Contributions of the ELENA Cohort to Study Autism Spectrum Disorder in Children and Adolescents from a Biopsychosocial Framework / Amaria BAGHDADLI in Journal of Autism and Developmental Disorders, 56-1 (January 2026)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 56-1 (January 2026) . - p.362-387 Titre : Contributions of the ELENA Cohort to Study Autism Spectrum Disorder in Children and Adolescents from a Biopsychosocial Framework Type de document : texte imprimé Auteurs : Amaria BAGHDADLI, Auteur ; Marianne PERIES, Auteur ; Julie LOUBERSAC, Auteur ; Cécile MICHELON, Auteur ; Cécile RATTAZ, Auteur ; Laetitia FERRANDO, Auteur ; Aurore DAVID, Auteur ; Kerim MUNIR, Auteur ; Marie-Christine PICOT, Auteur Article en page(s) : p.362-387 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental condition influenced by a myriad of developmental, biological, psychological, and socio-demographic factors. The ELENA cohort seeks to delineate the intricate interplay of these factors, facilitating the identification of risk factors and the development of targeted interventions. This paper emphasizes the clinical profiles of children and outlines key findings from a biopsychosocial perspective. The ELENA cohort, a multicenter initiative across French regional centers, conducted a systematic prospective analysis on children newly diagnosed with DSM-5 ASD between 2012 and 2019. This encompassed direct assessments and parent-reported questionnaires covering a broad spectrum of developmental, biological, psychological and socio-demographic measures. Embedded case–control studies further examined risk and protective factors, alongside specific environmental and psychosocial influences during pregnancy and early childhood. A subset of participants also contributed biospecimens, with data enhancement via linkage to French National Administrative Healthcare Databases. The study unveils baseline clinical characteristics for 876 children, average age 6 (SD ± 3.3) previously unreported in protocol descriptions. It highlights the study’s developmental biopsychosocial approach and its novel findings on children’s socio-adaptive functioning, ASD severity, comorbidities, quality of life and interventions. Employing developmental biopsychosocial insights offers a promising pathway to integrating health, social care, and experiential insights, ultimately aiming to enhance the future well-being and outcomes for children with ASD. This approach underscores the need of a holistic, interdisciplinary strategy in encouraging and supporting the ASD community. En ligne : https://doi.org/10.1007/s10803-024-06519-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580 [article] Contributions of the ELENA Cohort to Study Autism Spectrum Disorder in Children and Adolescents from a Biopsychosocial Framework [texte imprimé] / Amaria BAGHDADLI, Auteur ; Marianne PERIES, Auteur ; Julie LOUBERSAC, Auteur ; Cécile MICHELON, Auteur ; Cécile RATTAZ, Auteur ; Laetitia FERRANDO, Auteur ; Aurore DAVID, Auteur ; Kerim MUNIR, Auteur ; Marie-Christine PICOT, Auteur . - p.362-387. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 56-1 (January 2026) . - p.362-387 Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a complex neurodevelopmental condition influenced by a myriad of developmental, biological, psychological, and socio-demographic factors. The ELENA cohort seeks to delineate the intricate interplay of these factors, facilitating the identification of risk factors and the development of targeted interventions. This paper emphasizes the clinical profiles of children and outlines key findings from a biopsychosocial perspective. The ELENA cohort, a multicenter initiative across French regional centers, conducted a systematic prospective analysis on children newly diagnosed with DSM-5 ASD between 2012 and 2019. This encompassed direct assessments and parent-reported questionnaires covering a broad spectrum of developmental, biological, psychological and socio-demographic measures. Embedded case–control studies further examined risk and protective factors, alongside specific environmental and psychosocial influences during pregnancy and early childhood. A subset of participants also contributed biospecimens, with data enhancement via linkage to French National Administrative Healthcare Databases. The study unveils baseline clinical characteristics for 876 children, average age 6 (SD ± 3.3) previously unreported in protocol descriptions. It highlights the study’s developmental biopsychosocial approach and its novel findings on children’s socio-adaptive functioning, ASD severity, comorbidities, quality of life and interventions. Employing developmental biopsychosocial insights offers a promising pathway to integrating health, social care, and experiential insights, ultimately aiming to enhance the future well-being and outcomes for children with ASD. This approach underscores the need of a holistic, interdisciplinary strategy in encouraging and supporting the ASD community. En ligne : https://doi.org/10.1007/s10803-024-06519-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=580

Factors associated with age of diagnosis in children with autism spectrum disorders: Report from a French cohort / Cécile RATTAZ in Autism, 26-8 (November 2022)  

Public ISBD [article]  inAutism > 26-8 (November 2022) . - p.2108-2116 Titre : Factors associated with age of diagnosis in children with autism spectrum disorders: Report from a French cohort Type de document : texte imprimé Auteurs : Cécile RATTAZ, Auteur ; Julie LOUBERSAC, Auteur ; Cécile MICHELON, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Marie-Christine PICOT, Auteur ; Kerim M. MUNIR, Auteur ; Amaria BAGHDADLI, Auteur Article en page(s) : p.2108-2116 Langues : Anglais (eng) Mots-clés : Child  Adolescent  Humans  Child, Preschool  Autism Spectrum Disorder/diagnosis/epidemiology/complications  Cohort Studies  Intellectual Disability/complications  Early Diagnosis  Social Class  ELENA cohort  age of diagnosis  autism spectrum disorder  children Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is an early onset neurodevelopmental disorder and diagnosis can be made as early as 18 months of age. Early diagnosis of autism spectrum disorder is critical as it leads to early intervention. Age of autism spectrum disorder diagnosis has been linked to the child profile as autism spectrum disorder is characterized by strong heterogeneity, but is also influenced by socio-economic factors. There is paucity of data on age of diagnosis of autism spectrum disorder in France. We therefore examined the age of autism spectrum disorder diagnosis in 554 children and adolescents enrolled in the ELENA cohort study with respect to the influences of child profile, family antecedents, and socio-economic factors. The mean age of diagnosis was 4.9 years (Â+2.8 years). Early diagnosis, before 3 years of age, was related to the co-occurrence of intellectual disability, higher autism spectrum disorder symptom severity, and lower communicative abilities. Children in low socio-economic status families tended to have an earlier diagnosis, but these children also had greater degree of intellectual impairment compared to children in high socio-economic status families. The age of autism spectrum disorder diagnosis was not associated with the presence of an older sibling with autism spectrum disorder. The observed current trend of an inverse relationship between socio-economic status and age of diagnosis of autism spectrum disorder suggests equitable access to autism spectrum disorder services in France where health coverage is universal and free. Better screening of more subtle/less severe forms of autism spectrum disorder is needed, as well as further assessment of the link between the co-occurrence of autism spectrum disorder and intellectual impairment in children in lower socio-economic status families. En ligne : http://dx.doi.org/10.1177/13623613221077724 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Factors associated with age of diagnosis in children with autism spectrum disorders: Report from a French cohort [texte imprimé] / Cécile RATTAZ, Auteur ; Julie LOUBERSAC, Auteur ; Cécile MICHELON, Auteur ; Marie-Maude GEOFFRAY, Auteur ; Marie-Christine PICOT, Auteur ; Kerim M. MUNIR, Auteur ; Amaria BAGHDADLI, Auteur . - p.2108-2116. Langues : Anglais (eng) in Autism > 26-8 (November 2022) . - p.2108-2116 Mots-clés : Child  Adolescent  Humans  Child, Preschool  Autism Spectrum Disorder/diagnosis/epidemiology/complications  Cohort Studies  Intellectual Disability/complications  Early Diagnosis  Social Class  ELENA cohort  age of diagnosis  autism spectrum disorder  children Index. décimale : PER Périodiques Résumé : Autism spectrum disorder is an early onset neurodevelopmental disorder and diagnosis can be made as early as 18 months of age. Early diagnosis of autism spectrum disorder is critical as it leads to early intervention. Age of autism spectrum disorder diagnosis has been linked to the child profile as autism spectrum disorder is characterized by strong heterogeneity, but is also influenced by socio-economic factors. There is paucity of data on age of diagnosis of autism spectrum disorder in France. We therefore examined the age of autism spectrum disorder diagnosis in 554 children and adolescents enrolled in the ELENA cohort study with respect to the influences of child profile, family antecedents, and socio-economic factors. The mean age of diagnosis was 4.9 years (Â+2.8 years). Early diagnosis, before 3 years of age, was related to the co-occurrence of intellectual disability, higher autism spectrum disorder symptom severity, and lower communicative abilities. Children in low socio-economic status families tended to have an earlier diagnosis, but these children also had greater degree of intellectual impairment compared to children in high socio-economic status families. The age of autism spectrum disorder diagnosis was not associated with the presence of an older sibling with autism spectrum disorder. The observed current trend of an inverse relationship between socio-economic status and age of diagnosis of autism spectrum disorder suggests equitable access to autism spectrum disorder services in France where health coverage is universal and free. Better screening of more subtle/less severe forms of autism spectrum disorder is needed, as well as further assessment of the link between the co-occurrence of autism spectrum disorder and intellectual impairment in children in lower socio-economic status families. En ligne : http://dx.doi.org/10.1177/13623613221077724 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

---

1 (1 - 2 / 2) Par page : 25 50 100 200