Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach / Elise M. CARDINALE in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.917-929 Titre : Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach Type de document : Texte imprimé et/ou numérique Auteurs : Elise M. CARDINALE, Auteur ; Katharina KIRCANSKI, Auteur ; Julia BROOKS, Auteur ; Andrea L. GOLD, Auteur ; Kenneth E. TOWBIN, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur Article en page(s) : p.917-929 Langues : Anglais (eng) Mots-clés : anxiety  bifactor model  cortical structure  irritability  subcortical volume Index. décimale : PER Périodiques Résumé : Irritability and anxiety are two common clinical phenotypes that involve high-arousal negative affect states (anger and fear), and that frequently co-occur. Elucidating how these two forms of emotion dysregulation relate to perturbed neurodevelopment may benefit from alternate phenotyping strategies. One such strategy applies a bifactor latent variable approach that can parse shared versus unique mechanisms of these two phenotypes. Here, we aim to replicate and extend this approach and examine associations with neural structure in a large transdiagnostic sample of youth (N = 331; M = 13.57, SD = 2.69 years old; 45.92% male). FreeSurfer was used to extract cortical thickness, cortical surface area, and subcortical volume. The current findings replicated the bifactor model and demonstrate measurement invariance as a function of youth age and sex. There were no associations of youth's factor scores with cortical thickness, surface area, or subcortical volume. However, we found strong convergent and divergent validity between parent-reported irritability and anxiety factors with clinician-rated symptoms and impairment. A general negative affectivity factor was robustly associated with overall functional impairment across symptom domains. Together, these results support the utility of the bifactor model as an alternative phenotyping strategy for irritability and anxiety, which may aid in the development of targeted treatments. En ligne : http://dx.doi.org/10.1017/S095457941900035X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach [Texte imprimé et/ou numérique] / Elise M. CARDINALE, Auteur ; Katharina KIRCANSKI, Auteur ; Julia BROOKS, Auteur ; Andrea L. GOLD, Auteur ; Kenneth E. TOWBIN, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur . - p.917-929. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.917-929 Mots-clés : anxiety  bifactor model  cortical structure  irritability  subcortical volume Index. décimale : PER Périodiques Résumé : Irritability and anxiety are two common clinical phenotypes that involve high-arousal negative affect states (anger and fear), and that frequently co-occur. Elucidating how these two forms of emotion dysregulation relate to perturbed neurodevelopment may benefit from alternate phenotyping strategies. One such strategy applies a bifactor latent variable approach that can parse shared versus unique mechanisms of these two phenotypes. Here, we aim to replicate and extend this approach and examine associations with neural structure in a large transdiagnostic sample of youth (N = 331; M = 13.57, SD = 2.69 years old; 45.92% male). FreeSurfer was used to extract cortical thickness, cortical surface area, and subcortical volume. The current findings replicated the bifactor model and demonstrate measurement invariance as a function of youth age and sex. There were no associations of youth's factor scores with cortical thickness, surface area, or subcortical volume. However, we found strong convergent and divergent validity between parent-reported irritability and anxiety factors with clinician-rated symptoms and impairment. A general negative affectivity factor was robustly associated with overall functional impairment across symptom domains. Together, these results support the utility of the bifactor model as an alternative phenotyping strategy for irritability and anxiety, which may aid in the development of targeted treatments. En ligne : http://dx.doi.org/10.1017/S095457941900035X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Using ecological momentary assessment to enhance irritability phenotyping in a transdiagnostic sample of youth / Reut NAIM in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1734-1746 Titre : Using ecological momentary assessment to enhance irritability phenotyping in a transdiagnostic sample of youth Type de document : Texte imprimé et/ou numérique Auteurs : Reut NAIM, Auteur ; Ashley SMITH, Auteur ; Amanda CHUE, Auteur ; Hannah GRASSIE, Auteur ; Julia LINKE, Auteur ; Kelly DOMBEK, Auteur ; Shannon SHAUGHNESSY, Auteur ; Cheri MCNEIL, Auteur ; Elise M. CARDINALE, Auteur ; Courtney AGORSOR, Auteur ; Sofia CARDENAS, Auteur ; Julia BROOKS, Auteur ; Anni R. SUBAR, Auteur ; Emily L. JONES, Auteur ; Quyen B. DO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur ; Katharina KIRCANSKI, Auteur Article en page(s) : p.1734-1746 Langues : Anglais (eng) Mots-clés : disruptive mood dysregulation disorder  ecological momentary assessment  frustrative nonreward  irritability  transdiagnostic Index. décimale : PER Périodiques Résumé : Irritability is a transdiagnostic symptom dimension in developmental psychopathology, closely related to the Research Domain Criteria (RDoC) construct of frustrative nonreward. Consistent with the RDoC framework and calls for transdiagnostic, developmentally-sensitive assessment methods, we report data from a smartphone-based, naturalistic ecological momentary assessment (EMA) study of irritability. We assessed 109 children and adolescents (Mage = 12.55 years; 75.20% male) encompassing several diagnostic groups – disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), anxiety disorders (ANX), healthy volunteers (HV). The participants rated symptoms three times per day for 1 week. Compliance with the EMA protocol was high. As tested using multilevel modeling, EMA ratings of irritability were strongly and consistently associated with in-clinic, gold-standard measures of irritability. Further, EMA ratings of irritability were significantly related to subjective frustration during a laboratory task eliciting frustrative nonreward. Irritability levels exhibited an expected graduated pattern across diagnostic groups, and the different EMA items measuring irritability were significantly associated with one another within all groups, supporting the transdiagnostic phenomenology of irritability. Additional analyses utilized EMA ratings of anxiety as a comparison with respect to convergent validity and transdiagnostic phenomenology. The results support new measurement tools that can be used in future studies of irritability and frustrative nonreward. En ligne : http://dx.doi.org/10.1017/S0954579421000717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Using ecological momentary assessment to enhance irritability phenotyping in a transdiagnostic sample of youth [Texte imprimé et/ou numérique] / Reut NAIM, Auteur ; Ashley SMITH, Auteur ; Amanda CHUE, Auteur ; Hannah GRASSIE, Auteur ; Julia LINKE, Auteur ; Kelly DOMBEK, Auteur ; Shannon SHAUGHNESSY, Auteur ; Cheri MCNEIL, Auteur ; Elise M. CARDINALE, Auteur ; Courtney AGORSOR, Auteur ; Sofia CARDENAS, Auteur ; Julia BROOKS, Auteur ; Anni R. SUBAR, Auteur ; Emily L. JONES, Auteur ; Quyen B. DO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur ; Katharina KIRCANSKI, Auteur . - p.1734-1746. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1734-1746 Mots-clés : disruptive mood dysregulation disorder  ecological momentary assessment  frustrative nonreward  irritability  transdiagnostic Index. décimale : PER Périodiques Résumé : Irritability is a transdiagnostic symptom dimension in developmental psychopathology, closely related to the Research Domain Criteria (RDoC) construct of frustrative nonreward. Consistent with the RDoC framework and calls for transdiagnostic, developmentally-sensitive assessment methods, we report data from a smartphone-based, naturalistic ecological momentary assessment (EMA) study of irritability. We assessed 109 children and adolescents (Mage = 12.55 years; 75.20% male) encompassing several diagnostic groups – disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), anxiety disorders (ANX), healthy volunteers (HV). The participants rated symptoms three times per day for 1 week. Compliance with the EMA protocol was high. As tested using multilevel modeling, EMA ratings of irritability were strongly and consistently associated with in-clinic, gold-standard measures of irritability. Further, EMA ratings of irritability were significantly related to subjective frustration during a laboratory task eliciting frustrative nonreward. Irritability levels exhibited an expected graduated pattern across diagnostic groups, and the different EMA items measuring irritability were significantly associated with one another within all groups, supporting the transdiagnostic phenomenology of irritability. Additional analyses utilized EMA ratings of anxiety as a comparison with respect to convergent validity and transdiagnostic phenomenology. The results support new measurement tools that can be used in future studies of irritability and frustrative nonreward. En ligne : http://dx.doi.org/10.1017/S0954579421000717 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

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