Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism / Sarah SCHAUBROECK in Journal of Autism and Developmental Disorders, 56-2 (February 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-2 (February 2026) . - p.633-647 Titre : Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism Type de document : texte imprimé Auteurs : Sarah SCHAUBROECK, Auteur ; Ellen DEMURIE, Auteur ; Jannath BEGUM-ALI, Auteur ; Sven BÖLTE, Auteur ; Sofie BOTERBERG, Auteur ; Jan BUITELAAR, Auteur ; Tony CHARMAN, Auteur ; Terje FALCK-YTTER, Auteur ; Sabine HUNNIUS, Auteur ; Mark JOHNSON, Auteur ; Emily JONES, Auteur ; Greg PASCO, Auteur ; Carlijn VAN DEN BOOMEN, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur Article en page(s) : p.633-647 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study examined the recurrence rate of autism in siblings at elevated likelihood (EL) and the predictive validity of the Q-CHAT and ADOS-2 at 14 and 24 months (m) for a clinical best estimate (CBE) autism diagnosis at 3 years. 331 EL-siblings (47.9% girls) from the prospective longitudinal EuroSibs study underwent ADOS-2 assessments and caregivers completed the Q-CHAT at 14 m and 24 m. At 3 years CBE was determined using DSM-5 criteria. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were estimated. Autism recurrence rate was 25.7% [95% CI (21.1, 30.6)]. Q-CHAT sensitivity was 31.8% [95% CI (21.4, 43.6)] at 14 m and 30.6% [95% CI (20.7, 41.7)] at 24 m. Specificity was 81.2% [95% CI (75.4, 86.2)] at 14 m and 94.8% [95% CI (91.2, 97.2)] at 24 m. PPV was 35.6% [95% CI (24.2, 48.2)] at 14 m and 66.7% [95% CI (49.8, 81.1)] at 24 m. NPV was 78.5% [95% CI (72.6, 83.7)] and 79.9% [95% CI (74.7, 84.6)] respectively. ADOS-2 demonstrated a of 64.3% [95% CI (45.9, 80.2)] and 69.3% [95% CI (58.4, 79.0)] and a specificity of 71.1% [95% CI (60.3, 80.4)] and 68.7% [95% CI (62.5, 74.5)] at 14 m and 24 m respectively. PPV was 45% [95% CI (30.3, 60.4)] at 14 m and 41.9% [95% CI (33.5, 50.7)] at 24 m. NPV was 84.4% [95% CI (74.2, 91.8)] at 14 m and 87.3% [95% CI (81.9, 91.6)] at 24 m. Q-CHAT and ADOS-2 at 14 m and 24 m can aid in early differentiation between EL-siblings who need further assessment and those who do not, but neither has sufficient sensitivity and PPV for standalone CBE diagnosis prediction. En ligne : https://doi.org/10.1007/s10803-024-06585-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580 [article] Investigating the Predictive Validity of the Quantitative Checklist for Autism in Toddlers and the Autism Diagnostic Observation Schedule-2 in Children at Elevated Likelihood for Autism [texte imprimé] / Sarah SCHAUBROECK, Auteur ; Ellen DEMURIE, Auteur ; Jannath BEGUM-ALI, Auteur ; Sven BÖLTE, Auteur ; Sofie BOTERBERG, Auteur ; Jan BUITELAAR, Auteur ; Tony CHARMAN, Auteur ; Terje FALCK-YTTER, Auteur ; Sabine HUNNIUS, Auteur ; Mark JOHNSON, Auteur ; Emily JONES, Auteur ; Greg PASCO, Auteur ; Carlijn VAN DEN BOOMEN, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur . - p.633-647. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-2 (February 2026) . - p.633-647 Index. décimale : PER Périodiques Résumé : This study examined the recurrence rate of autism in siblings at elevated likelihood (EL) and the predictive validity of the Q-CHAT and ADOS-2 at 14 and 24 months (m) for a clinical best estimate (CBE) autism diagnosis at 3 years. 331 EL-siblings (47.9% girls) from the prospective longitudinal EuroSibs study underwent ADOS-2 assessments and caregivers completed the Q-CHAT at 14 m and 24 m. At 3 years CBE was determined using DSM-5 criteria. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were estimated. Autism recurrence rate was 25.7% [95% CI (21.1, 30.6)]. Q-CHAT sensitivity was 31.8% [95% CI (21.4, 43.6)] at 14 m and 30.6% [95% CI (20.7, 41.7)] at 24 m. Specificity was 81.2% [95% CI (75.4, 86.2)] at 14 m and 94.8% [95% CI (91.2, 97.2)] at 24 m. PPV was 35.6% [95% CI (24.2, 48.2)] at 14 m and 66.7% [95% CI (49.8, 81.1)] at 24 m. NPV was 78.5% [95% CI (72.6, 83.7)] and 79.9% [95% CI (74.7, 84.6)] respectively. ADOS-2 demonstrated a of 64.3% [95% CI (45.9, 80.2)] and 69.3% [95% CI (58.4, 79.0)] and a specificity of 71.1% [95% CI (60.3, 80.4)] and 68.7% [95% CI (62.5, 74.5)] at 14 m and 24 m respectively. PPV was 45% [95% CI (30.3, 60.4)] at 14 m and 41.9% [95% CI (33.5, 50.7)] at 24 m. NPV was 84.4% [95% CI (74.2, 91.8)] at 14 m and 87.3% [95% CI (81.9, 91.6)] at 24 m. Q-CHAT and ADOS-2 at 14 m and 24 m can aid in early differentiation between EL-siblings who need further assessment and those who do not, but neither has sufficient sensitivity and PPV for standalone CBE diagnosis prediction. En ligne : https://doi.org/10.1007/s10803-024-06585-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580

Is It Fear? Similar Brain Responses to Fearful and Neutral Faces in Infants with a Heightened Likelihood for Autism Spectrum Disorder / Renata DI LORENZO in Journal of Autism and Developmental Disorders, 51-3 (March 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.961-972 Titre : Is It Fear? Similar Brain Responses to Fearful and Neutral Faces in Infants with a Heightened Likelihood for Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Renata DI LORENZO, Auteur ; Nicolette M. MUNSTERS, Auteur ; Emma K. WARD, Auteur ; Maretha V. DE JONGE, Auteur ; Chantal KEMNER, Auteur ; Carlijn VAN DEN BOOMEN, Auteur Article en page(s) : p.961-972 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Emotion  Endophenotype  Event-related potentials  Infants  Spatial frequency Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) show atypical processing of facial expressions. Research with autistic toddlers suggests that abnormalities in processing of spatial frequencies (SFs) contribute to such differences. The current event-related-potential (ERP) study investigated differences between 10-month-old infants with high- and low-likelihood for ASD in SF processing and in discrimination of fearful and neutral faces, filtered to contain specific SF. Results indicate no group differences in general processing of higher (HSF, detailed) and lower-SF (LSF, global) information. However, unlike low-likelihood infants, high-likelihood infants do not discriminate between facial expressions when either the LSF or HSF information is available. Combined with previous findings in toddlers, the current results indicate a developmental delay in efficient processing of facial expressions in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04560-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Is It Fear? Similar Brain Responses to Fearful and Neutral Faces in Infants with a Heightened Likelihood for Autism Spectrum Disorder [texte imprimé] / Renata DI LORENZO, Auteur ; Nicolette M. MUNSTERS, Auteur ; Emma K. WARD, Auteur ; Maretha V. DE JONGE, Auteur ; Chantal KEMNER, Auteur ; Carlijn VAN DEN BOOMEN, Auteur . - p.961-972. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.961-972 Mots-clés : Autism spectrum disorder  Emotion  Endophenotype  Event-related potentials  Infants  Spatial frequency Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) show atypical processing of facial expressions. Research with autistic toddlers suggests that abnormalities in processing of spatial frequencies (SFs) contribute to such differences. The current event-related-potential (ERP) study investigated differences between 10-month-old infants with high- and low-likelihood for ASD in SF processing and in discrimination of fearful and neutral faces, filtered to contain specific SF. Results indicate no group differences in general processing of higher (HSF, detailed) and lower-SF (LSF, global) information. However, unlike low-likelihood infants, high-likelihood infants do not discriminate between facial expressions when either the LSF or HSF information is available. Combined with previous findings in toddlers, the current results indicate a developmental delay in efficient processing of facial expressions in ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04560-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

The stability of the Autism Diagnostic Observation Schedule-2 in children aged 14–36 months with elevated likelihood for autism / Sarah SCHAUBROECK in Journal of Child Psychology and Psychiatry, 67-6 (June 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-6 (June 2026) . - p.869-880 Titre : The stability of the Autism Diagnostic Observation Schedule-2 in children aged 14–36 months with elevated likelihood for autism Type de document : texte imprimé Auteurs : Sarah SCHAUBROECK, Auteur ; Ellen DEMURIE, Auteur ; Jannath BEGUM-ALI, Auteur ; Sven BÖLTE, Auteur ; Sofie BOTERBERG, Auteur ; Jan BUITELAAR, Auteur ; Tony CHARMAN, Auteur ; Terje FALCK-YTTER, Auteur ; Sabine HUNNIUS, Auteur ; Mark H. JOHNSON, Auteur ; Emily JONES, Auteur ; Iris OOSTERLING, Auteur ; Greg PASCO, Auteur ; Mirjam PIJL, Auteur ; Carlijn VAN DEN BOOMEN, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur Article en page(s) : p.869-880 Langues : Anglais (eng) Mots-clés : Autism  stability  ADOS  diagnosis  EL-siblings Index. décimale : PER Périodiques Résumé : Background This study investigated the stability of Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) classifications in a cohort of 304 siblings at elevated likelihood for autism (EL-siblings). Methods ADOS-2 assessments were conducted at 14, 24 and 36?months, with Clinical Best Estimate (CBE) autism diagnoses determined at 36?months. Results Our findings indicate that while some children have stable ADOS-2 classifications from early on, a significant proportion of the children show inconsistent classifications over time. The overall stability of ADOS-2 autism spectrum classifications increased from 14 to 36?months and agreement with CBE autism clinical diagnosis was moderate and increased with age. Conclusions Caution is warranted when interpreting individual ADOS-2 results, as they should always complement, and can never replace, a comprehensive clinical evaluation. These findings highlight the importance of continued follow-up beyond 14?months in young EL-children, a group for whom early assessment may be both feasible and beneficial and emphasises the need to integrate multiple assessment measures and multiple informants for accurate early autism identification. En ligne : https://doi.org/10.1111/jcpp.70078 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587 [article] The stability of the Autism Diagnostic Observation Schedule-2 in children aged 14–36 months with elevated likelihood for autism [texte imprimé] / Sarah SCHAUBROECK, Auteur ; Ellen DEMURIE, Auteur ; Jannath BEGUM-ALI, Auteur ; Sven BÖLTE, Auteur ; Sofie BOTERBERG, Auteur ; Jan BUITELAAR, Auteur ; Tony CHARMAN, Auteur ; Terje FALCK-YTTER, Auteur ; Sabine HUNNIUS, Auteur ; Mark H. JOHNSON, Auteur ; Emily JONES, Auteur ; Iris OOSTERLING, Auteur ; Greg PASCO, Auteur ; Mirjam PIJL, Auteur ; Carlijn VAN DEN BOOMEN, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur . - p.869-880. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-6 (June 2026) . - p.869-880 Mots-clés : Autism  stability  ADOS  diagnosis  EL-siblings Index. décimale : PER Périodiques Résumé : Background This study investigated the stability of Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) classifications in a cohort of 304 siblings at elevated likelihood for autism (EL-siblings). Methods ADOS-2 assessments were conducted at 14, 24 and 36?months, with Clinical Best Estimate (CBE) autism diagnoses determined at 36?months. Results Our findings indicate that while some children have stable ADOS-2 classifications from early on, a significant proportion of the children show inconsistent classifications over time. The overall stability of ADOS-2 autism spectrum classifications increased from 14 to 36?months and agreement with CBE autism clinical diagnosis was moderate and increased with age. Conclusions Caution is warranted when interpreting individual ADOS-2 results, as they should always complement, and can never replace, a comprehensive clinical evaluation. These findings highlight the importance of continued follow-up beyond 14?months in young EL-children, a group for whom early assessment may be both feasible and beneficial and emphasises the need to integrate multiple assessment measures and multiple informants for accurate early autism identification. En ligne : https://doi.org/10.1111/jcpp.70078 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587

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