Brief Report: Genetic Links Between Autism and Suicidal Behavior-A Preliminary Investigation / Emily DIBLASI in Journal of Autism and Developmental Disorders, 50-10 (October 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3525-3530 Titre : Brief Report: Genetic Links Between Autism and Suicidal Behavior-A Preliminary Investigation Type de document : Texte imprimé et/ou numérique Auteurs : Emily DIBLASI, Auteur ; Anne V. KIRBY, Auteur ; Eoin GAJ, Auteur ; Anna R. DOCHERTY, Auteur ; Brooks R. KEESHIN, Auteur ; Amanda V. BAKIAN, Auteur ; Hilary COON, Auteur Article en page(s) : p.3525-3530 Langues : Anglais (eng) Mots-clés : Autism  Gene set enrichment  Genetic  Suicide  publicly-available databases and existing published literature  no direct research  was conducted with human participants nor animals. No informed consent procedures  were used. Index. décimale : PER Périodiques Résumé : Evidence suggests there may be increased risk for suicidal behavior among individuals with autism spectrum disorder (ASD). An emerging body of research explores social factors that may contribute to increased risk, however little is known about the potential role of biological factors. The current project addresses this knowledge gap through a preliminary study of genes associated with both ASD and suicidal behavior. Gene set enrichment tests of eight genes strongly associated with both ASD and suicidal behavior revealed overrepresentation of nine biological processes, including cognition and synapse function, and 14 cellular components, including the neuron, the synapse, and the synaptic and postsynaptic membrane. These results can be used to inform future investigations of the biological underpinnings of suicidal behavior and ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04419-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Brief Report: Genetic Links Between Autism and Suicidal Behavior-A Preliminary Investigation [Texte imprimé et/ou numérique] / Emily DIBLASI, Auteur ; Anne V. KIRBY, Auteur ; Eoin GAJ, Auteur ; Anna R. DOCHERTY, Auteur ; Brooks R. KEESHIN, Auteur ; Amanda V. BAKIAN, Auteur ; Hilary COON, Auteur . - p.3525-3530. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-10 (October 2020) . - p.3525-3530 Mots-clés : Autism  Gene set enrichment  Genetic  Suicide  publicly-available databases and existing published literature  no direct research  was conducted with human participants nor animals. No informed consent procedures  were used. Index. décimale : PER Périodiques Résumé : Evidence suggests there may be increased risk for suicidal behavior among individuals with autism spectrum disorder (ASD). An emerging body of research explores social factors that may contribute to increased risk, however little is known about the potential role of biological factors. The current project addresses this knowledge gap through a preliminary study of genes associated with both ASD and suicidal behavior. Gene set enrichment tests of eight genes strongly associated with both ASD and suicidal behavior revealed overrepresentation of nine biological processes, including cognition and synapse function, and 14 cellular components, including the neuron, the synapse, and the synaptic and postsynaptic membrane. These results can be used to inform future investigations of the biological underpinnings of suicidal behavior and ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04419-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Understanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies - a commentary on Lannoy et al. (2022) / Salahudeen MIRZA in Journal of Child Psychology and Psychiatry, 64-6 (June 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.968-971 Titre : Understanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies - a commentary on Lannoy et al. (2022) Type de document : Texte imprimé et/ou numérique Auteurs : Salahudeen MIRZA, Auteur ; Anna R. DOCHERTY, Auteur ; Eric T. MONSON, Auteur ; Hilary COON, Auteur ; Brooks KEESHIN, Auteur ; Gabriel R. FRIES, Auteur Article en page(s) : p.968-971 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Preventing suicidal thoughts and behaviours (STB) among youth is a global public health priority. STB are known to have a heritable basis, and the development of risk for STB likely arises from complex gene-environment interactions across the life course. Lannoy et al. (Journal of Child Psychology and Psychiatry, 63, 2022 and 1164) describe a study in which polygenic risk for suicide attempt, as well as recent negative life events, were related to recent suicidal ideation in adolescents of about 17?years old. Building on this important work, we highlight several critical areas of focus for research in suicide genetics, including problems of measurement, as well as priorities for better uncovering the specific aetiological pathways to STB. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13778 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Understanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies - a commentary on Lannoy et al. (2022) [Texte imprimé et/ou numérique] / Salahudeen MIRZA, Auteur ; Anna R. DOCHERTY, Auteur ; Eric T. MONSON, Auteur ; Hilary COON, Auteur ; Brooks KEESHIN, Auteur ; Gabriel R. FRIES, Auteur . - p.968-971. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.968-971 Index. décimale : PER Périodiques Résumé : Preventing suicidal thoughts and behaviours (STB) among youth is a global public health priority. STB are known to have a heritable basis, and the development of risk for STB likely arises from complex gene-environment interactions across the life course. Lannoy et al. (Journal of Child Psychology and Psychiatry, 63, 2022 and 1164) describe a study in which polygenic risk for suicide attempt, as well as recent negative life events, were related to recent suicidal ideation in adolescents of about 17?years old. Building on this important work, we highlight several critical areas of focus for research in suicide genetics, including problems of measurement, as well as priorities for better uncovering the specific aetiological pathways to STB. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13778 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

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