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du CRA Rhône-Alpes
Centre Hospitalier le Vinatier
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Auteur Fiorenzo LAGHI
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Documents disponibles écrits par cet auteur (3)
Faire une suggestion Affiner la rechercheProgram for the Education and Enrichment of Relational Skills (PEERS®) for Italy: A Randomized Controlled Trial of a Social Skills Intervention for Autistic Adolescents / Laura Maria FATTA ; Elizabeth A. LAUGESON ; Dora BIANCHI ; Fiorenzo LAGHI ; Maria Luisa SCATTONI ; ITALIAN PEERS® TEAM SUPPORT GROUP in Journal of Autism and Developmental Disorders, 55-1 (January 2025)
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Titre : Program for the Education and Enrichment of Relational Skills (PEERS®) for Italy: A Randomized Controlled Trial of a Social Skills Intervention for Autistic Adolescents : Journal of Autism and Developmental Disorders Type de document : texte imprimé Auteurs : Laura Maria FATTA, Auteur ; Elizabeth A. LAUGESON, Auteur ; Dora BIANCHI, Auteur ; Fiorenzo LAGHI, Auteur ; Maria Luisa SCATTONI, Auteur ; ITALIAN PEERS® TEAM SUPPORT GROUP, Auteur Article en page(s) : p.202-220 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The Program for the Education and Enrichment of Relational Skills (PEERS®) is an intervention targeting social skills for autistic adolescents and those with other social challenges. The efficacy of the PEERS® on adolescents has been extensively explored but the program has not been validated in Italy. In the present study, we adapted PEERS® to Italian culture and evaluated its efficacy in an Italian sample. A Randomized Controlled Trial was conducted, analyzing the results of 37 autistic adolescents who were randomly assigned to two groups: experimental group (TG) and waitlist group (WL). The primary outcomes (social abilities) and secondary outcomes (co-occurring conditions, executive functions) were assessed at four time points. No differences were found at pre-treatment between groups on baseline measures and primary outcomes. At post-treatment, significant group differences emerged in primary outcomes (social knowledge and social performance) and secondary outcomes (emotion regulation). The groups' results pooled together (TG+WL) confirmed the findings at post-treatment and showed further changes in primary outcomes (global social competence and social cognition) and secondary outcomes (externalizing problems, emotive and behavioral total problems, functional problems related to depressive symptoms). The improvements were maintained at a 3-month follow-up, except for global social competence and social cognition. Additionally, new results emerged regarding internalizing problems and global executive functioning. The efficacy of the Italian version of PEERS® was ascertained on primary and secondary outcomes. Innovative findings on emotion regulation, behavioral problems, and depression symptoms also emerged. En ligne : https://doi.org/10.1007/s10803-023-06211-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546
in Journal of Autism and Developmental Disorders > 55-1 (January 2025) . - p.202-220[article] Program for the Education and Enrichment of Relational Skills (PEERS®) for Italy: A Randomized Controlled Trial of a Social Skills Intervention for Autistic Adolescents : Journal of Autism and Developmental Disorders [texte imprimé] / Laura Maria FATTA, Auteur ; Elizabeth A. LAUGESON, Auteur ; Dora BIANCHI, Auteur ; Fiorenzo LAGHI, Auteur ; Maria Luisa SCATTONI, Auteur ; ITALIAN PEERS® TEAM SUPPORT GROUP, Auteur . - p.202-220.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 55-1 (January 2025) . - p.202-220
Index. décimale : PER Périodiques Résumé : The Program for the Education and Enrichment of Relational Skills (PEERS®) is an intervention targeting social skills for autistic adolescents and those with other social challenges. The efficacy of the PEERS® on adolescents has been extensively explored but the program has not been validated in Italy. In the present study, we adapted PEERS® to Italian culture and evaluated its efficacy in an Italian sample. A Randomized Controlled Trial was conducted, analyzing the results of 37 autistic adolescents who were randomly assigned to two groups: experimental group (TG) and waitlist group (WL). The primary outcomes (social abilities) and secondary outcomes (co-occurring conditions, executive functions) were assessed at four time points. No differences were found at pre-treatment between groups on baseline measures and primary outcomes. At post-treatment, significant group differences emerged in primary outcomes (social knowledge and social performance) and secondary outcomes (emotion regulation). The groups' results pooled together (TG+WL) confirmed the findings at post-treatment and showed further changes in primary outcomes (global social competence and social cognition) and secondary outcomes (externalizing problems, emotive and behavioral total problems, functional problems related to depressive symptoms). The improvements were maintained at a 3-month follow-up, except for global social competence and social cognition. Additionally, new results emerged regarding internalizing problems and global executive functioning. The efficacy of the Italian version of PEERS® was ascertained on primary and secondary outcomes. Innovative findings on emotion regulation, behavioral problems, and depression symptoms also emerged. En ligne : https://doi.org/10.1007/s10803-023-06211-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 The cerebellum is linked to theory of mind alterations in autism. A direct clinical and MRI comparison between individuals with autism and cerebellar neurodegenerative pathologies / Silvia CLAUSI in Autism Research, 14-11 (November 2021)
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Titre : The cerebellum is linked to theory of mind alterations in autism. A direct clinical and MRI comparison between individuals with autism and cerebellar neurodegenerative pathologies Type de document : texte imprimé Auteurs : Silvia CLAUSI, Auteur ; Giusy OLIVITO, Auteur ; Libera SICILIANO, Auteur ; Michela LUPO, Auteur ; Fiorenzo LAGHI, Auteur ; Roberto BAIOCCO, Auteur ; Marie LEGGIO, Auteur Article en page(s) : p.2300-2313 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/diagnostic imaging Autistic Disorder Cerebellum/diagnostic imaging Humans Language Magnetic Resonance Imaging Theory of Mind cerebellar degenerative disease cerebellar structural changes mentalizing neurodevelopmental disorder voxel-based morphometry Index. décimale : PER Périodiques Résumé : In recent years, structural and functional alterations in the cerebellum have been reported in autism spectrum disorder (ASD). Intriguingly, recent studies demonstrated that the social behavioral profile of individuals with cerebellar pathologies is characterized by a theory of mind (ToM) impairment, one of the main behavioral hallmarks of ASD. The aim of the present study was to compare ToM abilities and underlying cerebello-cortical structural patterns between ASD individuals and individuals with cerebellar atrophy to further specify the cerebellar role in mentalizing alterations in ASD. Twenty-one adults with ASD without language and intellectual impairments (based on DSM-5), 36 individuals affected by degenerative cerebellar damage (CB), and 67 healthy participants were enrolled in the study. ToM abilities were assessed using the reading the mind in the eyes test and the faux pas test. One-way ANCOVA was conducted to compare the performances between the two cohorts. Three-dimensional T1-weighted magnetic resonance scans were collected, and a voxel-based morphometry analysis was performed to characterize the brain structural alterations in the two cohorts. ASD and CB participants had comparable ToM performance with similar difficulties in both the tests. CB and ASD participants showed an overlapping pattern of gray matter (GM) reduction in a specific cerebellar portion (Crus-II). Our study provides the first direct comparison of ToM abilities between ASD and CB individuals, boosting the idea that specific cerebellar structural alterations impact the mentalizing process. The present findings open a new perspective for considering the cerebellum as a potential target for treatment implementation. The present work will critically advance current knowledge about the cerebellar role in ToM alterations of ASD, in particular, elucidating the presence of common cerebellar structural abnormalities in ASD and cerebellar individuals that may underlie specific mentalizing alterations. These findings may pave the way for alternative therapeutic indications, such as cerebellar neuromodulation, with a strong clinical impact. LAY SUMMARY: The present work will critically advance current knowledge about the cerebellar role in theory of mind alterations of autism spectrum disorder (ASD), in particular, elucidating the presence of common cerebellar structural abnormalities in ASD and cerebellar individuals that may underlie specific mentalizing alterations. These findings may pave the way for alternative therapeutic indications, such as cerebellar neuromodulation, with a strong clinical impact. En ligne : http://dx.doi.org/10.1002/aur.2593 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450
in Autism Research > 14-11 (November 2021) . - p.2300-2313[article] The cerebellum is linked to theory of mind alterations in autism. A direct clinical and MRI comparison between individuals with autism and cerebellar neurodegenerative pathologies [texte imprimé] / Silvia CLAUSI, Auteur ; Giusy OLIVITO, Auteur ; Libera SICILIANO, Auteur ; Michela LUPO, Auteur ; Fiorenzo LAGHI, Auteur ; Roberto BAIOCCO, Auteur ; Marie LEGGIO, Auteur . - p.2300-2313.
Langues : Anglais (eng)
in Autism Research > 14-11 (November 2021) . - p.2300-2313
Mots-clés : Adult Autism Spectrum Disorder/diagnostic imaging Autistic Disorder Cerebellum/diagnostic imaging Humans Language Magnetic Resonance Imaging Theory of Mind cerebellar degenerative disease cerebellar structural changes mentalizing neurodevelopmental disorder voxel-based morphometry Index. décimale : PER Périodiques Résumé : In recent years, structural and functional alterations in the cerebellum have been reported in autism spectrum disorder (ASD). Intriguingly, recent studies demonstrated that the social behavioral profile of individuals with cerebellar pathologies is characterized by a theory of mind (ToM) impairment, one of the main behavioral hallmarks of ASD. The aim of the present study was to compare ToM abilities and underlying cerebello-cortical structural patterns between ASD individuals and individuals with cerebellar atrophy to further specify the cerebellar role in mentalizing alterations in ASD. Twenty-one adults with ASD without language and intellectual impairments (based on DSM-5), 36 individuals affected by degenerative cerebellar damage (CB), and 67 healthy participants were enrolled in the study. ToM abilities were assessed using the reading the mind in the eyes test and the faux pas test. One-way ANCOVA was conducted to compare the performances between the two cohorts. Three-dimensional T1-weighted magnetic resonance scans were collected, and a voxel-based morphometry analysis was performed to characterize the brain structural alterations in the two cohorts. ASD and CB participants had comparable ToM performance with similar difficulties in both the tests. CB and ASD participants showed an overlapping pattern of gray matter (GM) reduction in a specific cerebellar portion (Crus-II). Our study provides the first direct comparison of ToM abilities between ASD and CB individuals, boosting the idea that specific cerebellar structural alterations impact the mentalizing process. The present findings open a new perspective for considering the cerebellum as a potential target for treatment implementation. The present work will critically advance current knowledge about the cerebellar role in ToM alterations of ASD, in particular, elucidating the presence of common cerebellar structural abnormalities in ASD and cerebellar individuals that may underlie specific mentalizing alterations. These findings may pave the way for alternative therapeutic indications, such as cerebellar neuromodulation, with a strong clinical impact. LAY SUMMARY: The present work will critically advance current knowledge about the cerebellar role in theory of mind alterations of autism spectrum disorder (ASD), in particular, elucidating the presence of common cerebellar structural abnormalities in ASD and cerebellar individuals that may underlie specific mentalizing alterations. These findings may pave the way for alternative therapeutic indications, such as cerebellar neuromodulation, with a strong clinical impact. En ligne : http://dx.doi.org/10.1002/aur.2593 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 The Floor Effect on the ABAS-II in Adolescents with Autism Spectrum Disorder / Fiorenzo LAGHI in Journal of Autism and Developmental Disorders, 52-11 (November 2022)
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Titre : The Floor Effect on the ABAS-II in Adolescents with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Fiorenzo LAGHI, Auteur ; Rosa FERRI, Auteur ; Elvira CARAMUSCIO, Auteur ; Antonia LONIGRO, Auteur ; Monica REA, Auteur ; Lina PEZZUTI, Auteur Article en page(s) : p.4975-4985 Langues : Anglais (eng) Mots-clés : Adaptation, Psychological Adolescent Autism Spectrum Disorder Humans Abas-ii Adaptive behavior Adolescence Autism spectrum disorder Floor effect Index. décimale : PER Périodiques Résumé : The present study aimed at enhancing the assessment of adaptive behavior in adolescents with Autism Spectrum Disorder trough the Adaptive Behavior Assessment System-Second Edition. To overcome the limits underpinning floor effect, which are commonly observed with the traditional methods, the statistical Hessl method and its revision by Orsini, Pezzuti and Hulbert was adopted. The results showed a more variation using the former method compared to the latter: a greater impairment in Social versus Leisure skills emerged. Regarding the Conceptual domain, a greater deficit in Functional Academics was observed. In the Practical domain, we found a greater impairment in Self-Care skills. Conversely, Home Living skills appeared as a strength compared to other skills. The results are discussed in reference to literature. En ligne : http://dx.doi.org/10.1007/s10803-021-05369-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489
in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4975-4985[article] The Floor Effect on the ABAS-II in Adolescents with Autism Spectrum Disorder [texte imprimé] / Fiorenzo LAGHI, Auteur ; Rosa FERRI, Auteur ; Elvira CARAMUSCIO, Auteur ; Antonia LONIGRO, Auteur ; Monica REA, Auteur ; Lina PEZZUTI, Auteur . - p.4975-4985.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 52-11 (November 2022) . - p.4975-4985
Mots-clés : Adaptation, Psychological Adolescent Autism Spectrum Disorder Humans Abas-ii Adaptive behavior Adolescence Autism spectrum disorder Floor effect Index. décimale : PER Périodiques Résumé : The present study aimed at enhancing the assessment of adaptive behavior in adolescents with Autism Spectrum Disorder trough the Adaptive Behavior Assessment System-Second Edition. To overcome the limits underpinning floor effect, which are commonly observed with the traditional methods, the statistical Hessl method and its revision by Orsini, Pezzuti and Hulbert was adopted. The results showed a more variation using the former method compared to the latter: a greater impairment in Social versus Leisure skills emerged. Regarding the Conceptual domain, a greater deficit in Functional Academics was observed. In the Practical domain, we found a greater impairment in Self-Care skills. Conversely, Home Living skills appeared as a strength compared to other skills. The results are discussed in reference to literature. En ligne : http://dx.doi.org/10.1007/s10803-021-05369-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

