Incentive-elicited mesolimbic activation and externalizing symptomatology in adolescents / James M. BJORK in Journal of Child Psychology and Psychiatry, 51-7 (July 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.827-837 Titre : Incentive-elicited mesolimbic activation and externalizing symptomatology in adolescents Type de document : texte imprimé Auteurs : James M. BJORK, Auteur ; Gang CHEN, Auteur ; Ashley R. SMITH, Auteur ; Daniel W. HOMMER, Auteur Année de publication : 2010 Article en page(s) : p.827-837 Langues : Anglais (eng) Mots-clés : Conduct-disorder oppositional-defiant-disorder externalizing-disorders reward ventral-striatum nucleus-accumbens Index. décimale : PER Périodiques Résumé : Background: Opponent-process theories of externalizing disorders (ExD) attribute them to some combination of overactive reward processing systems and/or underactive behavior inhibition systems. Reward processing has been indexed by recruitment of incentive-motivational neurocircuitry of the ventral striatum (VS), including nucleus accumbens (NAcc). Methods: We used functional magnetic resonance imaging (fMRI) with an incentive task to determine whether externalizing symptomatology in adolescence is correlated with an enhanced VS recruitment by cues for rewards, or by deliveries of rewards. Twelve community-recruited adolescents with externalizing disorders (AED) and 12 age/gender-matched controls responded to targets to win or avoid losing $0, $0.20, $1, $5, or an unknown amount (ranging from $0.20 to $5). Results: Cues to respond for rewards activated the NAcc (relative to cues for no incentive), in both subject groups similarly, with greatest NAcc recruitment by cues for the largest reward. Loss-anticipatory NAcc signal increase was detected in a volume-of-interest analysis – but this increase occurred only in trials when subjects hit the target. Relative to controls, AED showed significantly elevated NAcc activation by a linear contrast between reward notification versus notification of failure to win reward. In a post hoc reanalysis, VS and pregenual anterior cingulate activation by the reward versus non-reward outcome contrast also directly correlated with Child Behavior Checklist (CBCL) Externalizing total scores (across all subjects) in lieu of a binary diagnosis. Finally, both groups showed right insula activation by loss notifications (contrasted with avoided losses). Conclusions: Externalizing behavior, whether assessed dimensionally with a questionnaire, or in the form of a diagnostic categorization, is associated with an exaggerated limbic response to outcomes of reward-directed behavior. This could be a neurobiological signature of the behavioral sensitivity to laboratory reward delivery that is characteristic of children with externalizing symptomatology. Of interest is future research on incentive-motivational processing in more severe, clinically referred AED. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02201.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] Incentive-elicited mesolimbic activation and externalizing symptomatology in adolescents [texte imprimé] / James M. BJORK, Auteur ; Gang CHEN, Auteur ; Ashley R. SMITH, Auteur ; Daniel W. HOMMER, Auteur . - 2010 . - p.827-837. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.827-837 Mots-clés : Conduct-disorder oppositional-defiant-disorder externalizing-disorders reward ventral-striatum nucleus-accumbens Index. décimale : PER Périodiques Résumé : Background: Opponent-process theories of externalizing disorders (ExD) attribute them to some combination of overactive reward processing systems and/or underactive behavior inhibition systems. Reward processing has been indexed by recruitment of incentive-motivational neurocircuitry of the ventral striatum (VS), including nucleus accumbens (NAcc). Methods: We used functional magnetic resonance imaging (fMRI) with an incentive task to determine whether externalizing symptomatology in adolescence is correlated with an enhanced VS recruitment by cues for rewards, or by deliveries of rewards. Twelve community-recruited adolescents with externalizing disorders (AED) and 12 age/gender-matched controls responded to targets to win or avoid losing $0, $0.20, $1, $5, or an unknown amount (ranging from $0.20 to $5). Results: Cues to respond for rewards activated the NAcc (relative to cues for no incentive), in both subject groups similarly, with greatest NAcc recruitment by cues for the largest reward. Loss-anticipatory NAcc signal increase was detected in a volume-of-interest analysis – but this increase occurred only in trials when subjects hit the target. Relative to controls, AED showed significantly elevated NAcc activation by a linear contrast between reward notification versus notification of failure to win reward. In a post hoc reanalysis, VS and pregenual anterior cingulate activation by the reward versus non-reward outcome contrast also directly correlated with Child Behavior Checklist (CBCL) Externalizing total scores (across all subjects) in lieu of a binary diagnosis. Finally, both groups showed right insula activation by loss notifications (contrasted with avoided losses). Conclusions: Externalizing behavior, whether assessed dimensionally with a questionnaire, or in the form of a diagnostic categorization, is associated with an exaggerated limbic response to outcomes of reward-directed behavior. This could be a neurobiological signature of the behavioral sensitivity to laboratory reward delivery that is characteristic of children with externalizing symptomatology. Of interest is future research on incentive-motivational processing in more severe, clinically referred AED. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02201.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

Using ecological momentary assessment to enhance irritability phenotyping in a transdiagnostic sample of youth / Reut NAIM in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1734-1746 Titre : Using ecological momentary assessment to enhance irritability phenotyping in a transdiagnostic sample of youth Type de document : texte imprimé Auteurs : Reut NAIM, Auteur ; Ashley SMITH, Auteur ; Amanda CHUE, Auteur ; Hannah GRASSIE, Auteur ; Julia LINKE, Auteur ; Kelly DOMBEK, Auteur ; Shannon SHAUGHNESSY, Auteur ; Cheri MCNEIL, Auteur ; Elise M. CARDINALE, Auteur ; Courtney AGORSOR, Auteur ; Sofia CARDENAS, Auteur ; Julia BROOKS, Auteur ; Anni R. SUBAR, Auteur ; Emily L. JONES, Auteur ; Quyen B. DO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur ; Katharina KIRCANSKI, Auteur Article en page(s) : p.1734-1746 Langues : Anglais (eng) Mots-clés : disruptive mood dysregulation disorder  ecological momentary assessment  frustrative nonreward  irritability  transdiagnostic Index. décimale : PER Périodiques Résumé : Irritability is a transdiagnostic symptom dimension in developmental psychopathology, closely related to the Research Domain Criteria (RDoC) construct of frustrative nonreward. Consistent with the RDoC framework and calls for transdiagnostic, developmentally-sensitive assessment methods, we report data from a smartphone-based, naturalistic ecological momentary assessment (EMA) study of irritability. We assessed 109 children and adolescents (Mage = 12.55 years; 75.20% male) encompassing several diagnostic groups – disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), anxiety disorders (ANX), healthy volunteers (HV). The participants rated symptoms three times per day for 1 week. Compliance with the EMA protocol was high. As tested using multilevel modeling, EMA ratings of irritability were strongly and consistently associated with in-clinic, gold-standard measures of irritability. Further, EMA ratings of irritability were significantly related to subjective frustration during a laboratory task eliciting frustrative nonreward. Irritability levels exhibited an expected graduated pattern across diagnostic groups, and the different EMA items measuring irritability were significantly associated with one another within all groups, supporting the transdiagnostic phenomenology of irritability. Additional analyses utilized EMA ratings of anxiety as a comparison with respect to convergent validity and transdiagnostic phenomenology. The results support new measurement tools that can be used in future studies of irritability and frustrative nonreward. En ligne : http://dx.doi.org/10.1017/S0954579421000717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Using ecological momentary assessment to enhance irritability phenotyping in a transdiagnostic sample of youth [texte imprimé] / Reut NAIM, Auteur ; Ashley SMITH, Auteur ; Amanda CHUE, Auteur ; Hannah GRASSIE, Auteur ; Julia LINKE, Auteur ; Kelly DOMBEK, Auteur ; Shannon SHAUGHNESSY, Auteur ; Cheri MCNEIL, Auteur ; Elise M. CARDINALE, Auteur ; Courtney AGORSOR, Auteur ; Sofia CARDENAS, Auteur ; Julia BROOKS, Auteur ; Anni R. SUBAR, Auteur ; Emily L. JONES, Auteur ; Quyen B. DO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur ; Katharina KIRCANSKI, Auteur . - p.1734-1746. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1734-1746 Mots-clés : disruptive mood dysregulation disorder  ecological momentary assessment  frustrative nonreward  irritability  transdiagnostic Index. décimale : PER Périodiques Résumé : Irritability is a transdiagnostic symptom dimension in developmental psychopathology, closely related to the Research Domain Criteria (RDoC) construct of frustrative nonreward. Consistent with the RDoC framework and calls for transdiagnostic, developmentally-sensitive assessment methods, we report data from a smartphone-based, naturalistic ecological momentary assessment (EMA) study of irritability. We assessed 109 children and adolescents (Mage = 12.55 years; 75.20% male) encompassing several diagnostic groups – disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), anxiety disorders (ANX), healthy volunteers (HV). The participants rated symptoms three times per day for 1 week. Compliance with the EMA protocol was high. As tested using multilevel modeling, EMA ratings of irritability were strongly and consistently associated with in-clinic, gold-standard measures of irritability. Further, EMA ratings of irritability were significantly related to subjective frustration during a laboratory task eliciting frustrative nonreward. Irritability levels exhibited an expected graduated pattern across diagnostic groups, and the different EMA items measuring irritability were significantly associated with one another within all groups, supporting the transdiagnostic phenomenology of irritability. Additional analyses utilized EMA ratings of anxiety as a comparison with respect to convergent validity and transdiagnostic phenomenology. The results support new measurement tools that can be used in future studies of irritability and frustrative nonreward. En ligne : http://dx.doi.org/10.1017/S0954579421000717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

---

1 (1 - 2 / 2) Par page : 25 50 100 200