Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders / Duncan E. ASTLE in Journal of Child Psychology and Psychiatry, 63-4 (April 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-4 (April 2022) . - p.397-417 Titre : Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : Duncan E. ASTLE, Auteur ; Joni HOLMES, Auteur ; Rogier. KIEVIT, Auteur ; Susan E. GATHERCOLE, Auteur Article en page(s) : p.397-417 Langues : Anglais (eng) Mots-clés : Adhd  Autism  Developmental Language Disorder  Neurodevelopmental disorders  learning difficulties  working memory Index. décimale : PER Périodiques Résumé : Practitioners frequently use diagnostic criteria to identify children with neurodevelopmental disorders and to guide intervention decisions. These criteria also provide the organising framework for much of the research focussing on these disorders. Study design, recruitment, analysis and theory are largely built on the assumption that diagnostic criteria reflect an underlying reality. However, there is growing concern that this assumption may not be a valid and that an alternative transdiagnostic approach may better serve our understanding of this large heterogeneous population of young people. This review draws on important developments over the past decade that have set the stage for much-needed breakthroughs in understanding neurodevelopmental disorders. We evaluate contemporary approaches to study design and recruitment, review the use of data-driven methods to characterise cognition, behaviour and neurobiology, and consider what alternative transdiagnostic models could mean for children and families. This review concludes that an overreliance on ill-fitting diagnostic criteria is impeding progress towards identifying the barriers that children encounter, understanding underpinning mechanisms and finding the best route to supporting them. En ligne : http://dx.doi.org/10.1111/jcpp.13481 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Annual Research Review: The transdiagnostic revolution in neurodevelopmental disorders [Texte imprimé et/ou numérique] / Duncan E. ASTLE, Auteur ; Joni HOLMES, Auteur ; Rogier. KIEVIT, Auteur ; Susan E. GATHERCOLE, Auteur . - p.397-417. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-4 (April 2022) . - p.397-417 Mots-clés : Adhd  Autism  Developmental Language Disorder  Neurodevelopmental disorders  learning difficulties  working memory Index. décimale : PER Périodiques Résumé : Practitioners frequently use diagnostic criteria to identify children with neurodevelopmental disorders and to guide intervention decisions. These criteria also provide the organising framework for much of the research focussing on these disorders. Study design, recruitment, analysis and theory are largely built on the assumption that diagnostic criteria reflect an underlying reality. However, there is growing concern that this assumption may not be a valid and that an alternative transdiagnostic approach may better serve our understanding of this large heterogeneous population of young people. This review draws on important developments over the past decade that have set the stage for much-needed breakthroughs in understanding neurodevelopmental disorders. We evaluate contemporary approaches to study design and recruitment, review the use of data-driven methods to characterise cognition, behaviour and neurobiology, and consider what alternative transdiagnostic models could mean for children and families. This review concludes that an overreliance on ill-fitting diagnostic criteria is impeding progress towards identifying the barriers that children encounter, understanding underpinning mechanisms and finding the best route to supporting them. En ligne : http://dx.doi.org/10.1111/jcpp.13481 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

Cognitive difficulties following adversity are not related to mental health: Findings from the ABCD study / Maria VEDECHKINA in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1876-1889 Titre : Cognitive difficulties following adversity are not related to mental health: Findings from the ABCD study Type de document : Texte imprimé et/ou numérique Auteurs : Maria VEDECHKINA, Auteur ; Joni HOLMES, Auteur Article en page(s) : p.1876-1889 Langues : Anglais (eng) Mots-clés : adolescent  adversity  childhood  cognition  mental health Index. décimale : PER Périodiques Résumé : Early life adversity is associated with differences in cognition and mental health that can impact on daily functioning. This study uses a hybrid machine-learning approach that combines random forest classification with hierarchical clustering to clarify whether there are cognitive differences between individuals who have experienced moderate-to-severe adversity relative to those have not experienced adversity, to explore whether different forms of adversity are associated with distinct cognitive alterations and whether these such alterations are related to mental health using data from the ABCD study (n = 5,955). Cognitive measures spanning language, reasoning, memory, risk-taking, affective control, and reward processing predicted whether a child had a history of adversity with reasonable accuracy (67%), and with good specificity and sensitivity (>70%). Two subgroups were identified within the adversity group and two within the no-adversity group that were distinguished by cognitive ability (low vs high). There was no evidence for specific associations between the type of adverse exposure and cognitive profile. Worse cognition predicted lower levels of mental health in unexposed children. However, while children who experience adversity had elevated mental health difficulties, their mental health did not differ as a function of cognitive ability, thus providing novel insight into the heterogeneity of psychiatric risk. En ligne : https://dx.doi.org/10.1017/S0954579423001220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Cognitive difficulties following adversity are not related to mental health: Findings from the ABCD study [Texte imprimé et/ou numérique] / Maria VEDECHKINA, Auteur ; Joni HOLMES, Auteur . - p.1876-1889. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1876-1889 Mots-clés : adolescent  adversity  childhood  cognition  mental health Index. décimale : PER Périodiques Résumé : Early life adversity is associated with differences in cognition and mental health that can impact on daily functioning. This study uses a hybrid machine-learning approach that combines random forest classification with hierarchical clustering to clarify whether there are cognitive differences between individuals who have experienced moderate-to-severe adversity relative to those have not experienced adversity, to explore whether different forms of adversity are associated with distinct cognitive alterations and whether these such alterations are related to mental health using data from the ABCD study (n = 5,955). Cognitive measures spanning language, reasoning, memory, risk-taking, affective control, and reward processing predicted whether a child had a history of adversity with reasonable accuracy (67%), and with good specificity and sensitivity (>70%). Two subgroups were identified within the adversity group and two within the no-adversity group that were distinguished by cognitive ability (low vs high). There was no evidence for specific associations between the type of adverse exposure and cognitive profile. Worse cognition predicted lower levels of mental health in unexposed children. However, while children who experience adversity had elevated mental health difficulties, their mental health did not differ as a function of cognitive ability, thus providing novel insight into the heterogeneity of psychiatric risk. En ligne : https://dx.doi.org/10.1017/S0954579423001220 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

Dimensions of internalizing symptoms are stable across early adolescence and predicted by executive functions: Longitudinal findings from the Adolescent Brain and Cognitive Development (ABCD) study / Maria VEDECHKINA in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1284-1293 Titre : Dimensions of internalizing symptoms are stable across early adolescence and predicted by executive functions: Longitudinal findings from the Adolescent Brain and Cognitive Development (ABCD) study Type de document : Texte imprimé et/ou numérique Auteurs : Maria VEDECHKINA, Auteur ; Marc BENNETT, Auteur ; Joni HOLMES, Auteur Article en page(s) : p.1284-1293 Langues : Anglais (eng) Mots-clés : Adolescent  Executive function  Internalising  Mental health  Transdiagnostic Index. décimale : PER Périodiques Résumé : Early adolescence is characterized by rapid changes in executive function and increased vulnerability to internalizing difficulties. The aim of this study was to explore whether internalizing symptoms are stable across early adolescence and to identify possible links with executive function. Using data from the Adolescent Brain and Cognitive Development Study (ABCD), we identified four dimensions of internalizing symptoms from item-level ratings on the Child Behavior Checklist at ages 10 (n = 10,841) and 12 (n = 5,846), with an invariant factor structure across time. These dimensions corresponded to anxiety, depression, withdrawal, and somatic problems. We then examined associations between these dimensions and three aspects of executive function at age 10 measured by the NIH Toolbox: inhibition, shifting and working memory. Worse shifting and inhibition at age 10 was associated with elevated symptoms of anxiety and withdrawal cross-sectionally, while poor inhibition was also uniquely associated with symptoms of depression. Longitudinal associations were more limited: Worse inhibition at age 10 predicted greater symptoms of withdrawal at age 12, while worse shifting predicted fewer symptoms of anxiety 2 years later. These findings suggest that poor executive function in early adolescence is associated with greater internalizing difficulties and poor inhibition may contribute to later social withdrawal. En ligne : https://dx.doi.org/10.1017/S0954579423000524 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Dimensions of internalizing symptoms are stable across early adolescence and predicted by executive functions: Longitudinal findings from the Adolescent Brain and Cognitive Development (ABCD) study [Texte imprimé et/ou numérique] / Maria VEDECHKINA, Auteur ; Marc BENNETT, Auteur ; Joni HOLMES, Auteur . - p.1284-1293. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1284-1293 Mots-clés : Adolescent  Executive function  Internalising  Mental health  Transdiagnostic Index. décimale : PER Périodiques Résumé : Early adolescence is characterized by rapid changes in executive function and increased vulnerability to internalizing difficulties. The aim of this study was to explore whether internalizing symptoms are stable across early adolescence and to identify possible links with executive function. Using data from the Adolescent Brain and Cognitive Development Study (ABCD), we identified four dimensions of internalizing symptoms from item-level ratings on the Child Behavior Checklist at ages 10 (n = 10,841) and 12 (n = 5,846), with an invariant factor structure across time. These dimensions corresponded to anxiety, depression, withdrawal, and somatic problems. We then examined associations between these dimensions and three aspects of executive function at age 10 measured by the NIH Toolbox: inhibition, shifting and working memory. Worse shifting and inhibition at age 10 was associated with elevated symptoms of anxiety and withdrawal cross-sectionally, while poor inhibition was also uniquely associated with symptoms of depression. Longitudinal associations were more limited: Worse inhibition at age 10 predicted greater symptoms of withdrawal at age 12, while worse shifting predicted fewer symptoms of anxiety 2 years later. These findings suggest that poor executive function in early adolescence is associated with greater internalizing difficulties and poor inhibition may contribute to later social withdrawal. En ligne : https://dx.doi.org/10.1017/S0954579423000524 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation / Silvana MAREVA in Journal of Child Psychology and Psychiatry, 64-2 (February 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-2 (February 2023) . - p.217-233 Titre : Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation Type de document : Texte imprimé et/ou numérique Auteurs : Silvana MAREVA, Auteur ; Danyal AKARCA, Auteur ; The CALM TEAM, Auteur ; Joni HOLMES, Auteur Article en page(s) : p.217-233 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Behavioural and language difficulties co-occur in multiple neurodevelopmental conditions. Our understanding of these problems has arguably been slowed by an overreliance on study designs that compare diagnostic groups and fail to capture the overlap across different neurodevelopmental disorders and the heterogeneity within them. Methods We recruited a large transdiagnostic cohort of children with complex needs (N=805) to identify distinct subgroups of children with common profiles of behavioural and language strengths and difficulties. We then investigated whether and how these data-driven groupings could be distinguished from a comparison sample (N=158) on measures of academic and socioemotional functioning and patterns of global and local white matter connectome organisation. Academic skills were assessed via standardised measures of reading and maths. Socioemotional functioning was captured by the parent-rated version of the Strengths and Difficulties Questionnaire. Results We identified three distinct subgroups of children, each with different levels of difficulties in structural language, pragmatic communication, and hot and cool executive functions. All three subgroups struggled with academic and socioemotional skills relative to the comparison sample, potentially representing three alternative but related developmental pathways to difficulties in these areas. The children with the weakest language skills had the most widespread difficulties with learning, whereas those with more pronounced difficulties with hot executive skills experienced the most severe difficulties in the socioemotional domain. Each data-driven subgroup could be distinguished from the comparison sample based on both shared and subgroup-unique patterns of neural white matter organisation. Children with the most pronounced deficits in language, cool executive, or hot executive function were differentiated from the comparison sample by altered connectivity in predominantly thalamocortical, temporal-parietal-occipital, and frontostriatal circuits, respectively. Conclusions These findings advance our understanding of commonly co-morbid behavioural and language problems and their relationship to behavioural outcomes and neurobiological substrates. En ligne : https://doi.org/10.1111/jcpp.13685 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation [Texte imprimé et/ou numérique] / Silvana MAREVA, Auteur ; Danyal AKARCA, Auteur ; The CALM TEAM, Auteur ; Joni HOLMES, Auteur . - p.217-233. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-2 (February 2023) . - p.217-233 Index. décimale : PER Périodiques Résumé : Background Behavioural and language difficulties co-occur in multiple neurodevelopmental conditions. Our understanding of these problems has arguably been slowed by an overreliance on study designs that compare diagnostic groups and fail to capture the overlap across different neurodevelopmental disorders and the heterogeneity within them. Methods We recruited a large transdiagnostic cohort of children with complex needs (N=805) to identify distinct subgroups of children with common profiles of behavioural and language strengths and difficulties. We then investigated whether and how these data-driven groupings could be distinguished from a comparison sample (N=158) on measures of academic and socioemotional functioning and patterns of global and local white matter connectome organisation. Academic skills were assessed via standardised measures of reading and maths. Socioemotional functioning was captured by the parent-rated version of the Strengths and Difficulties Questionnaire. Results We identified three distinct subgroups of children, each with different levels of difficulties in structural language, pragmatic communication, and hot and cool executive functions. All three subgroups struggled with academic and socioemotional skills relative to the comparison sample, potentially representing three alternative but related developmental pathways to difficulties in these areas. The children with the weakest language skills had the most widespread difficulties with learning, whereas those with more pronounced difficulties with hot executive skills experienced the most severe difficulties in the socioemotional domain. Each data-driven subgroup could be distinguished from the comparison sample based on both shared and subgroup-unique patterns of neural white matter organisation. Children with the most pronounced deficits in language, cool executive, or hot executive function were differentiated from the comparison sample by altered connectivity in predominantly thalamocortical, temporal-parietal-occipital, and frontostriatal circuits, respectively. Conclusions These findings advance our understanding of commonly co-morbid behavioural and language problems and their relationship to behavioural outcomes and neurobiological substrates. En ligne : https://doi.org/10.1111/jcpp.13685 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

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