Association of polychlorinated biphenyls and organochlorine pesticides with autism spectrum disorder in Jamaican children / MacKinsey A. BACH in Research in Autism Spectrum Disorders, 76 (August 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 76 (August 2020) . - p.101587 Titre : Association of polychlorinated biphenyls and organochlorine pesticides with autism spectrum disorder in Jamaican children Type de document : Texte imprimé et/ou numérique Auteurs : MacKinsey A. BACH, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur Article en page(s) : p.101587 Langues : Anglais (eng) Mots-clés : Polychlorinated biphenyls (PCBs)  Organochlorine (OC) pesticides  Autism spectrum disorder (ASD)  Glutathione S-transferase (GST) genes  Interaction  Jamaica Index. décimale : PER Périodiques Résumé : Background Polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides are suspected to play a role in autism spectrum disorder (ASD). Objectives To investigate associations of PCBs and OC pesticides with ASD in Jamaican children and explore possible interaction between PCBs or OC pesticides with glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1) in relation to ASD. Methods Participants included n?=?169 age- and sex-matched case-control pairs of Jamaican children 2?8?years old. Socioeconomic status and food frequency data were self-reported by the parents/guardians. Blood from each participant was analyzed for 100 PCB congeners and 17 OC pesticides and genotyped for three GST genes. PCBs and OC pesticides concentrations below the limit of detection (LoD) were replaced with (LoD/?2). We used conditional logistic regression (CLR) models to assess associations of PCBs and OC pesticides with ASD, individually or interactively with GST genes (GSTT1, GSTM1, GSTP1). Results We found inverse associations of PCB-153 [adjusted MOR (95 % CI)?=?0.44 (0.23, 0.86)] and PCB-180 [adjusted MOR (95 % CI)?=?0.52 (0.28, 0.95)] with ASD. When adjusted for covariates in a CLR the interaction between GSTM1 and PCB-153 became significant (P? En ligne : https://doi.org/10.1016/j.rasd.2020.101587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Association of polychlorinated biphenyls and organochlorine pesticides with autism spectrum disorder in Jamaican children [Texte imprimé et/ou numérique] / MacKinsey A. BACH, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur . - p.101587. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 76 (August 2020) . - p.101587 Mots-clés : Polychlorinated biphenyls (PCBs)  Organochlorine (OC) pesticides  Autism spectrum disorder (ASD)  Glutathione S-transferase (GST) genes  Interaction  Jamaica Index. décimale : PER Périodiques Résumé : Background Polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides are suspected to play a role in autism spectrum disorder (ASD). Objectives To investigate associations of PCBs and OC pesticides with ASD in Jamaican children and explore possible interaction between PCBs or OC pesticides with glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1) in relation to ASD. Methods Participants included n?=?169 age- and sex-matched case-control pairs of Jamaican children 2?8?years old. Socioeconomic status and food frequency data were self-reported by the parents/guardians. Blood from each participant was analyzed for 100 PCB congeners and 17 OC pesticides and genotyped for three GST genes. PCBs and OC pesticides concentrations below the limit of detection (LoD) were replaced with (LoD/?2). We used conditional logistic regression (CLR) models to assess associations of PCBs and OC pesticides with ASD, individually or interactively with GST genes (GSTT1, GSTM1, GSTP1). Results We found inverse associations of PCB-153 [adjusted MOR (95 % CI)?=?0.44 (0.23, 0.86)] and PCB-180 [adjusted MOR (95 % CI)?=?0.52 (0.28, 0.95)] with ASD. When adjusted for covariates in a CLR the interaction between GSTM1 and PCB-153 became significant (P? En ligne : https://doi.org/10.1016/j.rasd.2020.101587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

Interaction between a mixture of heavy metals (lead, mercury, arsenic, cadmium, manganese, aluminum) and GSTP1, GSTT1, and GSTM1 in relation to autism spectrum disorder / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 79 (November 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 79 (November 2020) . - 101681 Titre : Interaction between a mixture of heavy metals (lead, mercury, arsenic, cadmium, manganese, aluminum) and GSTP1, GSTT1, and GSTM1 in relation to autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MacKinsey A. BACH, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Katherine A. LOVELAND, Auteur Article en page(s) : 101681 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Glutathione S-transferase (GST) genes ( and )  Mixture analysis  Generalized weighted quantile sum regression (gWQS)  Heavy metals  Jamaica Index. décimale : PER Périodiques Résumé : Background Exposure to many environmental chemicals, including metals, often does not occur in isolation, hence requires assessment of the associations between exposure to mixtures of chemicals and human health. Objectives To investigate associations of a metal mixture of lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd), manganese (Mn), and aluminum (Al) in children with autism spectrum disorder (ASD), additively or interactively with each of three glutathione S-transferase (GST) genes (GSTP1, GSTT1, and GSTM1). Method Using data from 266 case-control pairs of Jamaican children (2–8 years old), we fitted negative and positive generalized weighted quantile sum (gWQS) regression models to assess the aforementioned associations. Results Based on additive and interactive negative gWQS models adjusted for maternal age, parental education, child’s parish, and seafood consumption, we found inverse associations of the overall mixture score with ASD [MOR (95 % CI) = 0.70 (0.49, 0.99); P? En ligne : https://doi.org/10.1016/j.rasd.2020.101681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Interaction between a mixture of heavy metals (lead, mercury, arsenic, cadmium, manganese, aluminum) and GSTP1, GSTT1, and GSTM1 in relation to autism spectrum disorder [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MacKinsey A. BACH, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Katherine A. LOVELAND, Auteur . - 101681. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 79 (November 2020) . - 101681 Mots-clés : Autism Spectrum Disorder  Glutathione S-transferase (GST) genes ( and )  Mixture analysis  Generalized weighted quantile sum regression (gWQS)  Heavy metals  Jamaica Index. décimale : PER Périodiques Résumé : Background Exposure to many environmental chemicals, including metals, often does not occur in isolation, hence requires assessment of the associations between exposure to mixtures of chemicals and human health. Objectives To investigate associations of a metal mixture of lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd), manganese (Mn), and aluminum (Al) in children with autism spectrum disorder (ASD), additively or interactively with each of three glutathione S-transferase (GST) genes (GSTP1, GSTT1, and GSTM1). Method Using data from 266 case-control pairs of Jamaican children (2–8 years old), we fitted negative and positive generalized weighted quantile sum (gWQS) regression models to assess the aforementioned associations. Results Based on additive and interactive negative gWQS models adjusted for maternal age, parental education, child’s parish, and seafood consumption, we found inverse associations of the overall mixture score with ASD [MOR (95 % CI) = 0.70 (0.49, 0.99); P? En ligne : https://doi.org/10.1016/j.rasd.2020.101681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

Perinatal Factors Associated with Autism Spectrum Disorder in Jamaican Children / Sepideh SAROUKHANI in Journal of Autism and Developmental Disorders, 50-9 (September 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3341-3357 Titre : Perinatal Factors Associated with Autism Spectrum Disorder in Jamaican Children Type de document : Texte imprimé et/ou numérique Auteurs : Sepideh SAROUKHANI, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; MacKinsey A. BACH, Auteur ; Jan BRESSLER, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H RAHBAR, Auteur Article en page(s) : p.3341-3357 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Cesarean delivery  Jamaica  Low birth weight  Preterm birth  interest. Maureen Samms-Vaughan declares that she has no conflict of interest.  MinJae Lee declares that she has no conflict of interest. MacKinsey A. Bach declares  that she has no conflict of interest. Jan Bressler declares that she has no conflict  of interest. Manouchehr Hessabi declares that he has no conflict of interest. Megan  L. Grove declares that she has no conflict of interest. Sydonnie  Shakespeare-Pellington declares that she has no conflict of interest. Katherine A.  Loveland declares that she has no conflict of interest. Mohammad H. Rahbar declares  that he has no conflict of interest. Index. décimale : PER Périodiques Résumé : Mode of delivery, preterm birth, and low birth weight (LBW) are hypothesized to be associated with autism spectrum disorder (ASD) in the offspring. Using data from 343 ASD cases (2-8 years) and their age- and sex-matched typically developing controls in Jamaica we investigated these hypotheses. Our statistical analyses revealed that the parish of residence could modify the association between cesarean delivery and ASD, with a difference found in this relationship in Kingston parish [matched odds ratio (MOR) (95% confidence interval (CI)) 2.30 (1.17-4.53)] and other parishes [MOR (95% CI) 0.87 (0.48-1.59)]. Although the associations of LBW and preterm birth with ASD were not significant, we observed a significant interaction between LBW and the household socioeconomic status. These findings require replication. En ligne : http://dx.doi.org/10.1007/s10803-019-04229-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Perinatal Factors Associated with Autism Spectrum Disorder in Jamaican Children [Texte imprimé et/ou numérique] / Sepideh SAROUKHANI, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; MinJae LEE, Auteur ; MacKinsey A. BACH, Auteur ; Jan BRESSLER, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H RAHBAR, Auteur . - p.3341-3357. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-9 (September 2020) . - p.3341-3357 Mots-clés : Autism spectrum disorder  Cesarean delivery  Jamaica  Low birth weight  Preterm birth  interest. Maureen Samms-Vaughan declares that she has no conflict of interest.  MinJae Lee declares that she has no conflict of interest. MacKinsey A. Bach declares  that she has no conflict of interest. Jan Bressler declares that she has no conflict  of interest. Manouchehr Hessabi declares that he has no conflict of interest. Megan  L. Grove declares that she has no conflict of interest. Sydonnie  Shakespeare-Pellington declares that she has no conflict of interest. Katherine A.  Loveland declares that she has no conflict of interest. Mohammad H. Rahbar declares  that he has no conflict of interest. Index. décimale : PER Périodiques Résumé : Mode of delivery, preterm birth, and low birth weight (LBW) are hypothesized to be associated with autism spectrum disorder (ASD) in the offspring. Using data from 343 ASD cases (2-8 years) and their age- and sex-matched typically developing controls in Jamaica we investigated these hypotheses. Our statistical analyses revealed that the parish of residence could modify the association between cesarean delivery and ASD, with a difference found in this relationship in Kingston parish [matched odds ratio (MOR) (95% confidence interval (CI)) 2.30 (1.17-4.53)] and other parishes [MOR (95% CI) 0.87 (0.48-1.59)]. Although the associations of LBW and preterm birth with ASD were not significant, we observed a significant interaction between LBW and the household socioeconomic status. These findings require replication. En ligne : http://dx.doi.org/10.1007/s10803-019-04229-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

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