p.410-414. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.410-414 Mots-clés : Autism  Autism spectrum disorder  Hhv-6  Herpesvirus Index. décimale : PER Périodiques Résumé : Previous research indicates that infection, especially from viruses in the family Herpesviridae, may play a role in the etiology of some cases of autism spectrum disorder (ASD). Using a case-control design and the polymerase chain reaction with site-specific primers, we screened newborn and childhood blood samples for the presence of eight human herpesviruses. Herpesvirus DNA was detected in 4 of 225 ASD individuals and 2 of 235 controls, with the most frequently detected virus being HHV-6B. Although this study does not detect a significant ASD-Herpesviridae association, it is limited by the use of site-specific primers. We suggest that new techniques using bioinformatics to search next-generation sequencing databases will be more revealing of possible ASD-virus associations. En ligne : http://dx.doi.org/10.1007/s10803-018-3691-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

HLA Immune Function Genes in Autism / Anthony R. TORRES in Autism Research and Treatment, (November 2011)  

Public ISBD [article]  inAutism Research and Treatment > (November 2011) . - 13 p. Titre : HLA Immune Function Genes in Autism Type de document : texte imprimé Auteurs : Anthony R. TORRES, Auteur ; Jonna B. WESTOVER, Auteur ; Allen J. ROSENSPIRE, Auteur Année de publication : 2011 Article en page(s) : 13 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The human leukocyte antigen (HLA) genes on chromosome 6 are instrumental in many innate and adaptive immune responses. The HLA genes/haplotypes can also be involved in immune dysfunction and autoimmune diseases. It is now becoming apparent that many of the non-antigen-presenting HLA genes make significant contributions to autoimmune diseases. Interestingly, it has been reported that autism subjects often have associations with HLA genes/haplotypes, suggesting an underlying dysregulation of the immune system mediated by HLA genes. Genetic studies have only succeeded in identifying autism-causing genes in a small number of subjects suggesting that the genome has not been adequately interrogated. Close examination of the HLA region in autism has been relatively ignored, largely due to extraordinary genetic complexity. It is our proposition that genetic polymorphisms in the HLA region, especially in the non-antigen-presenting regions, may be important in the etiology of autism in certain subjects. En ligne : http://dx.doi.org/10.1155/2012/959073 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153 [article] HLA Immune Function Genes in Autism [texte imprimé] / Anthony R. TORRES, Auteur ; Jonna B. WESTOVER, Auteur ; Allen J. ROSENSPIRE, Auteur . - 2011 . - 13 p. Langues : Anglais (eng) in Autism Research and Treatment > (November 2011) . - 13 p. Index. décimale : PER Périodiques Résumé : The human leukocyte antigen (HLA) genes on chromosome 6 are instrumental in many innate and adaptive immune responses. The HLA genes/haplotypes can also be involved in immune dysfunction and autoimmune diseases. It is now becoming apparent that many of the non-antigen-presenting HLA genes make significant contributions to autoimmune diseases. Interestingly, it has been reported that autism subjects often have associations with HLA genes/haplotypes, suggesting an underlying dysregulation of the immune system mediated by HLA genes. Genetic studies have only succeeded in identifying autism-causing genes in a small number of subjects suggesting that the genome has not been adequately interrogated. Close examination of the HLA region in autism has been relatively ignored, largely due to extraordinary genetic complexity. It is our proposition that genetic polymorphisms in the HLA region, especially in the non-antigen-presenting regions, may be important in the etiology of autism in certain subjects. En ligne : http://dx.doi.org/10.1155/2012/959073 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=153

Immune Dysfunction in Autism Spectrum Disorder / Jonna B. WESTOVER  

Public ISBD in Autism - A Neurodevelopmental Journey from Genes to Behaviour / Valsamma EAPEN   Titre : Immune Dysfunction in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Jonna B. WESTOVER, Auteur ; Thayne L. SWEETEN, Auteur ; Michael BENSON, Auteur ; Patricia BRAY-WARD, Auteur ; Anthony R. TORRES, Auteur Année de publication : 2011 Importance : p.343-368 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/22318 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143 in Autism - A Neurodevelopmental Journey from Genes to Behaviour / Valsamma EAPEN   Immune Dysfunction in Autism Spectrum Disorder [texte imprimé] / Jonna B. WESTOVER, Auteur ; Thayne L. SWEETEN, Auteur ; Michael BENSON, Auteur ; Patricia BRAY-WARD, Auteur ; Anthony R. TORRES, Auteur . - 2011 . - p.343-368. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques En ligne : http://dx.doi.org/10.5772/22318 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=143

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A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism / Anthony TORRES in Autism - Open Access, 6-2 ([01/03/2016])  

Public ISBD [article]  inAutism - Open Access > 6-2 [01/03/2016] . - 8 p. Titre : A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism Type de document : texte imprimé Auteurs : Anthony TORRES, Auteur ; Jonna WESTOVER, Auteur ; Michael BENSON, Auteur ; Randall JOHNSON, Auteur ; Annelise DYKES, Auteur Article en page(s) : 8 p. Langues : Anglais (eng) Mots-clés : Autism  Killer - cell immunoglobulin - like receptors(KIR)  Human leukocyte antigen (HLA) alleles  Transmission disequilibrium test (TDT)  KIR gene Index. décimale : PER Périodiques Résumé : The killing activity of natural killer cells is largely regulated by the binding of class I human leukocyte antigen cognate ligands to killer cell immunoglobulin - like receptor proteins. The killer cell immunoglobulin - like receptor gene - complex contains genes that activate and others that inhibit the killing state of natural killer cells depending on the binding of specific human leukocyte antigen cognate ligands. It has been suggested in previous publications that activating human leukocyte antigen / killer - cell immunoglobulin - like receptor complexes are increased in people with autism. We present data, which suggests that an activating cB01 / tA01 killer cell immunoglobulin – like receptor gene - content haplotype and the cognate ligand human leukocyte antigen - C1k that activates this haplotype is significantly increased in autism. This is an important observation suggesting that the interaction between two proteins encoded on different chromosomes increases natural killer cell killing in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410 [article] A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism [texte imprimé] / Anthony TORRES, Auteur ; Jonna WESTOVER, Auteur ; Michael BENSON, Auteur ; Randall JOHNSON, Auteur ; Annelise DYKES, Auteur . - 8 p. Langues : Anglais (eng) in Autism - Open Access > 6-2 [01/03/2016] . - 8 p. Mots-clés : Autism  Killer - cell immunoglobulin - like receptors(KIR)  Human leukocyte antigen (HLA) alleles  Transmission disequilibrium test (TDT)  KIR gene Index. décimale : PER Périodiques Résumé : The killing activity of natural killer cells is largely regulated by the binding of class I human leukocyte antigen cognate ligands to killer cell immunoglobulin - like receptor proteins. The killer cell immunoglobulin - like receptor gene - complex contains genes that activate and others that inhibit the killing state of natural killer cells depending on the binding of specific human leukocyte antigen cognate ligands. It has been suggested in previous publications that activating human leukocyte antigen / killer - cell immunoglobulin - like receptor complexes are increased in people with autism. We present data, which suggests that an activating cB01 / tA01 killer cell immunoglobulin – like receptor gene - content haplotype and the cognate ligand human leukocyte antigen - C1k that activates this haplotype is significantly increased in autism. This is an important observation suggesting that the interaction between two proteins encoded on different chromosomes increases natural killer cell killing in autism. En ligne : https://dx.doi.org/10.4172/2165-7890.1000171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=410

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