[article] 
inJournal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.720-729

Titre :	Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Lawrence SCAHILL, Auteur ; Kimberly A. STIGLER, Auteur ; James MULICK, Auteur ; Eric BUTTER, Auteur ; James DZIURA, Auteur ; Cynthia JOHNSON, Auteur ; Karen E. BEARSS, Auteur ; Louise RITZ, Auteur ; Christopher J. MCDOUGLE, Auteur ; Naomi SWIEZY, Auteur ; Michael G. AMAN, Auteur ; Benjamin L. HANDEN, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; Ann WAGNER, Auteur ; James T. MCCRACKEN, Auteur
Année de publication :	2009
Article en page(s) :	p.720-729
Langues :	Anglais (eng)
Mots-clés :	Autism Clinical-trial-methodology Risperidone Behavior-therapy
Index. décimale :	PER Périodiques
Résumé :	This paper presents the rationale for a 24-week, randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance, irritability and adaptive functioning. In this model, medication reduces tantrums, aggression and self-injury; parent training promotes improvement in noncompliance and adaptive functioning. Thus, medication and parent training target related, but separate, outcomes. At week 24, the medication was gradually withdrawn to determine whether subjects in the combined treatment group could be managed on a lower dose or off medication without relapse. Both symptom reduction and functional improvement are important clinical treatment targets. Thus, experimental evidence on the beneficial effects of combining pharmacotherapy and exportable behavioral interventions is needed to guide clinical practice.
En ligne :	http://dx.doi.org/10.1007/s10803-008-0675-2
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732

[article] Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; Kimberly A. STIGLER, Auteur ; James MULICK, Auteur ; Eric BUTTER, Auteur ; James DZIURA, Auteur ; Cynthia JOHNSON, Auteur ; Karen E. BEARSS, Auteur ; Louise RITZ, Auteur ; Christopher J. MCDOUGLE, Auteur ; Naomi SWIEZY, Auteur ; Michael G. AMAN, Auteur ; Benjamin L. HANDEN, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; Ann WAGNER, Auteur ; James T. MCCRACKEN, Auteur . - 2009 . - p.720-729.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.720-729

Mots-clés :	Autism Clinical-trial-methodology Risperidone Behavior-therapy
Index. décimale :	PER Périodiques
Résumé :	This paper presents the rationale for a 24-week, randomized trial designed to test whether risperidone plus structured parent training would be superior to risperidone only on measures of noncompliance, irritability and adaptive functioning. In this model, medication reduces tantrums, aggression and self-injury; parent training promotes improvement in noncompliance and adaptive functioning. Thus, medication and parent training target related, but separate, outcomes. At week 24, the medication was gradually withdrawn to determine whether subjects in the combined treatment group could be managed on a lower dose or off medication without relapse. Both symptom reduction and functional improvement are important clinical treatment targets. Thus, experimental evidence on the beneficial effects of combining pharmacotherapy and exportable behavioral interventions is needed to guide clinical practice.
En ligne :	http://dx.doi.org/10.1007/s10803-008-0675-2
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732