Adaptive trajectories and early risk factors in the autism spectrum: A 15-year prospective study / Amaria BAGHDADLI in Autism Research, 11-11 (November 2018)  

Public ISBD [article]  inAutism Research > 11-11 (November 2018) . - p.1455-1467 Titre : Adaptive trajectories and early risk factors in the autism spectrum: A 15-year prospective study Type de document : texte imprimé Auteurs : Amaria BAGHDADLI, Auteur ; Cécile MICHELON, Auteur ; Eric PERNON, Auteur ; Marie-Christine PICOT, Auteur ; Stéphanie MIOT, Auteur ; Sandrine SONIE, Auteur ; Cécile RATTAZ, Auteur ; Laurent MOTTRON, Auteur Article en page(s) : p.1455-1467 Langues : Anglais (eng) Mots-clés : adaptative level  autism spectrum  developmental trajectories  early adulthood Index. décimale : PER Périodiques Résumé : Little is known about long-term outcomes. We investigate the adaptive trajectories and their risk factors in ASD. Data were obtained from 281 children prospectively followed untill adulthood. The final sample consisted of 106 individuals. Vineland scores were collected at baseline (T1), 3 (T2), 10 (T3), and 15 (T4) years later. A group-based method was used to identify homogeneous patterns of adaptive skills trajectories. Results show that among the children initially categorized as autistic, 82.6% remained over the ADOS diagnostic threshold, 11.9% converted to atypical autism, and 5.4% fell under the ADOS threshold. Most atypical autism diagnoses were unstable. Most (81.7%) autistic participants had an ID at inclusion. At T1, 59.3% were nonverbal, but only 39% at T4. Most changes occurred between 4 and 8 years of age. Approximately 25% of participants exhibited a "high" growth trajectory, in which progress continues throughout adolescence, and 75% a "low" growth trajectory, characterized by greater autistic symptoms, intellectual disability, and lower language abilities reflected by high CARS scores, low apparent DQ, and speech difficulties, which mostly, but not always, predicted low trajectories. Our findings suggest that the adaptive prognosis of autism is mostly poor in this cohort, biased toward intellectual disability. However, changes in diagnostic, speech, and adaptive status are not uncommon, even for indivduals with low measured intelligence or apparent intellectual disability, and are sometimes difficult to predict. Autism Research 2018, 11: 1455-1467. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Most autism diagnoses given before 5 years of age are stable to adulthood, but one-fifth of individuals are no longer considered to be autistic, even in a cohort biased toward apparent intellectual disability. Conversely, atypical autism diagnoses are mostly unstable. One-third of children who are nonverbal at 5 years are verbal within 15 years, mostly before 8 years of age. Concerning adaptive behavior outcomes, only one-fourth of children exhibit a high-growth trajectory through at least 15 years. En ligne : http://dx.doi.org/10.1002/aur.2022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Adaptive trajectories and early risk factors in the autism spectrum: A 15-year prospective study [texte imprimé] / Amaria BAGHDADLI, Auteur ; Cécile MICHELON, Auteur ; Eric PERNON, Auteur ; Marie-Christine PICOT, Auteur ; Stéphanie MIOT, Auteur ; Sandrine SONIE, Auteur ; Cécile RATTAZ, Auteur ; Laurent MOTTRON, Auteur . - p.1455-1467. Langues : Anglais (eng) in Autism Research > 11-11 (November 2018) . - p.1455-1467 Mots-clés : adaptative level  autism spectrum  developmental trajectories  early adulthood Index. décimale : PER Périodiques Résumé : Little is known about long-term outcomes. We investigate the adaptive trajectories and their risk factors in ASD. Data were obtained from 281 children prospectively followed untill adulthood. The final sample consisted of 106 individuals. Vineland scores were collected at baseline (T1), 3 (T2), 10 (T3), and 15 (T4) years later. A group-based method was used to identify homogeneous patterns of adaptive skills trajectories. Results show that among the children initially categorized as autistic, 82.6% remained over the ADOS diagnostic threshold, 11.9% converted to atypical autism, and 5.4% fell under the ADOS threshold. Most atypical autism diagnoses were unstable. Most (81.7%) autistic participants had an ID at inclusion. At T1, 59.3% were nonverbal, but only 39% at T4. Most changes occurred between 4 and 8 years of age. Approximately 25% of participants exhibited a "high" growth trajectory, in which progress continues throughout adolescence, and 75% a "low" growth trajectory, characterized by greater autistic symptoms, intellectual disability, and lower language abilities reflected by high CARS scores, low apparent DQ, and speech difficulties, which mostly, but not always, predicted low trajectories. Our findings suggest that the adaptive prognosis of autism is mostly poor in this cohort, biased toward intellectual disability. However, changes in diagnostic, speech, and adaptive status are not uncommon, even for indivduals with low measured intelligence or apparent intellectual disability, and are sometimes difficult to predict. Autism Research 2018, 11: 1455-1467. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Most autism diagnoses given before 5 years of age are stable to adulthood, but one-fifth of individuals are no longer considered to be autistic, even in a cohort biased toward apparent intellectual disability. Conversely, atypical autism diagnoses are mostly unstable. One-third of children who are nonverbal at 5 years are verbal within 15 years, mostly before 8 years of age. Concerning adaptive behavior outcomes, only one-fourth of children exhibit a high-growth trajectory through at least 15 years. En ligne : http://dx.doi.org/10.1002/aur.2022 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Les biomarqueurs du vieillissement dans les TND dont l'autisme / Stéphanie MIOT in Bulletin Scientifique de l'arapi (Le), 55 (2025/1)

Public ISBD [article]  inBulletin Scientifique de l'arapi (Le) > 55 (2025/1) . - p.20-26 Titre : Les biomarqueurs du vieillissement dans les TND dont l'autisme Type de document : texte imprimé Auteurs : Stéphanie MIOT, Auteur ; Tom DAUCHEZ, Auteur ; Morgane PHELEP, Auteur Année de publication : 2025 Article en page(s) : p.20-26 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571 [article] Les biomarqueurs du vieillissement dans les TND dont l'autisme [texte imprimé] / Stéphanie MIOT, Auteur ; Tom DAUCHEZ, Auteur ; Morgane PHELEP, Auteur . - 2025 . - p.20-26. Langues : Français (fre) in Bulletin Scientifique de l'arapi (Le) > 55 (2025/1) . - p.20-26 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=571

A Call to Action to Implement Effective COVID-19 Prevention and Screening of Individuals with Severe Intellectual Developmental and Autism Spectrum Disorders / Amaria BAGHDADLI in Journal of Autism and Developmental Disorders, 51-7 (July 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2566-2568 Titre : A Call to Action to Implement Effective COVID-19 Prevention and Screening of Individuals with Severe Intellectual Developmental and Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Amaria BAGHDADLI, Auteur ; Marie-Christine PICOT, Auteur ; Stéphanie MIOT, Auteur ; Kerim M. MUNIR, Auteur Article en page(s) : p.2566-2568 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-020-04719-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452 [article] A Call to Action to Implement Effective COVID-19 Prevention and Screening of Individuals with Severe Intellectual Developmental and Autism Spectrum Disorders [texte imprimé] / Amaria BAGHDADLI, Auteur ; Marie-Christine PICOT, Auteur ; Stéphanie MIOT, Auteur ; Kerim M. MUNIR, Auteur . - p.2566-2568. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-7 (July 2021) . - p.2566-2568 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-020-04719-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=452

Multimorbidity patterns and subgroups among autistic adults with intellectual disability: Results from the EFAAR study / Stéphanie MIOT in Autism, 27-3 (April 2023)  

Public ISBD [article]  inAutism > 27-3 (April 2023) . - p.762-777 Titre : Multimorbidity patterns and subgroups among autistic adults with intellectual disability: Results from the EFAAR study Type de document : texte imprimé Auteurs : Stéphanie MIOT, Auteur ; Raphaël CHANCEL, Auteur ; Marianne PERIES, Auteur ; Sophie CREPIAT, Auteur ; Sylvie COUDERC, Auteur ; Eric PERNON, Auteur ; Marie-Christine PICOT, Auteur ; Véronique GONNIER, Auteur ; Claude JEANDEL, Auteur ; Hubert BLAIN, Auteur ; Amaria BAGHDADLI, Auteur Article en page(s) : p.762-777 Langues : Anglais (eng) Mots-clés : adults,autism spectrum disorder,intellectual disability,multimorbidity Index. décimale : PER Périodiques Résumé : Multimorbidity, defined as having two or more chronic health conditions, is associated with elevated polypharmacy and mortality. Autism spectrum disorder is a whole-body chronic health condition in which comorbidities - in particular co-occurring intellectual disability - contribute to high clinical heterogeneity, polypharmacy and premature mortality. We aimed to determine specific multimorbidity patterns among autism spectrum disorder+intellectual disability adults, and to identify participants' subgroups based on multimorbidity features. We used baseline examination data from a previous exploratory prospective multicentric study that included 63 autism spectrum disorder+intellectual disability adults. Multimorbidity patterns and subgroups were determined using clustering approaches. We observed 84.1% multimorbidity, significantly associated with age. We identified a dominant multimorbidity pattern, combining immune dysfunction, gastrointestinal disorders, neurological, and joint diseases. Four participants' subgroups could be distinguished by multimorbidity, autonomy and polypharmacy. Two clusters were distinguished by the prevalence and consequences of multimorbidity. One cluster involved women with endocrine disorders. The final cluster was composed of older adults with the lowest autism spectrum disorder severity but greater multimorbidity, including cardiovascular and kidney diseases. Our results support a role for the gut-brain axis in the pathophysiology of autism spectrum disorder+intellectual disability multimorbidity. Furthermore, we identified patient subgroups with specific needs, underscoring the importance of a holistic approach for autism spectrum disorder+intellectual disability adults.Lay abstractMultimorbidity relates to having multiple chronic health conditions. It is a risk factor for poor health and reduces life expectancy. Autistic people have multiple chronic health conditions and die prematurely, especially if they have an intellectual disability (autism spectrum disorder and intellectual disability). Certain pathophysiological processes observed in autism spectrum disorder are common to those related to the genesis and/or maintenance of multimorbidity. Furthermore, multimorbidity could be helpful in better identifying patient subgroups in autism spectrum disorder. It is therefore essential to better characterize multimorbidity and its consequences in the subgroup of autism spectrum disorder+intellectual disability individuals to offer them personalized care. We conducted a preliminary study of 63 autism spectrum disorder+intellectual disability adults to classify them according to their multimorbidity and search for a specific combination of chronic health conditions. We observed high and early multimorbidity in this sample and identified four classes of participants, distinguished by their multimorbidity status, independence and number of treatments. In addition, we observed a dominant combination of multimorbidity in our sample, combining immune dysfunction and gastrointestinal disorders, neurological and joint diseases. These findings support the hypothesis that an altered gut-brain relationship is involved in the risk of autism spectrum disorder, its outcome, and its association with chronic health conditions. Although larger studies are needed, our results suggest that subgroups of autism spectrum disorder+intellectual disability individuals can be identified based on their multimorbidity and potentially different ageing trajectories. A more comprehensive and personalized approach is needed to reduce the burden of multimorbidity and increase the quality of life and life expectancy in autism spectrum disorder/ intellectual disability. En ligne : https://doi.org/10.1177/13623613221121623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499 [article] Multimorbidity patterns and subgroups among autistic adults with intellectual disability: Results from the EFAAR study [texte imprimé] / Stéphanie MIOT, Auteur ; Raphaël CHANCEL, Auteur ; Marianne PERIES, Auteur ; Sophie CREPIAT, Auteur ; Sylvie COUDERC, Auteur ; Eric PERNON, Auteur ; Marie-Christine PICOT, Auteur ; Véronique GONNIER, Auteur ; Claude JEANDEL, Auteur ; Hubert BLAIN, Auteur ; Amaria BAGHDADLI, Auteur . - p.762-777. Langues : Anglais (eng) in Autism > 27-3 (April 2023) . - p.762-777 Mots-clés : adults,autism spectrum disorder,intellectual disability,multimorbidity Index. décimale : PER Périodiques Résumé : Multimorbidity, defined as having two or more chronic health conditions, is associated with elevated polypharmacy and mortality. Autism spectrum disorder is a whole-body chronic health condition in which comorbidities - in particular co-occurring intellectual disability - contribute to high clinical heterogeneity, polypharmacy and premature mortality. We aimed to determine specific multimorbidity patterns among autism spectrum disorder+intellectual disability adults, and to identify participants' subgroups based on multimorbidity features. We used baseline examination data from a previous exploratory prospective multicentric study that included 63 autism spectrum disorder+intellectual disability adults. Multimorbidity patterns and subgroups were determined using clustering approaches. We observed 84.1% multimorbidity, significantly associated with age. We identified a dominant multimorbidity pattern, combining immune dysfunction, gastrointestinal disorders, neurological, and joint diseases. Four participants' subgroups could be distinguished by multimorbidity, autonomy and polypharmacy. Two clusters were distinguished by the prevalence and consequences of multimorbidity. One cluster involved women with endocrine disorders. The final cluster was composed of older adults with the lowest autism spectrum disorder severity but greater multimorbidity, including cardiovascular and kidney diseases. Our results support a role for the gut-brain axis in the pathophysiology of autism spectrum disorder+intellectual disability multimorbidity. Furthermore, we identified patient subgroups with specific needs, underscoring the importance of a holistic approach for autism spectrum disorder+intellectual disability adults.Lay abstractMultimorbidity relates to having multiple chronic health conditions. It is a risk factor for poor health and reduces life expectancy. Autistic people have multiple chronic health conditions and die prematurely, especially if they have an intellectual disability (autism spectrum disorder and intellectual disability). Certain pathophysiological processes observed in autism spectrum disorder are common to those related to the genesis and/or maintenance of multimorbidity. Furthermore, multimorbidity could be helpful in better identifying patient subgroups in autism spectrum disorder. It is therefore essential to better characterize multimorbidity and its consequences in the subgroup of autism spectrum disorder+intellectual disability individuals to offer them personalized care. We conducted a preliminary study of 63 autism spectrum disorder+intellectual disability adults to classify them according to their multimorbidity and search for a specific combination of chronic health conditions. We observed high and early multimorbidity in this sample and identified four classes of participants, distinguished by their multimorbidity status, independence and number of treatments. In addition, we observed a dominant combination of multimorbidity in our sample, combining immune dysfunction and gastrointestinal disorders, neurological and joint diseases. These findings support the hypothesis that an altered gut-brain relationship is involved in the risk of autism spectrum disorder, its outcome, and its association with chronic health conditions. Although larger studies are needed, our results suggest that subgroups of autism spectrum disorder+intellectual disability individuals can be identified based on their multimorbidity and potentially different ageing trajectories. A more comprehensive and personalized approach is needed to reduce the burden of multimorbidity and increase the quality of life and life expectancy in autism spectrum disorder/ intellectual disability. En ligne : https://doi.org/10.1177/13623613221121623 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=499

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