Emotional maltreatment and neglect impact neural activation upon exclusion in early and mid-adolescence: An event-related fMRI study / Charlotte C. SCHULZ in Development and Psychopathology, 34-2 (May 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-2 (May 2022) . - 573-585 Titre : Emotional maltreatment and neglect impact neural activation upon exclusion in early and mid-adolescence: An event-related fMRI study Type de document : texte imprimé Auteurs : Charlotte C. SCHULZ, Auteur ; Kai VON KLITZING, Auteur ; Lorenz DESERNO, Auteur ; Margaret A. SHERIDAN, Auteur ; Michael J. CROWLEY, Auteur ; Margerete J.S. SCHOETT, Auteur ; Ferdinand HOFFMANN, Auteur ; Arno VILLRINGER, Auteur ; Pascal VRTIÄŒKA, Auteur ; Lars O. WHITE, Auteur Article en page(s) : 573-585 Langues : Anglais (eng) Mots-clés : adolescence  emotional maltreatment  neglect  fMRI  social exclusion Index. décimale : PER Périodiques Résumé : Child maltreatment gives rise to atypical patterns of social functioning with peers which might be particularly pronounced in early adolescence when peer influence typically peaks. Yet, few neuroimaging studies in adolescents use peer interaction paradigms to parse neural correlates of distinct maltreatment exposures. This fMRI study examines effects of abuse, neglect, and emotional maltreatment (EM) among 98 youth (n = 58 maltreated; n = 40 matched controls) using an event-related Cyberball paradigm affording assessment of both social exclusion and inclusion across early and mid-adolescence ( 13.5 years, n = 50; >13.5 years, n = 48). Younger adolescents showed increased activation to social exclusion versus inclusion in regions implicated in mentalizing (e.g., superior temporal gyrus). Individual exposure-specific analyses suggested that neglect and EM coincided with less reduction of activation to social exclusion relative to inclusion in the dorsal anterior cingulate cortex/pre-supplementary motor area (dACC/pre-SMA) among younger versus older adolescents. Integrative follow-up analyses showed that EM accounted for this dACC/pre-SMA activation pattern over and above other exposures. Moreover, age-independent results within respective exposure groups revealed that greater magnitude of neglect predicted blunted exclusion-related activity in the parahippocampal gyrus, while EM predicted increased activation to social exclusion in the precuneus/posterior cingulate cortex. En ligne : http://dx.doi.org/10.1017/s0954579421001681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Emotional maltreatment and neglect impact neural activation upon exclusion in early and mid-adolescence: An event-related fMRI study [texte imprimé] / Charlotte C. SCHULZ, Auteur ; Kai VON KLITZING, Auteur ; Lorenz DESERNO, Auteur ; Margaret A. SHERIDAN, Auteur ; Michael J. CROWLEY, Auteur ; Margerete J.S. SCHOETT, Auteur ; Ferdinand HOFFMANN, Auteur ; Arno VILLRINGER, Auteur ; Pascal VRTIÄŒKA, Auteur ; Lars O. WHITE, Auteur . - 573-585. Langues : Anglais (eng) in Development and Psychopathology > 34-2 (May 2022) . - 573-585 Mots-clés : adolescence  emotional maltreatment  neglect  fMRI  social exclusion Index. décimale : PER Périodiques Résumé : Child maltreatment gives rise to atypical patterns of social functioning with peers which might be particularly pronounced in early adolescence when peer influence typically peaks. Yet, few neuroimaging studies in adolescents use peer interaction paradigms to parse neural correlates of distinct maltreatment exposures. This fMRI study examines effects of abuse, neglect, and emotional maltreatment (EM) among 98 youth (n = 58 maltreated; n = 40 matched controls) using an event-related Cyberball paradigm affording assessment of both social exclusion and inclusion across early and mid-adolescence ( 13.5 years, n = 50; >13.5 years, n = 48). Younger adolescents showed increased activation to social exclusion versus inclusion in regions implicated in mentalizing (e.g., superior temporal gyrus). Individual exposure-specific analyses suggested that neglect and EM coincided with less reduction of activation to social exclusion relative to inclusion in the dorsal anterior cingulate cortex/pre-supplementary motor area (dACC/pre-SMA) among younger versus older adolescents. Integrative follow-up analyses showed that EM accounted for this dACC/pre-SMA activation pattern over and above other exposures. Moreover, age-independent results within respective exposure groups revealed that greater magnitude of neglect predicted blunted exclusion-related activity in the parahippocampal gyrus, while EM predicted increased activation to social exclusion in the precuneus/posterior cingulate cortex. En ligne : http://dx.doi.org/10.1017/s0954579421001681 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome / Lydia DUBOURG in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 13 p. Titre : Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome Type de document : texte imprimé Auteurs : Lydia DUBOURG, Auteur ; Pascal VRTIÄŒKA, Auteur ; Martin DEBBANE, Auteur ; Léa CHAMBAZ, Auteur ; Stephan ELIEZ, Auteur ; Maude SCHNEIDER, Auteur Année de publication : 2018 Article en page(s) : 13 p. Langues : Anglais (eng) Mots-clés : 22q11.2 deletion syndrome  Default mode network  Socio-emotional perception  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Social impairments are described as a common feature of the 22q11.2 deletion syndrome (22q11DS). However, the neural correlates underlying these impairments are largely unknown in this population. In this study, we investigated neural substrates of socio-emotional perception. METHODS: We used event-related functional magnetic resonance imaging (fMRI) to explore neural activity in individuals with 22q11DS and healthy controls during the visualization of stimuli varying in social (social or non-social) or emotional (positive or negative valence) content. RESULTS: Neural hyporesponsiveness in regions of the default mode network (inferior parietal lobule, precuneus, posterior and anterior cingulate cortex and frontal regions) in response to social versus non-social images was found in the 22q11DS population compared to controls. A similar pattern of activation for positive and negative emotional processing was observed in the two groups. No correlation between neural activation and social functioning was observed in patients with the 22q11DS. Finally, no social x valence interaction impairment was found in patients. CONCLUSIONS: Our results indicate atypical neural correlates of social perception in 22q11DS that appear to be independent of valence processing. Abnormalities in the social perception network may lead to social impairments observed in 22q11DS individuals. En ligne : http://dx.doi.org/10.1186/s11689-018-9232-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome [texte imprimé] / Lydia DUBOURG, Auteur ; Pascal VRTIÄŒKA, Auteur ; Martin DEBBANE, Auteur ; Léa CHAMBAZ, Auteur ; Stephan ELIEZ, Auteur ; Maude SCHNEIDER, Auteur . - 2018 . - 13 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 13 p. Mots-clés : 22q11.2 deletion syndrome  Default mode network  Socio-emotional perception  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Social impairments are described as a common feature of the 22q11.2 deletion syndrome (22q11DS). However, the neural correlates underlying these impairments are largely unknown in this population. In this study, we investigated neural substrates of socio-emotional perception. METHODS: We used event-related functional magnetic resonance imaging (fMRI) to explore neural activity in individuals with 22q11DS and healthy controls during the visualization of stimuli varying in social (social or non-social) or emotional (positive or negative valence) content. RESULTS: Neural hyporesponsiveness in regions of the default mode network (inferior parietal lobule, precuneus, posterior and anterior cingulate cortex and frontal regions) in response to social versus non-social images was found in the 22q11DS population compared to controls. A similar pattern of activation for positive and negative emotional processing was observed in the two groups. No correlation between neural activation and social functioning was observed in patients with the 22q11DS. Finally, no social x valence interaction impairment was found in patients. CONCLUSIONS: Our results indicate atypical neural correlates of social perception in 22q11DS that appear to be independent of valence processing. Abnormalities in the social perception network may lead to social impairments observed in 22q11DS individuals. En ligne : http://dx.doi.org/10.1186/s11689-018-9232-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

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