Association of urinary polycyclic aromatic hydrocarbon metabolites with symptoms among autistic children: A case-control study in Tianjin, China / Peiying LI in Autism Research, 15-10 (October 2022)  

Public ISBD [article]  inAutism Research > 15-10 (October 2022) . - p.1941-1960 Titre : Association of urinary polycyclic aromatic hydrocarbon metabolites with symptoms among autistic children: A case-control study in Tianjin, China Type de document : texte imprimé Auteurs : Peiying LI, Auteur ; Qiaoyun YANG, Auteur ; Yao LI, Auteur ; Yu HAN, Auteur ; Zhiyi QU, Auteur ; Lei GAO, Auteur ; Tingkai CUI, Auteur ; Wenjuan XIONG, Auteur ; Wei XI, Auteur ; Xin ZHANG, Auteur Article en page(s) : p.1941-1960 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  behavioral characteristics  case-control study  children  internal exposure  polycyclic aromatic hydrocarbon Index. décimale : PER Périodiques Résumé : Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are associated with altered neurodevelopment and various neurodevelopmental disorders. However, studies evaluating internal biomarkers of PAH exposure in reference to the severity of autism spectrum disorder (ASD) symptomology and autistic behaviors are scarce. Hence, we conducted a case-control study evaluating 12 urinary hydroxylated PAH metabolites (i.e., hydroxy-PAHs) in 101 children with autism and 101 neurotypical children, matching according to sex and age in a 1:1 ratio. In children with ASD, the severity of symptomology and autistic behaviors were assessed using the child autism rating scale (CARS) and the autism behavior checklist (ABC). We found that urinary levels of nine of the hydroxy-PAHs were statistically significantly higher in the ASD group, with the exception of 2-hydroxynaphthalene (2-OHNap) and 4-hydroxyphenanthrene (4-OHPhe). Moreover, urinary hydroxy-PAH levels were associated with ASD risk, with odds ratios ranging from 1.86 to 17.19. Exposures to 1-hydroxynaphthalene (1-OHNap,ÃŽ2 = 3.32), hydroxyphenanthrenes (1/2/3 + 9-OHPhes,ÃŽ2 = 3.41-5.12), 1-hydroxypyrene (1-OH-Pyr;ÃŽ2 = 3.91), 2-hydroxybenzofuran (2-OHDBF;ÃŽ2 = 3.93), and â‘OH-PAHs (ÃŽ2 = 4.67) were positively associated with CARS scores after adjusting for covariates (all p< 0.05). When applying the ABC scale, 1-OHPyr levels were positively associated with ABC total scores (ÃŽ2 = 18.54), with the strongest associations evidenced in regard to the social relatedness (ÃŽ2 = 6.51) and language domains (ÃŽ2 = 6.51) (all p< 0.05). Bayesian kernel machine regression (BKMR) showed consistent positive exposure responses for 1-OHNap, 1-OHPhe, and 3 + 9-OHPhe levels in regard to CARS scores, and for 1-OHPyr levels in regard to ABC total scores. Our findings suggest that children with ASD may have higher urinary levels of hydroxy-PAHs, and that these biomarker levels are associated with an increased odds of ASD, an increased severity of autism symptomology, and increased autistic behaviors in children with autism. LAY SUMMARY: We conducted an epidemiologic study evaluating the associations of urinary hydroxy-PAH levels with autism spectrum disorder (ASD), autism symptomology, and autistic behaviors. We found that urinary hydroxy-PAHs were statistically significantly associated with ASD. We note strong statistically significant associations between 1-OHNap, 1-OHPhe, and 3 + 9-OHPhe levels and increased severity of autism symptomology, as well as a strong statistically significant association between 1-OHPyr levels and behavioral characteristics within the social and linguistic domains. This work, if confirmed, will contribute to the future development of diagnostics for children with mild autism, as well as to environmental measures to promote the health and wellbeing of children with autism spectrum disorders. En ligne : http://dx.doi.org/10.1002/aur.2788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Association of urinary polycyclic aromatic hydrocarbon metabolites with symptoms among autistic children: A case-control study in Tianjin, China [texte imprimé] / Peiying LI, Auteur ; Qiaoyun YANG, Auteur ; Yao LI, Auteur ; Yu HAN, Auteur ; Zhiyi QU, Auteur ; Lei GAO, Auteur ; Tingkai CUI, Auteur ; Wenjuan XIONG, Auteur ; Wei XI, Auteur ; Xin ZHANG, Auteur . - p.1941-1960. Langues : Anglais (eng) in Autism Research > 15-10 (October 2022) . - p.1941-1960 Mots-clés : autism spectrum disorder  behavioral characteristics  case-control study  children  internal exposure  polycyclic aromatic hydrocarbon Index. décimale : PER Périodiques Résumé : Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are associated with altered neurodevelopment and various neurodevelopmental disorders. However, studies evaluating internal biomarkers of PAH exposure in reference to the severity of autism spectrum disorder (ASD) symptomology and autistic behaviors are scarce. Hence, we conducted a case-control study evaluating 12 urinary hydroxylated PAH metabolites (i.e., hydroxy-PAHs) in 101 children with autism and 101 neurotypical children, matching according to sex and age in a 1:1 ratio. In children with ASD, the severity of symptomology and autistic behaviors were assessed using the child autism rating scale (CARS) and the autism behavior checklist (ABC). We found that urinary levels of nine of the hydroxy-PAHs were statistically significantly higher in the ASD group, with the exception of 2-hydroxynaphthalene (2-OHNap) and 4-hydroxyphenanthrene (4-OHPhe). Moreover, urinary hydroxy-PAH levels were associated with ASD risk, with odds ratios ranging from 1.86 to 17.19. Exposures to 1-hydroxynaphthalene (1-OHNap,ÃŽ2 = 3.32), hydroxyphenanthrenes (1/2/3 + 9-OHPhes,ÃŽ2 = 3.41-5.12), 1-hydroxypyrene (1-OH-Pyr;ÃŽ2 = 3.91), 2-hydroxybenzofuran (2-OHDBF;ÃŽ2 = 3.93), and â‘OH-PAHs (ÃŽ2 = 4.67) were positively associated with CARS scores after adjusting for covariates (all p< 0.05). When applying the ABC scale, 1-OHPyr levels were positively associated with ABC total scores (ÃŽ2 = 18.54), with the strongest associations evidenced in regard to the social relatedness (ÃŽ2 = 6.51) and language domains (ÃŽ2 = 6.51) (all p< 0.05). Bayesian kernel machine regression (BKMR) showed consistent positive exposure responses for 1-OHNap, 1-OHPhe, and 3 + 9-OHPhe levels in regard to CARS scores, and for 1-OHPyr levels in regard to ABC total scores. Our findings suggest that children with ASD may have higher urinary levels of hydroxy-PAHs, and that these biomarker levels are associated with an increased odds of ASD, an increased severity of autism symptomology, and increased autistic behaviors in children with autism. LAY SUMMARY: We conducted an epidemiologic study evaluating the associations of urinary hydroxy-PAH levels with autism spectrum disorder (ASD), autism symptomology, and autistic behaviors. We found that urinary hydroxy-PAHs were statistically significantly associated with ASD. We note strong statistically significant associations between 1-OHNap, 1-OHPhe, and 3 + 9-OHPhe levels and increased severity of autism symptomology, as well as a strong statistically significant association between 1-OHPyr levels and behavioral characteristics within the social and linguistic domains. This work, if confirmed, will contribute to the future development of diagnostics for children with mild autism, as well as to environmental measures to promote the health and wellbeing of children with autism spectrum disorders. En ligne : http://dx.doi.org/10.1002/aur.2788 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Sensory Processing Problems and Comorbidities in Chinese Preschool Children with Autism Spectrum Disorders / Geng-fu WANG in Journal of Autism and Developmental Disorders, 49-10 (October 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-10 (October 2019) . - p.4097-4108 Titre : Sensory Processing Problems and Comorbidities in Chinese Preschool Children with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Geng-fu WANG, Auteur ; Wen-Lei LI, Auteur ; Yu HAN, Auteur ; Lei GAO, Auteur ; Wei DAI, Auteur ; Yuan-yuan SU, Auteur ; Xudong ZHANG, Auteur Article en page(s) : p.4097-4108 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Emotional and behavioral problems  Mealtime behavior  Preschool children  Sensory processing problems  Sleep dysfunction Index. décimale : PER Périodiques Résumé : Little is known about the relationship between sensory processing problems and sleep disturbances, emotional and behavioral problems and mealtime behavioral problems in Chinese children with autism spectrum disorders (ASDs). This study examined those relationships in Chinese preschool children with ASD using a case-control design. Atypical sensory processing was associated with increased risks of sleep disturbances, emotional and behavioral problems, and abnormal mealtime behaviors in the children with ASD, whereas sensory processing problems were significantly correlated with abnormal mealtime behaviors only in the typically developing children. Based on our findings, clinicians must collect information about sensory problems when a child with ASD experiences sleep disturbances and emotional and behavioral problems or presents abnormal mealtime behaviors. En ligne : http://dx.doi.org/10.1007/s10803-019-04125-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407 [article] Sensory Processing Problems and Comorbidities in Chinese Preschool Children with Autism Spectrum Disorders [texte imprimé] / Geng-fu WANG, Auteur ; Wen-Lei LI, Auteur ; Yu HAN, Auteur ; Lei GAO, Auteur ; Wei DAI, Auteur ; Yuan-yuan SU, Auteur ; Xudong ZHANG, Auteur . - p.4097-4108. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-10 (October 2019) . - p.4097-4108 Mots-clés : Autism spectrum disorders  Emotional and behavioral problems  Mealtime behavior  Preschool children  Sensory processing problems  Sleep dysfunction Index. décimale : PER Périodiques Résumé : Little is known about the relationship between sensory processing problems and sleep disturbances, emotional and behavioral problems and mealtime behavioral problems in Chinese children with autism spectrum disorders (ASDs). This study examined those relationships in Chinese preschool children with ASD using a case-control design. Atypical sensory processing was associated with increased risks of sleep disturbances, emotional and behavioral problems, and abnormal mealtime behaviors in the children with ASD, whereas sensory processing problems were significantly correlated with abnormal mealtime behaviors only in the typically developing children. Based on our findings, clinicians must collect information about sensory problems when a child with ASD experiences sleep disturbances and emotional and behavioral problems or presents abnormal mealtime behaviors. En ligne : http://dx.doi.org/10.1007/s10803-019-04125-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407

Systematic Review and Meta-Analysis of Abnormal Pubertal Timing in Children With Autism Spectrum Disorder (ASD) / Li TIAN in Autism Research, 19-2 (February 2026)  

Public ISBD [article]  inAutism Research > 19-2 (February 2026) . - e70182 Titre : Systematic Review and Meta-Analysis of Abnormal Pubertal Timing in Children With Autism Spectrum Disorder (ASD) Type de document : texte imprimé Auteurs : Li TIAN, Auteur ; Zhiming HU, Auteur ; Ishimwe Angelique BAPTITIAN, Auteur ; Guoyong ZHAO, Auteur ; Lei GAO, Auteur Article en page(s) : e70182 Langues : Anglais (eng) Mots-clés : autism Spectrum disorder (ASD)  meta-analysis  precocious puberty (PP)  pubertal timing Index. décimale : PER Périodiques Résumé : ABSTRACT This study aimed to synthesize evidence on the risk and patterns of abnormal pubertal timing, including precocious puberty (PP) and altered onset, in children with autism spectrum disorder (ASD) compared with typically developing (TD) peers. We conducted a systematic review and meta-analysis following the PRISMA guidelines, searching PubMed (n =?51), Web of Science (n =?91), and Cochrane Library (n =?19). After removing duplicates (n =?40), we screened 121 records and assessed 31 full-text articles, with 12 meeting the inclusion criteria (3 cohort studies on PP; 9 cohort studies on pubertal timing). Random-effects meta-analyses were performed to calculate pooled hazard ratios (HRs) for PP and standardized mean differences (SMDs) for pubertal timing. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Meta-analysis of three studies (42,017 ASD children; 3,424,004 TD children) revealed a significantly higher risk of PP in ASD children (pooled HR?=?3.64; 95% CI: 1.42?9.34; P =?0.007), with an absolute risk difference of 1.13% (prevalence: 1.2% in ASD vs. 0.07% in TD), indicating that 88 ASD children would need monitoring to identify one additional case of PP; this risk was particularly pronounced in females with ASD. In contrast, nine studies (856 ASD children; 648 TD children) found no significant overall difference in pubertal timing (SMD = ?0.22; 95% CI: ?0.91?0.46; P =?0.52), despite high heterogeneity (I2 =?96%). Funnel plot asymmetry suggested potential publication bias or methodological variations (e.g., confounder adjustments, diagnostic criteria). Sensitivity analysis confirmed the association between ASD and PP but highlighted instability in the effect size. Children with ASD exhibit a 3.6-fold increased relative risk of PP, particularly in females, though the absolute prevalence is low and the certainty of evidence is very low (per Grading of Recommendations Assessment, Development and Evaluation [GRADE] criteria), primarily due to high heterogeneity (I2 =?91%?96%) and potential biases. No consistent differences in pubertal timing were observed between ASD and TD children, likely reflecting methodological inconsistencies. Clinicians should enhance vigilance for PP in ASD children, without the need for routine screening. Future studies should adopt standardized, multi-method assessments to refine these findings. En ligne : https://doi.org/10.1002/aur.70182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582 [article] Systematic Review and Meta-Analysis of Abnormal Pubertal Timing in Children With Autism Spectrum Disorder (ASD) [texte imprimé] / Li TIAN, Auteur ; Zhiming HU, Auteur ; Ishimwe Angelique BAPTITIAN, Auteur ; Guoyong ZHAO, Auteur ; Lei GAO, Auteur . - e70182. Langues : Anglais (eng) in Autism Research > 19-2 (February 2026) . - e70182 Mots-clés : autism Spectrum disorder (ASD)  meta-analysis  precocious puberty (PP)  pubertal timing Index. décimale : PER Périodiques Résumé : ABSTRACT This study aimed to synthesize evidence on the risk and patterns of abnormal pubertal timing, including precocious puberty (PP) and altered onset, in children with autism spectrum disorder (ASD) compared with typically developing (TD) peers. We conducted a systematic review and meta-analysis following the PRISMA guidelines, searching PubMed (n =?51), Web of Science (n =?91), and Cochrane Library (n =?19). After removing duplicates (n =?40), we screened 121 records and assessed 31 full-text articles, with 12 meeting the inclusion criteria (3 cohort studies on PP; 9 cohort studies on pubertal timing). Random-effects meta-analyses were performed to calculate pooled hazard ratios (HRs) for PP and standardized mean differences (SMDs) for pubertal timing. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Meta-analysis of three studies (42,017 ASD children; 3,424,004 TD children) revealed a significantly higher risk of PP in ASD children (pooled HR?=?3.64; 95% CI: 1.42?9.34; P =?0.007), with an absolute risk difference of 1.13% (prevalence: 1.2% in ASD vs. 0.07% in TD), indicating that 88 ASD children would need monitoring to identify one additional case of PP; this risk was particularly pronounced in females with ASD. In contrast, nine studies (856 ASD children; 648 TD children) found no significant overall difference in pubertal timing (SMD = ?0.22; 95% CI: ?0.91?0.46; P =?0.52), despite high heterogeneity (I2 =?96%). Funnel plot asymmetry suggested potential publication bias or methodological variations (e.g., confounder adjustments, diagnostic criteria). Sensitivity analysis confirmed the association between ASD and PP but highlighted instability in the effect size. Children with ASD exhibit a 3.6-fold increased relative risk of PP, particularly in females, though the absolute prevalence is low and the certainty of evidence is very low (per Grading of Recommendations Assessment, Development and Evaluation [GRADE] criteria), primarily due to high heterogeneity (I2 =?91%?96%) and potential biases. No consistent differences in pubertal timing were observed between ASD and TD children, likely reflecting methodological inconsistencies. Clinicians should enhance vigilance for PP in ASD children, without the need for routine screening. Future studies should adopt standardized, multi-method assessments to refine these findings. En ligne : https://doi.org/10.1002/aur.70182 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582

---

1 (1 - 3 / 3) Par page : 25 50 100 200