Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD / Elana J. FORBES in Journal of Autism and Developmental Disorders, 56-6 (June 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-6 (June 2026) . - p.2391-2407 Titre : Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD Type de document : texte imprimé Auteurs : Elana J. FORBES, Auteur ; Jeggan TIEGO, Auteur ; Joshua LANGMEAD, Auteur ; Kathryn E. UNRUH, Auteur ; Matthew W. MOSCONI, Auteur ; Amy FINLAY, Auteur ; Kathryn KALLADY, Auteur ; Lydia MACLACHLAN, Auteur ; Mia MOSES, Auteur ; Kai CAPPEL, Auteur ; Rachael KNOTT, Auteur ; Tracey CHAU, Auteur ; Vishnu Priya Mohanakumar SINDHU, Auteur ; Alessio BELLATO, Auteur ; Madeleine J. GROOM, Auteur ; Rebecca KERESTES, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur Article en page(s) : p.2391-2407 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Oculomotor characteristics, including accuracy, timing, and sensorimotor processing, are considered sensitive intermediate phenotypes for understanding the etiology of neurodevelopmental conditions, such as autism and ADHD. Oculomotor characteristics have predominantly been studied separately in autism and ADHD. Despite the high rates of co-occurrence between these conditions, only one study has investigated oculomotor processes among those with co-occurring autism + ADHD. Four hundred and five (n = 405; 226 males) Australian children and adolescents aged 4 to 18 years (M = 9.64 years; SD = 3.20 years) with ADHD (n = 64), autism (n = 66), autism + ADHD (n = 146), or neurotypical individuals (n = 129) were compared across four different oculomotor tasks: visually guided saccade, anti-saccade, sinusoidal pursuit and step-ramp pursuit. Confirmatory analyses were conducted using separate datasets acquired from the University of Nottingham UK (n = 17 autism, n = 22 ADHD, n = 32 autism + ADHD, n = 30 neurotypical) and University of Kansas USA (n = 29 autism, n = 41 neurotypical). Linear mixed effect models controlling for sex, age and family revealed that children and adolescents with autism + ADHD exhibited increased variability in the accuracy of the final saccadic eye position compared to neurotypical children and adolescents. Autistic children and adolescents demonstrated a greater number of catch-up saccades during step-ramp pursuit compared to neurotypical children and adolescents. These findings suggest that select differences in saccadic precision are unique to autistic individuals with co-occurring ADHD, indicating that measuring basic sensorimotor processes may be useful for parsing neurodevelopment and clinical heterogeneity in autism. En ligne : https://doi.org/10.1007/s10803-024-06718-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588 [article] Oculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD [texte imprimé] / Elana J. FORBES, Auteur ; Jeggan TIEGO, Auteur ; Joshua LANGMEAD, Auteur ; Kathryn E. UNRUH, Auteur ; Matthew W. MOSCONI, Auteur ; Amy FINLAY, Auteur ; Kathryn KALLADY, Auteur ; Lydia MACLACHLAN, Auteur ; Mia MOSES, Auteur ; Kai CAPPEL, Auteur ; Rachael KNOTT, Auteur ; Tracey CHAU, Auteur ; Vishnu Priya Mohanakumar SINDHU, Auteur ; Alessio BELLATO, Auteur ; Madeleine J. GROOM, Auteur ; Rebecca KERESTES, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur . - p.2391-2407. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-6 (June 2026) . - p.2391-2407 Index. décimale : PER Périodiques Résumé : Oculomotor characteristics, including accuracy, timing, and sensorimotor processing, are considered sensitive intermediate phenotypes for understanding the etiology of neurodevelopmental conditions, such as autism and ADHD. Oculomotor characteristics have predominantly been studied separately in autism and ADHD. Despite the high rates of co-occurrence between these conditions, only one study has investigated oculomotor processes among those with co-occurring autism + ADHD. Four hundred and five (n = 405; 226 males) Australian children and adolescents aged 4 to 18 years (M = 9.64 years; SD = 3.20 years) with ADHD (n = 64), autism (n = 66), autism + ADHD (n = 146), or neurotypical individuals (n = 129) were compared across four different oculomotor tasks: visually guided saccade, anti-saccade, sinusoidal pursuit and step-ramp pursuit. Confirmatory analyses were conducted using separate datasets acquired from the University of Nottingham UK (n = 17 autism, n = 22 ADHD, n = 32 autism + ADHD, n = 30 neurotypical) and University of Kansas USA (n = 29 autism, n = 41 neurotypical). Linear mixed effect models controlling for sex, age and family revealed that children and adolescents with autism + ADHD exhibited increased variability in the accuracy of the final saccadic eye position compared to neurotypical children and adolescents. Autistic children and adolescents demonstrated a greater number of catch-up saccades during step-ramp pursuit compared to neurotypical children and adolescents. These findings suggest that select differences in saccadic precision are unique to autistic individuals with co-occurring ADHD, indicating that measuring basic sensorimotor processes may be useful for parsing neurodevelopment and clinical heterogeneity in autism. En ligne : https://doi.org/10.1007/s10803-024-06718-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588

Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits / Martina ARENELLA in Autism, 26-2 (February 2022)  

Public ISBD [article]  inAutism > 26-2 (February 2022) . - p.361-372 Titre : Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits Type de document : texte imprimé Auteurs : Martina ARENELLA, Auteur ; Gemma CADBY, Auteur ; Ward DE WITTE, Auteur ; Rebecca M. JONES, Auteur ; Andrew J.O. WHITEHOUSE, Auteur ; Eric K. MOSES, Auteur ; Alex FORNITO, Auteur ; Mark A. BELLGROVE, Auteur ; Ziarih HAWI, Auteur ; Beth P. JOHNSON, Auteur ; Jeggan TIEGO, Auteur ; Jan K. BUITELAAR, Auteur ; Lambertus A. KIEMENEY, Auteur ; Geert POELMANS, Auteur ; Janita B. BRALTEN, Auteur Article en page(s) : p.361-372 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  genetics  immune system  molecular and cellular biology  conflicts of interest with respect to the research, authorship and/or publication of  this article: In the past 3?years, J.K.B. has been a consultant to, member of  advisory board of and speaker for Takeda/Shire, Roche, Medice, Novartis, Angelini  and Servier. He is not an employee of any of these companies, and a stock  shareholder of any of these companies. He has no other financial or material  support, including expert testimony, patients and royalties. G.P. is the director of  Drug Target ID, Ltd. The other authors declare no conflict of interest. Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are complex, with a strong genetic basis. Genetic research in autism spectrum disorders is limited by the fact that these disorders are largely heterogeneous so that patients are variable in their clinical presentations. To address this limitation, we investigated the genetics of individual dimensions of the autism spectrum disorder phenotypes, or autistic-like traits. These autistic-like traits are continuous variations in autistic behaviours that occur in the general population. Therefore, we meta-analysed data from four different population cohorts in which autistic-like traits were measured. We performed a set of genetic analyses to identify common variants for autistic-like traits, understand how these variants related to autism spectrum disorders, and how they contribute to neurobiological processes. Our results showed genetic associations with specific autistic-like traits and a link to the immune system. We offer an example of the potential to use a dimensional approach when dealing with heterogeneous, complex disorder like autism spectrum disorder. Decomposing the complex autism spectrum disorder phenotype in its core features can inform on the specific biology of these features which is likely to account to clinical variability in patients. En ligne : http://dx.doi.org/10.1177/13623613211019547 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] Potential role for immune-related genes in autism spectrum disorders: Evidence from genome-wide association meta-analysis of autistic traits [texte imprimé] / Martina ARENELLA, Auteur ; Gemma CADBY, Auteur ; Ward DE WITTE, Auteur ; Rebecca M. JONES, Auteur ; Andrew J.O. WHITEHOUSE, Auteur ; Eric K. MOSES, Auteur ; Alex FORNITO, Auteur ; Mark A. BELLGROVE, Auteur ; Ziarih HAWI, Auteur ; Beth P. JOHNSON, Auteur ; Jeggan TIEGO, Auteur ; Jan K. BUITELAAR, Auteur ; Lambertus A. KIEMENEY, Auteur ; Geert POELMANS, Auteur ; Janita B. BRALTEN, Auteur . - p.361-372. Langues : Anglais (eng) in Autism > 26-2 (February 2022) . - p.361-372 Mots-clés : autism spectrum disorders  genetics  immune system  molecular and cellular biology  conflicts of interest with respect to the research, authorship and/or publication of  this article: In the past 3?years, J.K.B. has been a consultant to, member of  advisory board of and speaker for Takeda/Shire, Roche, Medice, Novartis, Angelini  and Servier. He is not an employee of any of these companies, and a stock  shareholder of any of these companies. He has no other financial or material  support, including expert testimony, patients and royalties. G.P. is the director of  Drug Target ID, Ltd. The other authors declare no conflict of interest. Index. décimale : PER Périodiques Résumé : Autism spectrum disorders are complex, with a strong genetic basis. Genetic research in autism spectrum disorders is limited by the fact that these disorders are largely heterogeneous so that patients are variable in their clinical presentations. To address this limitation, we investigated the genetics of individual dimensions of the autism spectrum disorder phenotypes, or autistic-like traits. These autistic-like traits are continuous variations in autistic behaviours that occur in the general population. Therefore, we meta-analysed data from four different population cohorts in which autistic-like traits were measured. We performed a set of genetic analyses to identify common variants for autistic-like traits, understand how these variants related to autism spectrum disorders, and how they contribute to neurobiological processes. Our results showed genetic associations with specific autistic-like traits and a link to the immune system. We offer an example of the potential to use a dimensional approach when dealing with heterogeneous, complex disorder like autism spectrum disorder. Decomposing the complex autism spectrum disorder phenotype in its core features can inform on the specific biology of these features which is likely to account to clinical variability in patients. En ligne : http://dx.doi.org/10.1177/13623613211019547 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology / Rachael KNOTT in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 55 p. Titre : The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology Type de document : texte imprimé Auteurs : Rachael KNOTT, Auteur ; Beth P. JOHNSON, Auteur ; Jeggan TIEGO, Auteur ; Olivia MELLAHN, Auteur ; Amy FINLAY, Auteur ; Kathryn KALLADY, Auteur ; Maria KOUSPOS, Auteur ; Vishnu Priya MOHANAKUMAR SINDHU, Auteur ; Ziarih HAWI, Auteur ; Aurina ARNATKEVICIUTE, Auteur ; Tracey CHAU, Auteur ; Dalia MARON, Auteur ; Emily-Clare MERCIECA, Auteur ; Kirsten FURLEY, Auteur ; Katrina HARRIS, Auteur ; Katrina WILLIAMS, Auteur ; Alexandra URE, Auteur ; Alex FORNITO, Auteur ; Kylie M. GRAY, Auteur ; David COGHILL, Auteur ; Ann NICHOLSON, Auteur ; Dinh PHUNG, Auteur ; Eva LOTH, Auteur ; Luke MASON, Auteur ; Dennis MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Mark A. BELLGROVE, Auteur Article en page(s) : 55 p. Langues : Anglais (eng) Mots-clés : Adhd  Asd  Cognition  Eye-tracking  Genetics  HiTOP  Neuroimaging  RDoC Index. décimale : PER Périodiques Résumé : BACKGROUND: ASD and ADHD are prevalent neurodevelopmental disorders that frequently co-occur and have strong evidence for a degree of shared genetic aetiology. Behavioural and neurocognitive heterogeneity in ASD and ADHD has hampered attempts to map the underlying genetics and neurobiology, predict intervention response, and improve diagnostic accuracy. Moving away from categorical conceptualisations of psychopathology to a dimensional approach is anticipated to facilitate discovery of data-driven clusters and enhance our understanding of the neurobiological and genetic aetiology of these conditions. The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project is one of the first large-scale, family-based studies to take a truly transdiagnostic approach to ASD and ADHD. Using a comprehensive phenotyping protocol capturing dimensional traits central to ASD and ADHD, the MAGNET project aims to identify data-driven clusters across ADHD-ASD spectra using deep phenotyping of symptoms and behaviours; investigate the degree of familiality for different dimensional ASD-ADHD phenotypes and clusters; and map the neurocognitive, brain imaging, and genetic correlates of these data-driven symptom-based clusters. METHODS: The MAGNET project will recruit 1,200 families with children who are either typically developing, or who display elevated ASD, ADHD, or ASD-ADHD traits, in addition to affected and unaffected biological siblings of probands, and parents. All children will be comprehensively phenotyped for behavioural symptoms, comorbidities, neurocognitive and neuroimaging traits and genetics. CONCLUSION: The MAGNET project will be the first large-scale family study to take a transdiagnostic approach to ASD-ADHD, utilising deep phenotyping across behavioural, neurocognitive, brain imaging and genetic measures. En ligne : http://dx.doi.org/10.1186/s13229-021-00457-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project design and methodologies: a dimensional approach to understanding neurobiological and genetic aetiology [texte imprimé] / Rachael KNOTT, Auteur ; Beth P. JOHNSON, Auteur ; Jeggan TIEGO, Auteur ; Olivia MELLAHN, Auteur ; Amy FINLAY, Auteur ; Kathryn KALLADY, Auteur ; Maria KOUSPOS, Auteur ; Vishnu Priya MOHANAKUMAR SINDHU, Auteur ; Ziarih HAWI, Auteur ; Aurina ARNATKEVICIUTE, Auteur ; Tracey CHAU, Auteur ; Dalia MARON, Auteur ; Emily-Clare MERCIECA, Auteur ; Kirsten FURLEY, Auteur ; Katrina HARRIS, Auteur ; Katrina WILLIAMS, Auteur ; Alexandra URE, Auteur ; Alex FORNITO, Auteur ; Kylie M. GRAY, Auteur ; David COGHILL, Auteur ; Ann NICHOLSON, Auteur ; Dinh PHUNG, Auteur ; Eva LOTH, Auteur ; Luke MASON, Auteur ; Dennis MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Mark A. BELLGROVE, Auteur . - 55 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 55 p. Mots-clés : Adhd  Asd  Cognition  Eye-tracking  Genetics  HiTOP  Neuroimaging  RDoC Index. décimale : PER Périodiques Résumé : BACKGROUND: ASD and ADHD are prevalent neurodevelopmental disorders that frequently co-occur and have strong evidence for a degree of shared genetic aetiology. Behavioural and neurocognitive heterogeneity in ASD and ADHD has hampered attempts to map the underlying genetics and neurobiology, predict intervention response, and improve diagnostic accuracy. Moving away from categorical conceptualisations of psychopathology to a dimensional approach is anticipated to facilitate discovery of data-driven clusters and enhance our understanding of the neurobiological and genetic aetiology of these conditions. The Monash Autism-ADHD genetics and neurodevelopment (MAGNET) project is one of the first large-scale, family-based studies to take a truly transdiagnostic approach to ASD and ADHD. Using a comprehensive phenotyping protocol capturing dimensional traits central to ASD and ADHD, the MAGNET project aims to identify data-driven clusters across ADHD-ASD spectra using deep phenotyping of symptoms and behaviours; investigate the degree of familiality for different dimensional ASD-ADHD phenotypes and clusters; and map the neurocognitive, brain imaging, and genetic correlates of these data-driven symptom-based clusters. METHODS: The MAGNET project will recruit 1,200 families with children who are either typically developing, or who display elevated ASD, ADHD, or ASD-ADHD traits, in addition to affected and unaffected biological siblings of probands, and parents. All children will be comprehensively phenotyped for behavioural symptoms, comorbidities, neurocognitive and neuroimaging traits and genetics. CONCLUSION: The MAGNET project will be the first large-scale family study to take a transdiagnostic approach to ASD-ADHD, utilising deep phenotyping across behavioural, neurocognitive, brain imaging and genetic measures. En ligne : http://dx.doi.org/10.1186/s13229-021-00457-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

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