A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder / Craig J.R. SEWALL in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.905-915 Titre : A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder Type de document : texte imprimé Auteurs : Craig J.R. SEWALL, Auteur ; Jeffrey M. GIRARD, Auteur ; John MERRANKO, Auteur ; Danella HAFEMAN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Michael STROBER, Auteur ; Heather HOWER, Auteur ; Lauren M. WEINSTOCK, Auteur ; Shirley YEN, Auteur ; Neal D. RYAN, Auteur ; Martin B. KELLER, Auteur ; Fangzi LIAO, Auteur ; Rasim S. DILER, Auteur ; Mary KAY GILL, Auteur ; David A. AXELSON, Auteur ; Boris BIRMAHER, Auteur ; Tina R. GOLDSTEIN, Auteur Article en page(s) : p.905-915 Langues : Anglais (eng) Mots-clés : Adolescent  Bayes Theorem  Bipolar Disorder/epidemiology  Humans  Multilevel Analysis  Risk Factors  Suicidal Ideation  Suicide, Attempted  Bayesian analysis  Suicide  adolescence  bipolar disorder  parent-child relationships  peer relationships Index. décimale : PER Périodiques Résumé : BACKGROUND: Youth with bipolar disorder (BD) are at high risk for suicidal thoughts and behaviors and frequently experience interpersonal impairment, which is a risk factor for suicide. Yet, no study to date has examined the longitudinal associations between relationship quality in family/peer domains and suicidal thoughts and behaviors among youth with BD. Thus, we investigated how between-person differences - reflecting the average relationship quality across time - and within-person changes, reflecting recent fluctuations in relationship quality, act as distal and/or proximal risk factors for suicidal ideation (SI) and suicide attempts. METHODS: We used longitudinal data from the Course and Outcome of Bipolar Youth Study (N = 413). Relationship quality variables were decomposed into stable (i.e., average) and varying (i.e., recent) components and entered, along with major clinical covariates, into separate Bayesian multilevel models predicting SI and suicide attempt. We also examined how the relationship quality effects interacted with age and sex. RESULTS: Poorer average relationship quality with parents (β = -.33, 95% Bayesian highest density interval (HDI) [-0.54, -0.11]) or friends (β = -.33, 95% HDI [-0.55, -0.11]) was longitudinally associated with increased risk of SI but not suicide attempt. Worsening recent relationship quality with parents (β = -.10, 95% HDI [-0.19, -0.03]) and, to a lesser extent, friends (β = -.06, 95% HDI [-0.15, 0.03]) was longitudinally associated with increased risk of SI, but only worsening recent relationship quality with parents was also associated with increased risk of suicide attempt (β = -.15, 95% HDI [-0.31, 0.01]). The effects of certain relationship quality variables were moderated by gender but not age. CONCLUSIONS: Among youth with BD, having poorer average relationship quality with peers and/or parents represents a distal risk factor for SI but not suicide attempts. Additionally, worsening recent relationship quality with parents may be a time-sensitive indicator of increased risk for SI or suicide attempt. En ligne : http://dx.doi.org/10.1111/jcpp.13343 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] A Bayesian multilevel analysis of the longitudinal associations between relationship quality and suicidal ideation and attempts among youth with bipolar disorder [texte imprimé] / Craig J.R. SEWALL, Auteur ; Jeffrey M. GIRARD, Auteur ; John MERRANKO, Auteur ; Danella HAFEMAN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Michael STROBER, Auteur ; Heather HOWER, Auteur ; Lauren M. WEINSTOCK, Auteur ; Shirley YEN, Auteur ; Neal D. RYAN, Auteur ; Martin B. KELLER, Auteur ; Fangzi LIAO, Auteur ; Rasim S. DILER, Auteur ; Mary KAY GILL, Auteur ; David A. AXELSON, Auteur ; Boris BIRMAHER, Auteur ; Tina R. GOLDSTEIN, Auteur . - p.905-915. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.905-915 Mots-clés : Adolescent  Bayes Theorem  Bipolar Disorder/epidemiology  Humans  Multilevel Analysis  Risk Factors  Suicidal Ideation  Suicide, Attempted  Bayesian analysis  Suicide  adolescence  bipolar disorder  parent-child relationships  peer relationships Index. décimale : PER Périodiques Résumé : BACKGROUND: Youth with bipolar disorder (BD) are at high risk for suicidal thoughts and behaviors and frequently experience interpersonal impairment, which is a risk factor for suicide. Yet, no study to date has examined the longitudinal associations between relationship quality in family/peer domains and suicidal thoughts and behaviors among youth with BD. Thus, we investigated how between-person differences - reflecting the average relationship quality across time - and within-person changes, reflecting recent fluctuations in relationship quality, act as distal and/or proximal risk factors for suicidal ideation (SI) and suicide attempts. METHODS: We used longitudinal data from the Course and Outcome of Bipolar Youth Study (N = 413). Relationship quality variables were decomposed into stable (i.e., average) and varying (i.e., recent) components and entered, along with major clinical covariates, into separate Bayesian multilevel models predicting SI and suicide attempt. We also examined how the relationship quality effects interacted with age and sex. RESULTS: Poorer average relationship quality with parents (β = -.33, 95% Bayesian highest density interval (HDI) [-0.54, -0.11]) or friends (β = -.33, 95% HDI [-0.55, -0.11]) was longitudinally associated with increased risk of SI but not suicide attempt. Worsening recent relationship quality with parents (β = -.10, 95% HDI [-0.19, -0.03]) and, to a lesser extent, friends (β = -.06, 95% HDI [-0.15, 0.03]) was longitudinally associated with increased risk of SI, but only worsening recent relationship quality with parents was also associated with increased risk of suicide attempt (β = -.15, 95% HDI [-0.31, 0.01]). The effects of certain relationship quality variables were moderated by gender but not age. CONCLUSIONS: Among youth with BD, having poorer average relationship quality with peers and/or parents represents a distal risk factor for SI but not suicide attempts. Additionally, worsening recent relationship quality with parents may be a time-sensitive indicator of increased risk for SI or suicide attempt. En ligne : http://dx.doi.org/10.1111/jcpp.13343 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder / Danella M. HAFEMAN in Journal of Child Psychology and Psychiatry, 64-10 (October 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1492-1500 Titre : Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder Type de document : texte imprimé Auteurs : Danella M. HAFEMAN, Auteur ; John MERRANKO, Auteur ; Heather M. JOSEPH, Auteur ; Tina R. GOLDSTEIN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jessica LEVENSON, Auteur ; David A. AXELSON, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Satish IYENGAR, Auteur ; Boris BIRMAHER, Auteur Article en page(s) : p.1492-1500 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Offspring of parents with bipolar disorder (BD-I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school-age offspring of parents with BD, we previously built a risk calculator to predict BPSD onset, which generates person-level risk scores. Here, we test whether preschool symptoms predict school-age BPSD risk. Methods We assessed 113 offspring of parents with BD 1-3 times during preschool years (2-5 years old) and then approximately every 2 years for a mean of 10.6 years. We used penalized (lasso) regression with linear mixed models to assess relationships between preschool mood, anxiety, and behavioral symptoms (parent-reported) and school-age predictors of BPSD onset (i.e., risk score, subthreshold manic symptoms, and mood lability), adjusting for demographics and parental symptomatology. Finally, we conducted survival analyses to assess associations between preschool symptoms and school-age onset of BPSD and mood disorder. Results Of 113 preschool offspring, 33 developed new-onset mood disorder, including 19 with new-onset BPSD. Preschool irritability, sleep problems, and parental factors were lasso-selected predictors of school-age risk scores. After accounting for demographic and parental factors, preschool symptoms were no longer significant. Lasso regressions to predict mood lability and subthreshold manic symptoms yielded similar predictors (irritability, sleep problems, and parental affective lability), but preschool symptoms remained predictive even after adjusting for parental factors (ps<.005). Exploratory analyses indicated that preschool irritability univariately predicted new-onset BPSD (p =?.02) and mood disorder (p =?.02). Conclusions These results provide initial prospective evidence that, as early as preschool, youth who will develop elevated risk scores, mood lability, and subthreshold manic symptoms are already showing symptomatology; these preschool symptoms also predict new-onset BPSD. While replication of findings in larger samples is warranted, results point to the need for earlier assessment of risk and development of early interventions. En ligne : https://doi.org/10.1111/jcpp.13739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512 [article] Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder [texte imprimé] / Danella M. HAFEMAN, Auteur ; John MERRANKO, Auteur ; Heather M. JOSEPH, Auteur ; Tina R. GOLDSTEIN, Auteur ; Benjamin I. GOLDSTEIN, Auteur ; Jessica LEVENSON, Auteur ; David A. AXELSON, Auteur ; Kelly MONK, Auteur ; Dara SAKOLSKY, Auteur ; Satish IYENGAR, Auteur ; Boris BIRMAHER, Auteur . - p.1492-1500. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-10 (October 2023) . - p.1492-1500 Index. décimale : PER Périodiques Résumé : Background Offspring of parents with bipolar disorder (BD-I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school-age offspring of parents with BD, we previously built a risk calculator to predict BPSD onset, which generates person-level risk scores. Here, we test whether preschool symptoms predict school-age BPSD risk. Methods We assessed 113 offspring of parents with BD 1-3 times during preschool years (2-5 years old) and then approximately every 2 years for a mean of 10.6 years. We used penalized (lasso) regression with linear mixed models to assess relationships between preschool mood, anxiety, and behavioral symptoms (parent-reported) and school-age predictors of BPSD onset (i.e., risk score, subthreshold manic symptoms, and mood lability), adjusting for demographics and parental symptomatology. Finally, we conducted survival analyses to assess associations between preschool symptoms and school-age onset of BPSD and mood disorder. Results Of 113 preschool offspring, 33 developed new-onset mood disorder, including 19 with new-onset BPSD. Preschool irritability, sleep problems, and parental factors were lasso-selected predictors of school-age risk scores. After accounting for demographic and parental factors, preschool symptoms were no longer significant. Lasso regressions to predict mood lability and subthreshold manic symptoms yielded similar predictors (irritability, sleep problems, and parental affective lability), but preschool symptoms remained predictive even after adjusting for parental factors (ps<.005). Exploratory analyses indicated that preschool irritability univariately predicted new-onset BPSD (p =?.02) and mood disorder (p =?.02). Conclusions These results provide initial prospective evidence that, as early as preschool, youth who will develop elevated risk scores, mood lability, and subthreshold manic symptoms are already showing symptomatology; these preschool symptoms also predict new-onset BPSD. While replication of findings in larger samples is warranted, results point to the need for earlier assessment of risk and development of early interventions. En ligne : https://doi.org/10.1111/jcpp.13739 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=512

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