Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands / A. LEFEBVRE in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2373-2382 Titre : Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands Type de document : Texte imprimé et/ou numérique Auteurs : A. LEFEBVRE, Auteur ; A. COHEN, Auteur ; A. MARUANI, Auteur ; Frédérique AMSELLEM, Auteur ; Anita BEGGIATO, Auteur ; Anouck AMESTOY, Auteur ; M. L. MOAL, Auteur ; D. UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; L. MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; M. LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; R. DELORME, Auteur Article en page(s) : p.2373-2382 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/genetics  Cognition  Humans  Obsessive-Compulsive Disorder/genetics  habits  heritability  neurodevelopment  phenotype Index. décimale : PER Périodiques Résumé : Repetitive behaviors (RB) represent a wide spectrum of symptoms ranging from sensory-motor stereotypies to complex cognitive rituals, frequently dichotomized as low- and high-order sub-groups of symptoms. Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (n = 1023). The discriminant analysis results in a classification of 81.1% of the controls (p? En ligne : http://dx.doi.org/10.1002/aur.2570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Discriminant value of repetitive behaviors in families with autism spectrum disorder and obsessional compulsive disorder probands [Texte imprimé et/ou numérique] / A. LEFEBVRE, Auteur ; A. COHEN, Auteur ; A. MARUANI, Auteur ; Frédérique AMSELLEM, Auteur ; Anita BEGGIATO, Auteur ; Anouck AMESTOY, Auteur ; M. L. MOAL, Auteur ; D. UMBRICHT, Auteur ; Christopher H. CHATHAM, Auteur ; L. MURTAGH, Auteur ; Manuel P. BOUVARD, Auteur ; M. LEBOYER, Auteur ; Thomas BOURGERON, Auteur ; R. DELORME, Auteur . - p.2373-2382. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2373-2382 Mots-clés : Autism Spectrum Disorder/complications/genetics  Cognition  Humans  Obsessive-Compulsive Disorder/genetics  habits  heritability  neurodevelopment  phenotype Index. décimale : PER Périodiques Résumé : Repetitive behaviors (RB) represent a wide spectrum of symptoms ranging from sensory-motor stereotypies to complex cognitive rituals, frequently dichotomized as low- and high-order sub-groups of symptoms. Even though these subgroups are considered as phenomenologically distinct in autism spectrum disorder (ASD) and obsessive-compulsive disorder (OCD), brain imaging and genetic studies suggest that they have common mechanisms and pathways. This discrepancy may be explained by the frequent intellectual disability reported in ASD, which blurs the RB expressivity. Given the high heritability of RB, that is, the diversity of symptoms expressed in the relatives are dependent on those expressed in their probands, we hypothesize that if RB expressed in ASD or OCD are two distinct entities, then the RB expressed in relatives will also reflect these two dimensions. We thus conduct a linear discriminant analysis on RB in both the relatives of probands with ASD and OCD and subjects from the general population (n = 1023). The discriminant analysis results in a classification of 81.1% of the controls (p? En ligne : http://dx.doi.org/10.1002/aur.2570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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