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Irritability in boys with autism spectrum disorders: an investigation of physiological reactivity / Nina MIKITA in Journal of Child Psychology and Psychiatry, 56-10 (October 2015)
[article]
Titre : Irritability in boys with autism spectrum disorders: an investigation of physiological reactivity Type de document : Texte imprimé et/ou numérique Auteurs : Nina MIKITA, Auteur ; Matthew J. HOLLOCKS, Auteur ; Andrew S. PAPADOPOULOS, Auteur ; Alexandra ASLANI, Auteur ; Simon HARRISON, Auteur ; Ellen LEIBENLUFT, Auteur ; Emily SIMONOFF, Auteur ; Argyris STRINGARIS, Auteur Article en page(s) : p.1118-1126 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders irritability cortisol heart rate psychosocial stress test Index. décimale : PER Périodiques Résumé : Background Irritability in people with autism spectrum disorders (ASD) is common and impairing, yet its mechanisms remain understudied. We investigated symptom reporting and mechanisms of irritability in ASD, focusing on the relation between irritability and physiological stress responses. Methods Forty-seven unmedicated boys with high-functioning ASD (hfASD) and 23 typically developing boys aged 10–16 years completed a psychosocial stress test. Changes in cortisol, heart rate and heart rate variability throughout the test were recorded. Self- and parent-reported measures of irritability were obtained. Irritability symptom reporting in the hfASD group was compared to two groups of boys without ASD: highly irritable boys (severe mood dysregulation, SMD; n = 40) and healthy-control boys (HC; n = 30). Results Boys with hfASD scored significantly higher on irritability than HC boys, and they reported a pattern of irritability symptoms closely resembling that of boys with SMD. The internal consistency of irritability in hfASD was high by parent- and self-report. Although boys with hfASD showed significant stress-induced changes in cortisol and heart rate, those who rated themselves as highly irritable had lower cortisol levels throughout the test compared to those low on irritability. Participants rated as highly irritable by their parents showed blunted cortisol and heart rate responses to stress. The effects of irritability on heart rate, but not cortisol, were accounted for by trait anxiety. Conclusions Irritability can be measured reliably in hfASD and is associated with distinct biological responses to stress. En ligne : http://dx.doi.org/10.1111/jcpp.12382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269
in Journal of Child Psychology and Psychiatry > 56-10 (October 2015) . - p.1118-1126[article] Irritability in boys with autism spectrum disorders: an investigation of physiological reactivity [Texte imprimé et/ou numérique] / Nina MIKITA, Auteur ; Matthew J. HOLLOCKS, Auteur ; Andrew S. PAPADOPOULOS, Auteur ; Alexandra ASLANI, Auteur ; Simon HARRISON, Auteur ; Ellen LEIBENLUFT, Auteur ; Emily SIMONOFF, Auteur ; Argyris STRINGARIS, Auteur . - p.1118-1126.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 56-10 (October 2015) . - p.1118-1126
Mots-clés : Autism spectrum disorders irritability cortisol heart rate psychosocial stress test Index. décimale : PER Périodiques Résumé : Background Irritability in people with autism spectrum disorders (ASD) is common and impairing, yet its mechanisms remain understudied. We investigated symptom reporting and mechanisms of irritability in ASD, focusing on the relation between irritability and physiological stress responses. Methods Forty-seven unmedicated boys with high-functioning ASD (hfASD) and 23 typically developing boys aged 10–16 years completed a psychosocial stress test. Changes in cortisol, heart rate and heart rate variability throughout the test were recorded. Self- and parent-reported measures of irritability were obtained. Irritability symptom reporting in the hfASD group was compared to two groups of boys without ASD: highly irritable boys (severe mood dysregulation, SMD; n = 40) and healthy-control boys (HC; n = 30). Results Boys with hfASD scored significantly higher on irritability than HC boys, and they reported a pattern of irritability symptoms closely resembling that of boys with SMD. The internal consistency of irritability in hfASD was high by parent- and self-report. Although boys with hfASD showed significant stress-induced changes in cortisol and heart rate, those who rated themselves as highly irritable had lower cortisol levels throughout the test compared to those low on irritability. Participants rated as highly irritable by their parents showed blunted cortisol and heart rate responses to stress. The effects of irritability on heart rate, but not cortisol, were accounted for by trait anxiety. Conclusions Irritability can be measured reliably in hfASD and is associated with distinct biological responses to stress. En ligne : http://dx.doi.org/10.1111/jcpp.12382 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=269 Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index / Carla B. KALVIN in Journal of Autism and Developmental Disorders, 51-5 (May 2021)
[article]
Titre : Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index Type de document : Texte imprimé et/ou numérique Auteurs : Carla B. KALVIN, Auteur ; Theresa R. GLADSTONE, Auteur ; Rebecca JORDAN, Auteur ; Sonia ROWLEY, Auteur ; Carolyn L. MARSH, Auteur ; Karim IBRAHIM, Auteur ; Denis G SUKHODOLSKY, Auteur Article en page(s) : p.1496-1507 Langues : Anglais (eng) Mots-clés : Anxiety Autism spectrum disorder Irritability Noncompliance treatment manual on CBT for anger and aggression in children. Other authors (C.B.K., T.R.G., R.J., S.R., C.L.M. and K.I.) have no biomedical financial interests or potential conflicts of interest to declare related to this present study. Index. décimale : PER Périodiques Résumé : Irritability is an impairing problem in children with ASD that may be associated with other behavioral and emotional concerns. The Affective Reactivity Index (ARI) is a parent-rated measure of irritability widely used in children with mood disorders, however, its utility in children with ASD remains unclear. In this study, we examined ARI parent ratings in children with ASD and contributions of parent-rated anxiety and noncompliance to irritability measured by the ARI. Participants included 81 children with ASD, aged 8-16 years. Results suggest that both anxiety and noncompliance contribute to irritability, but that anxiety only contributes to irritability in the absence of noncompliance. Further, the ARI is likely to be a useful measure of irritability in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04627-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445
in Journal of Autism and Developmental Disorders > 51-5 (May 2021) . - p.1496-1507[article] Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index [Texte imprimé et/ou numérique] / Carla B. KALVIN, Auteur ; Theresa R. GLADSTONE, Auteur ; Rebecca JORDAN, Auteur ; Sonia ROWLEY, Auteur ; Carolyn L. MARSH, Auteur ; Karim IBRAHIM, Auteur ; Denis G SUKHODOLSKY, Auteur . - p.1496-1507.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 51-5 (May 2021) . - p.1496-1507
Mots-clés : Anxiety Autism spectrum disorder Irritability Noncompliance treatment manual on CBT for anger and aggression in children. Other authors (C.B.K., T.R.G., R.J., S.R., C.L.M. and K.I.) have no biomedical financial interests or potential conflicts of interest to declare related to this present study. Index. décimale : PER Périodiques Résumé : Irritability is an impairing problem in children with ASD that may be associated with other behavioral and emotional concerns. The Affective Reactivity Index (ARI) is a parent-rated measure of irritability widely used in children with mood disorders, however, its utility in children with ASD remains unclear. In this study, we examined ARI parent ratings in children with ASD and contributions of parent-rated anxiety and noncompliance to irritability measured by the ARI. Participants included 81 children with ASD, aged 8-16 years. Results suggest that both anxiety and noncompliance contribute to irritability, but that anxiety only contributes to irritability in the absence of noncompliance. Further, the ARI is likely to be a useful measure of irritability in children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-020-04627-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 Observational measures of early irritability predict children's psychopathology risk / Ola MOHAMED ALI in Development and Psychopathology, 34-4 (October 2022)
[article]
Titre : Observational measures of early irritability predict children's psychopathology risk Type de document : Texte imprimé et/ou numérique Auteurs : Ola MOHAMED ALI, Auteur ; Lindsay N. GABEL, Auteur ; Kasey STANTON, Auteur ; Erin A. KAUFMAN, Auteur ; Daniel N. KLEIN, Auteur ; Elizabeth P. HAYDEN, Auteur Article en page(s) : p.1531-1543 Langues : Anglais (eng) Mots-clés : Affective Symptoms Anger Child Child, Preschool Female Humans Irritable Mood Mood Disorders Psychopathology children development irritability measurement observational parent report Index. décimale : PER Périodiques Résumé : Irritability is a transdiagnostic feature of diverse forms of psychopathology and a rapidly growing literature implicates the construct in child maladaptation. However, most irritability measures currently used are drawn from parent-report questionnaires not designed to measure irritability per se; furthermore, parent report methods have several important limitations. We therefore examined the utility of observational ratings of children's irritability in predicting later psychopathology symptoms. Four-hundred and nine 3-year-old children (208 girls) completed observational tasks tapping temperamental emotionality and parents completed questionnaires assessing child irritability and anger. Parent-reported child psychopathology symptoms were assessed concurrently to the irritability assessment and when children were 5 and 8 years old. Children's irritability observed during tasks that did not typically elicit anger predicted their later depressive and hyperactivity symptoms, above and beyond parent-reported irritability and context-appropriate observed anger. Our findings support the use of observational indices of irritability and have implications for the development of observational paradigms designed to assess this construct in childhood. En ligne : http://dx.doi.org/10.1017/s0954579421000183 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Development and Psychopathology > 34-4 (October 2022) . - p.1531-1543[article] Observational measures of early irritability predict children's psychopathology risk [Texte imprimé et/ou numérique] / Ola MOHAMED ALI, Auteur ; Lindsay N. GABEL, Auteur ; Kasey STANTON, Auteur ; Erin A. KAUFMAN, Auteur ; Daniel N. KLEIN, Auteur ; Elizabeth P. HAYDEN, Auteur . - p.1531-1543.
Langues : Anglais (eng)
in Development and Psychopathology > 34-4 (October 2022) . - p.1531-1543
Mots-clés : Affective Symptoms Anger Child Child, Preschool Female Humans Irritable Mood Mood Disorders Psychopathology children development irritability measurement observational parent report Index. décimale : PER Périodiques Résumé : Irritability is a transdiagnostic feature of diverse forms of psychopathology and a rapidly growing literature implicates the construct in child maladaptation. However, most irritability measures currently used are drawn from parent-report questionnaires not designed to measure irritability per se; furthermore, parent report methods have several important limitations. We therefore examined the utility of observational ratings of children's irritability in predicting later psychopathology symptoms. Four-hundred and nine 3-year-old children (208 girls) completed observational tasks tapping temperamental emotionality and parents completed questionnaires assessing child irritability and anger. Parent-reported child psychopathology symptoms were assessed concurrently to the irritability assessment and when children were 5 and 8 years old. Children's irritability observed during tasks that did not typically elicit anger predicted their later depressive and hyperactivity symptoms, above and beyond parent-reported irritability and context-appropriate observed anger. Our findings support the use of observational indices of irritability and have implications for the development of observational paradigms designed to assess this construct in childhood. En ligne : http://dx.doi.org/10.1017/s0954579421000183 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 Parenting and childhood irritability: Negative emotion socialization and parental control moderate the development of irritability / Sanjana RAVI in Development and Psychopathology, 35-3 (August 2023)
[article]
Titre : Parenting and childhood irritability: Negative emotion socialization and parental control moderate the development of irritability Type de document : Texte imprimé et/ou numérique Auteurs : Sanjana RAVI, Auteur ; Mazneen HAVEWALA, Auteur ; Katharina KIRCANSKI, Auteur ; Melissa A. BROTMAN, Auteur ; Leslie SCHNEIDER, Auteur ; Kathryn DEGNAN, Auteur ; Alisa ALMAS, Auteur ; Nathan FOX, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Courtney FILIPPI, Auteur Article en page(s) : p.1444-1453 Langues : Anglais (eng) Mots-clés : emotion socialization irritability parental control parenting psychopathology Index. décimale : PER Périodiques Résumé : Irritability, characterized by anger in response to frustration, is normative in childhood. While children typically show a decline in irritability from toddlerhood to school age, elevated irritability throughout childhood may predict later psychopathology. The current study (n = 78) examined associations between trajectories of irritability in early childhood (ages 2-7) and irritability in adolescence (age 12) and tested whether these associations are moderated by parenting behaviors. Results indicate that negative emotion socialization moderated trajectories of irritability - relative to children with low stable irritability, children who exhibited high stable irritability in early childhood and who had parents that exhibited greater negative emotion socialization behaviors had higher irritability in adolescence. Further, negative parental control behavior moderated trajectories of irritability - relative to children with low stable irritability, children who had high decreasing irritability in early childhood and who had parents who exhibited greater negative control behaviors had higher irritability in adolescence. In contrast, positive emotion socialization and control behaviors did not moderate the relations between early childhood irritability and later irritability in adolescence. These results suggest that both irritability in early childhood and negative parenting behaviors may jointly influence irritability in adolescence. The current study underscores the significance of negative parenting behaviors and could inform treatment. En ligne : http://dx.doi.org/10.1017/S0954579421001346 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511
in Development and Psychopathology > 35-3 (August 2023) . - p.1444-1453[article] Parenting and childhood irritability: Negative emotion socialization and parental control moderate the development of irritability [Texte imprimé et/ou numérique] / Sanjana RAVI, Auteur ; Mazneen HAVEWALA, Auteur ; Katharina KIRCANSKI, Auteur ; Melissa A. BROTMAN, Auteur ; Leslie SCHNEIDER, Auteur ; Kathryn DEGNAN, Auteur ; Alisa ALMAS, Auteur ; Nathan FOX, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Courtney FILIPPI, Auteur . - p.1444-1453.
Langues : Anglais (eng)
in Development and Psychopathology > 35-3 (August 2023) . - p.1444-1453
Mots-clés : emotion socialization irritability parental control parenting psychopathology Index. décimale : PER Périodiques Résumé : Irritability, characterized by anger in response to frustration, is normative in childhood. While children typically show a decline in irritability from toddlerhood to school age, elevated irritability throughout childhood may predict later psychopathology. The current study (n = 78) examined associations between trajectories of irritability in early childhood (ages 2-7) and irritability in adolescence (age 12) and tested whether these associations are moderated by parenting behaviors. Results indicate that negative emotion socialization moderated trajectories of irritability - relative to children with low stable irritability, children who exhibited high stable irritability in early childhood and who had parents that exhibited greater negative emotion socialization behaviors had higher irritability in adolescence. Further, negative parental control behavior moderated trajectories of irritability - relative to children with low stable irritability, children who had high decreasing irritability in early childhood and who had parents who exhibited greater negative control behaviors had higher irritability in adolescence. In contrast, positive emotion socialization and control behaviors did not moderate the relations between early childhood irritability and later irritability in adolescence. These results suggest that both irritability in early childhood and negative parenting behaviors may jointly influence irritability in adolescence. The current study underscores the significance of negative parenting behaviors and could inform treatment. En ligne : http://dx.doi.org/10.1017/S0954579421001346 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach / Elise M. CARDINALE in Development and Psychopathology, 31-3 (August 2019)
[article]
Titre : Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach Type de document : Texte imprimé et/ou numérique Auteurs : Elise M. CARDINALE, Auteur ; Katharina KIRCANSKI, Auteur ; Julia BROOKS, Auteur ; Andrea L. GOLD, Auteur ; Kenneth E. TOWBIN, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur Article en page(s) : p.917-929 Langues : Anglais (eng) Mots-clés : anxiety bifactor model cortical structure irritability subcortical volume Index. décimale : PER Périodiques Résumé : Irritability and anxiety are two common clinical phenotypes that involve high-arousal negative affect states (anger and fear), and that frequently co-occur. Elucidating how these two forms of emotion dysregulation relate to perturbed neurodevelopment may benefit from alternate phenotyping strategies. One such strategy applies a bifactor latent variable approach that can parse shared versus unique mechanisms of these two phenotypes. Here, we aim to replicate and extend this approach and examine associations with neural structure in a large transdiagnostic sample of youth (N = 331; M = 13.57, SD = 2.69 years old; 45.92% male). FreeSurfer was used to extract cortical thickness, cortical surface area, and subcortical volume. The current findings replicated the bifactor model and demonstrate measurement invariance as a function of youth age and sex. There were no associations of youth's factor scores with cortical thickness, surface area, or subcortical volume. However, we found strong convergent and divergent validity between parent-reported irritability and anxiety factors with clinician-rated symptoms and impairment. A general negative affectivity factor was robustly associated with overall functional impairment across symptom domains. Together, these results support the utility of the bifactor model as an alternative phenotyping strategy for irritability and anxiety, which may aid in the development of targeted treatments. En ligne : http://dx.doi.org/10.1017/S095457941900035X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403
in Development and Psychopathology > 31-3 (August 2019) . - p.917-929[article] Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach [Texte imprimé et/ou numérique] / Elise M. CARDINALE, Auteur ; Katharina KIRCANSKI, Auteur ; Julia BROOKS, Auteur ; Andrea L. GOLD, Auteur ; Kenneth E. TOWBIN, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur . - p.917-929.
Langues : Anglais (eng)
in Development and Psychopathology > 31-3 (August 2019) . - p.917-929
Mots-clés : anxiety bifactor model cortical structure irritability subcortical volume Index. décimale : PER Périodiques Résumé : Irritability and anxiety are two common clinical phenotypes that involve high-arousal negative affect states (anger and fear), and that frequently co-occur. Elucidating how these two forms of emotion dysregulation relate to perturbed neurodevelopment may benefit from alternate phenotyping strategies. One such strategy applies a bifactor latent variable approach that can parse shared versus unique mechanisms of these two phenotypes. Here, we aim to replicate and extend this approach and examine associations with neural structure in a large transdiagnostic sample of youth (N = 331; M = 13.57, SD = 2.69 years old; 45.92% male). FreeSurfer was used to extract cortical thickness, cortical surface area, and subcortical volume. The current findings replicated the bifactor model and demonstrate measurement invariance as a function of youth age and sex. There were no associations of youth's factor scores with cortical thickness, surface area, or subcortical volume. However, we found strong convergent and divergent validity between parent-reported irritability and anxiety factors with clinician-rated symptoms and impairment. A general negative affectivity factor was robustly associated with overall functional impairment across symptom domains. Together, these results support the utility of the bifactor model as an alternative phenotyping strategy for irritability and anxiety, which may aid in the development of targeted treatments. En ligne : http://dx.doi.org/10.1017/S095457941900035X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 The Network Structure of Irritability and Aggression in Individuals with Autism Spectrum Disorder / Tomoya HIROTA in Journal of Autism and Developmental Disorders, 50-4 (April 2020)
PermalinkUsing ecological momentary assessment to enhance irritability phenotyping in a transdiagnostic sample of youth / Reut NAIM in Development and Psychopathology, 33-5 (December 2021)
PermalinkAn Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder / A. S. LEWIS in Journal of Autism and Developmental Disorders, 48-8 (August 2018)
PermalinkAssociation between irritability and bias in attention orienting to threat in children and adolescents / Giovanni A. SALUM in Journal of Child Psychology and Psychiatry, 58-5 (May 2017)
PermalinkChildhood neurodevelopmental difficulties and risk of adolescent depression: the role of irritability / O. EYRE in Journal of Child Psychology and Psychiatry, 60-8 (August 2019)
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