Atypical Head Movement during Face-to-Face Interaction in Children with Autism Spectrum Disorder / Z. ZHAO in Autism Research, 14-6 (June 2021)  

Public ISBD [article]  inAutism Research > 14-6 (June 2021) . - p.1197-1208 Titre : Atypical Head Movement during Face-to-Face Interaction in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Z. ZHAO, Auteur ; Z. ZHU, Auteur ; X. ZHANG, Auteur ; H. TANG, Auteur ; J. XING, Auteur ; X. HU, Auteur ; J. LU, Auteur ; Q. PENG, Auteur ; X. QU, Auteur Article en page(s) : p.1197-1208 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Fixation, Ocular  Head Movements  Humans  Stereotyped Behavior  autism  biomarker  eye tracking  head movement  stereotypy Index. décimale : PER Périodiques Résumé : The present study implemented an objective head pose tracking technique-OpenFace 2.0 to quantify the three dimensional head movement. Children with autism spectrum disorder (ASD) and typical development (TD) were engaged in a structured conversation with an interlocutress while wearing an eye tracker. We computed the head movement stereotypy with multiscale entropy analysis. In addition, the head rotation range (RR) and the amount of rotation per minute (ARPM) were calculated to quantify the extent of head movement. Results demonstrated that the ASD group had significantly higher level of movement stereotypy, RR and ARPM in all the three directions of head movement. Further analyses revealed that the extent of head movement could be significantly explained by movement stereotypy, but not by the amount of visual fixation to the interlocutress. These results demonstrated the atypical head movement dynamics in children with ASD during live interaction. It is proposed that head movement might potentially provide novel objective biomarkers of ASD. LAY SUMMARY: Our study used an objective tool to quantify head movement in children with autism. Results showed that children with autism had more stereotyped and greater head movement. We suggest that head movement tracking technique be widely used in autism research. En ligne : http://dx.doi.org/10.1002/aur.2478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Atypical Head Movement during Face-to-Face Interaction in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Z. ZHAO, Auteur ; Z. ZHU, Auteur ; X. ZHANG, Auteur ; H. TANG, Auteur ; J. XING, Auteur ; X. HU, Auteur ; J. LU, Auteur ; Q. PENG, Auteur ; X. QU, Auteur . - p.1197-1208. Langues : Anglais (eng) in Autism Research > 14-6 (June 2021) . - p.1197-1208 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Fixation, Ocular  Head Movements  Humans  Stereotyped Behavior  autism  biomarker  eye tracking  head movement  stereotypy Index. décimale : PER Périodiques Résumé : The present study implemented an objective head pose tracking technique-OpenFace 2.0 to quantify the three dimensional head movement. Children with autism spectrum disorder (ASD) and typical development (TD) were engaged in a structured conversation with an interlocutress while wearing an eye tracker. We computed the head movement stereotypy with multiscale entropy analysis. In addition, the head rotation range (RR) and the amount of rotation per minute (ARPM) were calculated to quantify the extent of head movement. Results demonstrated that the ASD group had significantly higher level of movement stereotypy, RR and ARPM in all the three directions of head movement. Further analyses revealed that the extent of head movement could be significantly explained by movement stereotypy, but not by the amount of visual fixation to the interlocutress. These results demonstrated the atypical head movement dynamics in children with ASD during live interaction. It is proposed that head movement might potentially provide novel objective biomarkers of ASD. LAY SUMMARY: Our study used an objective tool to quantify head movement in children with autism. Results showed that children with autism had more stereotyped and greater head movement. We suggest that head movement tracking technique be widely used in autism research. En ligne : http://dx.doi.org/10.1002/aur.2478 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Decreased homotopic interhemispheric functional connectivity in children with autism spectrum disorder / S. YAO in Autism Research, 14-8 (August 2021)  

Public ISBD [article]  inAutism Research > 14-8 (August 2021) . - p.1609-1620 Titre : Decreased homotopic interhemispheric functional connectivity in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. YAO, Auteur ; M. ZHOU, Auteur ; Y. ZHANG, Auteur ; F. ZHOU, Auteur ; Q. ZHANG, Auteur ; Z. ZHAO, Auteur ; X. JIANG, Auteur ; X. XU, Auteur ; B. BECKER, Auteur ; K. M. KENDRICK, Auteur Article en page(s) : p.1609-1620 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping  Child  Child, Preschool  Corpus Callosum/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  autism spectrum disorder  children  corpus callosum  homotopic interhemispheric functional connectivity  resting-state Index. décimale : PER Périodiques Résumé : While several functional and structural changes occur in large-scale brain networks in autism spectrum disorder (ASD), reduced interhemispheric resting-state functional connectivity (rsFC) between homotopic regions may be of particular importance as a biomarker. ASD is an early-onset developmental disorder and neural alterations are often age-dependent. Although there is some evidence for homotopic interhemispheric rsFC alterations in language processing regions in ASD children, wider analyses using large data sets have not been performed. The present study, therefore, conducted a voxel-based homotopic interhemispheric rsFC analysis in 146 ASD and 175 typically developing children under-age 10 and examined associations with symptom severity in the autism brain imaging data exchange data sets. Given the role of corpus callosum (CC) in interhemispheric connectivity and reported CC volume changes in ASD we additionally examined whether there were parallel volumetric changes. Results demonstrated decreased homotopic rsFC in ASD children in the posterior cingulate cortex (PCC) and precuneus of the default mode network, the precentral gyrus of the mirror neuron system, and the caudate of the reward system. Homotopic rsFC of the PCC was associated with symptom severity. Furthermore, although no significant CC volume changes were found in ASD children, there was a significant negative correlation between the anterior CC volumes and homotopic rsFC strengths in the caudate. The present study shows that a reduced pattern of homotopic interhemispheric rsFC in ASD adults/adolescents is already present in children of 5-10?years old and further supports their potential use as a general ASD biomarker. LAY SUMMARY: Homotopic interhemispheric functional connectivity plays an important role in synchronizing activity between the two hemispheres and is altered in adults and adolescents with autism spectrum disorder (ASD). In the present study focused on children with ASD, we have observed a similar pattern of decreased homotopic connectivity, suggesting that alterations in homotopic interhemispheric connectivity may occur early in ASD and be a useful general biomarker across ages. En ligne : http://dx.doi.org/10.1002/aur.2523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Decreased homotopic interhemispheric functional connectivity in children with autism spectrum disorder [Texte imprimé et/ou numérique] / S. YAO, Auteur ; M. ZHOU, Auteur ; Y. ZHANG, Auteur ; F. ZHOU, Auteur ; Q. ZHANG, Auteur ; Z. ZHAO, Auteur ; X. JIANG, Auteur ; X. XU, Auteur ; B. BECKER, Auteur ; K. M. KENDRICK, Auteur . - p.1609-1620. Langues : Anglais (eng) in Autism Research > 14-8 (August 2021) . - p.1609-1620 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Brain Mapping  Child  Child, Preschool  Corpus Callosum/diagnostic imaging  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  autism spectrum disorder  children  corpus callosum  homotopic interhemispheric functional connectivity  resting-state Index. décimale : PER Périodiques Résumé : While several functional and structural changes occur in large-scale brain networks in autism spectrum disorder (ASD), reduced interhemispheric resting-state functional connectivity (rsFC) between homotopic regions may be of particular importance as a biomarker. ASD is an early-onset developmental disorder and neural alterations are often age-dependent. Although there is some evidence for homotopic interhemispheric rsFC alterations in language processing regions in ASD children, wider analyses using large data sets have not been performed. The present study, therefore, conducted a voxel-based homotopic interhemispheric rsFC analysis in 146 ASD and 175 typically developing children under-age 10 and examined associations with symptom severity in the autism brain imaging data exchange data sets. Given the role of corpus callosum (CC) in interhemispheric connectivity and reported CC volume changes in ASD we additionally examined whether there were parallel volumetric changes. Results demonstrated decreased homotopic rsFC in ASD children in the posterior cingulate cortex (PCC) and precuneus of the default mode network, the precentral gyrus of the mirror neuron system, and the caudate of the reward system. Homotopic rsFC of the PCC was associated with symptom severity. Furthermore, although no significant CC volume changes were found in ASD children, there was a significant negative correlation between the anterior CC volumes and homotopic rsFC strengths in the caudate. The present study shows that a reduced pattern of homotopic interhemispheric rsFC in ASD adults/adolescents is already present in children of 5-10?years old and further supports their potential use as a general ASD biomarker. LAY SUMMARY: Homotopic interhemispheric functional connectivity plays an important role in synchronizing activity between the two hemispheres and is altered in adults and adolescents with autism spectrum disorder (ASD). In the present study focused on children with ASD, we have observed a similar pattern of decreased homotopic connectivity, suggesting that alterations in homotopic interhemispheric connectivity may occur early in ASD and be a useful general biomarker across ages. En ligne : http://dx.doi.org/10.1002/aur.2523 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Excessive and less complex body movement in children with autism during face-to-face conversation: An objective approach to behavioral quantification / Z. ZHAO in Autism Research, 15-2 (February 2022)  

Public ISBD [article]  inAutism Research > 15-2 (February 2022) . - p.305-316 Titre : Excessive and less complex body movement in children with autism during face-to-face conversation: An objective approach to behavioral quantification Type de document : Texte imprimé et/ou numérique Auteurs : Z. ZHAO, Auteur ; H. TANG, Auteur ; C. ALVIAR, Auteur ; C. T. KELLO, Auteur ; X. ZHANG, Auteur ; X. HU, Auteur ; X. QU, Auteur ; J. LU, Auteur Article en page(s) : p.305-316 Langues : Anglais (eng) Mots-clés : autism  complexity matching  face-to-face  movement dynamics  social interaction  spectral analysis Index. décimale : PER Périodiques Résumé : The majority of existing studies investigating characteristics of overt social behavior in individuals with autism spectrum disorder (ASD) relied on informants' evaluation through questionnaires and behavioral coding techniques. As a novelty, this study aimed to quantify the complex movements produced during social interactions in order to test differences in ASD movement dynamics and their convergence, or lack thereof, during social interactions. Twenty children with ASD and twenty-three children with typical development (TD) were videotaped while engaged in a face-to-face conversation with an interviewer. An image differencing technique was utilized to extract the movement time series. Spectral analyses were conducted to quantify the average power of movement, and the fractal scaling of movement. The degree of complexity matching was calculated to capture the level of behavioral coordination between the interviewer and children. Results demonstrated that the average power was significantly higher (p? En ligne : http://dx.doi.org/10.1002/aur.2646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Excessive and less complex body movement in children with autism during face-to-face conversation: An objective approach to behavioral quantification [Texte imprimé et/ou numérique] / Z. ZHAO, Auteur ; H. TANG, Auteur ; C. ALVIAR, Auteur ; C. T. KELLO, Auteur ; X. ZHANG, Auteur ; X. HU, Auteur ; X. QU, Auteur ; J. LU, Auteur . - p.305-316. Langues : Anglais (eng) in Autism Research > 15-2 (February 2022) . - p.305-316 Mots-clés : autism  complexity matching  face-to-face  movement dynamics  social interaction  spectral analysis Index. décimale : PER Périodiques Résumé : The majority of existing studies investigating characteristics of overt social behavior in individuals with autism spectrum disorder (ASD) relied on informants' evaluation through questionnaires and behavioral coding techniques. As a novelty, this study aimed to quantify the complex movements produced during social interactions in order to test differences in ASD movement dynamics and their convergence, or lack thereof, during social interactions. Twenty children with ASD and twenty-three children with typical development (TD) were videotaped while engaged in a face-to-face conversation with an interviewer. An image differencing technique was utilized to extract the movement time series. Spectral analyses were conducted to quantify the average power of movement, and the fractal scaling of movement. The degree of complexity matching was calculated to capture the level of behavioral coordination between the interviewer and children. Results demonstrated that the average power was significantly higher (p? En ligne : http://dx.doi.org/10.1002/aur.2646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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