Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear / Elise M. CARDINALE in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.191-201 Titre : Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear Type de document : Texte imprimé et/ou numérique Auteurs : Elise M. CARDINALE, Auteur ; Andrew L. BREEDEN, Auteur ; Emily L. ROBERTSON, Auteur ; Leah M. LOZIER, Auteur ; John W. VANMETER, Auteur ; Abigail A. MARSH, Auteur Article en page(s) : p.191-201 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Callous–unemotional (CU) traits characterize a subgroup of youths with conduct problems who exhibit low empathy, fearlessness, and elevated externalizing behaviors. The current study examines the role of aberrant amygdala activity and functional connectivity during a socioemotional judgment task in youths with CU traits, and links these deficits to externalizing behaviors. Functional magnetic resonance imaging was used to compare neural responses in 18 healthy youths and 30 youths with conduct problems and varying levels of CU traits as they evaluated the acceptability of causing another person to experience each of several emotions, including fear. Neuroimaging analyses examined blood oxygenation level dependent responses and task-dependent functional connectivity. High-CU youths exhibited left amygdala hypoactivation relative to healthy controls and low-CU youths primarily during evaluations of causing others fear. CU traits moderated the relationship between externalizing behavior and both amygdala activity and patterns of functional connectivity. The present data suggest that CU youths' aberrant amygdala activity and connectivity affect how they make judgments about the acceptability of causing others emotional distress, and that these aberrations represent risk factors for externalizing behaviors like rule breaking and aggression. These findings suggest that reducing externalizing behaviors in high-CU youths may require interventions that influence affective sensitivity. En ligne : https://doi.org/10.1017/S0954579417000566 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3360 [article] Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear [Texte imprimé et/ou numérique] / Elise M. CARDINALE, Auteur ; Andrew L. BREEDEN, Auteur ; Emily L. ROBERTSON, Auteur ; Leah M. LOZIER, Auteur ; John W. VANMETER, Auteur ; Abigail A. MARSH, Auteur . - p.191-201. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.191-201 Index. décimale : PER Périodiques Résumé : Callous–unemotional (CU) traits characterize a subgroup of youths with conduct problems who exhibit low empathy, fearlessness, and elevated externalizing behaviors. The current study examines the role of aberrant amygdala activity and functional connectivity during a socioemotional judgment task in youths with CU traits, and links these deficits to externalizing behaviors. Functional magnetic resonance imaging was used to compare neural responses in 18 healthy youths and 30 youths with conduct problems and varying levels of CU traits as they evaluated the acceptability of causing another person to experience each of several emotions, including fear. Neuroimaging analyses examined blood oxygenation level dependent responses and task-dependent functional connectivity. High-CU youths exhibited left amygdala hypoactivation relative to healthy controls and low-CU youths primarily during evaluations of causing others fear. CU traits moderated the relationship between externalizing behavior and both amygdala activity and patterns of functional connectivity. The present data suggest that CU youths' aberrant amygdala activity and connectivity affect how they make judgments about the acceptability of causing others emotional distress, and that these aberrations represent risk factors for externalizing behaviors like rule breaking and aggression. These findings suggest that reducing externalizing behaviors in high-CU youths may require interventions that influence affective sensitivity. En ligne : https://doi.org/10.1017/S0954579417000566 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3360

Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear—CORRIGENDUM / Elise M. CARDINALE in Development and Psychopathology, 30-2 (May 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-2 (May 2018) . - p.717-718 Titre : Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear—CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Elise M. CARDINALE, Auteur ; Andrew L. BREEDEN, Auteur ; Emily L. ROBERTSON, Auteur ; Leah M. LOZIER, Auteur ; John W. VANMETER, Auteur ; Abigail A. MARSH, Auteur Article en page(s) : p.717-718 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579417001079 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3595 [article] Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear—CORRIGENDUM [Texte imprimé et/ou numérique] / Elise M. CARDINALE, Auteur ; Andrew L. BREEDEN, Auteur ; Emily L. ROBERTSON, Auteur ; Leah M. LOZIER, Auteur ; John W. VANMETER, Auteur ; Abigail A. MARSH, Auteur . - p.717-718. Langues : Anglais (eng) in Development and Psychopathology > 30-2 (May 2018) . - p.717-718 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579417001079 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3595

Inhibitory control and emotion dysregulation: A framework for research on anxiety / Elise M. CARDINALE in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.859-869 Titre : Inhibitory control and emotion dysregulation: A framework for research on anxiety Type de document : Texte imprimé et/ou numérique Auteurs : Elise M. CARDINALE, Auteur ; Anni R. SUBAR, Auteur ; Melissa A. BROTMAN, Auteur ; Ellen LEIBENLUFT, Auteur ; Katharina KIRCANSKI, Auteur ; Daniel S. PINE, Auteur Article en page(s) : p.859-869 Langues : Anglais (eng) Mots-clés : antisaccade task  anxiety eye movements  inhibitory control  latency Index. décimale : PER Périodiques Résumé : While emotional dysregulation is a broad construct, the current paper adopts a narrow approach to facilitate translational neuroscience research on pediatric anxiety. The paper first presents data on an adapted version of the antisaccade task and then integrates these data into a research framework. Data on an adapted version of the antisaccade task were collected in 57 youth, including 35 seeking treatment for an anxiety disorder. Associations were examined between performance on the antisaccade task and (a) age, (b) performance on other cognitive-control tasks (i.e., the stop-signal delay and flanker tasks), and (c) level of anxiety symptoms. Better performance on the antisaccade task occurred in older relative to younger subjects and correlated with better performance on the flanker task. Across the 57 youth, higher levels of anxiety correlated with shorter latency for correct antisaccades. These data can be placed within a three-step framework for translational neuroscience research. In the first step, a narrow index of emotion dysregulation is targeted. In the second step, this narrow index is linked to other correlated indicators of the same underlying narrow latent construct. In the third and final step, associations are examined with clinical outcomes and response to treatment. En ligne : http://dx.doi.org/10.1017/S0954579419000300 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4031 [article] Inhibitory control and emotion dysregulation: A framework for research on anxiety [Texte imprimé et/ou numérique] / Elise M. CARDINALE, Auteur ; Anni R. SUBAR, Auteur ; Melissa A. BROTMAN, Auteur ; Ellen LEIBENLUFT, Auteur ; Katharina KIRCANSKI, Auteur ; Daniel S. PINE, Auteur . - p.859-869. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.859-869 Mots-clés : antisaccade task  anxiety eye movements  inhibitory control  latency Index. décimale : PER Périodiques Résumé : While emotional dysregulation is a broad construct, the current paper adopts a narrow approach to facilitate translational neuroscience research on pediatric anxiety. The paper first presents data on an adapted version of the antisaccade task and then integrates these data into a research framework. Data on an adapted version of the antisaccade task were collected in 57 youth, including 35 seeking treatment for an anxiety disorder. Associations were examined between performance on the antisaccade task and (a) age, (b) performance on other cognitive-control tasks (i.e., the stop-signal delay and flanker tasks), and (c) level of anxiety symptoms. Better performance on the antisaccade task occurred in older relative to younger subjects and correlated with better performance on the flanker task. Across the 57 youth, higher levels of anxiety correlated with shorter latency for correct antisaccades. These data can be placed within a three-step framework for translational neuroscience research. In the first step, a narrow index of emotion dysregulation is targeted. In the second step, this narrow index is linked to other correlated indicators of the same underlying narrow latent construct. In the third and final step, associations are examined with clinical outcomes and response to treatment. En ligne : http://dx.doi.org/10.1017/S0954579419000300 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4031

Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach / Elise M. CARDINALE in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.917-929 Titre : Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach Type de document : Texte imprimé et/ou numérique Auteurs : Elise M. CARDINALE, Auteur ; Katharina KIRCANSKI, Auteur ; Julia BROOKS, Auteur ; Andrea L. GOLD, Auteur ; Kenneth E. TOWBIN, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur Article en page(s) : p.917-929 Langues : Anglais (eng) Mots-clés : anxiety  bifactor model  cortical structure  irritability  subcortical volume Index. décimale : PER Périodiques Résumé : Irritability and anxiety are two common clinical phenotypes that involve high-arousal negative affect states (anger and fear), and that frequently co-occur. Elucidating how these two forms of emotion dysregulation relate to perturbed neurodevelopment may benefit from alternate phenotyping strategies. One such strategy applies a bifactor latent variable approach that can parse shared versus unique mechanisms of these two phenotypes. Here, we aim to replicate and extend this approach and examine associations with neural structure in a large transdiagnostic sample of youth (N = 331; M = 13.57, SD = 2.69 years old; 45.92% male). FreeSurfer was used to extract cortical thickness, cortical surface area, and subcortical volume. The current findings replicated the bifactor model and demonstrate measurement invariance as a function of youth age and sex. There were no associations of youth's factor scores with cortical thickness, surface area, or subcortical volume. However, we found strong convergent and divergent validity between parent-reported irritability and anxiety factors with clinician-rated symptoms and impairment. A general negative affectivity factor was robustly associated with overall functional impairment across symptom domains. Together, these results support the utility of the bifactor model as an alternative phenotyping strategy for irritability and anxiety, which may aid in the development of targeted treatments. En ligne : http://dx.doi.org/10.1017/S095457941900035X Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4031 [article] Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach [Texte imprimé et/ou numérique] / Elise M. CARDINALE, Auteur ; Katharina KIRCANSKI, Auteur ; Julia BROOKS, Auteur ; Andrea L. GOLD, Auteur ; Kenneth E. TOWBIN, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur . - p.917-929. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.917-929 Mots-clés : anxiety  bifactor model  cortical structure  irritability  subcortical volume Index. décimale : PER Périodiques Résumé : Irritability and anxiety are two common clinical phenotypes that involve high-arousal negative affect states (anger and fear), and that frequently co-occur. Elucidating how these two forms of emotion dysregulation relate to perturbed neurodevelopment may benefit from alternate phenotyping strategies. One such strategy applies a bifactor latent variable approach that can parse shared versus unique mechanisms of these two phenotypes. Here, we aim to replicate and extend this approach and examine associations with neural structure in a large transdiagnostic sample of youth (N = 331; M = 13.57, SD = 2.69 years old; 45.92% male). FreeSurfer was used to extract cortical thickness, cortical surface area, and subcortical volume. The current findings replicated the bifactor model and demonstrate measurement invariance as a function of youth age and sex. There were no associations of youth's factor scores with cortical thickness, surface area, or subcortical volume. However, we found strong convergent and divergent validity between parent-reported irritability and anxiety factors with clinician-rated symptoms and impairment. A general negative affectivity factor was robustly associated with overall functional impairment across symptom domains. Together, these results support the utility of the bifactor model as an alternative phenotyping strategy for irritability and anxiety, which may aid in the development of targeted treatments. En ligne : http://dx.doi.org/10.1017/S095457941900035X Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4031

Using ecological momentary assessment to enhance irritability phenotyping in a transdiagnostic sample of youth / Reut NAIM in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1734-1746 Titre : Using ecological momentary assessment to enhance irritability phenotyping in a transdiagnostic sample of youth Type de document : Texte imprimé et/ou numérique Auteurs : Reut NAIM, Auteur ; Ashley SMITH, Auteur ; Amanda CHUE, Auteur ; Hannah GRASSIE, Auteur ; Julia LINKE, Auteur ; Kelly DOMBEK, Auteur ; Shannon SHAUGHNESSY, Auteur ; Cheri MCNEIL, Auteur ; Elise M. CARDINALE, Auteur ; Courtney AGORSOR, Auteur ; Sofia CARDENAS, Auteur ; Julia BROOKS, Auteur ; Anni R. SUBAR, Auteur ; Emily L. JONES, Auteur ; Quyen B. DO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur ; Katharina KIRCANSKI, Auteur Article en page(s) : p.1734-1746 Langues : Anglais (eng) Mots-clés : disruptive mood dysregulation disorder  ecological momentary assessment  frustrative nonreward  irritability  transdiagnostic Index. décimale : PER Périodiques Résumé : Irritability is a transdiagnostic symptom dimension in developmental psychopathology, closely related to the Research Domain Criteria (RDoC) construct of frustrative nonreward. Consistent with the RDoC framework and calls for transdiagnostic, developmentally-sensitive assessment methods, we report data from a smartphone-based, naturalistic ecological momentary assessment (EMA) study of irritability. We assessed 109 children and adolescents (Mage = 12.55 years; 75.20% male) encompassing several diagnostic groups – disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), anxiety disorders (ANX), healthy volunteers (HV). The participants rated symptoms three times per day for 1 week. Compliance with the EMA protocol was high. As tested using multilevel modeling, EMA ratings of irritability were strongly and consistently associated with in-clinic, gold-standard measures of irritability. Further, EMA ratings of irritability were significantly related to subjective frustration during a laboratory task eliciting frustrative nonreward. Irritability levels exhibited an expected graduated pattern across diagnostic groups, and the different EMA items measuring irritability were significantly associated with one another within all groups, supporting the transdiagnostic phenomenology of irritability. Additional analyses utilized EMA ratings of anxiety as a comparison with respect to convergent validity and transdiagnostic phenomenology. The results support new measurement tools that can be used in future studies of irritability and frustrative nonreward. En ligne : http://dx.doi.org/10.1017/S0954579421000717 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4579 [article] Using ecological momentary assessment to enhance irritability phenotyping in a transdiagnostic sample of youth [Texte imprimé et/ou numérique] / Reut NAIM, Auteur ; Ashley SMITH, Auteur ; Amanda CHUE, Auteur ; Hannah GRASSIE, Auteur ; Julia LINKE, Auteur ; Kelly DOMBEK, Auteur ; Shannon SHAUGHNESSY, Auteur ; Cheri MCNEIL, Auteur ; Elise M. CARDINALE, Auteur ; Courtney AGORSOR, Auteur ; Sofia CARDENAS, Auteur ; Julia BROOKS, Auteur ; Anni R. SUBAR, Auteur ; Emily L. JONES, Auteur ; Quyen B. DO, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur ; Katharina KIRCANSKI, Auteur . - p.1734-1746. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1734-1746 Mots-clés : disruptive mood dysregulation disorder  ecological momentary assessment  frustrative nonreward  irritability  transdiagnostic Index. décimale : PER Périodiques Résumé : Irritability is a transdiagnostic symptom dimension in developmental psychopathology, closely related to the Research Domain Criteria (RDoC) construct of frustrative nonreward. Consistent with the RDoC framework and calls for transdiagnostic, developmentally-sensitive assessment methods, we report data from a smartphone-based, naturalistic ecological momentary assessment (EMA) study of irritability. We assessed 109 children and adolescents (Mage = 12.55 years; 75.20% male) encompassing several diagnostic groups – disruptive mood dysregulation disorder (DMDD), attention-deficit/hyperactivity disorder (ADHD), anxiety disorders (ANX), healthy volunteers (HV). The participants rated symptoms three times per day for 1 week. Compliance with the EMA protocol was high. As tested using multilevel modeling, EMA ratings of irritability were strongly and consistently associated with in-clinic, gold-standard measures of irritability. Further, EMA ratings of irritability were significantly related to subjective frustration during a laboratory task eliciting frustrative nonreward. Irritability levels exhibited an expected graduated pattern across diagnostic groups, and the different EMA items measuring irritability were significantly associated with one another within all groups, supporting the transdiagnostic phenomenology of irritability. Additional analyses utilized EMA ratings of anxiety as a comparison with respect to convergent validity and transdiagnostic phenomenology. The results support new measurement tools that can be used in future studies of irritability and frustrative nonreward. En ligne : http://dx.doi.org/10.1017/S0954579421000717 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4579

---

1 (1 - 5 / 5)