Early adversities accelerate epigenetic aging into adulthood: a 10-year, within-subject analysis / William E. COPELAND in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1308-1315 Titre : Early adversities accelerate epigenetic aging into adulthood: a 10-year, within-subject analysis Type de document : texte imprimé Auteurs : William E. COPELAND, Auteur ; Lilly SHANAHAN, Auteur ; Ellen W. MCGINNIS, Auteur ; Karolina A. ABERG, Auteur ; Edwin J.C.G. VAN DEN OORD, Auteur Article en page(s) : p.1308-1315 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Cross-Sectional Studies  Risk Factors  Anxiety Disorders  Aging/genetics  Epigenesis, Genetic  Childhood  DNA methylation  adversity  aging  epigenetic  longitudinal Index. décimale : PER Périodiques Résumé : BACKGROUND: Longitudinal studies are needed to clarify whether early adversities are associated with advanced methylation age or if they actually accelerate methylation aging. This study test whether different dimensions of childhood adversity accelerate biological aging from childhood to adulthood, and, if so, via which mechanisms. METHODS: 381 participants provided one blood sample in childhood (average age 15.0; SD=2.3) and another in young adulthood (average age 23.1; SD=2.8). Participants and their parents provided a median of 6 childhood assessments (total=1,950 childhood observations), reporting exposures to different types of adversity dimensions (i.e. threat, material deprivation, loss, unpredictability). The blood samples were assayed to estimate DNA methylation age in both childhood and adulthood and also change in methylation age across this period. RESULTS: Cross-sectional associations between the childhood adversity dimensions and childhood measures of methylation age were non-significant. In contrast, multiple adversity dimensions were associated with accelerated within-person change in methylation age from adolescence to young adulthood. These associations attenuated in model testing all dimensions at the same time. Accelerated aging increased with increasing number of childhood adversities: Individuals with highest number of adversities experienced 2+ additional years of methylation aging compared to those with no exposure to childhood adversities. The association between total childhood adversity exposure and accelerated aging was partially explained by childhood depressive symptoms, but not anxiety or behavioral symptoms. CONCLUSIONS: Early adversities accelerate epigenetic aging long after they occur, in proportion to the total number of such experiences, and in a manner consistent with a shared effect that crosses multiple early dimensions of risk. En ligne : http://dx.doi.org/10.1111/jcpp.13575 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Early adversities accelerate epigenetic aging into adulthood: a 10-year, within-subject analysis [texte imprimé] / William E. COPELAND, Auteur ; Lilly SHANAHAN, Auteur ; Ellen W. MCGINNIS, Auteur ; Karolina A. ABERG, Auteur ; Edwin J.C.G. VAN DEN OORD, Auteur . - p.1308-1315. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-11 (November 2022) . - p.1308-1315 Mots-clés : Adolescent  Humans  Child  Young Adult  Adult  Cross-Sectional Studies  Risk Factors  Anxiety Disorders  Aging/genetics  Epigenesis, Genetic  Childhood  DNA methylation  adversity  aging  epigenetic  longitudinal Index. décimale : PER Périodiques Résumé : BACKGROUND: Longitudinal studies are needed to clarify whether early adversities are associated with advanced methylation age or if they actually accelerate methylation aging. This study test whether different dimensions of childhood adversity accelerate biological aging from childhood to adulthood, and, if so, via which mechanisms. METHODS: 381 participants provided one blood sample in childhood (average age 15.0; SD=2.3) and another in young adulthood (average age 23.1; SD=2.8). Participants and their parents provided a median of 6 childhood assessments (total=1,950 childhood observations), reporting exposures to different types of adversity dimensions (i.e. threat, material deprivation, loss, unpredictability). The blood samples were assayed to estimate DNA methylation age in both childhood and adulthood and also change in methylation age across this period. RESULTS: Cross-sectional associations between the childhood adversity dimensions and childhood measures of methylation age were non-significant. In contrast, multiple adversity dimensions were associated with accelerated within-person change in methylation age from adolescence to young adulthood. These associations attenuated in model testing all dimensions at the same time. Accelerated aging increased with increasing number of childhood adversities: Individuals with highest number of adversities experienced 2+ additional years of methylation aging compared to those with no exposure to childhood adversities. The association between total childhood adversity exposure and accelerated aging was partially explained by childhood depressive symptoms, but not anxiety or behavioral symptoms. CONCLUSIONS: Early adversities accelerate epigenetic aging long after they occur, in proportion to the total number of such experiences, and in a manner consistent with a shared effect that crosses multiple early dimensions of risk. En ligne : http://dx.doi.org/10.1111/jcpp.13575 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490

Impact of dimensions of early adversity on adult health and functioning: A 2-decade, longitudinal study / Ellen W. MCGINNIS in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 527-538 Titre : Impact of dimensions of early adversity on adult health and functioning: A 2-decade, longitudinal study Type de document : texte imprimé Auteurs : Ellen W. MCGINNIS, Auteur ; Margaret SHERIDAN, Auteur ; William E. COPELAND, Auteur Article en page(s) : 527-538 Langues : Anglais (eng) Mots-clés : child adversity  deprivation  life history  longitudinal  threat Index. décimale : PER Périodiques Résumé : Recent neurodevelopmental and evolutionary theories offer strong theoretical rationales and some empirical evidence to support the importance of specific dimensions of early adversity. However, studies have often been limited by omission of other adversity dimensions, singular outcomes, and short follow up durations. 1,420 participants in the community, Great Smoky Mountains Study, were assessed up to eight times between age 9 and 16 for four dimensions of early adversity: Threat, Material Deprivation, Unpredictability, and Loss (as well as a Cumulative Adversity measure). Participants were followed up to four times in adulthood (ages 19, 21, 25, and 30) to measure psychiatric disorders, substance disorder, and ?real-world? functioning. Every childhood adversity dimension was associated with multiple adult psychiatric, substance, or functional outcomes when tested simultaneously in a multivariable analysis that accounted for other childhood adversities. There was evidence of differential impact of dimensions of adversity exposure on proximal outcomes (e.g., material deprivation and IQ) and even on distal outcomes (e.g., threat and emotional functioning). There were similar levels of prediction between the best set of individual adversity scales and a single cumulative adversity measure when considering distal outcomes. All dimensions of childhood adversity have lasting, pleiotropic effects, on adult health and functioning, but these dimensions may act via distinct proximal pathways. En ligne : http://dx.doi.org/10.1017/s095457942100167x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Impact of dimensions of early adversity on adult health and functioning: A 2-decade, longitudinal study [texte imprimé] / Ellen W. MCGINNIS, Auteur ; Margaret SHERIDAN, Auteur ; William E. COPELAND, Auteur . - 527-538. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 527-538 Mots-clés : child adversity  deprivation  life history  longitudinal  threat Index. décimale : PER Périodiques Résumé : Recent neurodevelopmental and evolutionary theories offer strong theoretical rationales and some empirical evidence to support the importance of specific dimensions of early adversity. However, studies have often been limited by omission of other adversity dimensions, singular outcomes, and short follow up durations. 1,420 participants in the community, Great Smoky Mountains Study, were assessed up to eight times between age 9 and 16 for four dimensions of early adversity: Threat, Material Deprivation, Unpredictability, and Loss (as well as a Cumulative Adversity measure). Participants were followed up to four times in adulthood (ages 19, 21, 25, and 30) to measure psychiatric disorders, substance disorder, and ?real-world? functioning. Every childhood adversity dimension was associated with multiple adult psychiatric, substance, or functional outcomes when tested simultaneously in a multivariable analysis that accounted for other childhood adversities. There was evidence of differential impact of dimensions of adversity exposure on proximal outcomes (e.g., material deprivation and IQ) and even on distal outcomes (e.g., threat and emotional functioning). There were similar levels of prediction between the best set of individual adversity scales and a single cumulative adversity measure when considering distal outcomes. All dimensions of childhood adversity have lasting, pleiotropic effects, on adult health and functioning, but these dimensions may act via distinct proximal pathways. En ligne : http://dx.doi.org/10.1017/s095457942100167x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Maternal parenting predicts infant biobehavioral regulation among women with a history of childhood maltreatment / Cecilia MARTINEZ-TORTEYA in Development and Psychopathology, 26-2 (May 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-2 (May 2014) . - p.379-392 Titre : Maternal parenting predicts infant biobehavioral regulation among women with a history of childhood maltreatment Type de document : texte imprimé Auteurs : Cecilia MARTINEZ-TORTEYA, Auteur ; Carolyn J. DAYTON, Auteur ; Marjorie BEEGHLY, Auteur ; Julia S. SENG, Auteur ; Ellen W. MCGINNIS, Auteur ; Amanda BRODERICK, Auteur ; Katherine ROSENBLUM, Auteur ; Maria MUZIK, Auteur Article en page(s) : p.379-392 Index. décimale : PER Périodiques Résumé : Early biobehavioral regulation, a major influence of later adaptation, develops through dyadic interactions with caregivers. Thus, identification of maternal characteristics that can ameliorate or exacerbate infants’ innate vulnerabilities is key for infant well-being and long-term healthy development. The present study evaluated the influence of maternal parenting, postpartum psychopathology, history of childhood maltreatment, and demographic risk on infant behavioral and physiological (i.e., salivary cortisol) regulation using the still-face paradigm. Our sample included 153 women with high rates of childhood maltreatment experiences. Mother–infant dyads completed a multimethod assessment at 7 months of age. Structural equation modeling showed that maternal positive (i.e., sensitive, warm, engaged, and joyful) and negative (i.e., overcontrolling and hostile) behaviors during interactions were associated with concurrent maternal depressive symptoms, single parent status, and low family income. In turn, positive parenting predicted improved infant behavioral regulation (i.e., positive affect and social behaviors following the stressor) and decreased cortisol reactivity (i.e., posttask levels that were similar to or lower than baseline cortisol). These findings suggest increased risk for those women experiencing high levels of depressive symptoms postpartum and highlight the importance of maternal positive interactive behaviors during the first year for children's neurodevelopment. En ligne : http://dx.doi.org/10.1017/S0954579414000017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230 [article] Maternal parenting predicts infant biobehavioral regulation among women with a history of childhood maltreatment [texte imprimé] / Cecilia MARTINEZ-TORTEYA, Auteur ; Carolyn J. DAYTON, Auteur ; Marjorie BEEGHLY, Auteur ; Julia S. SENG, Auteur ; Ellen W. MCGINNIS, Auteur ; Amanda BRODERICK, Auteur ; Katherine ROSENBLUM, Auteur ; Maria MUZIK, Auteur . - p.379-392. in Development and Psychopathology > 26-2 (May 2014) . - p.379-392 Index. décimale : PER Périodiques Résumé : Early biobehavioral regulation, a major influence of later adaptation, develops through dyadic interactions with caregivers. Thus, identification of maternal characteristics that can ameliorate or exacerbate infants’ innate vulnerabilities is key for infant well-being and long-term healthy development. The present study evaluated the influence of maternal parenting, postpartum psychopathology, history of childhood maltreatment, and demographic risk on infant behavioral and physiological (i.e., salivary cortisol) regulation using the still-face paradigm. Our sample included 153 women with high rates of childhood maltreatment experiences. Mother–infant dyads completed a multimethod assessment at 7 months of age. Structural equation modeling showed that maternal positive (i.e., sensitive, warm, engaged, and joyful) and negative (i.e., overcontrolling and hostile) behaviors during interactions were associated with concurrent maternal depressive symptoms, single parent status, and low family income. In turn, positive parenting predicted improved infant behavioral regulation (i.e., positive affect and social behaviors following the stressor) and decreased cortisol reactivity (i.e., posttask levels that were similar to or lower than baseline cortisol). These findings suggest increased risk for those women experiencing high levels of depressive symptoms postpartum and highlight the importance of maternal positive interactive behaviors during the first year for children's neurodevelopment. En ligne : http://dx.doi.org/10.1017/S0954579414000017 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230

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