Association between atopic diseases and neurodevelopmental disabilities in a longitudinal birth cohort / Xueqi QU in Autism Research, 15-4 (April 2022)  

Public ISBD [article]  inAutism Research > 15-4 (April 2022) . - p.740-750 Titre : Association between atopic diseases and neurodevelopmental disabilities in a longitudinal birth cohort Type de document : Texte imprimé et/ou numérique Auteurs : Xueqi QU, Auteur ; Li-Ching LEE, Auteur ; Christine LADD-ACOSTA, Auteur ; Xiumei HONG, Auteur ; Yuelong JI, Auteur ; Luther G. KALB, Auteur ; Heather E. VOLK, Auteur ; Xiaobin WANG, Auteur Article en page(s) : p.740-750 Langues : Anglais (eng) Mots-clés : Asthma/complications/epidemiology  Attention Deficit Disorder with Hyperactivity/complications/epidemiology  Autism Spectrum Disorder/complications/epidemiology  Birth Cohort  Child  Dermatitis, Atopic/complications/epidemiology  Female  Humans  Infant, Newborn  Risk Factors  atopic diseases  children  neurodevelopmental disability  the United States  relevant to this article to disclose. Index. décimale : PER Périodiques Résumé : Reports on the association between the prevalence of atopic diseases and neurodevelopmental disabilities (NDs) have been inconsistent in the literature. We investigated whether autism spectrum disorder (ASD), attention deficit-hyperactivity disorders (ADHD), and other NDs are more prevalent in children with asthma, atopic dermatitis (AD) and allergic rhinitis (AR) compared to those without specific atopic conditions. A total of 2580 children enrolled at birth were followed prospectively, of which 119 have ASD, 423 have ADHD, 765 have other NDs, and 1273 have no NDs. Atopic diseases and NDs were defined based on physician diagnoses in electronic medical records. Logistic regressions adjusting for maternal and child characteristics estimated the associations between NDs (i.e., ASD, ADHD, and other NDs) and asthma, AD and AR, respectively. Children with asthma, AD or AR had a greater likelihood of having ADHD or other NDs compared with children without specific atopic conditions. The association between ASD and asthma diminished after adjusting for maternal and child factors. Either mothers or children having atopic conditions and both mothers and children with atopic conditions were associated with a higher prevalence of ADHD in children, compared with neither mothers nor children having atopic conditions. Children diagnosed with multiple atopic diseases were more likely to have NDs compared with those without or with only one type of atopic disease. In conclusion, in this U.S. urban birth cohort, children with atopic diseases had a higher co-morbidity of NDs. The findings have implications for etiologic research that searches for common early life antecedents of NDs and atopic conditions. Findings from this study also should raise awareness among health care providers and parents about the possible co-occurrence of both NDs and atopic conditions, which calls for coordinated efforts to screen, prevent and manage NDs and atopic conditions. En ligne : https://dx.doi.org/10.1002/aur.2680 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Association between atopic diseases and neurodevelopmental disabilities in a longitudinal birth cohort [Texte imprimé et/ou numérique] / Xueqi QU, Auteur ; Li-Ching LEE, Auteur ; Christine LADD-ACOSTA, Auteur ; Xiumei HONG, Auteur ; Yuelong JI, Auteur ; Luther G. KALB, Auteur ; Heather E. VOLK, Auteur ; Xiaobin WANG, Auteur . - p.740-750. Langues : Anglais (eng) in Autism Research > 15-4 (April 2022) . - p.740-750 Mots-clés : Asthma/complications/epidemiology  Attention Deficit Disorder with Hyperactivity/complications/epidemiology  Autism Spectrum Disorder/complications/epidemiology  Birth Cohort  Child  Dermatitis, Atopic/complications/epidemiology  Female  Humans  Infant, Newborn  Risk Factors  atopic diseases  children  neurodevelopmental disability  the United States  relevant to this article to disclose. Index. décimale : PER Périodiques Résumé : Reports on the association between the prevalence of atopic diseases and neurodevelopmental disabilities (NDs) have been inconsistent in the literature. We investigated whether autism spectrum disorder (ASD), attention deficit-hyperactivity disorders (ADHD), and other NDs are more prevalent in children with asthma, atopic dermatitis (AD) and allergic rhinitis (AR) compared to those without specific atopic conditions. A total of 2580 children enrolled at birth were followed prospectively, of which 119 have ASD, 423 have ADHD, 765 have other NDs, and 1273 have no NDs. Atopic diseases and NDs were defined based on physician diagnoses in electronic medical records. Logistic regressions adjusting for maternal and child characteristics estimated the associations between NDs (i.e., ASD, ADHD, and other NDs) and asthma, AD and AR, respectively. Children with asthma, AD or AR had a greater likelihood of having ADHD or other NDs compared with children without specific atopic conditions. The association between ASD and asthma diminished after adjusting for maternal and child factors. Either mothers or children having atopic conditions and both mothers and children with atopic conditions were associated with a higher prevalence of ADHD in children, compared with neither mothers nor children having atopic conditions. Children diagnosed with multiple atopic diseases were more likely to have NDs compared with those without or with only one type of atopic disease. In conclusion, in this U.S. urban birth cohort, children with atopic diseases had a higher co-morbidity of NDs. The findings have implications for etiologic research that searches for common early life antecedents of NDs and atopic conditions. Findings from this study also should raise awareness among health care providers and parents about the possible co-occurrence of both NDs and atopic conditions, which calls for coordinated efforts to screen, prevent and manage NDs and atopic conditions. En ligne : https://dx.doi.org/10.1002/aur.2680 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Maternal Mediterranean-Style Diet During Pregnancy and Child Social Impairment as Measured by the Social Responsiveness Scale / Xiaoyu CHE in Autism Research, 18-8 (August 2025)  

Public ISBD [article]  inAutism Research > 18-8 (August 2025) . - p.1693-1703 Titre : Maternal Mediterranean-Style Diet During Pregnancy and Child Social Impairment as Measured by the Social Responsiveness Scale Type de document : Texte imprimé et/ou numérique Auteurs : Xiaoyu CHE, Auteur ; Xueqi QU, Auteur ; Ramkripa RAGHAVEN, Auteur ; Colleen PEARSON, Auteur ; William ADAMS, Auteur ; Heather VOLK, Auteur ; Marilyn AUGUSTYN, Auteur ; Xiaobin WANG, Auteur Article en page(s) : p.1693-1703 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  children  dietary pattern  mediterranean-style diet  nutrition  pregnancy  social responsiveness scale Index. décimale : PER Périodiques Résumé : ABSTRACT While previous studies have examined the role of individual micronutrients in autism spectrum disorder (ASD), limited evidence exists on how maternal dietary patterns during pregnancy relate to broader social and communication outcomes. This study aimed to assess the association between adherence to a Mediterranean-style diet during pregnancy and measures of social impairment in a racially diverse, prospective birth cohort. We analyzed 821 mother?child pairs from the Boston Birth Cohort, including 52 children with an ASD diagnosis. Maternal Mediterranean-style Diet Scores (MSDS) during pregnancy were calculated using food frequency questionnaires administered 24?72?h after delivery. Child social impairment was assessed using Social Responsiveness Scale (SRS). Restricted cubic spline models were used to explore potential non-linear relationships between MSDS and SRS total scores. Linear regression models were used to quantify associations between MSDS tertiles and children's SRS total scores and scores across five SRS subdomains. An L-shape association was observed between maternal MSDS and SRS total scores. Compared to the children of mothers in the lowest MSDS tertiles, those in the middle (beta (95% CI)?=??4.95 (?9.59, ?0.31)) and highest tertiles (?5.13 (?9.48, ?0.79)) had significantly lower SRS total scores, indicating reduced social impairment. Associations were particularly pronounced in the social cognition and social communication subdomains. Greater maternal adherence to a Mediterranean-style diet during pregnancy was associated with better social interaction and communication development in children. These findings underscore the critical role of maternal nutrition in child neurodevelopment, highlighting potential targets for early risk assessment and prevention efforts. En ligne : https://doi.org/10.1002/aur.70077 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566 [article] Maternal Mediterranean-Style Diet During Pregnancy and Child Social Impairment as Measured by the Social Responsiveness Scale [Texte imprimé et/ou numérique] / Xiaoyu CHE, Auteur ; Xueqi QU, Auteur ; Ramkripa RAGHAVEN, Auteur ; Colleen PEARSON, Auteur ; William ADAMS, Auteur ; Heather VOLK, Auteur ; Marilyn AUGUSTYN, Auteur ; Xiaobin WANG, Auteur . - p.1693-1703. Langues : Anglais (eng) in Autism Research > 18-8 (August 2025) . - p.1693-1703 Mots-clés : autism spectrum disorder  children  dietary pattern  mediterranean-style diet  nutrition  pregnancy  social responsiveness scale Index. décimale : PER Périodiques Résumé : ABSTRACT While previous studies have examined the role of individual micronutrients in autism spectrum disorder (ASD), limited evidence exists on how maternal dietary patterns during pregnancy relate to broader social and communication outcomes. This study aimed to assess the association between adherence to a Mediterranean-style diet during pregnancy and measures of social impairment in a racially diverse, prospective birth cohort. We analyzed 821 mother?child pairs from the Boston Birth Cohort, including 52 children with an ASD diagnosis. Maternal Mediterranean-style Diet Scores (MSDS) during pregnancy were calculated using food frequency questionnaires administered 24?72?h after delivery. Child social impairment was assessed using Social Responsiveness Scale (SRS). Restricted cubic spline models were used to explore potential non-linear relationships between MSDS and SRS total scores. Linear regression models were used to quantify associations between MSDS tertiles and children's SRS total scores and scores across five SRS subdomains. An L-shape association was observed between maternal MSDS and SRS total scores. Compared to the children of mothers in the lowest MSDS tertiles, those in the middle (beta (95% CI)?=??4.95 (?9.59, ?0.31)) and highest tertiles (?5.13 (?9.48, ?0.79)) had significantly lower SRS total scores, indicating reduced social impairment. Associations were particularly pronounced in the social cognition and social communication subdomains. Greater maternal adherence to a Mediterranean-style diet during pregnancy was associated with better social interaction and communication development in children. These findings underscore the critical role of maternal nutrition in child neurodevelopment, highlighting potential targets for early risk assessment and prevention efforts. En ligne : https://doi.org/10.1002/aur.70077 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=566

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