A longitudinal functional magnetic resonance imaging study of task control circuits and bulimic symptoms over adolescence / Marilyn CYR in Journal of Child Psychology and Psychiatry, 59-7 (July 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.752-762 Titre : A longitudinal functional magnetic resonance imaging study of task control circuits and bulimic symptoms over adolescence Type de document : texte imprimé Auteurs : Marilyn CYR, Auteur ; Martine FONTAINE, Auteur ; Mihaela STEFAN, Auteur ; Kate TERRANOVA, Auteur ; Daniel C. KOPALA-SIBLEY, Auteur ; Evelyn ATTIA, Auteur ; Rachel MARSH, Auteur Article en page(s) : p.752-762 Langues : Anglais (eng) Mots-clés : Bulimia Nervosa  adolescence  functional magnetic resonance images  longitudinal studies  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous cross-sectional findings from adolescents and adults with Bulimia Nervosa (BN) suggest disturbances in fronto-striatal and cingulo-opercular task control circuits that support self-regulatory processes, including the resolution of cognitive conflict. Herein, we used longitudinal data to examine the developmental trajectories of such disturbances and how the functioning of these circuits relates to changes in BN symptoms over adolescence. METHODS: Thirty-two adolescent females with BN symptoms and 28 healthy control (HC) adolescents participated in the study. Functional magnetic resonance images (fMRI) during performance of a Simon task were acquired at three time points within 2-year intervals over adolescence. From the initial sample, 70% and 30% of the participants completed the second and third time points, respectively. Participants who completed all study time points did not differ from those lost to attrition on baseline demographic characteristics or any outcome measures. Using a region-of-interest approach, growth curve models tested group differences in the trajectory of conflict-related activation in task control circuits over time. Cross-lagged panel models examined transactional relationships between conflict-related activation in the same regions and BN symptoms over time. RESULTS: Growth curve models revealed different trajectories of conflict-related activation in right task control regions across BN and HC adolescents, such that HC but not BN adolescents showed activation decreases over time. These group differences were greatest when including only the BN adolescents whose symptoms remitted over time. Cross-lagged panel models revealed that less frequent bulimic episodes at first follow-up predicted later increases in conflict-related activation in bilateral task control regions. CONCLUSIONS: These longitudinal findings suggest overengagement of task control circuits in BN adolescents, especially those most resilient to persistent illness. Such overengagement may compensate for regulatory disturbances, allowing them to regulate eating behaviors over development. Thus, task control circuits may constitute targets for early interventions that enhance self-regulatory control. En ligne : http://dx.doi.org/10.1111/jcpp.12840 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] A longitudinal functional magnetic resonance imaging study of task control circuits and bulimic symptoms over adolescence [texte imprimé] / Marilyn CYR, Auteur ; Martine FONTAINE, Auteur ; Mihaela STEFAN, Auteur ; Kate TERRANOVA, Auteur ; Daniel C. KOPALA-SIBLEY, Auteur ; Evelyn ATTIA, Auteur ; Rachel MARSH, Auteur . - p.752-762. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-7 (July 2018) . - p.752-762 Mots-clés : Bulimia Nervosa  adolescence  functional magnetic resonance images  longitudinal studies  self-control Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous cross-sectional findings from adolescents and adults with Bulimia Nervosa (BN) suggest disturbances in fronto-striatal and cingulo-opercular task control circuits that support self-regulatory processes, including the resolution of cognitive conflict. Herein, we used longitudinal data to examine the developmental trajectories of such disturbances and how the functioning of these circuits relates to changes in BN symptoms over adolescence. METHODS: Thirty-two adolescent females with BN symptoms and 28 healthy control (HC) adolescents participated in the study. Functional magnetic resonance images (fMRI) during performance of a Simon task were acquired at three time points within 2-year intervals over adolescence. From the initial sample, 70% and 30% of the participants completed the second and third time points, respectively. Participants who completed all study time points did not differ from those lost to attrition on baseline demographic characteristics or any outcome measures. Using a region-of-interest approach, growth curve models tested group differences in the trajectory of conflict-related activation in task control circuits over time. Cross-lagged panel models examined transactional relationships between conflict-related activation in the same regions and BN symptoms over time. RESULTS: Growth curve models revealed different trajectories of conflict-related activation in right task control regions across BN and HC adolescents, such that HC but not BN adolescents showed activation decreases over time. These group differences were greatest when including only the BN adolescents whose symptoms remitted over time. Cross-lagged panel models revealed that less frequent bulimic episodes at first follow-up predicted later increases in conflict-related activation in bilateral task control regions. CONCLUSIONS: These longitudinal findings suggest overengagement of task control circuits in BN adolescents, especially those most resilient to persistent illness. Such overengagement may compensate for regulatory disturbances, allowing them to regulate eating behaviors over development. Thus, task control circuits may constitute targets for early interventions that enhance self-regulatory control. En ligne : http://dx.doi.org/10.1111/jcpp.12840 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder / David PAGLIACCIO in Journal of Child Psychology and Psychiatry, 61-12 (December 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1299-1308 Titre : Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder Type de document : texte imprimé Auteurs : David PAGLIACCIO, Auteur ; Jiook CHA, Auteur ; Xiaofu HE, Auteur ; Marilyn CYR, Auteur ; Paula YANES-LUKIN, Auteur ; Pablo GOLDBERG, Auteur ; Martine FONTAINE, Auteur ; Moira A. RYNN, Auteur ; Rachel MARSH, Auteur Article en page(s) : p.1299-1308 Langues : Anglais (eng) Mots-clés : Child development  Cognitive therapy  Magnetic resonance imaging  Obsessive-compulsive disorder  Structural MRI (sMRI) Index. décimale : PER Périodiques Résumé : BACKGROUND: Cognitive behavioral therapy (CBT) is an effective, first-line treatment for pediatric obsessive-compulsive disorder (OCD). While neural predictors of treatment outcomes have been identified in adults with OCD, robust predictors are lacking for pediatric patients. Herein, we sought to identify brain structural markers of CBT response in youth with OCD. METHODS: Twenty-eight children/adolescents with OCD and 27 matched healthy participants (7- to 18-year-olds, M = 11.71 years, SD = 3.29) completed high-resolution structural and diffusion MRI (all unmedicated at time of scanning). Patients with OCD then completed 12-16 sessions of CBT. Subcortical volume and cortical thickness were estimated using FreeSurfer. Structural connectivity (streamline counts) was estimated using MRtrix. RESULTS: Thinner cortex in nine frontoparietal regions significantly predicted improvement in Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) scores (all ts > 3.4, FDR-corrected ps < .05). These included middle and superior frontal, angular, lingual, precentral, superior temporal, and supramarginal gyri (SMG). Vertex-wise analyses confirmed a significant left SMG cluster, showing large effect size (Cohen's d = 1.42) with 72.22% specificity and 90.00% sensitivity in predicting CBT response. Ten structural connections between cingulo-opercular regions exhibited fewer streamline counts in OCD (all ts > 3.12, Cohen's ds > 0.92) compared with healthy participants. These connections predicted post-treatment CY-BOCS scores, beyond pretreatment severity and demographics, though not above and beyond cortical thickness. CONCLUSIONS: The current study identified group differences in structural connectivity (reduced among cingulo-opercular regions) and cortical thickness predictors of CBT response (thinner frontoparietal cortices) in unmedicated children/adolescents with OCD. These data suggest, for the first time, that cortical and white matter features of task control circuits may be useful in identifying which pediatric patients respond best to individual CBT. En ligne : http://dx.doi.org/10.1111/jcpp.13191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Structural neural markers of response to cognitive behavioral therapy in pediatric obsessive-compulsive disorder [texte imprimé] / David PAGLIACCIO, Auteur ; Jiook CHA, Auteur ; Xiaofu HE, Auteur ; Marilyn CYR, Auteur ; Paula YANES-LUKIN, Auteur ; Pablo GOLDBERG, Auteur ; Martine FONTAINE, Auteur ; Moira A. RYNN, Auteur ; Rachel MARSH, Auteur . - p.1299-1308. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1299-1308 Mots-clés : Child development  Cognitive therapy  Magnetic resonance imaging  Obsessive-compulsive disorder  Structural MRI (sMRI) Index. décimale : PER Périodiques Résumé : BACKGROUND: Cognitive behavioral therapy (CBT) is an effective, first-line treatment for pediatric obsessive-compulsive disorder (OCD). While neural predictors of treatment outcomes have been identified in adults with OCD, robust predictors are lacking for pediatric patients. Herein, we sought to identify brain structural markers of CBT response in youth with OCD. METHODS: Twenty-eight children/adolescents with OCD and 27 matched healthy participants (7- to 18-year-olds, M = 11.71 years, SD = 3.29) completed high-resolution structural and diffusion MRI (all unmedicated at time of scanning). Patients with OCD then completed 12-16 sessions of CBT. Subcortical volume and cortical thickness were estimated using FreeSurfer. Structural connectivity (streamline counts) was estimated using MRtrix. RESULTS: Thinner cortex in nine frontoparietal regions significantly predicted improvement in Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) scores (all ts > 3.4, FDR-corrected ps < .05). These included middle and superior frontal, angular, lingual, precentral, superior temporal, and supramarginal gyri (SMG). Vertex-wise analyses confirmed a significant left SMG cluster, showing large effect size (Cohen's d = 1.42) with 72.22% specificity and 90.00% sensitivity in predicting CBT response. Ten structural connections between cingulo-opercular regions exhibited fewer streamline counts in OCD (all ts > 3.12, Cohen's ds > 0.92) compared with healthy participants. These connections predicted post-treatment CY-BOCS scores, beyond pretreatment severity and demographics, though not above and beyond cortical thickness. CONCLUSIONS: The current study identified group differences in structural connectivity (reduced among cingulo-opercular regions) and cortical thickness predictors of CBT response (thinner frontoparietal cortices) in unmedicated children/adolescents with OCD. These data suggest, for the first time, that cortical and white matter features of task control circuits may be useful in identifying which pediatric patients respond best to individual CBT. En ligne : http://dx.doi.org/10.1111/jcpp.13191 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

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