An Observational Study of Social Interaction Skills and Behaviors in Cornelia de Lange, Fragile X and Rubinstein-Taybi Syndromes / Katherine ELLIS in Journal of Autism and Developmental Disorders, 50-11 (November 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4001-4010 Titre : An Observational Study of Social Interaction Skills and Behaviors in Cornelia de Lange, Fragile X and Rubinstein-Taybi Syndromes Type de document : Texte imprimé et/ou numérique Auteurs : Katherine ELLIS, Auteur ; Chris OLIVER, Auteur ; Chrysi STEFANIDOU, Auteur ; Ian APPERLY, Auteur ; Jo MOSS, Auteur Article en page(s) : p.4001-4010 Langues : Anglais (eng) Mots-clés : Eye gaze  Fragile X syndrome  Genetics behavioural  Neurodevelopmental disorders  Social behavior Index. décimale : PER Périodiques Résumé : We directly assessed the broader aspects of sociability (social enjoyment, social motivation, social interaction skills and social discomfort) in individuals with Cornelia de Lange (CdLS), fragile X (FXS) and Rubinstein-Taybi syndromes (RTS), and their association with autism characteristics and chronological age in these groups. Individuals with FXS (p?< 0.01) and RTS (p?< 0.01) showed poorer quality of eye contact compared to individuals with CdLS. Individuals with FXS showed less person and more object attention than individuals with CdLS (p?< 0.01). Associations between sociability and autism characteristics and chronological age differed between groups, which may indicate divergence in the development and aetiology of different components of sociability across these groups. Findings indicate that individuals with CdLS, FXS and RTS show unique profiles of sociability. En ligne : http://dx.doi.org/10.1007/s10803-020-04440-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] An Observational Study of Social Interaction Skills and Behaviors in Cornelia de Lange, Fragile X and Rubinstein-Taybi Syndromes [Texte imprimé et/ou numérique] / Katherine ELLIS, Auteur ; Chris OLIVER, Auteur ; Chrysi STEFANIDOU, Auteur ; Ian APPERLY, Auteur ; Jo MOSS, Auteur . - p.4001-4010. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4001-4010 Mots-clés : Eye gaze  Fragile X syndrome  Genetics behavioural  Neurodevelopmental disorders  Social behavior Index. décimale : PER Périodiques Résumé : We directly assessed the broader aspects of sociability (social enjoyment, social motivation, social interaction skills and social discomfort) in individuals with Cornelia de Lange (CdLS), fragile X (FXS) and Rubinstein-Taybi syndromes (RTS), and their association with autism characteristics and chronological age in these groups. Individuals with FXS (p?< 0.01) and RTS (p?< 0.01) showed poorer quality of eye contact compared to individuals with CdLS. Individuals with FXS showed less person and more object attention than individuals with CdLS (p?< 0.01). Associations between sociability and autism characteristics and chronological age differed between groups, which may indicate divergence in the development and aetiology of different components of sociability across these groups. Findings indicate that individuals with CdLS, FXS and RTS show unique profiles of sociability. En ligne : http://dx.doi.org/10.1007/s10803-020-04440-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Characteristics of autism spectrum disorder in Cornelia de Lange syndrome / Jo MOSS in Journal of Child Psychology and Psychiatry, 53-8 (August 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-8 (August 2012) . - p.883-891 Titre : Characteristics of autism spectrum disorder in Cornelia de Lange syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Jo MOSS, Auteur ; Patricia HOWLIN, Auteur ; Iliana MAGIATI, Auteur ; Chris OLIVER, Auteur Année de publication : 2012 Article en page(s) : p.883-891 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Cornelia de Lange syndrome  behavioural phenotypes  genetic syndromes  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : Background:  The prevalence of autism spectrum disorder (ASD) symptomatology is comparatively high in Cornelia de Lange syndrome (CdLS). However, the profile and developmental trajectories of these ASD characteristics are potentially different to those observed in individuals with idiopathic ASD. In this study we examine the ASD profile in CdLS in comparison to a matched group of individuals with ASD. Method:  The Autism Diagnostic Observation Schedule (ADOS) was administered to 20 individuals with CdLS (mean age = 11.34; range = 6–13 years) and 20 individuals with idiopathic ASD (mean age = 10.42; range = 8–11 years). Participants were matched according to adaptive behaviour and receptive language skills. Results:  Sixty-five percent (N = 13) of individuals with CdLS met the cut-off score for autism on the total ADOS score. Further analysis at domain and item level indicated that individuals with CdLS showed significantly less repetitive behaviour, (specifically sensory interests); more eye contact, more gestures and less stereotyped speech than the ASD group. The CdLS group also showed higher levels of anxiety. Conclusions:  The comparison between CdLS and idiopathic ASD indicates subtle group differences in the profile of ASD symptomatology that are not accounted for by degree of intellectual disability or receptive language skills. These differences may not be evident when relying solely upon clinical and domain level scores, but may be distinguishing features of the ASD presentations in the two disorders. The findings have implications for the conceptualisation and assessment of ASD in individuals with genetic syndromes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02540.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177 [article] Characteristics of autism spectrum disorder in Cornelia de Lange syndrome [Texte imprimé et/ou numérique] / Jo MOSS, Auteur ; Patricia HOWLIN, Auteur ; Iliana MAGIATI, Auteur ; Chris OLIVER, Auteur . - 2012 . - p.883-891. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-8 (August 2012) . - p.883-891 Mots-clés : Autism spectrum disorder  Cornelia de Lange syndrome  behavioural phenotypes  genetic syndromes  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : Background:  The prevalence of autism spectrum disorder (ASD) symptomatology is comparatively high in Cornelia de Lange syndrome (CdLS). However, the profile and developmental trajectories of these ASD characteristics are potentially different to those observed in individuals with idiopathic ASD. In this study we examine the ASD profile in CdLS in comparison to a matched group of individuals with ASD. Method:  The Autism Diagnostic Observation Schedule (ADOS) was administered to 20 individuals with CdLS (mean age = 11.34; range = 6–13 years) and 20 individuals with idiopathic ASD (mean age = 10.42; range = 8–11 years). Participants were matched according to adaptive behaviour and receptive language skills. Results:  Sixty-five percent (N = 13) of individuals with CdLS met the cut-off score for autism on the total ADOS score. Further analysis at domain and item level indicated that individuals with CdLS showed significantly less repetitive behaviour, (specifically sensory interests); more eye contact, more gestures and less stereotyped speech than the ASD group. The CdLS group also showed higher levels of anxiety. Conclusions:  The comparison between CdLS and idiopathic ASD indicates subtle group differences in the profile of ASD symptomatology that are not accounted for by degree of intellectual disability or receptive language skills. These differences may not be evident when relying solely upon clinical and domain level scores, but may be distinguishing features of the ASD presentations in the two disorders. The findings have implications for the conceptualisation and assessment of ASD in individuals with genetic syndromes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02540.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177

Delineation of Behavioral Phenotypes in Genetic Syndromes: Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity / Chris OLIVER in Journal of Autism and Developmental Disorders, 41-8 (August 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1019-1032 Titre : Delineation of Behavioral Phenotypes in Genetic Syndromes: Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity Type de document : Texte imprimé et/ou numérique Auteurs : Chris OLIVER, Auteur ; Katy BERG, Auteur ; Jo MOSS, Auteur ; Kate ARRON, Auteur ; Cheryl BURBIDGE, Auteur Année de publication : 2011 Article en page(s) : p.1019-1032 Langues : Anglais (eng) Mots-clés : Behavioral phenotype  Autism spectrum disorder  Hyperactivity  Impulsivity  Affect  Genetic syndromes Index. décimale : PER Périodiques Résumé : We investigated autism spectrum disorder (ASD) symptomatology, hyperactivity and affect in seven genetic syndromes; Angelman (AS; n = 104), Cri du Chat (CdCS; 58), Cornelia de Lange (CdLS; 101), Fragile X (FXS; 191), Prader-Willi (PWS; 189), Smith-Magenis (SMS; 42) and Lowe (LS; 56) syndromes (age range 4–51). ASD symptomatology was heightened in CdLS and FXS. High levels of impulsivity were seen in SMS, AS, CdCS, FXS and adults with CdLS. Negative affect was prominent in adults with CdLS, while positive affect was prominent in adults with AS and FXS. Heightened levels of overactivity and impulsivity were identified in FXS, AS and SMS while low levels were identified in PWS. These findings confirm and extend previously reported behavioral phenotypes. En ligne : http://dx.doi.org/10.1007/s10803-010-1125-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Delineation of Behavioral Phenotypes in Genetic Syndromes: Characteristics of Autism Spectrum Disorder, Affect and Hyperactivity [Texte imprimé et/ou numérique] / Chris OLIVER, Auteur ; Katy BERG, Auteur ; Jo MOSS, Auteur ; Kate ARRON, Auteur ; Cheryl BURBIDGE, Auteur . - 2011 . - p.1019-1032. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1019-1032 Mots-clés : Behavioral phenotype  Autism spectrum disorder  Hyperactivity  Impulsivity  Affect  Genetic syndromes Index. décimale : PER Périodiques Résumé : We investigated autism spectrum disorder (ASD) symptomatology, hyperactivity and affect in seven genetic syndromes; Angelman (AS; n = 104), Cri du Chat (CdCS; 58), Cornelia de Lange (CdLS; 101), Fragile X (FXS; 191), Prader-Willi (PWS; 189), Smith-Magenis (SMS; 42) and Lowe (LS; 56) syndromes (age range 4–51). ASD symptomatology was heightened in CdLS and FXS. High levels of impulsivity were seen in SMS, AS, CdCS, FXS and adults with CdLS. Negative affect was prominent in adults with CdLS, while positive affect was prominent in adults with AS and FXS. Heightened levels of overactivity and impulsivity were identified in FXS, AS and SMS while low levels were identified in PWS. These findings confirm and extend previously reported behavioral phenotypes. En ligne : http://dx.doi.org/10.1007/s10803-010-1125-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Persistence and predictors of self-injurious behaviour in autism: a ten-year prospective cohort study / Catherine LAVERTY in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 8 p. Titre : Persistence and predictors of self-injurious behaviour in autism: a ten-year prospective cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Catherine LAVERTY, Auteur ; Chris OLIVER, Auteur ; Jo MOSS, Auteur ; Lisa NELSON, Auteur ; Caroline RICHARDS, Auteur Article en page(s) : 8 p. Langues : Anglais (eng) Mots-clés : Autism  Impulsivity  Prevalence  Risk marker  Self-injury  Self-restraint Index. décimale : PER Périodiques Résumé : BACKGROUND: Self-injurious behaviours, such as head banging, hair pulling, skin picking and scratching, are common in individuals with autism. Despite high prevalence rates, there is a paucity of longitudinal research to refine models of risk and mechanism and inform service planning. In this longitudinal study, we investigated self-injury in a cohort of individuals with autism over 10?years to identify behavioural and demographic characteristics associated with persistent self-injury. METHODS: Carers of 67 individuals with autism completed questionnaires relating to the presence of self-injury and relevant risk markers at T (1) (mean [SD] age in years 13.4 [7.7]) and T (3) (mean [SD] age in years 23.9 [7.7]) 10?years later. Forty-six of these also took part at T (2) (3?years after initial participation). Analysis assessed demographic and behavioural risk markers for self-injury, as well as the predictive value of items assessed at T (1)and T (2.) RESULTS: Self-injury was persistent in 44% of individuals over the 10-year period, with behavioural characteristics of impulsivity (p < .001) and overactivity (p = .002), identified as risk markers for persistence. A predictive model of self-injury was derived from LASSO analysis, with baseline impulsivity, interest and pleasure, stereotyped behaviour, social communication and adaptive functioning predicting self-injury over 10?years. CONCLUSIONS: In this unique longitudinal investigation into the persistence of self-injury in a non-clinical sample of individuals with autism over a 10?year period, we have identified a novel, robust and stable profile of behavioural characteristics associated with persistent self-injury. Findings support an early intervention strategy targeted towards individuals identified to be at a higher risk of developing self-injurious behaviour. En ligne : http://dx.doi.org/10.1186/s13229-019-0307-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Persistence and predictors of self-injurious behaviour in autism: a ten-year prospective cohort study [Texte imprimé et/ou numérique] / Catherine LAVERTY, Auteur ; Chris OLIVER, Auteur ; Jo MOSS, Auteur ; Lisa NELSON, Auteur ; Caroline RICHARDS, Auteur . - 8 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 8 p. Mots-clés : Autism  Impulsivity  Prevalence  Risk marker  Self-injury  Self-restraint Index. décimale : PER Périodiques Résumé : BACKGROUND: Self-injurious behaviours, such as head banging, hair pulling, skin picking and scratching, are common in individuals with autism. Despite high prevalence rates, there is a paucity of longitudinal research to refine models of risk and mechanism and inform service planning. In this longitudinal study, we investigated self-injury in a cohort of individuals with autism over 10?years to identify behavioural and demographic characteristics associated with persistent self-injury. METHODS: Carers of 67 individuals with autism completed questionnaires relating to the presence of self-injury and relevant risk markers at T (1) (mean [SD] age in years 13.4 [7.7]) and T (3) (mean [SD] age in years 23.9 [7.7]) 10?years later. Forty-six of these also took part at T (2) (3?years after initial participation). Analysis assessed demographic and behavioural risk markers for self-injury, as well as the predictive value of items assessed at T (1)and T (2.) RESULTS: Self-injury was persistent in 44% of individuals over the 10-year period, with behavioural characteristics of impulsivity (p < .001) and overactivity (p = .002), identified as risk markers for persistence. A predictive model of self-injury was derived from LASSO analysis, with baseline impulsivity, interest and pleasure, stereotyped behaviour, social communication and adaptive functioning predicting self-injury over 10?years. CONCLUSIONS: In this unique longitudinal investigation into the persistence of self-injury in a non-clinical sample of individuals with autism over a 10?year period, we have identified a novel, robust and stable profile of behavioural characteristics associated with persistent self-injury. Findings support an early intervention strategy targeted towards individuals identified to be at a higher risk of developing self-injurious behaviour. En ligne : http://dx.doi.org/10.1186/s13229-019-0307-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Prevalence and Risk-Markers of Self-Harm in Autistic Children and Adults / Lucy LICENCE in Journal of Autism and Developmental Disorders, 50-10 (October 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3561-3574 Titre : Prevalence and Risk-Markers of Self-Harm in Autistic Children and Adults Type de document : Texte imprimé et/ou numérique Auteurs : Lucy LICENCE, Auteur ; Chris OLIVER, Auteur ; Jo MOSS, Auteur ; Caroline RICHARDS, Auteur Article en page(s) : p.3561-3574 Langues : Anglais (eng) Mots-clés : Affect  Autism  Impulsivity  Prevalence  Risk-marker  Self-harm Index. décimale : PER Périodiques Résumé : Self-harm is purportedly common in autistic individuals, but under-researched, particularly in younger samples and those without intellectual disability. This study aimed to describe prevalence, profile and correlates of self-harm in autistic individuals without impairments in adaptive functioning. Parents of autistic participants (n?=?83) completed questionnaires regarding the presence/topography of self-harm, demographic characteristics, autism severity, age of diagnosis, affect, activity levels and repetitive behaviour. 24.10% of participants engaged in self-harm. Self-harm was associated with significantly higher levels of impulsivity, over-activity, negative affect, compulsive behaviour and insistence on sameness. Low mood and overactivity/impulsivity predicted the presence of self-harm, with the model correctly classifying 82.9% of cases. Findings highlight a role for impaired behavioural inhibition and low mood in the aetiological mechanisms underpinning self-harm in autism. En ligne : http://dx.doi.org/10.1007/s10803-019-04260-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Prevalence and Risk-Markers of Self-Harm in Autistic Children and Adults [Texte imprimé et/ou numérique] / Lucy LICENCE, Auteur ; Chris OLIVER, Auteur ; Jo MOSS, Auteur ; Caroline RICHARDS, Auteur . - p.3561-3574. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3561-3574 Mots-clés : Affect  Autism  Impulsivity  Prevalence  Risk-marker  Self-harm Index. décimale : PER Périodiques Résumé : Self-harm is purportedly common in autistic individuals, but under-researched, particularly in younger samples and those without intellectual disability. This study aimed to describe prevalence, profile and correlates of self-harm in autistic individuals without impairments in adaptive functioning. Parents of autistic participants (n?=?83) completed questionnaires regarding the presence/topography of self-harm, demographic characteristics, autism severity, age of diagnosis, affect, activity levels and repetitive behaviour. 24.10% of participants engaged in self-harm. Self-harm was associated with significantly higher levels of impulsivity, over-activity, negative affect, compulsive behaviour and insistence on sameness. Low mood and overactivity/impulsivity predicted the presence of self-harm, with the model correctly classifying 82.9% of cases. Findings highlight a role for impaired behavioural inhibition and low mood in the aetiological mechanisms underpinning self-harm in autism. En ligne : http://dx.doi.org/10.1007/s10803-019-04260-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Prevalence of autism spectrum disorder symptomatology and related behavioural characteristics in individuals with Down syndrome / Jo MOSS in Autism, 17-4 (July 2013)  

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Social Anxiety in Cornelia de Lange Syndrome / Caroline RICHARDS in Journal of Autism and Developmental Disorders, 39-8 (August 2009)  

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Stability of the Autism Diagnostic Interview—Revised from Pre-School to Elementary School Age in Children with Autism Spectrum Disorders / Jo MOSS in Journal of Autism and Developmental Disorders, 38-6 (July 2008)  

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The prevalence and profile of autism in Sturge-Weber syndrome / Jenny SLONEEM in Journal of Autism and Developmental Disorders, 52-5 (May 2022)  

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