Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity / André SCHULZ in Development and Psychopathology, 34-3 (August 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-3 (August 2022) . - p.1013-1024 Titre : Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity Type de document : Texte imprimé et/ou numérique Auteurs : André SCHULZ, Auteur ; Christian E. DEUTER, Auteur ; Ion-Hideo BREDEN, Auteur ; Claus VOGELE, Auteur ; Katja WINGENFELD, Auteur ; Christian OTTE, Auteur ; Linn K. KUEHL, Auteur Article en page(s) : p.1013-1024 Langues : Anglais (eng) Mots-clés : alpha2-adrenergic receptors  childhood trauma  interoception  major depressive disorder  stress Index. décimale : PER Périodiques Résumé : Acute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamic “pituitary “adrenocortical axis. This study aimed to investigate the effect of SAM axis activation on interoceptive accuracy (IAcc). Central alpha2-adrenergic receptors represent a negative feedback mechanism of the SAM axis. Major depressive disorder and adverse childhood experiences (ACE) are associated with alterations in the biological stress systems, including central alpha2-adrenergic receptors. Here, healthy individuals with and without ACE as well as depressive patients with and without ACE (n = 114; all without antidepressant medication) were tested after yohimbine (alpha2-adrenergic antagonist) and placebo. We assessed IAcc and sensibility in a heartbeat counting task. Increases in systolic and diastolic blood pressure after yohimbine confirmed successful SAM axis activation. IAcc decreased after yohimbine only in the healthy group with ACE, but remained unchanged in all other groups (Group × Drug interaction). This effect may be due to selective upregulation of alpha2-adrenergic receptors after childhood trauma, which reduces capacity for attention focus on heartbeats. The sympathetic neural pathway including alpha2-adrenergic circuitries may be essential for mediating interoceptive signal transmission. Suppressed processing of physical sensations in stressful situations may represent an adaptive response in healthy individuals who experienced ACE. En ligne : http://dx.doi.org/10.1017/S0954579420001613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Noradrenergic activation induced by yohimbine decreases interoceptive accuracy in healthy individuals with childhood adversity [Texte imprimé et/ou numérique] / André SCHULZ, Auteur ; Christian E. DEUTER, Auteur ; Ion-Hideo BREDEN, Auteur ; Claus VOGELE, Auteur ; Katja WINGENFELD, Auteur ; Christian OTTE, Auteur ; Linn K. KUEHL, Auteur . - p.1013-1024. Langues : Anglais (eng) in Development and Psychopathology > 34-3 (August 2022) . - p.1013-1024 Mots-clés : alpha2-adrenergic receptors  childhood trauma  interoception  major depressive disorder  stress Index. décimale : PER Périodiques Résumé : Acute stress affects interoception, but it remains unclear if this is due to activation of the sympatho-adreno-medullary (SAM) or hypothalamic “pituitary “adrenocortical axis. This study aimed to investigate the effect of SAM axis activation on interoceptive accuracy (IAcc). Central alpha2-adrenergic receptors represent a negative feedback mechanism of the SAM axis. Major depressive disorder and adverse childhood experiences (ACE) are associated with alterations in the biological stress systems, including central alpha2-adrenergic receptors. Here, healthy individuals with and without ACE as well as depressive patients with and without ACE (n = 114; all without antidepressant medication) were tested after yohimbine (alpha2-adrenergic antagonist) and placebo. We assessed IAcc and sensibility in a heartbeat counting task. Increases in systolic and diastolic blood pressure after yohimbine confirmed successful SAM axis activation. IAcc decreased after yohimbine only in the healthy group with ACE, but remained unchanged in all other groups (Group × Drug interaction). This effect may be due to selective upregulation of alpha2-adrenergic receptors after childhood trauma, which reduces capacity for attention focus on heartbeats. The sympathetic neural pathway including alpha2-adrenergic circuitries may be essential for mediating interoceptive signal transmission. Suppressed processing of physical sensations in stressful situations may represent an adaptive response in healthy individuals who experienced ACE. En ligne : http://dx.doi.org/10.1017/S0954579420001613 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Stress effects on cognitive function in patients with major depressive disorder: Does childhood trauma play a role? / Linn K. KUEHL in Development and Psychopathology, 32-3 (August 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-3 (August 2020) . - p.1007-1016 Titre : Stress effects on cognitive function in patients with major depressive disorder: Does childhood trauma play a role? Type de document : Texte imprimé et/ou numérique Auteurs : Linn K. KUEHL, Auteur ; Katharina SCHULTEBRAUCKS, Auteur ; Christian E. DEUTER, Auteur ; Anita MAY, Auteur ; Carsten SPITZER, Auteur ; Christian OTTE, Auteur ; Katja WINGENFELD, Auteur Article en page(s) : p.1007-1016 Langues : Anglais (eng) Mots-clés : adverse childhood experiences  attention  major depressive disorder  memory  trier social stress test Index. décimale : PER Périodiques Résumé : Impaired cognitive functioning constitutes an important symptom of major depressive disorder (MDD), potentially associated with elevated cortisol levels. Adverse childhood experiences (ACE) enhance the risk for MDD and can contribute to disturbances in the stress systems, including cortisol and cognitive functions. In healthy participants, cortisol administration as well as acute stress can affect cognitive performance. In the current study, we tested cognitive performance in MDD patients with (N = 32) and without (N = 52) ACE and healthy participants with (N = 22) and without (N = 37) ACE after psychosocial stress induction (Trier Social Stress Test, TSST) and a control condition (Placebo-TSST). MDD predicted lower performance in verbal learning and both selective and sustained attention, while ACE predicted lower performance in psychomotoric speed and working memory. There were no interaction effects of MDD and ACE. After stress, MDD patients were more likely to show lower performance in working memory as well as in selective and sustained attention compared with participants without MDD. Individuals with ACE were more likely to show lower performance in verbal memory after stress compared with individuals without ACE. Our results indicate negative effects of MDD and ACE on distinct cognitive domains. Furthermore, MDD and/or ACE seem to enhance susceptibility for stress-related cognitive impairments. En ligne : http://dx.doi.org/10.1017/s0954579419000932 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Stress effects on cognitive function in patients with major depressive disorder: Does childhood trauma play a role? [Texte imprimé et/ou numérique] / Linn K. KUEHL, Auteur ; Katharina SCHULTEBRAUCKS, Auteur ; Christian E. DEUTER, Auteur ; Anita MAY, Auteur ; Carsten SPITZER, Auteur ; Christian OTTE, Auteur ; Katja WINGENFELD, Auteur . - p.1007-1016. Langues : Anglais (eng) in Development and Psychopathology > 32-3 (August 2020) . - p.1007-1016 Mots-clés : adverse childhood experiences  attention  major depressive disorder  memory  trier social stress test Index. décimale : PER Périodiques Résumé : Impaired cognitive functioning constitutes an important symptom of major depressive disorder (MDD), potentially associated with elevated cortisol levels. Adverse childhood experiences (ACE) enhance the risk for MDD and can contribute to disturbances in the stress systems, including cortisol and cognitive functions. In healthy participants, cortisol administration as well as acute stress can affect cognitive performance. In the current study, we tested cognitive performance in MDD patients with (N = 32) and without (N = 52) ACE and healthy participants with (N = 22) and without (N = 37) ACE after psychosocial stress induction (Trier Social Stress Test, TSST) and a control condition (Placebo-TSST). MDD predicted lower performance in verbal learning and both selective and sustained attention, while ACE predicted lower performance in psychomotoric speed and working memory. There were no interaction effects of MDD and ACE. After stress, MDD patients were more likely to show lower performance in working memory as well as in selective and sustained attention compared with participants without MDD. Individuals with ACE were more likely to show lower performance in verbal memory after stress compared with individuals without ACE. Our results indicate negative effects of MDD and ACE on distinct cognitive domains. Furthermore, MDD and/or ACE seem to enhance susceptibility for stress-related cognitive impairments. En ligne : http://dx.doi.org/10.1017/s0954579419000932 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

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