Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition / Tomer SHECHNER in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.179-189 Titre : Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition Type de document : Texte imprimé et/ou numérique Auteurs : Tomer SHECHNER, Auteur ; Nathan A. FOX, Auteur ; Jamie A. MASH, Auteur ; Johanna M. JARCHO, Auteur ; Gang CHEN, Auteur ; Ellen LEIBENLUFT, Auteur ; Daniel S. PINE, Auteur ; Jennifer C. BRITTON, Auteur Article en page(s) : p.179-189 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Behavioral inhibition (BI) is a temperament identified in early childhood that is associated with risk for anxiety disorders, yet only about half of behaviorally inhibited children manifest anxiety later in life. We compared brain function and behavior during extinction recall in a sample of nonanxious young adults characterized in childhood with BI (n = 22) or with no BI (n = 28). Three weeks after undergoing fear conditioning and extinction, participants completed a functional magnetic resonance imaging extinction recall task assessing memory and threat differentiation for conditioned stimuli. While self-report and psychophysiological measures of differential conditioning and extinction were similar across groups, BI-related differences in brain function emerged during extinction recall. Childhood BI was associated with greater activation in subgenual anterior cingulate cortex in response to cues signaling safety. This pattern of results may reflect neural correlates that promote resilience against anxiety in a temperamentally at-risk population. En ligne : https://doi.org/10.1017/S0954579417000554 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Differences in neural response to extinction recall in young adults with or without history of behavioral inhibition [Texte imprimé et/ou numérique] / Tomer SHECHNER, Auteur ; Nathan A. FOX, Auteur ; Jamie A. MASH, Auteur ; Johanna M. JARCHO, Auteur ; Gang CHEN, Auteur ; Ellen LEIBENLUFT, Auteur ; Daniel S. PINE, Auteur ; Jennifer C. BRITTON, Auteur . - p.179-189. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.179-189 Index. décimale : PER Périodiques Résumé : Behavioral inhibition (BI) is a temperament identified in early childhood that is associated with risk for anxiety disorders, yet only about half of behaviorally inhibited children manifest anxiety later in life. We compared brain function and behavior during extinction recall in a sample of nonanxious young adults characterized in childhood with BI (n = 22) or with no BI (n = 28). Three weeks after undergoing fear conditioning and extinction, participants completed a functional magnetic resonance imaging extinction recall task assessing memory and threat differentiation for conditioned stimuli. While self-report and psychophysiological measures of differential conditioning and extinction were similar across groups, BI-related differences in brain function emerged during extinction recall. Childhood BI was associated with greater activation in subgenual anterior cingulate cortex in response to cues signaling safety. This pattern of results may reflect neural correlates that promote resilience against anxiety in a temperamentally at-risk population. En ligne : https://doi.org/10.1017/S0954579417000554 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

Incentive-elicited mesolimbic activation and externalizing symptomatology in adolescents / James M. BJORK in Journal of Child Psychology and Psychiatry, 51-7 (July 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.827-837 Titre : Incentive-elicited mesolimbic activation and externalizing symptomatology in adolescents Type de document : Texte imprimé et/ou numérique Auteurs : James M. BJORK, Auteur ; Gang CHEN, Auteur ; Ashley R. SMITH, Auteur ; Daniel W. HOMMER, Auteur Année de publication : 2010 Article en page(s) : p.827-837 Langues : Anglais (eng) Mots-clés : Conduct-disorder oppositional-defiant-disorder externalizing-disorders reward ventral-striatum nucleus-accumbens Index. décimale : PER Périodiques Résumé : Background: Opponent-process theories of externalizing disorders (ExD) attribute them to some combination of overactive reward processing systems and/or underactive behavior inhibition systems. Reward processing has been indexed by recruitment of incentive-motivational neurocircuitry of the ventral striatum (VS), including nucleus accumbens (NAcc). Methods: We used functional magnetic resonance imaging (fMRI) with an incentive task to determine whether externalizing symptomatology in adolescence is correlated with an enhanced VS recruitment by cues for rewards, or by deliveries of rewards. Twelve community-recruited adolescents with externalizing disorders (AED) and 12 age/gender-matched controls responded to targets to win or avoid losing $0, $0.20, $1, $5, or an unknown amount (ranging from $0.20 to $5). Results: Cues to respond for rewards activated the NAcc (relative to cues for no incentive), in both subject groups similarly, with greatest NAcc recruitment by cues for the largest reward. Loss-anticipatory NAcc signal increase was detected in a volume-of-interest analysis – but this increase occurred only in trials when subjects hit the target. Relative to controls, AED showed significantly elevated NAcc activation by a linear contrast between reward notification versus notification of failure to win reward. In a post hoc reanalysis, VS and pregenual anterior cingulate activation by the reward versus non-reward outcome contrast also directly correlated with Child Behavior Checklist (CBCL) Externalizing total scores (across all subjects) in lieu of a binary diagnosis. Finally, both groups showed right insula activation by loss notifications (contrasted with avoided losses). Conclusions: Externalizing behavior, whether assessed dimensionally with a questionnaire, or in the form of a diagnostic categorization, is associated with an exaggerated limbic response to outcomes of reward-directed behavior. This could be a neurobiological signature of the behavioral sensitivity to laboratory reward delivery that is characteristic of children with externalizing symptomatology. Of interest is future research on incentive-motivational processing in more severe, clinically referred AED. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02201.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] Incentive-elicited mesolimbic activation and externalizing symptomatology in adolescents [Texte imprimé et/ou numérique] / James M. BJORK, Auteur ; Gang CHEN, Auteur ; Ashley R. SMITH, Auteur ; Daniel W. HOMMER, Auteur . - 2010 . - p.827-837. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.827-837 Mots-clés : Conduct-disorder oppositional-defiant-disorder externalizing-disorders reward ventral-striatum nucleus-accumbens Index. décimale : PER Périodiques Résumé : Background: Opponent-process theories of externalizing disorders (ExD) attribute them to some combination of overactive reward processing systems and/or underactive behavior inhibition systems. Reward processing has been indexed by recruitment of incentive-motivational neurocircuitry of the ventral striatum (VS), including nucleus accumbens (NAcc). Methods: We used functional magnetic resonance imaging (fMRI) with an incentive task to determine whether externalizing symptomatology in adolescence is correlated with an enhanced VS recruitment by cues for rewards, or by deliveries of rewards. Twelve community-recruited adolescents with externalizing disorders (AED) and 12 age/gender-matched controls responded to targets to win or avoid losing $0, $0.20, $1, $5, or an unknown amount (ranging from $0.20 to $5). Results: Cues to respond for rewards activated the NAcc (relative to cues for no incentive), in both subject groups similarly, with greatest NAcc recruitment by cues for the largest reward. Loss-anticipatory NAcc signal increase was detected in a volume-of-interest analysis – but this increase occurred only in trials when subjects hit the target. Relative to controls, AED showed significantly elevated NAcc activation by a linear contrast between reward notification versus notification of failure to win reward. In a post hoc reanalysis, VS and pregenual anterior cingulate activation by the reward versus non-reward outcome contrast also directly correlated with Child Behavior Checklist (CBCL) Externalizing total scores (across all subjects) in lieu of a binary diagnosis. Finally, both groups showed right insula activation by loss notifications (contrasted with avoided losses). Conclusions: Externalizing behavior, whether assessed dimensionally with a questionnaire, or in the form of a diagnostic categorization, is associated with an exaggerated limbic response to outcomes of reward-directed behavior. This could be a neurobiological signature of the behavioral sensitivity to laboratory reward delivery that is characteristic of children with externalizing symptomatology. Of interest is future research on incentive-motivational processing in more severe, clinically referred AED. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02201.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

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