Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation / Michelle PEARL in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70344 Titre : Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation Type de document : texte imprimé Auteurs : Michelle PEARL, Auteur ; Kimberly BERGER, Auteur ; Piera M. CIRILLO, Auteur ; Nickilou Y. KRIGBAUM, Auteur ; Victor POON, Auteur ; Gayle C. WINDHAM, Auteur ; Barbara A. COHN, Auteur Année de publication : 2026 Article en page(s) : p.e70344 Langues : Anglais (eng) Mots-clés : alcoholic beverages  autism spectrum disorder  coffee  grandparents  prenatal exposure delayed effects  smoking  tea Index. décimale : PER Périodiques Résumé : ABSTRACT Exogenous prenatal exposures may affect neurodevelopment across multiple generations. We investigated grandmother and grandfather smoking, alcohol, coffee, and tea consumption during pregnancy in relation to their grandchildren's risk of autism spectrum disorder (ASD). Pregnant participants (grandparent generation) in the Child Health and Development Studies (CHDS) were interviewed between 1959 and 1967 about their own and their partners' smoking and consumption of alcohol, coffee, and tea. CHDS participant records were linked to 18,053 third-generation California births from 1989 to 2014, from which ASD cases were identified from Department of Developmental Services records. We estimated adjusted relative risk (aRR) of ASD associated with grandparents' smoking and consumption of alcoholic beverages, coffee, and tea from log-binomial regression models adjusted for grandparents' age, education, and grandmother's race. Grandfather's overall tobacco smoking (including pipes and cigars) during their partner's pregnancy was related to grandchild ASD (aRR?=?1.76, 95% confidence interval [1.05, 2.96]), as was grandfathers' cigarette smoking (aRR?=?1.67 [1.01, 2.76]), particularly smoking 20 or more cigarettes per day (aRR?=?1.91 [1.03, 3.55]), relative to no smoking. Alcohol consumption of five or more drinks of hard liquor per week by grandfathers was associated with ASD in grandchildren (aRR?=?2.90 [1.24, 6.79], relative to none), as was total consumption of nine or more total alcoholic drinks (aRR?=?1.87 [1.00, 3.51] relative to En ligne : https://doi.org/10.1002/aur.70344 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] Grandparent Prenatal Tobacco, Alcohol, Coffee, and Tea Consumption and Autism in the Third Generation [texte imprimé] / Michelle PEARL, Auteur ; Kimberly BERGER, Auteur ; Piera M. CIRILLO, Auteur ; Nickilou Y. KRIGBAUM, Auteur ; Victor POON, Auteur ; Gayle C. WINDHAM, Auteur ; Barbara A. COHN, Auteur . - 2026 . - p.e70344. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70344 Mots-clés : alcoholic beverages  autism spectrum disorder  coffee  grandparents  prenatal exposure delayed effects  smoking  tea Index. décimale : PER Périodiques Résumé : ABSTRACT Exogenous prenatal exposures may affect neurodevelopment across multiple generations. We investigated grandmother and grandfather smoking, alcohol, coffee, and tea consumption during pregnancy in relation to their grandchildren's risk of autism spectrum disorder (ASD). Pregnant participants (grandparent generation) in the Child Health and Development Studies (CHDS) were interviewed between 1959 and 1967 about their own and their partners' smoking and consumption of alcohol, coffee, and tea. CHDS participant records were linked to 18,053 third-generation California births from 1989 to 2014, from which ASD cases were identified from Department of Developmental Services records. We estimated adjusted relative risk (aRR) of ASD associated with grandparents' smoking and consumption of alcoholic beverages, coffee, and tea from log-binomial regression models adjusted for grandparents' age, education, and grandmother's race. Grandfather's overall tobacco smoking (including pipes and cigars) during their partner's pregnancy was related to grandchild ASD (aRR?=?1.76, 95% confidence interval [1.05, 2.96]), as was grandfathers' cigarette smoking (aRR?=?1.67 [1.01, 2.76]), particularly smoking 20 or more cigarettes per day (aRR?=?1.91 [1.03, 3.55]), relative to no smoking. Alcohol consumption of five or more drinks of hard liquor per week by grandfathers was associated with ASD in grandchildren (aRR?=?2.90 [1.24, 6.79], relative to none), as was total consumption of nine or more total alcoholic drinks (aRR?=?1.87 [1.00, 3.51] relative to En ligne : https://doi.org/10.1002/aur.70344 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD) or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups / Gayle C. WINDHAM in Autism Research, 13-12 (December 2020)  

Public ISBD [article]  inAutism Research > 13-12 (December 2020) . - p.2216-2229 Titre : Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD) or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups Type de document : texte imprimé Auteurs : Gayle C. WINDHAM, Auteur ; Michelle PEARL, Auteur ; Victor POON, Auteur ; Kimberly BERGER, Auteur ; Jasmine W. SORIANO, Auteur ; Darryl EYLES, Auteur ; Kristen LYALL, Auteur ; Martin KHARRAZI, Auteur ; Lisa A. CROEN, Auteur Article en page(s) : p.2216-2229 Langues : Anglais (eng) Mots-clés : 25(oh)d  Asd  autism  hydroxy-vitamin D  intellectual disability  race/ethnic differences  sex differences  vitamin D Index. décimale : PER Périodiques Résumé : Increasing vitamin D deficiency and evidence for vitamin D's role in brain and immune function have recently led to studies of neurodevelopment; however, few are specific to autism spectrum disorder (ASD) and vitamin D in pregnancy, a likely susceptibility period. We examined this in a case-control study of 2000-2003 Southern Californian births; ASD and intellectual disability (ID) were identified through the Department of Developmental Services and controls from birth certificates (N = 534, 181, and 421, respectively, in this analysis). Total 25-Hydroxyvitamin D (25(OH)D) was measured in mid-pregnancy serum, categorized as deficient (<50 nmol/L), insufficient (50-74 nmol/L), or sufficient (≥75 nmol/L, referent category), and examined continuously (per 25 nmol/L). Crude and adjusted odds ratios (AORs) and 95% confidence intervals (95% CI) were calculated. Non-linearity was examined with cubic splines. AORs (95% CI) for ASD were 0.79 (0.49-1.3) for maternal deficiency (9.5%), 0.93 (0.68-1.3) for insufficiency (25.6%), and 0.95 (0.86, 1.05) for linear continuous 25(OH)D. Results were similarly null for ASD with or without ID, and ID only. Interactions were observed; non-Hispanic whites (NHW) (AOR = 0.82, 95% CI = 0.69-0.98) and males (AOR = 0.89, 95% CI = 0.80-0.99) had protective associations for ASD with continuous 25(OH)D. A positive association with ASD was observed in females (AOR = 1.40, 95% CI = 1.06-1.85). With splines, a non-linear inverted j-shaped pattern was seen overall (P = 0.009 for non-linearity), with the peak around 100 nmol/L; a non-linear pattern was not observed among NHW, females, nor for ID. Our findings from a large study of ASD and prenatal vitamin D levels indicate that further research is needed to investigate non-linear patterns and potentially vulnerable sub-groups. LAY SUMMARY: We studied whether mothers' vitamin D levels during pregnancy were related to their children having autism (or low IQ) later. Low vitamin D levels were not related to greater risk of autism or low IQ in children overall. With higher levels of mothers' vitamin D, risk of autism went down in boys, but went up in girls. Risk of autism also went down in children of non-Hispanic white mothers with higher vitamin D levels, but we did not find a relation in other race/ethnic groups. En ligne : http://dx.doi.org/10.1002/aur.2424 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Maternal Vitamin D Levels During Pregnancy in Association With Autism Spectrum Disorders (ASD) or Intellectual Disability (ID) in Offspring; Exploring Non-linear Patterns and Demographic Sub-groups [texte imprimé] / Gayle C. WINDHAM, Auteur ; Michelle PEARL, Auteur ; Victor POON, Auteur ; Kimberly BERGER, Auteur ; Jasmine W. SORIANO, Auteur ; Darryl EYLES, Auteur ; Kristen LYALL, Auteur ; Martin KHARRAZI, Auteur ; Lisa A. CROEN, Auteur . - p.2216-2229. Langues : Anglais (eng) in Autism Research > 13-12 (December 2020) . - p.2216-2229 Mots-clés : 25(oh)d  Asd  autism  hydroxy-vitamin D  intellectual disability  race/ethnic differences  sex differences  vitamin D Index. décimale : PER Périodiques Résumé : Increasing vitamin D deficiency and evidence for vitamin D's role in brain and immune function have recently led to studies of neurodevelopment; however, few are specific to autism spectrum disorder (ASD) and vitamin D in pregnancy, a likely susceptibility period. We examined this in a case-control study of 2000-2003 Southern Californian births; ASD and intellectual disability (ID) were identified through the Department of Developmental Services and controls from birth certificates (N = 534, 181, and 421, respectively, in this analysis). Total 25-Hydroxyvitamin D (25(OH)D) was measured in mid-pregnancy serum, categorized as deficient (<50 nmol/L), insufficient (50-74 nmol/L), or sufficient (≥75 nmol/L, referent category), and examined continuously (per 25 nmol/L). Crude and adjusted odds ratios (AORs) and 95% confidence intervals (95% CI) were calculated. Non-linearity was examined with cubic splines. AORs (95% CI) for ASD were 0.79 (0.49-1.3) for maternal deficiency (9.5%), 0.93 (0.68-1.3) for insufficiency (25.6%), and 0.95 (0.86, 1.05) for linear continuous 25(OH)D. Results were similarly null for ASD with or without ID, and ID only. Interactions were observed; non-Hispanic whites (NHW) (AOR = 0.82, 95% CI = 0.69-0.98) and males (AOR = 0.89, 95% CI = 0.80-0.99) had protective associations for ASD with continuous 25(OH)D. A positive association with ASD was observed in females (AOR = 1.40, 95% CI = 1.06-1.85). With splines, a non-linear inverted j-shaped pattern was seen overall (P = 0.009 for non-linearity), with the peak around 100 nmol/L; a non-linear pattern was not observed among NHW, females, nor for ID. Our findings from a large study of ASD and prenatal vitamin D levels indicate that further research is needed to investigate non-linear patterns and potentially vulnerable sub-groups. LAY SUMMARY: We studied whether mothers' vitamin D levels during pregnancy were related to their children having autism (or low IQ) later. Low vitamin D levels were not related to greater risk of autism or low IQ in children overall. With higher levels of mothers' vitamin D, risk of autism went down in boys, but went up in girls. Risk of autism also went down in children of non-Hispanic white mothers with higher vitamin D levels, but we did not find a relation in other race/ethnic groups. En ligne : http://dx.doi.org/10.1002/aur.2424 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california / Gayle C. WINDHAM in Autism Research, 12-6 (June 2019)  

Public ISBD [article]  inAutism Research > 12-6 (June 2019) . - p.989-998 Titre : Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california Type de document : texte imprimé Auteurs : Gayle C. WINDHAM, Auteur ; Michelle PEARL, Auteur ; Meredith C. ANDERSON, Auteur ; Victor POON, Auteur ; Darryl EYLES, Auteur ; Karen L. JONES, Auteur ; Kristen LYALL, Auteur ; Martin KHARRAZI, Auteur ; Lisa A. CROEN, Auteur Année de publication : 2019 Article en page(s) : p.989-998 Langues : Anglais (eng) Mots-clés : Asd  autism  hydroxy-vitamin D  intellectual disability  vitamin D Index. décimale : PER Périodiques Résumé : Vitamin D deficiency has been increasing concurrently with prevalence of autism spectrum disorders (ASD), and emerging evidence suggests vitamin D is involved in brain development. Most prior studies of ASD examined vitamin D levels in children already diagnosed, but a few examined levels during perinatal development, the more likely susceptibility period. Therefore, we examined newborn vitamin D levels in a case-control study conducted among births in 2000-2003 in southern California. Children with ASD (N = 563) or intellectual disability (ID) (N = 190) were identified from the Department of Developmental Services and compared to population controls (N = 436) identified from birth certificates. 25-hydroxyvitamin D (25(OH)D) was measured in archived newborn dried blood spots by a sensitive assay and corrected to sera equivalents. We categorized 25(OH) D levels as deficient (<50 nmol/L), insufficient (50-74 nmol/L), and sufficient (>/=75 nmol/L), and also examined continuous levels, using logistic regression. The adjusted odds ratios (AOR) and 95% confidence intervals for ASD were 0.96 (0.64-1.4) for 25(OH)D deficiency (14% of newborns) and 1.2 (0.86-1.6) for insufficiency (26% of newborns). The AORs for continuous 25(OH)D (per 25 nmol/L) were 1.0 (0.91-1.09) for ASD and 1.14 (1.0-1.30) for ID. Thus, in this relatively large study of measured newborn vitamin D levels, our results do not support the hypothesis of lower 25(OH)D being associated with higher risk of ASD (or ID), although we observed suggestion of interactions with sex and race/ethnicity. 25(OH)D levels were relatively high (median 84 nmol/L in controls), so results may differ in populations with higher prevalence of low vitamin D levels. Autism Res 2019, 12: 989-998. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We studied whether vitamin D levels measured at birth were related to whether a child later developed autism (or low IQ). Our results did not show that children with autism, or low IQ, overall had lower vitamin D levels at birth than children without autism. Vitamin D levels were fairly high, on average, in these children born in Southern California. En ligne : https://dx.doi.org/10.1002/aur.2092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case-control study in california [texte imprimé] / Gayle C. WINDHAM, Auteur ; Michelle PEARL, Auteur ; Meredith C. ANDERSON, Auteur ; Victor POON, Auteur ; Darryl EYLES, Auteur ; Karen L. JONES, Auteur ; Kristen LYALL, Auteur ; Martin KHARRAZI, Auteur ; Lisa A. CROEN, Auteur . - 2019 . - p.989-998. Langues : Anglais (eng) in Autism Research > 12-6 (June 2019) . - p.989-998 Mots-clés : Asd  autism  hydroxy-vitamin D  intellectual disability  vitamin D Index. décimale : PER Périodiques Résumé : Vitamin D deficiency has been increasing concurrently with prevalence of autism spectrum disorders (ASD), and emerging evidence suggests vitamin D is involved in brain development. Most prior studies of ASD examined vitamin D levels in children already diagnosed, but a few examined levels during perinatal development, the more likely susceptibility period. Therefore, we examined newborn vitamin D levels in a case-control study conducted among births in 2000-2003 in southern California. Children with ASD (N = 563) or intellectual disability (ID) (N = 190) were identified from the Department of Developmental Services and compared to population controls (N = 436) identified from birth certificates. 25-hydroxyvitamin D (25(OH)D) was measured in archived newborn dried blood spots by a sensitive assay and corrected to sera equivalents. We categorized 25(OH) D levels as deficient (<50 nmol/L), insufficient (50-74 nmol/L), and sufficient (>/=75 nmol/L), and also examined continuous levels, using logistic regression. The adjusted odds ratios (AOR) and 95% confidence intervals for ASD were 0.96 (0.64-1.4) for 25(OH)D deficiency (14% of newborns) and 1.2 (0.86-1.6) for insufficiency (26% of newborns). The AORs for continuous 25(OH)D (per 25 nmol/L) were 1.0 (0.91-1.09) for ASD and 1.14 (1.0-1.30) for ID. Thus, in this relatively large study of measured newborn vitamin D levels, our results do not support the hypothesis of lower 25(OH)D being associated with higher risk of ASD (or ID), although we observed suggestion of interactions with sex and race/ethnicity. 25(OH)D levels were relatively high (median 84 nmol/L in controls), so results may differ in populations with higher prevalence of low vitamin D levels. Autism Res 2019, 12: 989-998. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We studied whether vitamin D levels measured at birth were related to whether a child later developed autism (or low IQ). Our results did not show that children with autism, or low IQ, overall had lower vitamin D levels at birth than children without autism. Vitamin D levels were fairly high, on average, in these children born in Southern California. En ligne : https://dx.doi.org/10.1002/aur.2092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

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