52 recherche sur le mot-clé 'Cross-Sectional Studies'

Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis / Pilar GARCES in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 22 p. Titre : Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis Type de document : Texte imprimé et/ou numérique Auteurs : Pilar GARCES, Auteur ; Sarah BAUMEISTER, Auteur ; Luke MASON, Auteur ; Christopher H. CHATHAM, Auteur ; Stefan HOLIGA, Auteur ; Juergen DUKART, Auteur ; Emily J. H. JONES, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; Sarah DURSTON, Auteur ; Bob ORANJE, Auteur ; Antonio M. PERSICO, Auteur ; Christian F. BECKMANN, Auteur ; Thomas BOUGERON, Auteur ; Flavio DELL'ACQUA, Auteur ; Christine ECKER, Auteur ; Carolin MOESSNANG, Auteur ; Tony CHARMAN, Auteur ; Julian TILLMANN, Auteur ; Declan G. M. MURPHY, Auteur ; Mark H. JOHNSON, Auteur ; Eva LOTH, Auteur ; Daniel BRANDEIS, Auteur ; Joerg F. HIPP, Auteur Article en page(s) : 22 p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Brain/diagnostic imaging  Brain Mapping/methods  Child  Cross-Sectional Studies  Electroencephalography/methods  Humans  Magnetic Resonance Imaging/methods  Reproducibility of Results  Autism spectrum disorder  Eeg  Functional connectivity  Power spectrum  Resting state Index. décimale : PER Périodiques Résumé : BACKGROUND: Understanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a window into spontaneous local and long-range neuronal synchronization and has been investigated in many ASD studies, but results are inconsistent. Unbiased investigation in large and comprehensive samples focusing on replicability is needed. METHODS: We quantified resting state EEG alpha peak metrics, power spectrum (PS, 2-32 Hz) and functional connectivity (FC) in 411 children, adolescents and adults (n=212 ASD, n=199 neurotypicals [NT], all with IQ?>?75). We performed analyses in source-space using individual head models derived from the participants' MRIs. We tested for differences in mean and variance between the ASD and NT groups for both PS and FC using linear mixed effects models accounting for age, sex, IQ and site effects. Then, we used machine learning to assess whether a multivariate combination of EEG features could better separate ASD and NT participants. All analyses were embedded within a train-validation approach (70%-30% split). RESULTS: In the training dataset, we found an interaction between age and group for the reactivity to eye opening (p=.042 uncorrected), and a significant but weak multivariate ASD vs. NT classification performance for PS and FC (sensitivity 0.52-0.62, specificity 0.59-0.73). None of these findings replicated significantly in the validation dataset, although the effect size in the validation dataset overlapped with the prediction interval from the training dataset. LIMITATIONS: The statistical power to detect weak effects-of the magnitude of those found in the training dataset-in the validation dataset is small, and we cannot fully conclude on the reproducibility of the training dataset's effects. CONCLUSIONS: This suggests that PS and FC values in ASD and NT have a strong overlap, and that differences between both groups (in both mean and variance) have, at best, a small effect size. Larger studies would be needed to investigate and replicate such potential effects. En ligne : http://dx.doi.org/10.1186/s13229-022-00500-x Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4778 [article] Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis [Texte imprimé et/ou numérique] / Pilar GARCES, Auteur ; Sarah BAUMEISTER, Auteur ; Luke MASON, Auteur ; Christopher H. CHATHAM, Auteur ; Stefan HOLIGA, Auteur ; Juergen DUKART, Auteur ; Emily J. H. JONES, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; Sarah DURSTON, Auteur ; Bob ORANJE, Auteur ; Antonio M. PERSICO, Auteur ; Christian F. BECKMANN, Auteur ; Thomas BOUGERON, Auteur ; Flavio DELL'ACQUA, Auteur ; Christine ECKER, Auteur ; Carolin MOESSNANG, Auteur ; Tony CHARMAN, Auteur ; Julian TILLMANN, Auteur ; Declan G. M. MURPHY, Auteur ; Mark H. JOHNSON, Auteur ; Eva LOTH, Auteur ; Daniel BRANDEIS, Auteur ; Joerg F. HIPP, Auteur . - 22 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 22 p. Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Brain/diagnostic imaging  Brain Mapping/methods  Child  Cross-Sectional Studies  Electroencephalography/methods  Humans  Magnetic Resonance Imaging/methods  Reproducibility of Results  Autism spectrum disorder  Eeg  Functional connectivity  Power spectrum  Resting state Index. décimale : PER Périodiques Résumé : BACKGROUND: Understanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a window into spontaneous local and long-range neuronal synchronization and has been investigated in many ASD studies, but results are inconsistent. Unbiased investigation in large and comprehensive samples focusing on replicability is needed. METHODS: We quantified resting state EEG alpha peak metrics, power spectrum (PS, 2-32 Hz) and functional connectivity (FC) in 411 children, adolescents and adults (n=212 ASD, n=199 neurotypicals [NT], all with IQ?>?75). We performed analyses in source-space using individual head models derived from the participants' MRIs. We tested for differences in mean and variance between the ASD and NT groups for both PS and FC using linear mixed effects models accounting for age, sex, IQ and site effects. Then, we used machine learning to assess whether a multivariate combination of EEG features could better separate ASD and NT participants. All analyses were embedded within a train-validation approach (70%-30% split). RESULTS: In the training dataset, we found an interaction between age and group for the reactivity to eye opening (p=.042 uncorrected), and a significant but weak multivariate ASD vs. NT classification performance for PS and FC (sensitivity 0.52-0.62, specificity 0.59-0.73). None of these findings replicated significantly in the validation dataset, although the effect size in the validation dataset overlapped with the prediction interval from the training dataset. LIMITATIONS: The statistical power to detect weak effects-of the magnitude of those found in the training dataset-in the validation dataset is small, and we cannot fully conclude on the reproducibility of the training dataset's effects. CONCLUSIONS: This suggests that PS and FC values in ASD and NT have a strong overlap, and that differences between both groups (in both mean and variance) have, at best, a small effect size. Larger studies would be needed to investigate and replicate such potential effects. En ligne : http://dx.doi.org/10.1186/s13229-022-00500-x Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4778

The impact of COVID-19 on autism research: A cross-sectional analysis of discontinued or suspended clinical trials / Monika NEALE in Autism Research, 15-8 (August 2022)  

Public ISBD [article]  inAutism Research > 15-8 (August 2022) . - p.1560-1564 Titre : The impact of COVID-19 on autism research: A cross-sectional analysis of discontinued or suspended clinical trials Type de document : Texte imprimé et/ou numérique Auteurs : Monika NEALE, Auteur ; Elizabeth LANDERS, Auteur ; Nicholas B. SAJJADI, Auteur ; Anya MAZUR-MOSIEWICZ, Auteur ; Micah HARTWELL, Auteur Article en page(s) : p.1560-1564 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology  Autistic Disorder/epidemiology  covid-19  Cross-Sectional Studies  Humans  Pandemics  Covid-19  autism  clinical trials  discontinuation  pandemic Index. décimale : PER Périodiques Résumé : Due to uncertainties associated with the COVID-19 public health crisis, several clinical trials had to be withdrawn or postponed. Our investigation aimed to assess the rate of discontinuation of clinical trials focusing on Autism Spectrum Disorder. Of the 197 registered trials included in our systematic review, 15 (7.6%) were discontinued, with nearly half of these explicitly citing COVID-19 as their reason for discontinuation. Pharmacological trials were six times more likely to be discontinued during the pandemic than non-pharmacological studies. The difference between the likelihood of discontinuation was statistically significant (OR: 6.13; 95% CI: 1.22-30.71). There was no evidence of association between funding source and reasons for discontinuation. Limitations, along with implications for future trials are discussed. LAY SUMMARY: We investigated the impact of the COVID-19 pandemic on the discontinuation rate of autism clinical trials. We found that drug trials were six times more likely to be discontinued during the pandemic compared to behavioral, diagnostic, and nutritional trials. The overall discontinuation rate was notably lower in autism clinical trials than in other areas of medical research. We recommend an examination of the methodology of the continued autism trials to assess their applicability in other fields. En ligne : http://dx.doi.org/10.1002/aur.2764 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4836 [article] The impact of COVID-19 on autism research: A cross-sectional analysis of discontinued or suspended clinical trials [Texte imprimé et/ou numérique] / Monika NEALE, Auteur ; Elizabeth LANDERS, Auteur ; Nicholas B. SAJJADI, Auteur ; Anya MAZUR-MOSIEWICZ, Auteur ; Micah HARTWELL, Auteur . - p.1560-1564. Langues : Anglais (eng) in Autism Research > 15-8 (August 2022) . - p.1560-1564 Mots-clés : Autism Spectrum Disorder/epidemiology  Autistic Disorder/epidemiology  covid-19  Cross-Sectional Studies  Humans  Pandemics  Covid-19  autism  clinical trials  discontinuation  pandemic Index. décimale : PER Périodiques Résumé : Due to uncertainties associated with the COVID-19 public health crisis, several clinical trials had to be withdrawn or postponed. Our investigation aimed to assess the rate of discontinuation of clinical trials focusing on Autism Spectrum Disorder. Of the 197 registered trials included in our systematic review, 15 (7.6%) were discontinued, with nearly half of these explicitly citing COVID-19 as their reason for discontinuation. Pharmacological trials were six times more likely to be discontinued during the pandemic than non-pharmacological studies. The difference between the likelihood of discontinuation was statistically significant (OR: 6.13; 95% CI: 1.22-30.71). There was no evidence of association between funding source and reasons for discontinuation. Limitations, along with implications for future trials are discussed. LAY SUMMARY: We investigated the impact of the COVID-19 pandemic on the discontinuation rate of autism clinical trials. We found that drug trials were six times more likely to be discontinued during the pandemic compared to behavioral, diagnostic, and nutritional trials. The overall discontinuation rate was notably lower in autism clinical trials than in other areas of medical research. We recommend an examination of the methodology of the continued autism trials to assess their applicability in other fields. En ligne : http://dx.doi.org/10.1002/aur.2764 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4836

An Australian Cross-Sectional Survey of Parents' Experiences of Emergency Department Visits Among Children with Autism Spectrum Disorder / Alice GARRICK in Journal of Autism and Developmental Disorders, 52-5 (May 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-5 (May 2022) . - p.2046-2060 Titre : An Australian Cross-Sectional Survey of Parents' Experiences of Emergency Department Visits Among Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alice GARRICK, Auteur ; Marie L. LEE, Auteur ; Carrington SCARFFE, Auteur ; Tony ATTWOOD, Auteur ; Kirsten FURLEY, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur Article en page(s) : p.2046-2060 Langues : Anglais (eng) Mots-clés : Australia/epidemiology  Autism Spectrum Disorder/epidemiology  Child  Cross-Sectional Studies  Emergency Service, Hospital  Humans  Parents  Attention deficit hyperactivity disorder  Autism spectrum disorders  Comorbidity  Emergency department  Survey Index. décimale : PER Périodiques Résumé : Parents of children with ASD who had attended an Australian emergency department (ED; n=421) completed a questionnaire relating to their experiences in the ED, including (1) child's reason for presentation and existing comorbidities, (2) quality of care during the visit (3) child's behaviour during visit, e.g. sensory responses to the ED environment, and disruptive behaviours. Children with comorbid ASD and intellectual disability were more likely to present with gastrointestinal issues and seizures, while those with comorbid ASD and oppositional defiant disorder were more likely to present with self-injury. ED staff awareness of ASD-related issues, including communication and expression of pain, were common difficulties for parents. The ED environment (e.g. lights, sounds, waiting areas), exacerbated child anxiety and led to disruptive behaviour. En ligne : http://dx.doi.org/10.1007/s10803-021-05091-9 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4762 [article] An Australian Cross-Sectional Survey of Parents' Experiences of Emergency Department Visits Among Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Alice GARRICK, Auteur ; Marie L. LEE, Auteur ; Carrington SCARFFE, Auteur ; Tony ATTWOOD, Auteur ; Kirsten FURLEY, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur . - p.2046-2060. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-5 (May 2022) . - p.2046-2060 Mots-clés : Australia/epidemiology  Autism Spectrum Disorder/epidemiology  Child  Cross-Sectional Studies  Emergency Service, Hospital  Humans  Parents  Attention deficit hyperactivity disorder  Autism spectrum disorders  Comorbidity  Emergency department  Survey Index. décimale : PER Périodiques Résumé : Parents of children with ASD who had attended an Australian emergency department (ED; n=421) completed a questionnaire relating to their experiences in the ED, including (1) child's reason for presentation and existing comorbidities, (2) quality of care during the visit (3) child's behaviour during visit, e.g. sensory responses to the ED environment, and disruptive behaviours. Children with comorbid ASD and intellectual disability were more likely to present with gastrointestinal issues and seizures, while those with comorbid ASD and oppositional defiant disorder were more likely to present with self-injury. ED staff awareness of ASD-related issues, including communication and expression of pain, were common difficulties for parents. The ED environment (e.g. lights, sounds, waiting areas), exacerbated child anxiety and led to disruptive behaviour. En ligne : http://dx.doi.org/10.1007/s10803-021-05091-9 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4762

High Depression Symptoms and Burnout Levels Among Parents of Children with Autism Spectrum Disorders: A Multi-Center, Cross-Sectional, Case-Control Study / MÖ KÜTÜK in Journal of Autism and Developmental Disorders, 51-11 (November 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4086-4099 Titre : High Depression Symptoms and Burnout Levels Among Parents of Children with Autism Spectrum Disorders: A Multi-Center, Cross-Sectional, Case-Control Study Type de document : Texte imprimé et/ou numérique Auteurs : MÖ KÜTÜK, Auteur ; A. E. TUFAN, Auteur ; F. KILIÇASLAN, Auteur ; G. GÜLER, Auteur ; F. ÇELIK, Auteur ; E. ALTINTA?, Auteur ; C. GOKCEN, Auteur ; M. KARADA?, Auteur ; Ç YEKTA?, Auteur ; T. MUTLUER, Auteur ; H. KANDEMIR, Auteur ; A. BÜBER, Auteur ; Z. TOPAL, Auteur ; U. ACIKBAS, Auteur ; A. GIRAY, Auteur ; Ö KÜTÜK, Auteur Article en page(s) : p.4086-4099 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology  Burnout, Psychological/epidemiology  Case-Control Studies  Child  Cross-Sectional Studies  Depression/epidemiology  Female  Humans  Male  Mothers  Parents  Stress, Psychological  Asd  Burnout  Depression  Parent Index. décimale : PER Périodiques Résumé : The diagnosis of autism spectrum disorder (ASD) in a child affects family processes, increases parenting stress and marital conflicts, and may lead to parental psychopathology. It may also affect the prognosis for their children. The aim of this study is to determine depression and burnout levels as well as their predictors among parents of children with ASD compared with those of healthy children. We also sought to evaluate rate of complementary and alternative medicine (CAM) interventions among parents and explore the associations of this phenomenon in an exploratory fashion. 145 children with ASD and 127 control children were enrolled along with their mothers and fathers. Beck Depression Inventory and Maslach Burnout Inventory were used to evaluate parents' depression symptoms and burnout levels. Symptoms of children with ASDs were evaluated according to the Childhood Autism Rating Scale by the clinicians. Family, child and CAM variables were screened by means of a sociodemographic data form. Descriptive, bivariate and correlation analyses were used in statistical evaluations. Predictors of burnout were evaluated with multiple regression analysis. Burnout and depression levels among parents of children with ASD were significantly elevated compared to controls. Burnout levels of mothers were significantly elevated compared to fathers while depression scores of fathers were significantly elevated compared to mothers. Maternal burnout was significantly predicted by presence of functional speech in child while paternal burnout was significantly predicted by paternal vocation. Maternal depression was associated with paternal depression, lack of speech in child and attendance of child to special education services. Paternal depression was associated with autistic symptom severity and maternal depression. More than half the parents sought CAM interventions. Education level did not affect search for CAM interventions while both maternal and paternal psychopathology and presence of epilepsy among children increased use of CAM methods. Psychological support should be provided to both mothers and fathers of a child receiving a diagnosis of ASD. Addressing parents' burnout and stress levels and facilitating their negotiation of knowledge on etiology and treatments for ASD may be beneficial for the family unit as a whole. En ligne : http://dx.doi.org/10.1007/s10803-021-04874-4 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4541 [article] High Depression Symptoms and Burnout Levels Among Parents of Children with Autism Spectrum Disorders: A Multi-Center, Cross-Sectional, Case-Control Study [Texte imprimé et/ou numérique] / MÖ KÜTÜK, Auteur ; A. E. TUFAN, Auteur ; F. KILIÇASLAN, Auteur ; G. GÜLER, Auteur ; F. ÇELIK, Auteur ; E. ALTINTA?, Auteur ; C. GOKCEN, Auteur ; M. KARADA?, Auteur ; Ç YEKTA?, Auteur ; T. MUTLUER, Auteur ; H. KANDEMIR, Auteur ; A. BÜBER, Auteur ; Z. TOPAL, Auteur ; U. ACIKBAS, Auteur ; A. GIRAY, Auteur ; Ö KÜTÜK, Auteur . - p.4086-4099. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4086-4099 Mots-clés : Autism Spectrum Disorder/epidemiology  Burnout, Psychological/epidemiology  Case-Control Studies  Child  Cross-Sectional Studies  Depression/epidemiology  Female  Humans  Male  Mothers  Parents  Stress, Psychological  Asd  Burnout  Depression  Parent Index. décimale : PER Périodiques Résumé : The diagnosis of autism spectrum disorder (ASD) in a child affects family processes, increases parenting stress and marital conflicts, and may lead to parental psychopathology. It may also affect the prognosis for their children. The aim of this study is to determine depression and burnout levels as well as their predictors among parents of children with ASD compared with those of healthy children. We also sought to evaluate rate of complementary and alternative medicine (CAM) interventions among parents and explore the associations of this phenomenon in an exploratory fashion. 145 children with ASD and 127 control children were enrolled along with their mothers and fathers. Beck Depression Inventory and Maslach Burnout Inventory were used to evaluate parents' depression symptoms and burnout levels. Symptoms of children with ASDs were evaluated according to the Childhood Autism Rating Scale by the clinicians. Family, child and CAM variables were screened by means of a sociodemographic data form. Descriptive, bivariate and correlation analyses were used in statistical evaluations. Predictors of burnout were evaluated with multiple regression analysis. Burnout and depression levels among parents of children with ASD were significantly elevated compared to controls. Burnout levels of mothers were significantly elevated compared to fathers while depression scores of fathers were significantly elevated compared to mothers. Maternal burnout was significantly predicted by presence of functional speech in child while paternal burnout was significantly predicted by paternal vocation. Maternal depression was associated with paternal depression, lack of speech in child and attendance of child to special education services. Paternal depression was associated with autistic symptom severity and maternal depression. More than half the parents sought CAM interventions. Education level did not affect search for CAM interventions while both maternal and paternal psychopathology and presence of epilepsy among children increased use of CAM methods. Psychological support should be provided to both mothers and fathers of a child receiving a diagnosis of ASD. Addressing parents' burnout and stress levels and facilitating their negotiation of knowledge on etiology and treatments for ASD may be beneficial for the family unit as a whole. En ligne : http://dx.doi.org/10.1007/s10803-021-04874-4 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4541

Mental health, broad autism phenotype and psychological inflexibility in mothers of young children with autism spectrum disorder in Australia: A cross-sectional survey / Kavindri KULASINGHE in Autism, 25-5 (July 2021)  

Public ISBD [article]  inAutism > 25-5 (July 2021) . - p.1187-1202 Titre : Mental health, broad autism phenotype and psychological inflexibility in mothers of young children with autism spectrum disorder in Australia: A cross-sectional survey Type de document : Texte imprimé et/ou numérique Auteurs : Kavindri KULASINGHE, Auteur ; Koa WHITTINGHAM, Auteur ; Amy E. MITCHELL, Auteur Article en page(s) : p.1187-1202 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Child, Preschool  Cross-Sectional Studies  Female  Humans  Mental Health  Mothers  Parenting  Phenotype  Stress, Psychological/epidemiology  broad autism phenotype  maternal mental health  psychological inflexibility Index. décimale : PER Périodiques Résumé : Mothers of children with autism tend to have poorer mental health outcomes compared to most mothers. Lack of social support, parenting challenges and relationship difficulties are more common for mothers of children with autism and can all affect maternal mental health. Mothers of children with autism are also more likely to have some autistic features, called the broad autism phenotype, that can contribute to poorer mental health; however, how these factors relate to one another are unclear. This study found that mothers who were less flexible in their thinking and behaviour and had more difficult parenting experiences tended to have poorer mental health. Mothers with more autistic features were less flexible in their thinking and behaviour, which, in turn, was linked to greater symptoms of depression, anxiety and stress. Mothers with greater autistic features also reported more difficult parenting experiences, which was in turn linked with greater symptoms of anxiety and depression. This study suggests that supporting mothers of young children with autism to manage parenting challenges and become more flexible with their thinking and behaviour could help to improve their mental health. En ligne : http://dx.doi.org/10.1177/1362361320984625 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4755 [article] Mental health, broad autism phenotype and psychological inflexibility in mothers of young children with autism spectrum disorder in Australia: A cross-sectional survey [Texte imprimé et/ou numérique] / Kavindri KULASINGHE, Auteur ; Koa WHITTINGHAM, Auteur ; Amy E. MITCHELL, Auteur . - p.1187-1202. Langues : Anglais (eng) in Autism > 25-5 (July 2021) . - p.1187-1202 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Child, Preschool  Cross-Sectional Studies  Female  Humans  Mental Health  Mothers  Parenting  Phenotype  Stress, Psychological/epidemiology  broad autism phenotype  maternal mental health  psychological inflexibility Index. décimale : PER Périodiques Résumé : Mothers of children with autism tend to have poorer mental health outcomes compared to most mothers. Lack of social support, parenting challenges and relationship difficulties are more common for mothers of children with autism and can all affect maternal mental health. Mothers of children with autism are also more likely to have some autistic features, called the broad autism phenotype, that can contribute to poorer mental health; however, how these factors relate to one another are unclear. This study found that mothers who were less flexible in their thinking and behaviour and had more difficult parenting experiences tended to have poorer mental health. Mothers with more autistic features were less flexible in their thinking and behaviour, which, in turn, was linked to greater symptoms of depression, anxiety and stress. Mothers with greater autistic features also reported more difficult parenting experiences, which was in turn linked with greater symptoms of anxiety and depression. This study suggests that supporting mothers of young children with autism to manage parenting challenges and become more flexible with their thinking and behaviour could help to improve their mental health. En ligne : http://dx.doi.org/10.1177/1362361320984625 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4755

Mental health, broad autism phenotype and psychological inflexibility in mothers of young children with autism spectrum disorder in Australia: A cross-sectional survey / Kavindri KULASINGHE in Autism, 26-5 (July 2022)  

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Understanding the relationships between trauma type and individual posttraumatic stress symptoms: a cross-sectional study of a clinical sample of children and adolescents / Marianne Skogbrott BIRKELAND in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

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Asymmetry of fusiform structure in autism spectrum disorder: trajectory and association with symptom severity / C. C. DOUGHERTY in Molecular Autism, 7 (2016)  

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Autistic adults have poorer quality healthcare and worse health based on self-report data / Elizabeth WEIR in Molecular Autism, 13 (2022)  

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Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms / G. SUGRANYES in Journal of Child Psychology and Psychiatry, 62-6 (June 2021)  

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