Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system / Henriette ACOSTA in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1027-1042 Titre : Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system Type de document : Texte imprimé et/ou numérique Auteurs : Henriette ACOSTA, Auteur ; Katri KANTOJARVI, Auteur ; Jetro J. TUULARI, Auteur ; John D. LEWIS, Auteur ; Niloofar HASHEMPOUR, Auteur ; Noora M. SCHEININ, Auteur ; Satu J. LEHTOLA, Auteur ; Saara NOLVI, Auteur ; Vladimir S. FONOV, Auteur ; D. Louis COLLINS, Auteur ; Alan C. EVANS, Auteur ; Riitta PARKKOLA, Auteur ; Tuire LÄHDESMÄKI, Auteur ; Jani SAUNAVAARA, Auteur ; Harri MERISAARI, Auteur ; Linnea KARLSSON, Auteur ; Tiina PAUNIO, Auteur ; Hasse KARLSSON, Auteur Article en page(s) : p.1027-1042 Langues : Anglais (eng) Mots-clés : MRI  SDQ  amygdala  hyperactivity  prenatal stress Index. décimale : PER Périodiques Résumé : Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap. In Finnish mother-infant dyads, we investigated the association of a cumulative prenatal adversity sum score (PRE-AS) with (a) child emotional and behavioral problems assessed with the Strengths and Difficulties Questionnaire at 4 and 5 years (N = 1568, 45.3% female), (b) infant amygdalar and hippocampal volumes (subsample N = 122), and (c) its moderation by a hippocampal-specific coexpression polygenic risk score based on the serotonin transporter (SLC6A4) gene. We found that higher PRE-AS was linked to greater child emotional and behavioral problems at both time points, with partly stronger associations in boys than in girls. Higher PRE-AS was associated with larger bilateral infant amygdalar volumes in girls compared to boys, while no associations were found for hippocampal volumes. Further, hyperactivity/inattention in 4-year-old girls was related to both genotype and PRE-AS, the latter partially mediated by right amygdalar volumes as preliminary evidence suggests. Our study is the first to demonstrate a dose-dependent sexually dimorphic relationship between cumulative prenatal adversity and infant amygdalar volumes. En ligne : https://dx.doi.org/10.1017/S0954579423000275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system [Texte imprimé et/ou numérique] / Henriette ACOSTA, Auteur ; Katri KANTOJARVI, Auteur ; Jetro J. TUULARI, Auteur ; John D. LEWIS, Auteur ; Niloofar HASHEMPOUR, Auteur ; Noora M. SCHEININ, Auteur ; Satu J. LEHTOLA, Auteur ; Saara NOLVI, Auteur ; Vladimir S. FONOV, Auteur ; D. Louis COLLINS, Auteur ; Alan C. EVANS, Auteur ; Riitta PARKKOLA, Auteur ; Tuire LÄHDESMÄKI, Auteur ; Jani SAUNAVAARA, Auteur ; Harri MERISAARI, Auteur ; Linnea KARLSSON, Auteur ; Tiina PAUNIO, Auteur ; Hasse KARLSSON, Auteur . - p.1027-1042. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1027-1042 Mots-clés : MRI  SDQ  amygdala  hyperactivity  prenatal stress Index. décimale : PER Périodiques Résumé : Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap. In Finnish mother-infant dyads, we investigated the association of a cumulative prenatal adversity sum score (PRE-AS) with (a) child emotional and behavioral problems assessed with the Strengths and Difficulties Questionnaire at 4 and 5 years (N = 1568, 45.3% female), (b) infant amygdalar and hippocampal volumes (subsample N = 122), and (c) its moderation by a hippocampal-specific coexpression polygenic risk score based on the serotonin transporter (SLC6A4) gene. We found that higher PRE-AS was linked to greater child emotional and behavioral problems at both time points, with partly stronger associations in boys than in girls. Higher PRE-AS was associated with larger bilateral infant amygdalar volumes in girls compared to boys, while no associations were found for hippocampal volumes. Further, hyperactivity/inattention in 4-year-old girls was related to both genotype and PRE-AS, the latter partially mediated by right amygdalar volumes as preliminary evidence suggests. Our study is the first to demonstrate a dose-dependent sexually dimorphic relationship between cumulative prenatal adversity and infant amygdalar volumes. En ligne : https://dx.doi.org/10.1017/S0954579423000275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts / Hanna C. GUSTAFSSON in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1837-1848 Titre : Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts Type de document : Texte imprimé et/ou numérique Auteurs : Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.1837-1848 Langues : Anglais (eng) Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques Résumé : High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research Domain Criteria (RDoC) concepts that may enrich a multilevel mechanistic map of psychopathology risk. Utilizing both variable-centered and person-centered approaches, the current study examined whether levels and trajectories of infant negative and positive emotionality, considered either in isolation or together, predicted children's ADHD symptoms at 4 to 8 years of age. In variable-centered analyses, higher levels of infant negative affect (at as early as 3 months of age) were associated with childhood ADHD symptoms. Findings for positive affect failed to reach statistical threshold. Results from person-centered trajectory analyses suggest that additional information is gained by simultaneously considering the trajectories of positive and negative emotionality. Specifically, only when exhibiting moderate, stable or low levels of positive affect did negative affect and its trajectory relate to child ADHD symptoms. These findings add to a growing literature that suggests that infant negative emotionality is a promising early life marker of future ADHD risk and suggest secondarily that moderation by positive affectivity warrants more consideration. En ligne : http://dx.doi.org/10.1017/S0954579421001012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts [Texte imprimé et/ou numérique] / Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur . - p.1837-1848. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1837-1848 Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques Résumé : High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research Domain Criteria (RDoC) concepts that may enrich a multilevel mechanistic map of psychopathology risk. Utilizing both variable-centered and person-centered approaches, the current study examined whether levels and trajectories of infant negative and positive emotionality, considered either in isolation or together, predicted children's ADHD symptoms at 4 to 8 years of age. In variable-centered analyses, higher levels of infant negative affect (at as early as 3 months of age) were associated with childhood ADHD symptoms. Findings for positive affect failed to reach statistical threshold. Results from person-centered trajectory analyses suggest that additional information is gained by simultaneously considering the trajectories of positive and negative emotionality. Specifically, only when exhibiting moderate, stable or low levels of positive affect did negative affect and its trajectory relate to child ADHD symptoms. These findings add to a growing literature that suggests that infant negative emotionality is a promising early life marker of future ADHD risk and suggest secondarily that moderation by positive affectivity warrants more consideration. En ligne : http://dx.doi.org/10.1017/S0954579421001012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts – CORRIGENDUM / Hanna C. GUSTAFSSON in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1882-1882 Titre : Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts – CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.1882-1882 Langues : Anglais (eng) Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579421001425 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts – CORRIGENDUM [Texte imprimé et/ou numérique] / Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur . - p.1882-1882. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1882-1882 Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579421001425 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Infant gut microbiota and negative and fear reactivity / Venla HUOVINEN in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.2016-2031 Titre : Infant gut microbiota and negative and fear reactivity Type de document : Texte imprimé et/ou numérique Auteurs : Venla HUOVINEN, Auteur ; Anna-Katariina AATSINKI, Auteur ; Eeva-Leena KATAJA, Auteur ; Eveliina MUNUKKA, Auteur ; Anniina KESKITALO, Auteur ; Santosh LAMICHHANE, Auteur ; Peppi RAUNIONIEMI, Auteur ; David J. BRIDGETT, Auteur ; Leo LAHTI, Auteur ; Siobhain M. O?MAHONY, Auteur ; Alex DICKENS, Auteur ; Riikka KORJA, Auteur ; Hasse KARLSSON, Auteur ; Saara NOLVI, Auteur ; Linnea KARLSSON, Auteur Article en page(s) : p.2016-2031 Langues : Anglais (eng) Mots-clés : alpha diversity  beta diversity  fear reactivity  genus abundance  negative reactivity Index. décimale : PER Périodiques Résumé : Background:Studies indicate that gut microbiota is related to neurodevelopmental and behavioral outcomes. Accordingly, early gut microbiota composition (GMC) has been linked to child temperament, but research is still scarce. The aim of this study was to examine how early GMC at 2.5 months is associated with child negative and fear reactivity at 8 and 12 months since they are potentially important intermediate phenotypes of later child psychiatric disorders.Methods:Our study population was 330 infants enrolled in the longitudinal FinnBrain Birth Cohort Study. Gut microbiota composition was analyzed using stool sample 16s rRNA sequencing. Negative and fear reactivity were assessed using the Laboratory Temperament Assessment Battery (Lab-TAB) at child?s age of 8 months (n =150) and the Infant Behavior Questionnaire-Revised Short Form (IBQ-R SF) at child?s age of 12 months (n = 276).Conclusions:We found a positive association between alpha diversity and reported fear reactivity and differing microbial community composition based on negative reactivity for boys. Isobutyric acid correlated with observed negative reactivity, however, this association attenuated in the linear model. Several genera were associated with the selected infant temperament traits. This study adds to the growing literature on links between infant gut microbiota and temperament informing future mechanistic studies. En ligne : https://dx.doi.org/10.1017/S0954579423001396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Infant gut microbiota and negative and fear reactivity [Texte imprimé et/ou numérique] / Venla HUOVINEN, Auteur ; Anna-Katariina AATSINKI, Auteur ; Eeva-Leena KATAJA, Auteur ; Eveliina MUNUKKA, Auteur ; Anniina KESKITALO, Auteur ; Santosh LAMICHHANE, Auteur ; Peppi RAUNIONIEMI, Auteur ; David J. BRIDGETT, Auteur ; Leo LAHTI, Auteur ; Siobhain M. O?MAHONY, Auteur ; Alex DICKENS, Auteur ; Riikka KORJA, Auteur ; Hasse KARLSSON, Auteur ; Saara NOLVI, Auteur ; Linnea KARLSSON, Auteur . - p.2016-2031. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.2016-2031 Mots-clés : alpha diversity  beta diversity  fear reactivity  genus abundance  negative reactivity Index. décimale : PER Périodiques Résumé : Background:Studies indicate that gut microbiota is related to neurodevelopmental and behavioral outcomes. Accordingly, early gut microbiota composition (GMC) has been linked to child temperament, but research is still scarce. The aim of this study was to examine how early GMC at 2.5 months is associated with child negative and fear reactivity at 8 and 12 months since they are potentially important intermediate phenotypes of later child psychiatric disorders.Methods:Our study population was 330 infants enrolled in the longitudinal FinnBrain Birth Cohort Study. Gut microbiota composition was analyzed using stool sample 16s rRNA sequencing. Negative and fear reactivity were assessed using the Laboratory Temperament Assessment Battery (Lab-TAB) at child?s age of 8 months (n =150) and the Infant Behavior Questionnaire-Revised Short Form (IBQ-R SF) at child?s age of 12 months (n = 276).Conclusions:We found a positive association between alpha diversity and reported fear reactivity and differing microbial community composition based on negative reactivity for boys. Isobutyric acid correlated with observed negative reactivity, however, this association attenuated in the linear model. Several genera were associated with the selected infant temperament traits. This study adds to the growing literature on links between infant gut microbiota and temperament informing future mechanistic studies. En ligne : https://dx.doi.org/10.1017/S0954579423001396 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

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