TH1/Treg ratio may be a marker of autism in children with immune dysfunction / Zu-Qing NIE in Research in Autism Spectrum Disorders, 101 (March 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 101 (March 2023) . - 102085 Titre : TH1/Treg ratio may be a marker of autism in children with immune dysfunction Type de document : Texte imprimé et/ou numérique Auteurs : Zu-Qing NIE, Auteur ; Dong HAN, Auteur ; Kun ZHANG, Auteur ; Meng LI, Auteur ; Ho-Keun KWON, Auteur ; Sin-Hyeog IM, Auteur ; Li XU, Auteur ; Ji-chun YANG, Auteur ; Zhi-Wei LI, Auteur ; Xin-Wei HUANG, Auteur ; Jie WEN, Auteur ; Yang SHU-JUN, Auteur ; Fang YIN, Auteur ; Chen SHEN, Auteur ; Paul ASHWOOD, Auteur ; Chuan-Yuan KANG, Auteur ; Xia CAO, Auteur Article en page(s) : 102085 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  T cells  Regulation  Cytokines  T helper  T helper-1  T regulatory cell  Neurodevelopment  Immune Index. décimale : PER Périodiques Résumé : Evidence suggests a link between autism spectrum disorder (ASD), behavioral symptoms in the context of ASD, and presence of an altered immune function. Several studies have highlighted differences in T-lymphocyte subpopulations, their activation status, and their response to stimulation in children and adults with ASD. These T cell abnormalities have often been associated with more impaired behaviors. However, few studies have attempted to address whether T cell subsets have the potential to serve as biomarkers in ASD. Moreover, although many studies have been performed in Western populations, few (if any) have been performed in Asian populations in mainland China. In this study we used intracellular cytokine flow cytometry to assess the frequencies of CD4+ T-cell subpopulations (T-helper (TH) 1, TH2, TH17, Foxp3+ regulatory T cells (Treg) as well as CD8+, subpopulations of T cytotoxic (TC) 1, TC2, and TC17 in 82 children with ASD and 50 healthy typical developing children from the Second Affiliated Hospital of Kunming Medical University of Yunnan province. To further elucidate immune status cytokine levels were also measured in the plasma and serum using a bead-based cytokine assay. Our results showed that the frequency of circulating Treg cells and the levels of active TGF-Î21 in plasma were lower in children with ASD than in healthy controls. In contrast, the frequencies of TH1, TH2, TH17 and TC1 cells were increased. Proinflammatory cytokine levels of TNF-Î+, IL-4, IL-5 and IL-17A were higher in the plasma of children with ASD compared to typical controls. We also found an association between the severity of behavior impairments in ASD children and altered immune responses as measured using the effector T cell responses and regulatory responses (using Teff/Treg ratios). Higher the Teff/Treg ratios, were associated with more severe problematic behavioral symptoms. Further, the potential biomarker relevance of Teff/Treg ratio was evaluated by the receiver operating characteristics curve. Data suggests that high TH1/Treg cell ratios could also be used as a potential marker for the diagnosis of children with ASD. Overall, our data suggest an imbalance in inflammatory and regulatory immune responses in ASD. Ratios of inflammatory/regulatory cells or cell frequencies such as Teff/Treg cells may be useful biomarkers for children with ASD with immune dysfunction. En ligne : https://doi.org/10.1016/j.rasd.2022.102085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] TH1/Treg ratio may be a marker of autism in children with immune dysfunction [Texte imprimé et/ou numérique] / Zu-Qing NIE, Auteur ; Dong HAN, Auteur ; Kun ZHANG, Auteur ; Meng LI, Auteur ; Ho-Keun KWON, Auteur ; Sin-Hyeog IM, Auteur ; Li XU, Auteur ; Ji-chun YANG, Auteur ; Zhi-Wei LI, Auteur ; Xin-Wei HUANG, Auteur ; Jie WEN, Auteur ; Yang SHU-JUN, Auteur ; Fang YIN, Auteur ; Chen SHEN, Auteur ; Paul ASHWOOD, Auteur ; Chuan-Yuan KANG, Auteur ; Xia CAO, Auteur . - 102085. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 101 (March 2023) . - 102085 Mots-clés : Autism spectrum disorder (ASD)  T cells  Regulation  Cytokines  T helper  T helper-1  T regulatory cell  Neurodevelopment  Immune Index. décimale : PER Périodiques Résumé : Evidence suggests a link between autism spectrum disorder (ASD), behavioral symptoms in the context of ASD, and presence of an altered immune function. Several studies have highlighted differences in T-lymphocyte subpopulations, their activation status, and their response to stimulation in children and adults with ASD. These T cell abnormalities have often been associated with more impaired behaviors. However, few studies have attempted to address whether T cell subsets have the potential to serve as biomarkers in ASD. Moreover, although many studies have been performed in Western populations, few (if any) have been performed in Asian populations in mainland China. In this study we used intracellular cytokine flow cytometry to assess the frequencies of CD4+ T-cell subpopulations (T-helper (TH) 1, TH2, TH17, Foxp3+ regulatory T cells (Treg) as well as CD8+, subpopulations of T cytotoxic (TC) 1, TC2, and TC17 in 82 children with ASD and 50 healthy typical developing children from the Second Affiliated Hospital of Kunming Medical University of Yunnan province. To further elucidate immune status cytokine levels were also measured in the plasma and serum using a bead-based cytokine assay. Our results showed that the frequency of circulating Treg cells and the levels of active TGF-Î21 in plasma were lower in children with ASD than in healthy controls. In contrast, the frequencies of TH1, TH2, TH17 and TC1 cells were increased. Proinflammatory cytokine levels of TNF-Î+, IL-4, IL-5 and IL-17A were higher in the plasma of children with ASD compared to typical controls. We also found an association between the severity of behavior impairments in ASD children and altered immune responses as measured using the effector T cell responses and regulatory responses (using Teff/Treg ratios). Higher the Teff/Treg ratios, were associated with more severe problematic behavioral symptoms. Further, the potential biomarker relevance of Teff/Treg ratio was evaluated by the receiver operating characteristics curve. Data suggests that high TH1/Treg cell ratios could also be used as a potential marker for the diagnosis of children with ASD. Overall, our data suggest an imbalance in inflammatory and regulatory immune responses in ASD. Ratios of inflammatory/regulatory cells or cell frequencies such as Teff/Treg cells may be useful biomarkers for children with ASD with immune dysfunction. En ligne : https://doi.org/10.1016/j.rasd.2022.102085 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

The mediating role of gaze patterns in the association of child sleep disturbances and core symptoms of autism spectrum disorder / Guangshuai WANG in Autism Research, 15-9 (September 2022)  

Public ISBD [article]  inAutism Research > 15-9 (September 2022) . - p.1719-1731 Titre : The mediating role of gaze patterns in the association of child sleep disturbances and core symptoms of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Guangshuai WANG, Auteur ; Jingying CHEN, Auteur ; Kun ZHANG, Auteur ; Suyun TANG, Auteur ; Guanghai WANG, Auteur Article en page(s) : p.1719-1731 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/epidemiology/psychology  Child  Humans  Parents  Sleep  Sleep Wake Disorders/complications/epidemiology  Surveys and Questionnaires  atypical gaze patterns  autism core symptoms  autism spectrum disorder  facial emotion recognition  sleep disturbances Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) are at high risk for sleep disturbances, but the mechanism underlying the association between sleep disturbances and ASD core symptoms is largely unknown. This study examined the relationship between sleep disturbances and ASD core symptoms, and the mediating role of gaze patterns during the facial emotion recognition (FER) task. The study included 57 children with ASD and 59 age- and intelligence-matched typically developing (TD) controls aged 3-7years. Parents reported their children's sleep disturbances and ASD core symptoms using the Children's Sleep Habits Questionnaire (CSHQ) and Social Communication Questionnaire (SCQ). Children's gaze patterns during the FER task were recorded by an eye tracking method. We found (1) ASD children had more severe sleep disturbances than TD children; (2) ASD children had atypical gaze patterns and poor FER task performance as determined by lower accuracy and longer reaction time; (3) sleep disturbances were significantly associated with ASD core symptoms of social interaction, communication, and restricted, repetitive and stereotyped patterns of behavior; and (4) atypical gaze patterns partially mediated the association between sleep disturbances and ASD core symptoms. These findings suggest the need for more comprehensive clinical interventions and more effective sleep interventions to improve ASD core symptoms. LAY SUMMARY: Sleep disturbances are very common in children with autism spectrum disorder (ASD). The current study found that sleep disturbances were significantly associated with ASD core symptoms, and gaze patterns during facial emotion recognition task could partially mediate this relationship. En ligne : http://dx.doi.org/10.1002/aur.2737 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] The mediating role of gaze patterns in the association of child sleep disturbances and core symptoms of autism spectrum disorder [Texte imprimé et/ou numérique] / Guangshuai WANG, Auteur ; Jingying CHEN, Auteur ; Kun ZHANG, Auteur ; Suyun TANG, Auteur ; Guanghai WANG, Auteur . - p.1719-1731. Langues : Anglais (eng) in Autism Research > 15-9 (September 2022) . - p.1719-1731 Mots-clés : Autism Spectrum Disorder/complications/epidemiology/psychology  Child  Humans  Parents  Sleep  Sleep Wake Disorders/complications/epidemiology  Surveys and Questionnaires  atypical gaze patterns  autism core symptoms  autism spectrum disorder  facial emotion recognition  sleep disturbances Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) are at high risk for sleep disturbances, but the mechanism underlying the association between sleep disturbances and ASD core symptoms is largely unknown. This study examined the relationship between sleep disturbances and ASD core symptoms, and the mediating role of gaze patterns during the facial emotion recognition (FER) task. The study included 57 children with ASD and 59 age- and intelligence-matched typically developing (TD) controls aged 3-7years. Parents reported their children's sleep disturbances and ASD core symptoms using the Children's Sleep Habits Questionnaire (CSHQ) and Social Communication Questionnaire (SCQ). Children's gaze patterns during the FER task were recorded by an eye tracking method. We found (1) ASD children had more severe sleep disturbances than TD children; (2) ASD children had atypical gaze patterns and poor FER task performance as determined by lower accuracy and longer reaction time; (3) sleep disturbances were significantly associated with ASD core symptoms of social interaction, communication, and restricted, repetitive and stereotyped patterns of behavior; and (4) atypical gaze patterns partially mediated the association between sleep disturbances and ASD core symptoms. These findings suggest the need for more comprehensive clinical interventions and more effective sleep interventions to improve ASD core symptoms. LAY SUMMARY: Sleep disturbances are very common in children with autism spectrum disorder (ASD). The current study found that sleep disturbances were significantly associated with ASD core symptoms, and gaze patterns during facial emotion recognition task could partially mediate this relationship. En ligne : http://dx.doi.org/10.1002/aur.2737 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

Validity and Cutoff Score of the Autism Mental Status Exam for an Autism Spectrum Disorder Diagnosis in Chinese Children / Dong HAN ; Huizhi ZHOU ; Chen YANG ; Kun ZHANG ; Shi CHEN ; Runxu YANG ; Xia CAO ; David GRODBERG ; Xudong ZHAO ; Chuanyuan KANG in Journal of Autism and Developmental Disorders, 53-12 (December 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-12 (December 2023) . - p.4822-4829 Titre : Validity and Cutoff Score of the Autism Mental Status Exam for an Autism Spectrum Disorder Diagnosis in Chinese Children Type de document : Texte imprimé et/ou numérique Auteurs : Dong HAN, Auteur ; Huizhi ZHOU, Auteur ; Chen YANG, Auteur ; Kun ZHANG, Auteur ; Shi CHEN, Auteur ; Runxu YANG, Auteur ; Xia CAO, Auteur ; David GRODBERG, Auteur ; Xudong ZHAO, Auteur ; Chuanyuan KANG, Auteur Article en page(s) : p.4822-4829 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The Autism Mental Status exam (AMSE) has demonstrated excellent sensitivity and specificity in Western high-risk population with suspected autism spectrum disorder (ASD). This study aimed to evaluate the psychometric properties of the AMSE in a sample of high-risk Chinese children, and to determine the optimal cutoff score of the Chinese version of the AMSE in supporting ASD diagnosis. 66 young children aged from 2 to 11 years with suspected ASD were enrolled in the present study. A diagnosis of ASD or non-ASD was determined by a Best Estimate Diagnosis protocol according to the DSM-5 criteria. Receiver operating characteristic (ROC) curve analysis was conducted to assess the validity of the AMSE and search for the most effective cutoff score. The ROC curve analysis yields the area under the ROC curve of 0.98 which represents excellent diagnostic accuracy. Findings indicate the optimal cutoff score of the Chinese version of the AMSE was estimated as 6, producing the highest sensitivity of 98% and a specificity of 87%. Preliminary findings of the study suggest the AMSE has promising psychometric properties as an assessment tool for identifying ASD symptoms and supporting diagnostic decision-making in high-risk Chinese children population. En ligne : https://doi.org/10.1007/s10803-022-05730-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=516 [article] Validity and Cutoff Score of the Autism Mental Status Exam for an Autism Spectrum Disorder Diagnosis in Chinese Children [Texte imprimé et/ou numérique] / Dong HAN, Auteur ; Huizhi ZHOU, Auteur ; Chen YANG, Auteur ; Kun ZHANG, Auteur ; Shi CHEN, Auteur ; Runxu YANG, Auteur ; Xia CAO, Auteur ; David GRODBERG, Auteur ; Xudong ZHAO, Auteur ; Chuanyuan KANG, Auteur . - p.4822-4829. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-12 (December 2023) . - p.4822-4829 Index. décimale : PER Périodiques Résumé : The Autism Mental Status exam (AMSE) has demonstrated excellent sensitivity and specificity in Western high-risk population with suspected autism spectrum disorder (ASD). This study aimed to evaluate the psychometric properties of the AMSE in a sample of high-risk Chinese children, and to determine the optimal cutoff score of the Chinese version of the AMSE in supporting ASD diagnosis. 66 young children aged from 2 to 11 years with suspected ASD were enrolled in the present study. A diagnosis of ASD or non-ASD was determined by a Best Estimate Diagnosis protocol according to the DSM-5 criteria. Receiver operating characteristic (ROC) curve analysis was conducted to assess the validity of the AMSE and search for the most effective cutoff score. The ROC curve analysis yields the area under the ROC curve of 0.98 which represents excellent diagnostic accuracy. Findings indicate the optimal cutoff score of the Chinese version of the AMSE was estimated as 6, producing the highest sensitivity of 98% and a specificity of 87%. Preliminary findings of the study suggest the AMSE has promising psychometric properties as an assessment tool for identifying ASD symptoms and supporting diagnostic decision-making in high-risk Chinese children population. En ligne : https://doi.org/10.1007/s10803-022-05730-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=516

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