Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs / Basmah H. ALFAGEH in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4817-4827 Titre : Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs Type de document : Texte imprimé et/ou numérique Auteurs : Basmah H. ALFAGEH, Auteur ; Frank M. C. BESAG, Auteur ; Le GAO, Auteur ; Tian-Tian MA, Auteur ; Kenneth K. C. MAN, Auteur ; Ian C. K. WONG, Auteur ; Ruth BRAUER, Auteur Article en page(s) : p.4817-4827 Langues : Anglais (eng) Mots-clés : Antipsychotic Agents/adverse effects  Autism Spectrum Disorder/drug therapy/epidemiology  Cohort Studies  Humans  Psychotropic Drugs/therapeutic use  Retrospective Studies  Seizures/chemically induced/drug therapy/epidemiology  Antipsychotic medication  Autism spectrum disorder (ASD)  Incident seizure  Psychotropic medication Index. décimale : PER Périodiques Résumé : There are many case reports of seizures apparently associated with the prescription of antipsychotics. This study aimed to examine whether there is an association between the prescription of antipsychotics and incident seizures in individuals with autism spectrum disorder using retrospective data based on patients' chart review. A cohort study was conducted to compare the rate of incident seizure between 3923 users of antipsychotics with 10,086 users of other psychotropics. This was followed by a self-controlled case series (SCCS) analysis of 149 patients to eliminate the effect of time-invariant confounders. The results showed no evidence of increased risk of seizure after exposure to antipsychotic agents (Hazard Ratio 1.28, 95% CI 0.74-2.19) compared to other psychotropics. En ligne : http://dx.doi.org/10.1007/s10803-021-05208-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs [Texte imprimé et/ou numérique] / Basmah H. ALFAGEH, Auteur ; Frank M. C. BESAG, Auteur ; Le GAO, Auteur ; Tian-Tian MA, Auteur ; Kenneth K. C. MAN, Auteur ; Ian C. K. WONG, Auteur ; Ruth BRAUER, Auteur . - p.4817-4827. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4817-4827 Mots-clés : Antipsychotic Agents/adverse effects  Autism Spectrum Disorder/drug therapy/epidemiology  Cohort Studies  Humans  Psychotropic Drugs/therapeutic use  Retrospective Studies  Seizures/chemically induced/drug therapy/epidemiology  Antipsychotic medication  Autism spectrum disorder (ASD)  Incident seizure  Psychotropic medication Index. décimale : PER Périodiques Résumé : There are many case reports of seizures apparently associated with the prescription of antipsychotics. This study aimed to examine whether there is an association between the prescription of antipsychotics and incident seizures in individuals with autism spectrum disorder using retrospective data based on patients' chart review. A cohort study was conducted to compare the rate of incident seizure between 3923 users of antipsychotics with 10,086 users of other psychotropics. This was followed by a self-controlled case series (SCCS) analysis of 149 patients to eliminate the effect of time-invariant confounders. The results showed no evidence of increased risk of seizure after exposure to antipsychotic agents (Hazard Ratio 1.28, 95% CI 0.74-2.19) compared to other psychotropics. En ligne : http://dx.doi.org/10.1007/s10803-021-05208-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

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