Communicative intentions in autism spectrum disorder / Magdalena SCHÃœTZ in Research in Autism Spectrum Disorders, 79 (November 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 79 (November 2020) . - 101666 Titre : Communicative intentions in autism spectrum disorder Type de document : texte imprimé Auteurs : Magdalena SCHÃœTZ, Auteur ; Angela CIARAMIDARO, Auteur ; Anne MARTINELLI, Auteur ; Ramona ÖLLER, Auteur ; Daniela HARTMANN, Auteur ; Grit HEIN, Auteur ; Vassil IOTZOV, Auteur ; Livia COLLE, Auteur ; Cristina BECCHIO, Auteur ; Henrik WALTER, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : 101666 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  fMRI  Intention  Communication  Social interaction Index. décimale : PER Périodiques Résumé : Background Deficits in social communication and interaction are among the core symptoms of Autism Spectrum Disorder (ASD). Intention understanding in particular has been shown to be impaired in ASD. However, only one previous study has explicitly assessed the understanding of communicative intentions in ASD. Thus, the aim of the present study was to compare neural activation during the observation of communicative and non-communicative actions in participants with ASD and typically developing (TD) controls using functional magnetic resonance imaging (fMRI). Based on recent findings that show that the degree of involvement of the observer has an impact on neural activation, the present study included first- and third-person perspective stimuli. Method Twenty-five male TD (mean age 20.41 ± 3.39) and twenty-two male participants with ASD (mean age 18.60 ± 3.55) were included. Stimuli consisted of videos in which actors performed an action with an everyday object. Actions were either private or communicative; communicative actions were either directed at the observer (first-person) or at a third person. Results The ASD group showed reduced activation in the human middle temporal complex (hMT+) across all conditions. However, modulation of activation in response to different conditions remained intact in ASD. Additionally, while TD showed an increase in premotor cortex (PMC) activation in response to communicative actions directed at them, the ASD group showed a decrease in activation. Conclusions These findings suggest an early processing deficit with regard to human biological motion in ASD. Furthermore, results reflect a reduced preparedness for social interactions in ASD compared to TD when addressed directly. En ligne : https://doi.org/10.1016/j.rasd.2020.101666 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Communicative intentions in autism spectrum disorder [texte imprimé] / Magdalena SCHÃœTZ, Auteur ; Angela CIARAMIDARO, Auteur ; Anne MARTINELLI, Auteur ; Ramona ÖLLER, Auteur ; Daniela HARTMANN, Auteur ; Grit HEIN, Auteur ; Vassil IOTZOV, Auteur ; Livia COLLE, Auteur ; Cristina BECCHIO, Auteur ; Henrik WALTER, Auteur ; Christine M. FREITAG, Auteur . - 101666. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 79 (November 2020) . - 101666 Mots-clés : Autism spectrum disorder  fMRI  Intention  Communication  Social interaction Index. décimale : PER Périodiques Résumé : Background Deficits in social communication and interaction are among the core symptoms of Autism Spectrum Disorder (ASD). Intention understanding in particular has been shown to be impaired in ASD. However, only one previous study has explicitly assessed the understanding of communicative intentions in ASD. Thus, the aim of the present study was to compare neural activation during the observation of communicative and non-communicative actions in participants with ASD and typically developing (TD) controls using functional magnetic resonance imaging (fMRI). Based on recent findings that show that the degree of involvement of the observer has an impact on neural activation, the present study included first- and third-person perspective stimuli. Method Twenty-five male TD (mean age 20.41 ± 3.39) and twenty-two male participants with ASD (mean age 18.60 ± 3.55) were included. Stimuli consisted of videos in which actors performed an action with an everyday object. Actions were either private or communicative; communicative actions were either directed at the observer (first-person) or at a third person. Results The ASD group showed reduced activation in the human middle temporal complex (hMT+) across all conditions. However, modulation of activation in response to different conditions remained intact in ASD. Additionally, while TD showed an increase in premotor cortex (PMC) activation in response to communicative actions directed at them, the ASD group showed a decrease in activation. Conclusions These findings suggest an early processing deficit with regard to human biological motion in ASD. Furthermore, results reflect a reduced preparedness for social interactions in ASD compared to TD when addressed directly. En ligne : https://doi.org/10.1016/j.rasd.2020.101666 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

Intention Attribution in Children and Adolescents with Autism Spectrum Disorder: An EEG Study / Magdalena SCHÃœTZ in Journal of Autism and Developmental Disorders, 53-4 (April 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1431-1443 Titre : Intention Attribution in Children and Adolescents with Autism Spectrum Disorder: An EEG Study Type de document : texte imprimé Auteurs : Magdalena SCHÃœTZ, Auteur ; Sara BOXHOORN, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Hannah MÖSSINGER, Auteur ; Christine M. FREITAG, Auteur ; Christina LUCKHARDT, Auteur Article en page(s) : p.1431-1443 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The ability to infer intentions from observed behavior and predict actions based on this inference, known as intention attribution (IA), has been hypothesized to be impaired in individuals with autism spectrum disorder (ASD). The underlying neural processes, however, have not been conclusively determined. The aim of this study was to examine the neural signature of IA in children and adolescents with ASD, and to elucidate potential links to contextual updating processes using electroencephalography. Results did not indicate that IA or early contextual updating was impaired in ASD. However, there was evidence of aberrant processing of expectation violations in ASD, particularly if the expectation was based on IA. Results are discussed within the context of impaired predictive coding in ASD. En ligne : https://doi.org/10.1007/s10803-021-05358-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] Intention Attribution in Children and Adolescents with Autism Spectrum Disorder: An EEG Study [texte imprimé] / Magdalena SCHÃœTZ, Auteur ; Sara BOXHOORN, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Hannah MÖSSINGER, Auteur ; Christine M. FREITAG, Auteur ; Christina LUCKHARDT, Auteur . - p.1431-1443. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-4 (April 2023) . - p.1431-1443 Index. décimale : PER Périodiques Résumé : The ability to infer intentions from observed behavior and predict actions based on this inference, known as intention attribution (IA), has been hypothesized to be impaired in individuals with autism spectrum disorder (ASD). The underlying neural processes, however, have not been conclusively determined. The aim of this study was to examine the neural signature of IA in children and adolescents with ASD, and to elucidate potential links to contextual updating processes using electroencephalography. Results did not indicate that IA or early contextual updating was impaired in ASD. However, there was evidence of aberrant processing of expectation violations in ASD, particularly if the expectation was based on IA. Results are discussed within the context of impaired predictive coding in ASD. En ligne : https://doi.org/10.1007/s10803-021-05358-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study / Christina LUCKHARDT in Autism Research, 18-9 (September 2025)  

Public ISBD [article]  inAutism Research > 18-9 (September 2025) . - p.1861-1876 Titre : Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study Type de document : texte imprimé Auteurs : Christina LUCKHARDT, Auteur ; Magdalena SCHÃœTZ, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Sara BOXHOORN, Auteur ; Christine ECKER, Auteur ; Hanna MÖSSINGER, Auteur ; Julia SIEMANN, Auteur ; Fabienne SCHLECHTER, Auteur ; Miguel CASTELO-BRANCO, Auteur ; Helena C. PEREIRA, Auteur ; Marianne LATINUS, Auteur ; Camille RICOU, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Ricardo SALVADOR, Auteur ; Giulio RUFFINI, Auteur ; Rafal NOWAK, Auteur ; Michael SINIATCHKIN, Auteur ; Astrid DEMPFLE, Auteur ; Christine M. FREITAG, Auteur ; Magdalena SCHÃœTZ, Auteur Article en page(s) : p.1861-1876 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham-controlled, double-blind parallel-group Phase-IIa trial, we investigated feasibility, safety, and effect sizes of 10 sessions of anodal tDCS of the bilateral TPJ at 2 mA as an add-on to computer-based social cognitive training in 10- to 17-year-old youth with autism. Feasibility of recruitment was low, with only 11% of screened individuals being randomized to tDCS (N=12) or sham (N=12). In contrast, retention in the study, data collection, intervention adherence, and technical feasibility were mostly excellent. No serious adverse events occurred, and stimulation was well tolerated. There were no differences in the prespecified primary outcome social responsiveness between sham and tDCS immediately after the intervention (standardized estimated effect size [ES]=0.098; 95%-confidence interval [95% CI] 1.043;1.240), but the sham group showed a trend for better social responsiveness at the 4 week follow-up (ES=1.106; 95% CI 0.054; 2.270). Secondary outcomes including questionnaires and event-related potentials showed improved compulsive behavior and quality of life by tDCS. High technical feasibility, participant retention, and safety highlight the potential of tDCS in autism and may inform future improvements in the feasibility of recruitment. The differential pattern of effect estimates indicates positive, but also potential negative effects of tDCS, which may vary due to tDCS stimulation parameters. The trial was prospectively registered in the German Clinical Trials Register (Deutsches Register für klinische Studien, DRKS, DRKS00014732). En ligne : https://doi.org/10.1002/aur.70084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Transcranial Direct Current Stimulation of the Temporoparietal Junction in Autism Spectrum Disorder: Results of a Phase-IIa Randomized, Double-Blind, Sham-Controlled Feasibility Study [texte imprimé] / Christina LUCKHARDT, Auteur ; Magdalena SCHÃœTZ, Auteur ; Andreas M. MÃœHLHERR, Auteur ; Sara BOXHOORN, Auteur ; Christine ECKER, Auteur ; Hanna MÖSSINGER, Auteur ; Julia SIEMANN, Auteur ; Fabienne SCHLECHTER, Auteur ; Miguel CASTELO-BRANCO, Auteur ; Helena C. PEREIRA, Auteur ; Marianne LATINUS, Auteur ; Camille RICOU, Auteur ; Frédérique BONNET-BRILHAULT, Auteur ; Ricardo SALVADOR, Auteur ; Giulio RUFFINI, Auteur ; Rafal NOWAK, Auteur ; Michael SINIATCHKIN, Auteur ; Astrid DEMPFLE, Auteur ; Christine M. FREITAG, Auteur ; Magdalena SCHÃœTZ, Auteur . - p.1861-1876. Langues : Anglais (eng) in Autism Research > 18-9 (September 2025) . - p.1861-1876 Index. décimale : PER Périodiques Résumé : ABSTRACT Activation of the temporoparietal junction (TPJ) is reduced in autism spectrum disorder (ASD) during social cognitive tasks. Therefore, anodal transcranial direct current stimulation (tDCS) of the TPJ may enhance social cognitive abilities in autistic individuals. In a multicenter, randomized, sham-controlled, double-blind parallel-group Phase-IIa trial, we investigated feasibility, safety, and effect sizes of 10 sessions of anodal tDCS of the bilateral TPJ at 2 mA as an add-on to computer-based social cognitive training in 10- to 17-year-old youth with autism. Feasibility of recruitment was low, with only 11% of screened individuals being randomized to tDCS (N=12) or sham (N=12). In contrast, retention in the study, data collection, intervention adherence, and technical feasibility were mostly excellent. No serious adverse events occurred, and stimulation was well tolerated. There were no differences in the prespecified primary outcome social responsiveness between sham and tDCS immediately after the intervention (standardized estimated effect size [ES]=0.098; 95%-confidence interval [95% CI] 1.043;1.240), but the sham group showed a trend for better social responsiveness at the 4 week follow-up (ES=1.106; 95% CI 0.054; 2.270). Secondary outcomes including questionnaires and event-related potentials showed improved compulsive behavior and quality of life by tDCS. High technical feasibility, participant retention, and safety highlight the potential of tDCS in autism and may inform future improvements in the feasibility of recruitment. The differential pattern of effect estimates indicates positive, but also potential negative effects of tDCS, which may vary due to tDCS stimulation parameters. The trial was prospectively registered in the German Clinical Trials Register (Deutsches Register für klinische Studien, DRKS, DRKS00014732). En ligne : https://doi.org/10.1002/aur.70084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

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