58 recherche sur le mot-clé 'Cross-Sectional Studies'

Age-related changes in neural responses to sensory stimulation in autism: a cross-sectional study / Kaitlin K. CUMMINGS ; Susan Y. BOOKHEIMER ; Mirella DAPRETTO ; Shulamite A. GREEN in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 38 p. Titre : Age-related changes in neural responses to sensory stimulation in autism: a cross-sectional study Type de document : Texte imprimé et/ou numérique Auteurs : Kaitlin K. CUMMINGS, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Shulamite A. GREEN, Auteur Article en page(s) : 38 p. Langues : Anglais (eng) Mots-clés : Adolescent  Child  Humans  *Autistic Disorder/diagnostic imaging  *Autism Spectrum Disorder  Cross-Sectional Studies  Prefrontal Cortex/diagnostic imaging  Cerebellum  Magnetic Resonance Imaging/methods  Autism spectrum disorder  Development  Neural activity  Sensory over-responsivity  Sensory processing  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory over-responsivity (SOR) is an impairing sensory processing challenge in autism spectrum disorder (ASD) which shows heterogenous developmental trajectories and appears to improve into adulthood in some but not all autistic individuals. However, the neural mechanisms underlying interindividual differences in these trajectories are currently unknown. METHODS: Here, we used functional magnetic resonance imaging (fMRI) to investigate the association between age and neural activity linearly and nonlinearly in response to mildly aversive sensory stimulation as well as how SOR severity moderates this association. Participants included 52 ASD (14F) and 41 (13F) typically developing (TD) youth, aged 8.6-18.0 years. RESULTS: We found that in pre-teens, ASD children showed widespread activation differences in sensorimotor, frontal and cerebellar regions compared to TD children, while there were fewer differences between ASD and TD teens. In TD youth, older age was associated with less activation in the prefrontal cortex. In contrast, in ASD youth, older age was associated with more engagement of sensory integration and emotion regulation regions. In particular, orbitofrontal and medial prefrontal cortices showed a nonlinear relationship with age in ASD, with an especially steep increase in sensory-evoked neural activity during the mid-to-late teen years. There was also an interaction between age and SOR severity in ASD youth such that these age-related trends were more apparent in youth with higher SOR. LIMITATIONS: The cross-sectional design limits causal interpretations of the data. Future longitudinal studies will be instrumental in determining how prefrontal engagement and SOR co-develop across adolescence. CONCLUSIONS: Our results suggest that enhanced recruitment of prefrontal regions may underlie age-related decreases in SOR for a subgroup of ASD youth. En ligne : https://dx.doi.org/10.1186/s13229-023-00571-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 [article] Age-related changes in neural responses to sensory stimulation in autism: a cross-sectional study [Texte imprimé et/ou numérique] / Kaitlin K. CUMMINGS, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Shulamite A. GREEN, Auteur . - 38 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 38 p. Mots-clés : Adolescent  Child  Humans  *Autistic Disorder/diagnostic imaging  *Autism Spectrum Disorder  Cross-Sectional Studies  Prefrontal Cortex/diagnostic imaging  Cerebellum  Magnetic Resonance Imaging/methods  Autism spectrum disorder  Development  Neural activity  Sensory over-responsivity  Sensory processing  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory over-responsivity (SOR) is an impairing sensory processing challenge in autism spectrum disorder (ASD) which shows heterogenous developmental trajectories and appears to improve into adulthood in some but not all autistic individuals. However, the neural mechanisms underlying interindividual differences in these trajectories are currently unknown. METHODS: Here, we used functional magnetic resonance imaging (fMRI) to investigate the association between age and neural activity linearly and nonlinearly in response to mildly aversive sensory stimulation as well as how SOR severity moderates this association. Participants included 52 ASD (14F) and 41 (13F) typically developing (TD) youth, aged 8.6-18.0 years. RESULTS: We found that in pre-teens, ASD children showed widespread activation differences in sensorimotor, frontal and cerebellar regions compared to TD children, while there were fewer differences between ASD and TD teens. In TD youth, older age was associated with less activation in the prefrontal cortex. In contrast, in ASD youth, older age was associated with more engagement of sensory integration and emotion regulation regions. In particular, orbitofrontal and medial prefrontal cortices showed a nonlinear relationship with age in ASD, with an especially steep increase in sensory-evoked neural activity during the mid-to-late teen years. There was also an interaction between age and SOR severity in ASD youth such that these age-related trends were more apparent in youth with higher SOR. LIMITATIONS: The cross-sectional design limits causal interpretations of the data. Future longitudinal studies will be instrumental in determining how prefrontal engagement and SOR co-develop across adolescence. CONCLUSIONS: Our results suggest that enhanced recruitment of prefrontal regions may underlie age-related decreases in SOR for a subgroup of ASD youth. En ligne : https://dx.doi.org/10.1186/s13229-023-00571-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518

Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis / Pilar GARCES in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 22 p. Titre : Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis Type de document : Texte imprimé et/ou numérique Auteurs : Pilar GARCES, Auteur ; Sarah BAUMEISTER, Auteur ; Luke MASON, Auteur ; Christopher H. CHATHAM, Auteur ; Stefan HOLIGA, Auteur ; Juergen DUKART, Auteur ; Emily J. H. JONES, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; Sarah DURSTON, Auteur ; Bob ORANJE, Auteur ; Antonio M. PERSICO, Auteur ; Christian F. BECKMANN, Auteur ; Thomas BOUGERON, Auteur ; Flavio DELL'ACQUA, Auteur ; Christine ECKER, Auteur ; Carolin MOESSNANG, Auteur ; Tony CHARMAN, Auteur ; Julian TILLMANN, Auteur ; Declan G. M. MURPHY, Auteur ; Mark H. JOHNSON, Auteur ; Eva LOTH, Auteur ; Daniel BRANDEIS, Auteur ; Joerg F. HIPP, Auteur Article en page(s) : 22 p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Brain/diagnostic imaging  Brain Mapping/methods  Child  Cross-Sectional Studies  Electroencephalography/methods  Humans  Magnetic Resonance Imaging/methods  Reproducibility of Results  Autism spectrum disorder  Eeg  Functional connectivity  Power spectrum  Resting state Index. décimale : PER Périodiques Résumé : BACKGROUND: Understanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a window into spontaneous local and long-range neuronal synchronization and has been investigated in many ASD studies, but results are inconsistent. Unbiased investigation in large and comprehensive samples focusing on replicability is needed. METHODS: We quantified resting state EEG alpha peak metrics, power spectrum (PS, 2-32 Hz) and functional connectivity (FC) in 411 children, adolescents and adults (n=212 ASD, n=199 neurotypicals [NT], all with IQ?>?75). We performed analyses in source-space using individual head models derived from the participants' MRIs. We tested for differences in mean and variance between the ASD and NT groups for both PS and FC using linear mixed effects models accounting for age, sex, IQ and site effects. Then, we used machine learning to assess whether a multivariate combination of EEG features could better separate ASD and NT participants. All analyses were embedded within a train-validation approach (70%-30% split). RESULTS: In the training dataset, we found an interaction between age and group for the reactivity to eye opening (p=.042 uncorrected), and a significant but weak multivariate ASD vs. NT classification performance for PS and FC (sensitivity 0.52-0.62, specificity 0.59-0.73). None of these findings replicated significantly in the validation dataset, although the effect size in the validation dataset overlapped with the prediction interval from the training dataset. LIMITATIONS: The statistical power to detect weak effects-of the magnitude of those found in the training dataset-in the validation dataset is small, and we cannot fully conclude on the reproducibility of the training dataset's effects. CONCLUSIONS: This suggests that PS and FC values in ASD and NT have a strong overlap, and that differences between both groups (in both mean and variance) have, at best, a small effect size. Larger studies would be needed to investigate and replicate such potential effects. En ligne : http://dx.doi.org/10.1186/s13229-022-00500-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis [Texte imprimé et/ou numérique] / Pilar GARCES, Auteur ; Sarah BAUMEISTER, Auteur ; Luke MASON, Auteur ; Christopher H. CHATHAM, Auteur ; Stefan HOLIGA, Auteur ; Juergen DUKART, Auteur ; Emily J. H. JONES, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; Sarah DURSTON, Auteur ; Bob ORANJE, Auteur ; Antonio M. PERSICO, Auteur ; Christian F. BECKMANN, Auteur ; Thomas BOUGERON, Auteur ; Flavio DELL'ACQUA, Auteur ; Christine ECKER, Auteur ; Carolin MOESSNANG, Auteur ; Tony CHARMAN, Auteur ; Julian TILLMANN, Auteur ; Declan G. M. MURPHY, Auteur ; Mark H. JOHNSON, Auteur ; Eva LOTH, Auteur ; Daniel BRANDEIS, Auteur ; Joerg F. HIPP, Auteur . - 22 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 22 p. Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Brain/diagnostic imaging  Brain Mapping/methods  Child  Cross-Sectional Studies  Electroencephalography/methods  Humans  Magnetic Resonance Imaging/methods  Reproducibility of Results  Autism spectrum disorder  Eeg  Functional connectivity  Power spectrum  Resting state Index. décimale : PER Périodiques Résumé : BACKGROUND: Understanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a window into spontaneous local and long-range neuronal synchronization and has been investigated in many ASD studies, but results are inconsistent. Unbiased investigation in large and comprehensive samples focusing on replicability is needed. METHODS: We quantified resting state EEG alpha peak metrics, power spectrum (PS, 2-32 Hz) and functional connectivity (FC) in 411 children, adolescents and adults (n=212 ASD, n=199 neurotypicals [NT], all with IQ?>?75). We performed analyses in source-space using individual head models derived from the participants' MRIs. We tested for differences in mean and variance between the ASD and NT groups for both PS and FC using linear mixed effects models accounting for age, sex, IQ and site effects. Then, we used machine learning to assess whether a multivariate combination of EEG features could better separate ASD and NT participants. All analyses were embedded within a train-validation approach (70%-30% split). RESULTS: In the training dataset, we found an interaction between age and group for the reactivity to eye opening (p=.042 uncorrected), and a significant but weak multivariate ASD vs. NT classification performance for PS and FC (sensitivity 0.52-0.62, specificity 0.59-0.73). None of these findings replicated significantly in the validation dataset, although the effect size in the validation dataset overlapped with the prediction interval from the training dataset. LIMITATIONS: The statistical power to detect weak effects-of the magnitude of those found in the training dataset-in the validation dataset is small, and we cannot fully conclude on the reproducibility of the training dataset's effects. CONCLUSIONS: This suggests that PS and FC values in ASD and NT have a strong overlap, and that differences between both groups (in both mean and variance) have, at best, a small effect size. Larger studies would be needed to investigate and replicate such potential effects. En ligne : http://dx.doi.org/10.1186/s13229-022-00500-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

The impact of COVID-19 on autism research: A cross-sectional analysis of discontinued or suspended clinical trials / Monika NEALE in Autism Research, 15-8 (August 2022)  

Public ISBD [article]  inAutism Research > 15-8 (August 2022) . - p.1560-1564 Titre : The impact of COVID-19 on autism research: A cross-sectional analysis of discontinued or suspended clinical trials Type de document : Texte imprimé et/ou numérique Auteurs : Monika NEALE, Auteur ; Elizabeth LANDERS, Auteur ; Nicholas B. SAJJADI, Auteur ; Anya MAZUR-MOSIEWICZ, Auteur ; Micah HARTWELL, Auteur Article en page(s) : p.1560-1564 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology  Autistic Disorder/epidemiology  covid-19  Cross-Sectional Studies  Humans  Pandemics  Covid-19  autism  clinical trials  discontinuation  pandemic Index. décimale : PER Périodiques Résumé : Due to uncertainties associated with the COVID-19 public health crisis, several clinical trials had to be withdrawn or postponed. Our investigation aimed to assess the rate of discontinuation of clinical trials focusing on Autism Spectrum Disorder. Of the 197 registered trials included in our systematic review, 15 (7.6%) were discontinued, with nearly half of these explicitly citing COVID-19 as their reason for discontinuation. Pharmacological trials were six times more likely to be discontinued during the pandemic than non-pharmacological studies. The difference between the likelihood of discontinuation was statistically significant (OR: 6.13; 95% CI: 1.22-30.71). There was no evidence of association between funding source and reasons for discontinuation. Limitations, along with implications for future trials are discussed. LAY SUMMARY: We investigated the impact of the COVID-19 pandemic on the discontinuation rate of autism clinical trials. We found that drug trials were six times more likely to be discontinued during the pandemic compared to behavioral, diagnostic, and nutritional trials. The overall discontinuation rate was notably lower in autism clinical trials than in other areas of medical research. We recommend an examination of the methodology of the continued autism trials to assess their applicability in other fields. En ligne : http://dx.doi.org/10.1002/aur.2764 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] The impact of COVID-19 on autism research: A cross-sectional analysis of discontinued or suspended clinical trials [Texte imprimé et/ou numérique] / Monika NEALE, Auteur ; Elizabeth LANDERS, Auteur ; Nicholas B. SAJJADI, Auteur ; Anya MAZUR-MOSIEWICZ, Auteur ; Micah HARTWELL, Auteur . - p.1560-1564. Langues : Anglais (eng) in Autism Research > 15-8 (August 2022) . - p.1560-1564 Mots-clés : Autism Spectrum Disorder/epidemiology  Autistic Disorder/epidemiology  covid-19  Cross-Sectional Studies  Humans  Pandemics  Covid-19  autism  clinical trials  discontinuation  pandemic Index. décimale : PER Périodiques Résumé : Due to uncertainties associated with the COVID-19 public health crisis, several clinical trials had to be withdrawn or postponed. Our investigation aimed to assess the rate of discontinuation of clinical trials focusing on Autism Spectrum Disorder. Of the 197 registered trials included in our systematic review, 15 (7.6%) were discontinued, with nearly half of these explicitly citing COVID-19 as their reason for discontinuation. Pharmacological trials were six times more likely to be discontinued during the pandemic than non-pharmacological studies. The difference between the likelihood of discontinuation was statistically significant (OR: 6.13; 95% CI: 1.22-30.71). There was no evidence of association between funding source and reasons for discontinuation. Limitations, along with implications for future trials are discussed. LAY SUMMARY: We investigated the impact of the COVID-19 pandemic on the discontinuation rate of autism clinical trials. We found that drug trials were six times more likely to be discontinued during the pandemic compared to behavioral, diagnostic, and nutritional trials. The overall discontinuation rate was notably lower in autism clinical trials than in other areas of medical research. We recommend an examination of the methodology of the continued autism trials to assess their applicability in other fields. En ligne : http://dx.doi.org/10.1002/aur.2764 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

An Australian Cross-Sectional Survey of Parents' Experiences of Emergency Department Visits Among Children with Autism Spectrum Disorder / Alice GARRICK in Journal of Autism and Developmental Disorders, 52-5 (May 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-5 (May 2022) . - p.2046-2060 Titre : An Australian Cross-Sectional Survey of Parents' Experiences of Emergency Department Visits Among Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Alice GARRICK, Auteur ; Marie L. LEE, Auteur ; Carrington SCARFFE, Auteur ; Tony ATTWOOD, Auteur ; Kirsten FURLEY, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur Article en page(s) : p.2046-2060 Langues : Anglais (eng) Mots-clés : Australia/epidemiology  Autism Spectrum Disorder/epidemiology  Child  Cross-Sectional Studies  Emergency Service, Hospital  Humans  Parents  Attention deficit hyperactivity disorder  Autism spectrum disorders  Comorbidity  Emergency department  Survey Index. décimale : PER Périodiques Résumé : Parents of children with ASD who had attended an Australian emergency department (ED; n=421) completed a questionnaire relating to their experiences in the ED, including (1) child's reason for presentation and existing comorbidities, (2) quality of care during the visit (3) child's behaviour during visit, e.g. sensory responses to the ED environment, and disruptive behaviours. Children with comorbid ASD and intellectual disability were more likely to present with gastrointestinal issues and seizures, while those with comorbid ASD and oppositional defiant disorder were more likely to present with self-injury. ED staff awareness of ASD-related issues, including communication and expression of pain, were common difficulties for parents. The ED environment (e.g. lights, sounds, waiting areas), exacerbated child anxiety and led to disruptive behaviour. En ligne : http://dx.doi.org/10.1007/s10803-021-05091-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] An Australian Cross-Sectional Survey of Parents' Experiences of Emergency Department Visits Among Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Alice GARRICK, Auteur ; Marie L. LEE, Auteur ; Carrington SCARFFE, Auteur ; Tony ATTWOOD, Auteur ; Kirsten FURLEY, Auteur ; Mark A. BELLGROVE, Auteur ; Beth P. JOHNSON, Auteur . - p.2046-2060. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-5 (May 2022) . - p.2046-2060 Mots-clés : Australia/epidemiology  Autism Spectrum Disorder/epidemiology  Child  Cross-Sectional Studies  Emergency Service, Hospital  Humans  Parents  Attention deficit hyperactivity disorder  Autism spectrum disorders  Comorbidity  Emergency department  Survey Index. décimale : PER Périodiques Résumé : Parents of children with ASD who had attended an Australian emergency department (ED; n=421) completed a questionnaire relating to their experiences in the ED, including (1) child's reason for presentation and existing comorbidities, (2) quality of care during the visit (3) child's behaviour during visit, e.g. sensory responses to the ED environment, and disruptive behaviours. Children with comorbid ASD and intellectual disability were more likely to present with gastrointestinal issues and seizures, while those with comorbid ASD and oppositional defiant disorder were more likely to present with self-injury. ED staff awareness of ASD-related issues, including communication and expression of pain, were common difficulties for parents. The ED environment (e.g. lights, sounds, waiting areas), exacerbated child anxiety and led to disruptive behaviour. En ligne : http://dx.doi.org/10.1007/s10803-021-05091-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

High Depression Symptoms and Burnout Levels Among Parents of Children with Autism Spectrum Disorders: A Multi-Center, Cross-Sectional, Case-Control Study / MÖ KÜTÜK in Journal of Autism and Developmental Disorders, 51-11 (November 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4086-4099 Titre : High Depression Symptoms and Burnout Levels Among Parents of Children with Autism Spectrum Disorders: A Multi-Center, Cross-Sectional, Case-Control Study Type de document : Texte imprimé et/ou numérique Auteurs : MÖ KÜTÜK, Auteur ; A. E. TUFAN, Auteur ; F. KILIÇASLAN, Auteur ; G. GÜLER, Auteur ; F. ÇELIK, Auteur ; E. ALTINTA?, Auteur ; C. GOKCEN, Auteur ; M. KARADA?, Auteur ; Ç YEKTA?, Auteur ; T. MUTLUER, Auteur ; H. KANDEMIR, Auteur ; A. BÜBER, Auteur ; Z. TOPAL, Auteur ; U. ACIKBAS, Auteur ; A. GIRAY, Auteur ; Ö KÜTÜK, Auteur Article en page(s) : p.4086-4099 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/epidemiology  Burnout, Psychological/epidemiology  Case-Control Studies  Child  Cross-Sectional Studies  Depression/epidemiology  Female  Humans  Male  Mothers  Parents  Stress, Psychological  Asd  Burnout  Depression  Parent Index. décimale : PER Périodiques Résumé : The diagnosis of autism spectrum disorder (ASD) in a child affects family processes, increases parenting stress and marital conflicts, and may lead to parental psychopathology. It may also affect the prognosis for their children. The aim of this study is to determine depression and burnout levels as well as their predictors among parents of children with ASD compared with those of healthy children. We also sought to evaluate rate of complementary and alternative medicine (CAM) interventions among parents and explore the associations of this phenomenon in an exploratory fashion. 145 children with ASD and 127 control children were enrolled along with their mothers and fathers. Beck Depression Inventory and Maslach Burnout Inventory were used to evaluate parents' depression symptoms and burnout levels. Symptoms of children with ASDs were evaluated according to the Childhood Autism Rating Scale by the clinicians. Family, child and CAM variables were screened by means of a sociodemographic data form. Descriptive, bivariate and correlation analyses were used in statistical evaluations. Predictors of burnout were evaluated with multiple regression analysis. Burnout and depression levels among parents of children with ASD were significantly elevated compared to controls. Burnout levels of mothers were significantly elevated compared to fathers while depression scores of fathers were significantly elevated compared to mothers. Maternal burnout was significantly predicted by presence of functional speech in child while paternal burnout was significantly predicted by paternal vocation. Maternal depression was associated with paternal depression, lack of speech in child and attendance of child to special education services. Paternal depression was associated with autistic symptom severity and maternal depression. More than half the parents sought CAM interventions. Education level did not affect search for CAM interventions while both maternal and paternal psychopathology and presence of epilepsy among children increased use of CAM methods. Psychological support should be provided to both mothers and fathers of a child receiving a diagnosis of ASD. Addressing parents' burnout and stress levels and facilitating their negotiation of knowledge on etiology and treatments for ASD may be beneficial for the family unit as a whole. En ligne : http://dx.doi.org/10.1007/s10803-021-04874-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] High Depression Symptoms and Burnout Levels Among Parents of Children with Autism Spectrum Disorders: A Multi-Center, Cross-Sectional, Case-Control Study [Texte imprimé et/ou numérique] / MÖ KÜTÜK, Auteur ; A. E. TUFAN, Auteur ; F. KILIÇASLAN, Auteur ; G. GÜLER, Auteur ; F. ÇELIK, Auteur ; E. ALTINTA?, Auteur ; C. GOKCEN, Auteur ; M. KARADA?, Auteur ; Ç YEKTA?, Auteur ; T. MUTLUER, Auteur ; H. KANDEMIR, Auteur ; A. BÜBER, Auteur ; Z. TOPAL, Auteur ; U. ACIKBAS, Auteur ; A. GIRAY, Auteur ; Ö KÜTÜK, Auteur . - p.4086-4099. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.4086-4099 Mots-clés : Autism Spectrum Disorder/epidemiology  Burnout, Psychological/epidemiology  Case-Control Studies  Child  Cross-Sectional Studies  Depression/epidemiology  Female  Humans  Male  Mothers  Parents  Stress, Psychological  Asd  Burnout  Depression  Parent Index. décimale : PER Périodiques Résumé : The diagnosis of autism spectrum disorder (ASD) in a child affects family processes, increases parenting stress and marital conflicts, and may lead to parental psychopathology. It may also affect the prognosis for their children. The aim of this study is to determine depression and burnout levels as well as their predictors among parents of children with ASD compared with those of healthy children. We also sought to evaluate rate of complementary and alternative medicine (CAM) interventions among parents and explore the associations of this phenomenon in an exploratory fashion. 145 children with ASD and 127 control children were enrolled along with their mothers and fathers. Beck Depression Inventory and Maslach Burnout Inventory were used to evaluate parents' depression symptoms and burnout levels. Symptoms of children with ASDs were evaluated according to the Childhood Autism Rating Scale by the clinicians. Family, child and CAM variables were screened by means of a sociodemographic data form. Descriptive, bivariate and correlation analyses were used in statistical evaluations. Predictors of burnout were evaluated with multiple regression analysis. Burnout and depression levels among parents of children with ASD were significantly elevated compared to controls. Burnout levels of mothers were significantly elevated compared to fathers while depression scores of fathers were significantly elevated compared to mothers. Maternal burnout was significantly predicted by presence of functional speech in child while paternal burnout was significantly predicted by paternal vocation. Maternal depression was associated with paternal depression, lack of speech in child and attendance of child to special education services. Paternal depression was associated with autistic symptom severity and maternal depression. More than half the parents sought CAM interventions. Education level did not affect search for CAM interventions while both maternal and paternal psychopathology and presence of epilepsy among children increased use of CAM methods. Psychological support should be provided to both mothers and fathers of a child receiving a diagnosis of ASD. Addressing parents' burnout and stress levels and facilitating their negotiation of knowledge on etiology and treatments for ASD may be beneficial for the family unit as a whole. En ligne : http://dx.doi.org/10.1007/s10803-021-04874-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

Mental health, broad autism phenotype and psychological inflexibility in mothers of young children with autism spectrum disorder in Australia: A cross-sectional survey / Kavindri KULASINGHE in Autism, 25-5 (July 2021)  

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Mental health, broad autism phenotype and psychological inflexibility in mothers of young children with autism spectrum disorder in Australia: A cross-sectional survey / Kavindri KULASINGHE in Autism, 26-5 (July 2022)  

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Understanding the relationships between trauma type and individual posttraumatic stress symptoms: a cross-sectional study of a clinical sample of children and adolescents / Marianne Skogbrott BIRKELAND in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

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The association between social camouflage and mental health among autistic people in Japan and the UK: a cross-cultural study / Fumiyo OSHIMA in Molecular Autism, 15 (2024)  

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Additive interaction between birth asphyxia and febrile seizures on autism spectrum disorder: a population-based study / Yi MAO in Molecular Autism, 15 (2024)  

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