33 recherche sur le mot-clé '*autism spectrum disorder'

d-Cycloserine enhances durability of social skills training in autism spectrum disorder / L. K. WINK in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 2p. Titre : d-Cycloserine enhances durability of social skills training in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : L. K. WINK, Auteur ; N. F. MINSHAWI, Auteur ; R. C. SHAFFER, Auteur ; M. H. PLAWECKI, Auteur ; D. J. POSEY, Auteur ; P. S. HORN, Auteur ; R. ADAMS, Auteur ; Ernest V. PEDAPATI, Auteur ; T. L. SCHAEFER, Auteur ; C. J. MCDOUGLE, Auteur ; N. B. SWIEZY, Auteur ; C. A. ERICKSON, Auteur Article en page(s) : 2p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/*drug therapy/psychology  Child  Child, Preschool  Cycloserine/*administration & dosage/pharmacology  Double-Blind Method  Drug Administration Schedule  Female  Humans  Learning/*drug effects  Male  Severity of Illness Index  Social Behavior  Treatment Outcome  *Autism  *Autism spectrum disorder  *Social skills training  *d-Cycloserine Index. décimale : PER Périodiques Résumé : BACKGROUND: d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability. METHODS: Study participants included 60 outpatient youth with ASD, ages 5-11 years, all with IQ above 70, and significantly impaired social functioning who completed a 10-week active treatment phase during which they received weekly single doses of 50 mg of DCS or placebo administered 30 min prior to group social skills training. Following the 10-week active treatment phase, blinded follow-up assessments occurred at week 11 and week 22. The primary outcome measure for our durability of treatment evaluation was the parent-rated social responsiveness scale (SRS) total raw score at week 22. RESULTS: Analysis of the SRS total raw score demonstrated significant decrease for the DCS group compared to the placebo group (p = 0.042) indicating greater maintenance of treatment effect in the DCS group. DCS was well tolerated, with irritability being the most frequently reported adverse effect in both groups. CONCLUSIONS: The findings of this study suggest that DCS may help youth with ASD to maintain skills gained during sort-term social skills training. Larger-scale studies with longer follow-up will be necessary to further understand the long-term impact of DCS paired with structured social skills training. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01086475. En ligne : http://dx.doi.org/10.1186/s13229-017-0116-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331 [article] d-Cycloserine enhances durability of social skills training in autism spectrum disorder [Texte imprimé et/ou numérique] / L. K. WINK, Auteur ; N. F. MINSHAWI, Auteur ; R. C. SHAFFER, Auteur ; M. H. PLAWECKI, Auteur ; D. J. POSEY, Auteur ; P. S. HORN, Auteur ; R. ADAMS, Auteur ; Ernest V. PEDAPATI, Auteur ; T. L. SCHAEFER, Auteur ; C. J. MCDOUGLE, Auteur ; N. B. SWIEZY, Auteur ; C. A. ERICKSON, Auteur . - 2p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 2p. Mots-clés : Autism Spectrum Disorder/*drug therapy/psychology  Child  Child, Preschool  Cycloserine/*administration & dosage/pharmacology  Double-Blind Method  Drug Administration Schedule  Female  Humans  Learning/*drug effects  Male  Severity of Illness Index  Social Behavior  Treatment Outcome  *Autism  *Autism spectrum disorder  *Social skills training  *d-Cycloserine Index. décimale : PER Périodiques Résumé : BACKGROUND: d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability. METHODS: Study participants included 60 outpatient youth with ASD, ages 5-11 years, all with IQ above 70, and significantly impaired social functioning who completed a 10-week active treatment phase during which they received weekly single doses of 50 mg of DCS or placebo administered 30 min prior to group social skills training. Following the 10-week active treatment phase, blinded follow-up assessments occurred at week 11 and week 22. The primary outcome measure for our durability of treatment evaluation was the parent-rated social responsiveness scale (SRS) total raw score at week 22. RESULTS: Analysis of the SRS total raw score demonstrated significant decrease for the DCS group compared to the placebo group (p = 0.042) indicating greater maintenance of treatment effect in the DCS group. DCS was well tolerated, with irritability being the most frequently reported adverse effect in both groups. CONCLUSIONS: The findings of this study suggest that DCS may help youth with ASD to maintain skills gained during sort-term social skills training. Larger-scale studies with longer follow-up will be necessary to further understand the long-term impact of DCS paired with structured social skills training. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01086475. En ligne : http://dx.doi.org/10.1186/s13229-017-0116-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=331

Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study / D. ENDRES in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 10p. Titre : Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study Type de document : Texte imprimé et/ou numérique Auteurs : D. ENDRES, Auteur ; L. TEBARTZ VAN ELST, Auteur ; S. A. MEYER, Auteur ; B. FEIGE, Auteur ; K. NICKEL, Auteur ; A. BUBL, Auteur ; A. RIEDEL, Auteur ; D. EBERT, Auteur ; T. LANGE, Auteur ; V. GLAUCHE, Auteur ; Monica BISCALDI, Auteur ; A. PHILIPSEN, Auteur ; S. J. MAIER, Auteur ; E. PERLOV, Auteur Article en page(s) : 10p. Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/metabolism/*psychology  Female  Glutathione/*metabolism  Humans  Male  Middle Aged  Prefrontal Cortex/*metabolism  Proton Magnetic Resonance Spectroscopy/*methods  *Anterior cingulate cortex  *Asperger syndrome  *Autism spectrum disorder  *Dlpfc  *Glutathione  *MR spectroscopy Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by difficulties in social communication, unusually restricted, repetitive behavior and interests, and specific abnormalities in language and perception. The precise etiology of ASD is still unknown and probably heterogeneous. In a subgroup of patients, toxic environmental exposure might lead to an imbalance between oxidative stress and anti-oxidant systems. Previous serum and postmortem studies measuring levels of glutathione (GSH), the main cellular free radical scavenger in the brain, have supported the hypothesis that this compound might play a role in the pathophysiology of autism. METHODS: Using the method of single-voxel proton magnetic resonance spectroscopy (MRS), we analyzed the GSH signal in the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (DLPFC) of 24 ASD patients with normal or above average IQs and 18 matched control subjects. We hypothesized that we would find decreased GSH concentrations in both regions. RESULTS: We did not find overall group differences in neurometabolites including GSH, neither in the dorsal ACC (Wilks' lambda test; p = 0.429) nor in the DLPFC (p = 0.288). In the dACC, we found a trend for decreased GSH signals in ASD patients (p = 0.076). CONCLUSIONS: We were unable to confirm our working hypothesis regarding decreased GSH concentrations in the ASD group. Further studies combining MRS, serum, and cerebrospinal fluid measurements of GSH metabolism including other regions of interest or even whole brain spectroscopy are needed. En ligne : http://dx.doi.org/10.1186/s13229-017-0122-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Glutathione metabolism in the prefrontal brain of adults with high-functioning autism spectrum disorder: an MRS study [Texte imprimé et/ou numérique] / D. ENDRES, Auteur ; L. TEBARTZ VAN ELST, Auteur ; S. A. MEYER, Auteur ; B. FEIGE, Auteur ; K. NICKEL, Auteur ; A. BUBL, Auteur ; A. RIEDEL, Auteur ; D. EBERT, Auteur ; T. LANGE, Auteur ; V. GLAUCHE, Auteur ; Monica BISCALDI, Auteur ; A. PHILIPSEN, Auteur ; S. J. MAIER, Auteur ; E. PERLOV, Auteur . - 10p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 10p. Mots-clés : Adult  Autism Spectrum Disorder/metabolism/*psychology  Female  Glutathione/*metabolism  Humans  Male  Middle Aged  Prefrontal Cortex/*metabolism  Proton Magnetic Resonance Spectroscopy/*methods  *Anterior cingulate cortex  *Asperger syndrome  *Autism spectrum disorder  *Dlpfc  *Glutathione  *MR spectroscopy Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disease characterized by difficulties in social communication, unusually restricted, repetitive behavior and interests, and specific abnormalities in language and perception. The precise etiology of ASD is still unknown and probably heterogeneous. In a subgroup of patients, toxic environmental exposure might lead to an imbalance between oxidative stress and anti-oxidant systems. Previous serum and postmortem studies measuring levels of glutathione (GSH), the main cellular free radical scavenger in the brain, have supported the hypothesis that this compound might play a role in the pathophysiology of autism. METHODS: Using the method of single-voxel proton magnetic resonance spectroscopy (MRS), we analyzed the GSH signal in the dorsal anterior cingulate cortex (dACC) and the dorsolateral prefrontal cortex (DLPFC) of 24 ASD patients with normal or above average IQs and 18 matched control subjects. We hypothesized that we would find decreased GSH concentrations in both regions. RESULTS: We did not find overall group differences in neurometabolites including GSH, neither in the dorsal ACC (Wilks' lambda test; p = 0.429) nor in the DLPFC (p = 0.288). In the dACC, we found a trend for decreased GSH signals in ASD patients (p = 0.076). CONCLUSIONS: We were unable to confirm our working hypothesis regarding decreased GSH concentrations in the ASD group. Further studies combining MRS, serum, and cerebrospinal fluid measurements of GSH metabolism including other regions of interest or even whole brain spectroscopy are needed. En ligne : http://dx.doi.org/10.1186/s13229-017-0122-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Assessing the convergence of self-report and informant measures for adults with autism spectrum disorder / Rachel K. SANDERCOCK in Autism, 24-8 (November 2020)  

Public ISBD [article]  inAutism > 24-8 (November 2020) . - p.2256-2268 Titre : Assessing the convergence of self-report and informant measures for adults with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Rachel K. SANDERCOCK, Auteur ; Elena M. LAMARCHE, Auteur ; Mark R. KLINGER, Auteur ; Laura G. KLINGER, Auteur Article en page(s) : p.2256-2268 Langues : Anglais (eng) Mots-clés : *adults  *assessment  *autism spectrum disorder  *self-report Index. décimale : PER Périodiques Résumé : Self-report measures are frequently used for research and clinical assessments of adults with autism spectrum disorder. However, there has been little research examining agreement between self-report and informant-report in this population. Valid self-report measures are essential for conducting research with and providing high quality clinical services for adults with autism spectrum disorder. This study collected measures from 40 pairs of adults with autism spectrum disorder and their caregivers on measures of symptom severity, daily living skills, quality of life, and unmet service needs. Caregiver and self-report responses were highly associated with one another on all measures, though there were significant gaps between scores on the measures of daily living skills and quality of life. It is also important to understand how each informant's responses relate to outcomes in the areas of employment and independent living. Using self-report and caregiver-report together better predicted outcomes for the adult with autism spectrum disorder than scores from either individual reporter alone. These findings show that there is unique and valuable information provided by both adults with autism spectrum disorder and their caregivers; a multi-informant approach is important for obtaining the most comprehensive picture of current functioning, identifying unmet service needs, and creating treatment plans. This research also highlights the importance of including and prioritizing self-report perspectives in shaping service planning. En ligne : http://dx.doi.org/10.1177/1362361320942981 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Assessing the convergence of self-report and informant measures for adults with autism spectrum disorder [Texte imprimé et/ou numérique] / Rachel K. SANDERCOCK, Auteur ; Elena M. LAMARCHE, Auteur ; Mark R. KLINGER, Auteur ; Laura G. KLINGER, Auteur . - p.2256-2268. Langues : Anglais (eng) in Autism > 24-8 (November 2020) . - p.2256-2268 Mots-clés : *adults  *assessment  *autism spectrum disorder  *self-report Index. décimale : PER Périodiques Résumé : Self-report measures are frequently used for research and clinical assessments of adults with autism spectrum disorder. However, there has been little research examining agreement between self-report and informant-report in this population. Valid self-report measures are essential for conducting research with and providing high quality clinical services for adults with autism spectrum disorder. This study collected measures from 40 pairs of adults with autism spectrum disorder and their caregivers on measures of symptom severity, daily living skills, quality of life, and unmet service needs. Caregiver and self-report responses were highly associated with one another on all measures, though there were significant gaps between scores on the measures of daily living skills and quality of life. It is also important to understand how each informant's responses relate to outcomes in the areas of employment and independent living. Using self-report and caregiver-report together better predicted outcomes for the adult with autism spectrum disorder than scores from either individual reporter alone. These findings show that there is unique and valuable information provided by both adults with autism spectrum disorder and their caregivers; a multi-informant approach is important for obtaining the most comprehensive picture of current functioning, identifying unmet service needs, and creating treatment plans. This research also highlights the importance of including and prioritizing self-report perspectives in shaping service planning. En ligne : http://dx.doi.org/10.1177/1362361320942981 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Attributions, causal beliefs, and help-seeking behavior of parents of children with autism spectrum disorder and sleep problems / Laurie MCLAY in Autism, 24-7 (October 2020)  

Public ISBD [article]  inAutism > 24-7 (October 2020) . - p.1829-1840 Titre : Attributions, causal beliefs, and help-seeking behavior of parents of children with autism spectrum disorder and sleep problems Type de document : Texte imprimé et/ou numérique Auteurs : Laurie MCLAY, Auteur ; Sarah G. HANSEN, Auteur ; Amarie CARNETT, Auteur ; Karyn G. FRANCE, Auteur ; Neville M. BLAMPIED, Auteur Article en page(s) : p.1829-1840 Langues : Anglais (eng) Mots-clés : *autism spectrum disorder  *help-seeking  *parent attributions  *parental beliefs  *seep  *sleep treatment Index. décimale : PER Périodiques Résumé : Sleep problems are commonly reported among parents of children with autism spectrum disorder (ASD). Without effective treatment, such problems are unlikely to resolve. To date, we know very little about how and why parents of children with ASD seek help for sleep disturbance. Via an online survey, we gathered information about how parents make sense of their children's sleep problems, beliefs about their causes, sources of information, and help-seeking behavior. The analysis of responses from 244 parents revealed that parents commonly view sleep problems (a) as a consequence of their child's ASD, and unlikely to change over time (stable), and (b) as located within the child (intrinsic), stable over time, and difficult to treat. Despite this, parents also rated sleep problems as being important to treat. Eighty-two percent of parents surveyed reported seeking some kind of help for their child's sleep disturbance, and the average parent had tried six different treatment strategies, most commonly medical approaches (e.g. melatonin). The alignment between parents' treatment choices and those strategies that are supported by research was poor, but belief in the effectiveness of treatments was closely related to how often the treatment was used. These findings have important implications for parental education and clinical practice in the treatment of sleep problems in children with ASD. En ligne : http://dx.doi.org/10.1177/1362361320924216 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Attributions, causal beliefs, and help-seeking behavior of parents of children with autism spectrum disorder and sleep problems [Texte imprimé et/ou numérique] / Laurie MCLAY, Auteur ; Sarah G. HANSEN, Auteur ; Amarie CARNETT, Auteur ; Karyn G. FRANCE, Auteur ; Neville M. BLAMPIED, Auteur . - p.1829-1840. Langues : Anglais (eng) in Autism > 24-7 (October 2020) . - p.1829-1840 Mots-clés : *autism spectrum disorder  *help-seeking  *parent attributions  *parental beliefs  *seep  *sleep treatment Index. décimale : PER Périodiques Résumé : Sleep problems are commonly reported among parents of children with autism spectrum disorder (ASD). Without effective treatment, such problems are unlikely to resolve. To date, we know very little about how and why parents of children with ASD seek help for sleep disturbance. Via an online survey, we gathered information about how parents make sense of their children's sleep problems, beliefs about their causes, sources of information, and help-seeking behavior. The analysis of responses from 244 parents revealed that parents commonly view sleep problems (a) as a consequence of their child's ASD, and unlikely to change over time (stable), and (b) as located within the child (intrinsic), stable over time, and difficult to treat. Despite this, parents also rated sleep problems as being important to treat. Eighty-two percent of parents surveyed reported seeking some kind of help for their child's sleep disturbance, and the average parent had tried six different treatment strategies, most commonly medical approaches (e.g. melatonin). The alignment between parents' treatment choices and those strategies that are supported by research was poor, but belief in the effectiveness of treatments was closely related to how often the treatment was used. These findings have important implications for parental education and clinical practice in the treatment of sleep problems in children with ASD. En ligne : http://dx.doi.org/10.1177/1362361320924216 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Atypical social communication is associated with positive initial impressions among peers with autism spectrum disorder / Jessica E. GRANIERI in Autism, 24-7 (October 2020)  

Public ISBD [article]  inAutism > 24-7 (October 2020) . - p.1841-1848 Titre : Atypical social communication is associated with positive initial impressions among peers with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jessica E. GRANIERI, Auteur ; Morgan L. MCNAIR, Auteur ; Alan H. GERBER, Auteur ; Rebecca F. REIFLER, Auteur ; Matthew D. LERNER, Auteur Article en page(s) : p.1841-1848 Langues : Anglais (eng) Mots-clés : *atypical communication  *autism spectrum disorder  *friendship  *social communication  *youth Index. décimale : PER Périodiques Résumé : Atypical social communication is a key indicator of autism spectrum disorder and has long been presumed to interfere with friendship formation and first impressions among typically developing youth. However, emerging literature suggests that such atypicalities may function differently among groups of peers with autism spectrum disorder. The current study aimed to investigate the relationship between atypical social communication patterns and first impression sociometric ratings by peers in groups of youth with autism spectrum disorder. Findings suggest that, contrary to typically developing individuals, several forms of atypical communication among youth with autism spectrum disorder are associated with more positive first impressions by others with autism spectrum disorder. This suggests that interventions designed to increase friendships among youth with autism spectrum disorder may benefit from reframing their approach to addressing atypical social communication. En ligne : http://dx.doi.org/10.1177/1362361320924906 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Atypical social communication is associated with positive initial impressions among peers with autism spectrum disorder [Texte imprimé et/ou numérique] / Jessica E. GRANIERI, Auteur ; Morgan L. MCNAIR, Auteur ; Alan H. GERBER, Auteur ; Rebecca F. REIFLER, Auteur ; Matthew D. LERNER, Auteur . - p.1841-1848. Langues : Anglais (eng) in Autism > 24-7 (October 2020) . - p.1841-1848 Mots-clés : *atypical communication  *autism spectrum disorder  *friendship  *social communication  *youth Index. décimale : PER Périodiques Résumé : Atypical social communication is a key indicator of autism spectrum disorder and has long been presumed to interfere with friendship formation and first impressions among typically developing youth. However, emerging literature suggests that such atypicalities may function differently among groups of peers with autism spectrum disorder. The current study aimed to investigate the relationship between atypical social communication patterns and first impression sociometric ratings by peers in groups of youth with autism spectrum disorder. Findings suggest that, contrary to typically developing individuals, several forms of atypical communication among youth with autism spectrum disorder are associated with more positive first impressions by others with autism spectrum disorder. This suggests that interventions designed to increase friendships among youth with autism spectrum disorder may benefit from reframing their approach to addressing atypical social communication. En ligne : http://dx.doi.org/10.1177/1362361320924906 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Autism spectrum disorder/Takiw?tanga: An Integrated Data Infrastructure-based approach to autism spectrum disorder research in New Zealand / Nicholas J. BOWDEN in Autism, 24-8 (November 2020)  

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Comparing sleep patterns between children with autism spectrum disorder and children with typical development: A matched case-control study / Andy Cy TSE in Autism, 24-8 (November 2020)  

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Examining the relationship between parent physical activity support behaviour and physical activity among children and youth with autism spectrum disorder / Denver M. BROWN in Autism, 24-7 (October 2020)  

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Lower circulating endocannabinoid levels in children with autism spectrum disorder / Adi ARAN in Molecular Autism, 10 (2019)  

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Measuring change in facial emotion recognition in individuals with autism spectrum disorder: A systematic review / Andrea Trubanova WIECKOWSKI in Autism, 24-7 (October 2020)  

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