Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear / Elise M. CARDINALE in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.191-201 Titre : Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear Type de document : Texte imprimé et/ou numérique Auteurs : Elise M. CARDINALE, Auteur ; Andrew L. BREEDEN, Auteur ; Emily L. ROBERTSON, Auteur ; Leah M. LOZIER, Auteur ; John W. VANMETER, Auteur ; Abigail A. MARSH, Auteur Article en page(s) : p.191-201 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Callous–unemotional (CU) traits characterize a subgroup of youths with conduct problems who exhibit low empathy, fearlessness, and elevated externalizing behaviors. The current study examines the role of aberrant amygdala activity and functional connectivity during a socioemotional judgment task in youths with CU traits, and links these deficits to externalizing behaviors. Functional magnetic resonance imaging was used to compare neural responses in 18 healthy youths and 30 youths with conduct problems and varying levels of CU traits as they evaluated the acceptability of causing another person to experience each of several emotions, including fear. Neuroimaging analyses examined blood oxygenation level dependent responses and task-dependent functional connectivity. High-CU youths exhibited left amygdala hypoactivation relative to healthy controls and low-CU youths primarily during evaluations of causing others fear. CU traits moderated the relationship between externalizing behavior and both amygdala activity and patterns of functional connectivity. The present data suggest that CU youths' aberrant amygdala activity and connectivity affect how they make judgments about the acceptability of causing others emotional distress, and that these aberrations represent risk factors for externalizing behaviors like rule breaking and aggression. These findings suggest that reducing externalizing behaviors in high-CU youths may require interventions that influence affective sensitivity. En ligne : https://doi.org/10.1017/S0954579417000566 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear [Texte imprimé et/ou numérique] / Elise M. CARDINALE, Auteur ; Andrew L. BREEDEN, Auteur ; Emily L. ROBERTSON, Auteur ; Leah M. LOZIER, Auteur ; John W. VANMETER, Auteur ; Abigail A. MARSH, Auteur . - p.191-201. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.191-201 Index. décimale : PER Périodiques Résumé : Callous–unemotional (CU) traits characterize a subgroup of youths with conduct problems who exhibit low empathy, fearlessness, and elevated externalizing behaviors. The current study examines the role of aberrant amygdala activity and functional connectivity during a socioemotional judgment task in youths with CU traits, and links these deficits to externalizing behaviors. Functional magnetic resonance imaging was used to compare neural responses in 18 healthy youths and 30 youths with conduct problems and varying levels of CU traits as they evaluated the acceptability of causing another person to experience each of several emotions, including fear. Neuroimaging analyses examined blood oxygenation level dependent responses and task-dependent functional connectivity. High-CU youths exhibited left amygdala hypoactivation relative to healthy controls and low-CU youths primarily during evaluations of causing others fear. CU traits moderated the relationship between externalizing behavior and both amygdala activity and patterns of functional connectivity. The present data suggest that CU youths' aberrant amygdala activity and connectivity affect how they make judgments about the acceptability of causing others emotional distress, and that these aberrations represent risk factors for externalizing behaviors like rule breaking and aggression. These findings suggest that reducing externalizing behaviors in high-CU youths may require interventions that influence affective sensitivity. En ligne : https://doi.org/10.1017/S0954579417000566 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear—CORRIGENDUM / Elise M. CARDINALE in Development and Psychopathology, 30-2 (May 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-2 (May 2018) . - p.717-718 Titre : Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear—CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Elise M. CARDINALE, Auteur ; Andrew L. BREEDEN, Auteur ; Emily L. ROBERTSON, Auteur ; Leah M. LOZIER, Auteur ; John W. VANMETER, Auteur ; Abigail A. MARSH, Auteur Article en page(s) : p.717-718 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579417001079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359 [article] Externalizing behavior severity in youths with callous–unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear—CORRIGENDUM [Texte imprimé et/ou numérique] / Elise M. CARDINALE, Auteur ; Andrew L. BREEDEN, Auteur ; Emily L. ROBERTSON, Auteur ; Leah M. LOZIER, Auteur ; John W. VANMETER, Auteur ; Abigail A. MARSH, Auteur . - p.717-718. Langues : Anglais (eng) in Development and Psychopathology > 30-2 (May 2018) . - p.717-718 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579417001079 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359

Inhibitory control and emotion dysregulation: A framework for research on anxiety / Elise M. CARDINALE in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.859-869 Titre : Inhibitory control and emotion dysregulation: A framework for research on anxiety Type de document : Texte imprimé et/ou numérique Auteurs : Elise M. CARDINALE, Auteur ; Anni R. SUBAR, Auteur ; Melissa A. BROTMAN, Auteur ; Ellen LEIBENLUFT, Auteur ; Katharina KIRCANSKI, Auteur ; Daniel S. PINE, Auteur Article en page(s) : p.859-869 Langues : Anglais (eng) Mots-clés : antisaccade task  anxiety eye movements  inhibitory control  latency Index. décimale : PER Périodiques Résumé : While emotional dysregulation is a broad construct, the current paper adopts a narrow approach to facilitate translational neuroscience research on pediatric anxiety. The paper first presents data on an adapted version of the antisaccade task and then integrates these data into a research framework. Data on an adapted version of the antisaccade task were collected in 57 youth, including 35 seeking treatment for an anxiety disorder. Associations were examined between performance on the antisaccade task and (a) age, (b) performance on other cognitive-control tasks (i.e., the stop-signal delay and flanker tasks), and (c) level of anxiety symptoms. Better performance on the antisaccade task occurred in older relative to younger subjects and correlated with better performance on the flanker task. Across the 57 youth, higher levels of anxiety correlated with shorter latency for correct antisaccades. These data can be placed within a three-step framework for translational neuroscience research. In the first step, a narrow index of emotion dysregulation is targeted. In the second step, this narrow index is linked to other correlated indicators of the same underlying narrow latent construct. In the third and final step, associations are examined with clinical outcomes and response to treatment. En ligne : http://dx.doi.org/10.1017/S0954579419000300 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Inhibitory control and emotion dysregulation: A framework for research on anxiety [Texte imprimé et/ou numérique] / Elise M. CARDINALE, Auteur ; Anni R. SUBAR, Auteur ; Melissa A. BROTMAN, Auteur ; Ellen LEIBENLUFT, Auteur ; Katharina KIRCANSKI, Auteur ; Daniel S. PINE, Auteur . - p.859-869. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.859-869 Mots-clés : antisaccade task  anxiety eye movements  inhibitory control  latency Index. décimale : PER Périodiques Résumé : While emotional dysregulation is a broad construct, the current paper adopts a narrow approach to facilitate translational neuroscience research on pediatric anxiety. The paper first presents data on an adapted version of the antisaccade task and then integrates these data into a research framework. Data on an adapted version of the antisaccade task were collected in 57 youth, including 35 seeking treatment for an anxiety disorder. Associations were examined between performance on the antisaccade task and (a) age, (b) performance on other cognitive-control tasks (i.e., the stop-signal delay and flanker tasks), and (c) level of anxiety symptoms. Better performance on the antisaccade task occurred in older relative to younger subjects and correlated with better performance on the flanker task. Across the 57 youth, higher levels of anxiety correlated with shorter latency for correct antisaccades. These data can be placed within a three-step framework for translational neuroscience research. In the first step, a narrow index of emotion dysregulation is targeted. In the second step, this narrow index is linked to other correlated indicators of the same underlying narrow latent construct. In the third and final step, associations are examined with clinical outcomes and response to treatment. En ligne : http://dx.doi.org/10.1017/S0954579419000300 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach / Elise M. CARDINALE in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.917-929 Titre : Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach Type de document : Texte imprimé et/ou numérique Auteurs : Elise M. CARDINALE, Auteur ; Katharina KIRCANSKI, Auteur ; Julia BROOKS, Auteur ; Andrea L. GOLD, Auteur ; Kenneth E. TOWBIN, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur Article en page(s) : p.917-929 Langues : Anglais (eng) Mots-clés : anxiety  bifactor model  cortical structure  irritability  subcortical volume Index. décimale : PER Périodiques Résumé : Irritability and anxiety are two common clinical phenotypes that involve high-arousal negative affect states (anger and fear), and that frequently co-occur. Elucidating how these two forms of emotion dysregulation relate to perturbed neurodevelopment may benefit from alternate phenotyping strategies. One such strategy applies a bifactor latent variable approach that can parse shared versus unique mechanisms of these two phenotypes. Here, we aim to replicate and extend this approach and examine associations with neural structure in a large transdiagnostic sample of youth (N = 331; M = 13.57, SD = 2.69 years old; 45.92% male). FreeSurfer was used to extract cortical thickness, cortical surface area, and subcortical volume. The current findings replicated the bifactor model and demonstrate measurement invariance as a function of youth age and sex. There were no associations of youth's factor scores with cortical thickness, surface area, or subcortical volume. However, we found strong convergent and divergent validity between parent-reported irritability and anxiety factors with clinician-rated symptoms and impairment. A general negative affectivity factor was robustly associated with overall functional impairment across symptom domains. Together, these results support the utility of the bifactor model as an alternative phenotyping strategy for irritability and anxiety, which may aid in the development of targeted treatments. En ligne : http://dx.doi.org/10.1017/S095457941900035X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Parsing neurodevelopmental features of irritability and anxiety: Replication and validation of a latent variable approach [Texte imprimé et/ou numérique] / Elise M. CARDINALE, Auteur ; Katharina KIRCANSKI, Auteur ; Julia BROOKS, Auteur ; Andrea L. GOLD, Auteur ; Kenneth E. TOWBIN, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur . - p.917-929. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.917-929 Mots-clés : anxiety  bifactor model  cortical structure  irritability  subcortical volume Index. décimale : PER Périodiques Résumé : Irritability and anxiety are two common clinical phenotypes that involve high-arousal negative affect states (anger and fear), and that frequently co-occur. Elucidating how these two forms of emotion dysregulation relate to perturbed neurodevelopment may benefit from alternate phenotyping strategies. One such strategy applies a bifactor latent variable approach that can parse shared versus unique mechanisms of these two phenotypes. Here, we aim to replicate and extend this approach and examine associations with neural structure in a large transdiagnostic sample of youth (N = 331; M = 13.57, SD = 2.69 years old; 45.92% male). FreeSurfer was used to extract cortical thickness, cortical surface area, and subcortical volume. The current findings replicated the bifactor model and demonstrate measurement invariance as a function of youth age and sex. There were no associations of youth's factor scores with cortical thickness, surface area, or subcortical volume. However, we found strong convergent and divergent validity between parent-reported irritability and anxiety factors with clinician-rated symptoms and impairment. A general negative affectivity factor was robustly associated with overall functional impairment across symptom domains. Together, these results support the utility of the bifactor model as an alternative phenotyping strategy for irritability and anxiety, which may aid in the development of targeted treatments. En ligne : http://dx.doi.org/10.1017/S095457941900035X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Sleepless nights, sour moods: daily sleep-irritability links in a pediatric clinical sample / Miryam KIDERMAN ; Katharina KIRCANSKI ; Elise M. CARDINALE ; Daniel S. PINE ; Ellen LEIBENLUFT ; Melissa A. BROTMAN ; Reut NAIM in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1175-1183 Titre : Sleepless nights, sour moods: daily sleep-irritability links in a pediatric clinical sample Type de document : Texte imprimé et/ou numérique Auteurs : Miryam KIDERMAN, Auteur ; Katharina KIRCANSKI, Auteur ; Elise M. CARDINALE, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur ; Reut NAIM, Auteur Article en page(s) : p.1175-1183 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Sleep, or a lack thereof, is strongly related to mood dysregulation. Although considerable research uses symptom scales to examine this relation, few studies use longitudinal, real-time methods focused on pediatric irritability. This study leveraged an ecological momentary assessment (EMA) protocol, assessing bidirectional associations between momentary irritability symptoms and daily sleep duration in a transdiagnostic pediatric sample enriched for irritability. Methods A total of N = 125 youth (Mage = 12.58?years, SD = 2.56?years; 74% male; 68.8% White) completed digital, in vivo surveys three times a day for 7?days. For a subset of youth, their parents also completed the EMA protocol. Trait irritability was measured using youth-, parent-, and clinician-report to test its potential moderating effect on the association between sleep duration and momentary irritability. Results Results from multilevel modeling dynamically linked sleep to irritability. Specifically, according to youth- and parent-report, decreased sleep duration was associated with increased morning irritability (bs????.09, ps < .049). A bidirectional association between parent-reported nightly sleep duration and anger was found-increased evening anger related to decreased nightly sleep duration, and decreased sleep duration related to increased morning anger (bs????.17, ps < .019). Trait irritability moderated this association, which was stronger for more irritable youth (b = ?.03, p < .027). Conclusions This study adds to the literature and suggests sleep-irritability dynamics as a potential treatment target. En ligne : https://doi.org/10.1111/jcpp.13959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Sleepless nights, sour moods: daily sleep-irritability links in a pediatric clinical sample [Texte imprimé et/ou numérique] / Miryam KIDERMAN, Auteur ; Katharina KIRCANSKI, Auteur ; Elise M. CARDINALE, Auteur ; Daniel S. PINE, Auteur ; Ellen LEIBENLUFT, Auteur ; Melissa A. BROTMAN, Auteur ; Reut NAIM, Auteur . - p.1175-1183. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1175-1183 Index. décimale : PER Périodiques Résumé : Background Sleep, or a lack thereof, is strongly related to mood dysregulation. Although considerable research uses symptom scales to examine this relation, few studies use longitudinal, real-time methods focused on pediatric irritability. This study leveraged an ecological momentary assessment (EMA) protocol, assessing bidirectional associations between momentary irritability symptoms and daily sleep duration in a transdiagnostic pediatric sample enriched for irritability. Methods A total of N = 125 youth (Mage = 12.58?years, SD = 2.56?years; 74% male; 68.8% White) completed digital, in vivo surveys three times a day for 7?days. For a subset of youth, their parents also completed the EMA protocol. Trait irritability was measured using youth-, parent-, and clinician-report to test its potential moderating effect on the association between sleep duration and momentary irritability. Results Results from multilevel modeling dynamically linked sleep to irritability. Specifically, according to youth- and parent-report, decreased sleep duration was associated with increased morning irritability (bs????.09, ps < .049). A bidirectional association between parent-reported nightly sleep duration and anger was found-increased evening anger related to decreased nightly sleep duration, and decreased sleep duration related to increased morning anger (bs????.17, ps < .019). Trait irritability moderated this association, which was stronger for more irritable youth (b = ?.03, p < .027). Conclusions This study adds to the literature and suggests sleep-irritability dynamics as a potential treatment target. En ligne : https://doi.org/10.1111/jcpp.13959 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Using ecological momentary assessment to enhance irritability phenotyping in a transdiagnostic sample of youth / Reut NAIM in Development and Psychopathology, 33-5 (December 2021)  

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