Atypical social communication is associated with positive initial impressions among peers with autism spectrum disorder / Jessica E. GRANIERI in Autism, 24-7 (October 2020)  

Public ISBD [article]  inAutism > 24-7 (October 2020) . - p.1841-1848 Titre : Atypical social communication is associated with positive initial impressions among peers with autism spectrum disorder Type de document : texte imprimé Auteurs : Jessica E. GRANIERI, Auteur ; Morgan L. MCNAIR, Auteur ; Alan H. GERBER, Auteur ; Rebecca F. REIFLER, Auteur ; Matthew D. LERNER, Auteur Article en page(s) : p.1841-1848 Langues : Anglais (eng) Mots-clés : *atypical communication  *autism spectrum disorder  *friendship  *social communication  *youth Index. décimale : PER Périodiques Résumé : Atypical social communication is a key indicator of autism spectrum disorder and has long been presumed to interfere with friendship formation and first impressions among typically developing youth. However, emerging literature suggests that such atypicalities may function differently among groups of peers with autism spectrum disorder. The current study aimed to investigate the relationship between atypical social communication patterns and first impression sociometric ratings by peers in groups of youth with autism spectrum disorder. Findings suggest that, contrary to typically developing individuals, several forms of atypical communication among youth with autism spectrum disorder are associated with more positive first impressions by others with autism spectrum disorder. This suggests that interventions designed to increase friendships among youth with autism spectrum disorder may benefit from reframing their approach to addressing atypical social communication. En ligne : http://dx.doi.org/10.1177/1362361320924906 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Atypical social communication is associated with positive initial impressions among peers with autism spectrum disorder [texte imprimé] / Jessica E. GRANIERI, Auteur ; Morgan L. MCNAIR, Auteur ; Alan H. GERBER, Auteur ; Rebecca F. REIFLER, Auteur ; Matthew D. LERNER, Auteur . - p.1841-1848. Langues : Anglais (eng) in Autism > 24-7 (October 2020) . - p.1841-1848 Mots-clés : *atypical communication  *autism spectrum disorder  *friendship  *social communication  *youth Index. décimale : PER Périodiques Résumé : Atypical social communication is a key indicator of autism spectrum disorder and has long been presumed to interfere with friendship formation and first impressions among typically developing youth. However, emerging literature suggests that such atypicalities may function differently among groups of peers with autism spectrum disorder. The current study aimed to investigate the relationship between atypical social communication patterns and first impression sociometric ratings by peers in groups of youth with autism spectrum disorder. Findings suggest that, contrary to typically developing individuals, several forms of atypical communication among youth with autism spectrum disorder are associated with more positive first impressions by others with autism spectrum disorder. This suggests that interventions designed to increase friendships among youth with autism spectrum disorder may benefit from reframing their approach to addressing atypical social communication. En ligne : http://dx.doi.org/10.1177/1362361320924906 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally / Catherine E. BARRETT in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 42p. Titre : Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally Type de document : texte imprimé Auteurs : Catherine E. BARRETT, Auteur ; Thomas M. HENNESSEY, Auteur ; Katelyn M. GORDON, Auteur ; Steve J. RYAN, Auteur ; Morgan L. MCNAIR, Auteur ; Kerry J. RESSLER, Auteur ; Donald G. RAINNIE, Auteur Article en page(s) : 42p. Langues : Anglais (eng) Mots-clés : Autism  Basolateral amygdala  Protein kinase A  Proteomics  RNA sequencing  Social behavior  Transcriptomics  Valproic acid Index. décimale : PER Périodiques Résumé : BACKGROUND: The amygdala controls socioemotional behavior and has consistently been implicated in the etiology of autism spectrum disorder (ASD). Precocious amygdala development is commonly reported in ASD youth with the degree of overgrowth positively correlated to the severity of ASD symptoms. Prenatal exposure to VPA leads to an ASD phenotype in both humans and rats and has become a commonly used tool to model the complexity of ASD symptoms in the laboratory. Here, we examined abnormalities in gene expression in the amygdala and socioemotional behavior across development in the valproic acid (VPA) rat model of ASD. METHODS: Rat dams received oral gavage of VPA (500 mg/kg) or saline daily between E11 and 13. Socioemotional behavior was tracked across development in both sexes. RNA sequencing and proteomics were performed on amygdala samples from male rats across development. RESULTS: Effects of VPA on time spent in social proximity and anxiety-like behavior were sex dependent, with social abnormalities presenting in males and heightened anxiety in females. Across time VPA stunted developmental and immune, but enhanced cellular death and disorder, pathways in the amygdala relative to saline controls. At postnatal day 10, gene pathways involved in nervous system and cellular development displayed predicted activations in prenatally exposed VPA amygdala samples. By juvenile age, however, transcriptomic and proteomic pathways displayed reductions in cellular growth and neural development. Alterations in immune pathways, calcium signaling, Rho GTPases, and protein kinase A signaling were also observed. CONCLUSIONS: As behavioral, developmental, and genomic alterations are similar to those reported in ASD, these results lend support to prenatal exposure to VPA as a useful tool for understanding how developmental insults to molecular pathways in the amygdala give rise to ASD-related syndromes. En ligne : http://dx.doi.org/10.1186/s13229-017-0160-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally [texte imprimé] / Catherine E. BARRETT, Auteur ; Thomas M. HENNESSEY, Auteur ; Katelyn M. GORDON, Auteur ; Steve J. RYAN, Auteur ; Morgan L. MCNAIR, Auteur ; Kerry J. RESSLER, Auteur ; Donald G. RAINNIE, Auteur . - 42p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 42p. Mots-clés : Autism  Basolateral amygdala  Protein kinase A  Proteomics  RNA sequencing  Social behavior  Transcriptomics  Valproic acid Index. décimale : PER Périodiques Résumé : BACKGROUND: The amygdala controls socioemotional behavior and has consistently been implicated in the etiology of autism spectrum disorder (ASD). Precocious amygdala development is commonly reported in ASD youth with the degree of overgrowth positively correlated to the severity of ASD symptoms. Prenatal exposure to VPA leads to an ASD phenotype in both humans and rats and has become a commonly used tool to model the complexity of ASD symptoms in the laboratory. Here, we examined abnormalities in gene expression in the amygdala and socioemotional behavior across development in the valproic acid (VPA) rat model of ASD. METHODS: Rat dams received oral gavage of VPA (500 mg/kg) or saline daily between E11 and 13. Socioemotional behavior was tracked across development in both sexes. RNA sequencing and proteomics were performed on amygdala samples from male rats across development. RESULTS: Effects of VPA on time spent in social proximity and anxiety-like behavior were sex dependent, with social abnormalities presenting in males and heightened anxiety in females. Across time VPA stunted developmental and immune, but enhanced cellular death and disorder, pathways in the amygdala relative to saline controls. At postnatal day 10, gene pathways involved in nervous system and cellular development displayed predicted activations in prenatally exposed VPA amygdala samples. By juvenile age, however, transcriptomic and proteomic pathways displayed reductions in cellular growth and neural development. Alterations in immune pathways, calcium signaling, Rho GTPases, and protein kinase A signaling were also observed. CONCLUSIONS: As behavioral, developmental, and genomic alterations are similar to those reported in ASD, these results lend support to prenatal exposure to VPA as a useful tool for understanding how developmental insults to molecular pathways in the amygdala give rise to ASD-related syndromes. En ligne : http://dx.doi.org/10.1186/s13229-017-0160-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Examining the Process and Impact of Social Problem Solving in Autistic Children / Morgan L. MCNAIR in Journal of Autism and Developmental Disorders, 55-3 (March 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-3 (March 2025) . - p.789-802 Titre : Examining the Process and Impact of Social Problem Solving in Autistic Children Type de document : texte imprimé Auteurs : Morgan L. MCNAIR, Auteur ; Victoria MONDEJAR, Auteur ; Erin J. LIBSACK, Auteur ; Nicole H. MORDEKAI, Auteur ; Clark MCKOWN, Auteur ; Nicole M. RUSSO-PONSARAN, Auteur ; Matthew D. LERNER, Auteur Article en page(s) : p.789-802 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Social problem solving (SPS) represents a social cognitive reasoning process that gives way to behavior when individuals are navigating challenging social situations. Autistic individuals have been shown to struggle with specific aspects of SPS, which, in turn, has been related to social difficulties in children. However, no previous work has measured how SPS components not only relate to one another but also discretely and conjointly predict autism-related symptoms and social difficulties in autistic children, specifically. Fifty-eight autistic children (44 male; 6-10 years old, Mage=8.67, SDage=1.31) completed a self-administered, computerized assessment of SPS. To elucidate how SPS components discretely, and combined, contribute to autism-related symptoms and social difficulties, commonality analyses were conducted for each measure assessing autism-related symptoms and social difficulties. Socially normative problem identification, goal preference, and solution preference were related to fewer parent-reported autism-related social difficulties. Measures related to autism symptomatology, social perspective taking, and emotion recognition were not significantly associated with discrete SPS components in this sample. The problem identification aspect of SPS contributed the most unique variance to parent-reported autism-related social difficulties, while shared variance across all SPS components accounted for substantial variance in both parent-reported autism-related social difficulties models. Results suggest that SPS components are interrelated, but distinct, constructs in the autistic population. These findings not only further clarify the impact of SPS components on autism-related symptoms and social difficulties, but also have implications for refining SPS-focused interventions in the autistic population. En ligne : https://doi.org/10.1007/s10803-024-06261-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Examining the Process and Impact of Social Problem Solving in Autistic Children [texte imprimé] / Morgan L. MCNAIR, Auteur ; Victoria MONDEJAR, Auteur ; Erin J. LIBSACK, Auteur ; Nicole H. MORDEKAI, Auteur ; Clark MCKOWN, Auteur ; Nicole M. RUSSO-PONSARAN, Auteur ; Matthew D. LERNER, Auteur . - p.789-802. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-3 (March 2025) . - p.789-802 Index. décimale : PER Périodiques Résumé : Social problem solving (SPS) represents a social cognitive reasoning process that gives way to behavior when individuals are navigating challenging social situations. Autistic individuals have been shown to struggle with specific aspects of SPS, which, in turn, has been related to social difficulties in children. However, no previous work has measured how SPS components not only relate to one another but also discretely and conjointly predict autism-related symptoms and social difficulties in autistic children, specifically. Fifty-eight autistic children (44 male; 6-10 years old, Mage=8.67, SDage=1.31) completed a self-administered, computerized assessment of SPS. To elucidate how SPS components discretely, and combined, contribute to autism-related symptoms and social difficulties, commonality analyses were conducted for each measure assessing autism-related symptoms and social difficulties. Socially normative problem identification, goal preference, and solution preference were related to fewer parent-reported autism-related social difficulties. Measures related to autism symptomatology, social perspective taking, and emotion recognition were not significantly associated with discrete SPS components in this sample. The problem identification aspect of SPS contributed the most unique variance to parent-reported autism-related social difficulties, while shared variance across all SPS components accounted for substantial variance in both parent-reported autism-related social difficulties models. Results suggest that SPS components are interrelated, but distinct, constructs in the autistic population. These findings not only further clarify the impact of SPS components on autism-related symptoms and social difficulties, but also have implications for refining SPS-focused interventions in the autistic population. En ligne : https://doi.org/10.1007/s10803-024-06261-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder / Paul A. CONSTABLE in Journal of Autism and Developmental Disorders, 50-8 (August 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2874-2885 Titre : Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Paul A. CONSTABLE, Auteur ; Edward R. RITVO, Auteur ; Ariella R. RITVO, Auteur ; Irene O. LEE, Auteur ; Morgan L. MCNAIR, Auteur ; Dylan STAHL, Auteur ; Jane SOWDEN, Auteur ; Stephen QUINN, Auteur ; David H. SKUSE, Auteur ; Dorothy A. THOMPSON, Auteur ; James C. MCPARTLAND, Auteur Article en page(s) : p.2874-2885 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Electroretinogram  b-wave Index. décimale : PER Périodiques Résumé : Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m(-2) white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p < .001) and slower b-wave peak times (p < .001). Photopic hill models showed the peaks of the component Gaussian (p = .035) and logistic functions (p = .014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04396-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428 [article] Light-Adapted Electroretinogram Differences in Autism Spectrum Disorder [texte imprimé] / Paul A. CONSTABLE, Auteur ; Edward R. RITVO, Auteur ; Ariella R. RITVO, Auteur ; Irene O. LEE, Auteur ; Morgan L. MCNAIR, Auteur ; Dylan STAHL, Auteur ; Jane SOWDEN, Auteur ; Stephen QUINN, Auteur ; David H. SKUSE, Auteur ; Dorothy A. THOMPSON, Auteur ; James C. MCPARTLAND, Auteur . - p.2874-2885. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2874-2885 Mots-clés : Autism spectrum disorder  Electroretinogram  b-wave Index. décimale : PER Périodiques Résumé : Light-adapted (LA) electroretinograms (ERGs) from 90 individuals with autism spectrum disorder (ASD), mean age (13.0 ± 4.2), were compared to 87 control subjects, mean age (13.8 ± 4.8). LA-ERGs were produced by a random series of nine different Troland based, full-field flash strengths and the ISCEV standard flash at 2/s on a 30 cd m(-2) white background. A random effects mixed model analysis showed the ASD group had smaller b- and a-wave amplitudes at high flash strengths (p < .001) and slower b-wave peak times (p < .001). Photopic hill models showed the peaks of the component Gaussian (p = .035) and logistic functions (p = .014) differed significantly between groups. Retinal neurophysiology assessed by LA-ERG provides insight into neural development in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04396-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428

Seeking contexts that promote neurodiverse social success: Patterns of behavior during minimally-structured interaction settings in autistic and non-autistic youth / Morgan L. MCNAIR in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1669-1684 Titre : Seeking contexts that promote neurodiverse social success: Patterns of behavior during minimally-structured interaction settings in autistic and non-autistic youth Type de document : texte imprimé Auteurs : Morgan L. MCNAIR, Auteur ; Elliot Gavin KEENAN, Auteur ; Abigail P. HOUCK, Auteur ; Matthew D. LERNER, Auteur Article en page(s) : p.1669-1684 Langues : Anglais (eng) Mots-clés : autism  naturalistic interaction  social behavior  social demands Index. décimale : PER Périodiques Résumé : While peer interaction differences are considered a central feature of autism, little is known regarding the nature of these interactions via directly-observed measurement of naturalistic (i.e., minimally-structured) groups of autistic and non-autistic adolescent peers. 148 autistic and non-autistic adolescents (111 male, Mage = 14.22, SDage = 1.90; MIQ = 103.22, SDIQ = 15.80) participated in a 50-minute, minimally-structured, naturalistic peer interaction paradigm with activities of varying social demands: an incidental social demand (eating in a room with peers), a physical social demand (playing a physically-interactive game), and a verbal social demand (playing a verbal game). While autistic youth exhibited fewer overall interaction behaviors than non-autistic youth, the two groups did not differ in amount of positive, negative, and low-level interaction behaviors. Within activities, autistic and non-autistic youth only differed in positive interaction behaviors during the context of a verbal social demand. Youth who displayed more positive interaction behaviors during this same activity had less autism spectrum disorder symptomatology, controlling for nested group effects and relevant covariates. These results point toward subtle differences in social demands across naturalistic settings that can either support or impede prosocial interaction for autistic youth, providing a guidepost for identifying settings that best promote social success for neurodiverse populations. En ligne : https://dx.doi.org/10.1017/S0954579423000950 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Seeking contexts that promote neurodiverse social success: Patterns of behavior during minimally-structured interaction settings in autistic and non-autistic youth [texte imprimé] / Morgan L. MCNAIR, Auteur ; Elliot Gavin KEENAN, Auteur ; Abigail P. HOUCK, Auteur ; Matthew D. LERNER, Auteur . - p.1669-1684. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1669-1684 Mots-clés : autism  naturalistic interaction  social behavior  social demands Index. décimale : PER Périodiques Résumé : While peer interaction differences are considered a central feature of autism, little is known regarding the nature of these interactions via directly-observed measurement of naturalistic (i.e., minimally-structured) groups of autistic and non-autistic adolescent peers. 148 autistic and non-autistic adolescents (111 male, Mage = 14.22, SDage = 1.90; MIQ = 103.22, SDIQ = 15.80) participated in a 50-minute, minimally-structured, naturalistic peer interaction paradigm with activities of varying social demands: an incidental social demand (eating in a room with peers), a physical social demand (playing a physically-interactive game), and a verbal social demand (playing a verbal game). While autistic youth exhibited fewer overall interaction behaviors than non-autistic youth, the two groups did not differ in amount of positive, negative, and low-level interaction behaviors. Within activities, autistic and non-autistic youth only differed in positive interaction behaviors during the context of a verbal social demand. Youth who displayed more positive interaction behaviors during this same activity had less autism spectrum disorder symptomatology, controlling for nested group effects and relevant covariates. These results point toward subtle differences in social demands across naturalistic settings that can either support or impede prosocial interaction for autistic youth, providing a guidepost for identifying settings that best promote social success for neurodiverse populations. En ligne : https://dx.doi.org/10.1017/S0954579423000950 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

Trajectories of internalizing symptoms among autistic and nonautistic youth during the COVID-19 pandemic / Talena C. DAY in Autism Research, 16-7 (July 2023)  

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