Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs / Basmah H. ALFAGEH in Journal of Autism and Developmental Disorders, 52-11 (November 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4817-4827 Titre : Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs Type de document : Texte imprimé et/ou numérique Auteurs : Basmah H. ALFAGEH, Auteur ; Frank M. C. BESAG, Auteur ; Le GAO, Auteur ; Tian-Tian MA, Auteur ; Kenneth K. C. MAN, Auteur ; Ian C. K. WONG, Auteur ; Ruth BRAUER, Auteur Article en page(s) : p.4817-4827 Langues : Anglais (eng) Mots-clés : Antipsychotic Agents/adverse effects  Autism Spectrum Disorder/drug therapy/epidemiology  Cohort Studies  Humans  Psychotropic Drugs/therapeutic use  Retrospective Studies  Seizures/chemically induced/drug therapy/epidemiology  Antipsychotic medication  Autism spectrum disorder (ASD)  Incident seizure  Psychotropic medication Index. décimale : PER Périodiques Résumé : There are many case reports of seizures apparently associated with the prescription of antipsychotics. This study aimed to examine whether there is an association between the prescription of antipsychotics and incident seizures in individuals with autism spectrum disorder using retrospective data based on patients' chart review. A cohort study was conducted to compare the rate of incident seizure between 3923 users of antipsychotics with 10,086 users of other psychotropics. This was followed by a self-controlled case series (SCCS) analysis of 149 patients to eliminate the effect of time-invariant confounders. The results showed no evidence of increased risk of seizure after exposure to antipsychotic agents (Hazard Ratio 1.28, 95% CI 0.74-2.19) compared to other psychotropics. En ligne : http://dx.doi.org/10.1007/s10803-021-05208-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Antipsychotic Medication and Risk of Incident Seizure in People with Autism Spectrum Disorder: Analyses with Cohort and Within Individual Study Designs [Texte imprimé et/ou numérique] / Basmah H. ALFAGEH, Auteur ; Frank M. C. BESAG, Auteur ; Le GAO, Auteur ; Tian-Tian MA, Auteur ; Kenneth K. C. MAN, Auteur ; Ian C. K. WONG, Auteur ; Ruth BRAUER, Auteur . - p.4817-4827. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4817-4827 Mots-clés : Antipsychotic Agents/adverse effects  Autism Spectrum Disorder/drug therapy/epidemiology  Cohort Studies  Humans  Psychotropic Drugs/therapeutic use  Retrospective Studies  Seizures/chemically induced/drug therapy/epidemiology  Antipsychotic medication  Autism spectrum disorder (ASD)  Incident seizure  Psychotropic medication Index. décimale : PER Périodiques Résumé : There are many case reports of seizures apparently associated with the prescription of antipsychotics. This study aimed to examine whether there is an association between the prescription of antipsychotics and incident seizures in individuals with autism spectrum disorder using retrospective data based on patients' chart review. A cohort study was conducted to compare the rate of incident seizure between 3923 users of antipsychotics with 10,086 users of other psychotropics. This was followed by a self-controlled case series (SCCS) analysis of 149 patients to eliminate the effect of time-invariant confounders. The results showed no evidence of increased risk of seizure after exposure to antipsychotic agents (Hazard Ratio 1.28, 95% CI 0.74-2.19) compared to other psychotropics. En ligne : http://dx.doi.org/10.1007/s10803-021-05208-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

Psychotropic Medication Prescribing for Neuropsychiatric Comorbidities in Individuals Diagnosed with Autism Spectrum Disorder (ASD) in the UK / Basmah H. ALFAGEH in Journal of Autism and Developmental Disorders, 50-2 (February 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-2 (February 2020) . - p.625-633 Titre : Psychotropic Medication Prescribing for Neuropsychiatric Comorbidities in Individuals Diagnosed with Autism Spectrum Disorder (ASD) in the UK Type de document : Texte imprimé et/ou numérique Auteurs : Basmah H. ALFAGEH, Auteur ; Kenneth K. C. MAN, Auteur ; Frank M. C. BESAG, Auteur ; Tariq M. ALHAWASSI, Auteur ; Ian C. K. WONG, Auteur ; Ruth BRAUER, Auteur Article en page(s) : p.625-633 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Incidence  Prevalence  Psychotropic medication Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a lifelong disorder. In the UK, risperidone is the only psychotropic medication approved for the management of the behavioural symptoms that may accompany autism. This is a population-based study aimed to provide an evaluation of the changing trend in the incidence and prevalence of ASD and to analyse the pattern of psychotropic medication prescribing in the UK. 20,194 patients with ASD were identified. The prevalence increased 3.3-fold from 0.109 per 100 persons in 2009 to 0.355 per 100 persons in 2016. Approximately one-third of the identified cohort was prescribed at least one psychotropic medication. Although the medications approved to manage the symptoms of ASD are limited, the prescribing of such medications is increasing. En ligne : http://dx.doi.org/10.1007/s10803-019-04291-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 [article] Psychotropic Medication Prescribing for Neuropsychiatric Comorbidities in Individuals Diagnosed with Autism Spectrum Disorder (ASD) in the UK [Texte imprimé et/ou numérique] / Basmah H. ALFAGEH, Auteur ; Kenneth K. C. MAN, Auteur ; Frank M. C. BESAG, Auteur ; Tariq M. ALHAWASSI, Auteur ; Ian C. K. WONG, Auteur ; Ruth BRAUER, Auteur . - p.625-633. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-2 (February 2020) . - p.625-633 Mots-clés : Autism spectrum disorder  Incidence  Prevalence  Psychotropic medication Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a lifelong disorder. In the UK, risperidone is the only psychotropic medication approved for the management of the behavioural symptoms that may accompany autism. This is a population-based study aimed to provide an evaluation of the changing trend in the incidence and prevalence of ASD and to analyse the pattern of psychotropic medication prescribing in the UK. 20,194 patients with ASD were identified. The prevalence increased 3.3-fold from 0.109 per 100 persons in 2009 to 0.355 per 100 persons in 2016. Approximately one-third of the identified cohort was prescribed at least one psychotropic medication. Although the medications approved to manage the symptoms of ASD are limited, the prescribing of such medications is increasing. En ligne : http://dx.doi.org/10.1007/s10803-019-04291-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416

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