Large-scale cohort studies in mental health research ? strengths and limitations / Isabel MORALES-MUÑOZ in Journal of Child Psychology and Psychiatry, 66-7 (July 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-7 (July 2025) . - p.929-931 Titre : Large-scale cohort studies in mental health research ? strengths and limitations Type de document : Texte imprimé et/ou numérique Auteurs : Isabel MORALES-MUÑOZ, Auteur Article en page(s) : p.929-931 Langues : Anglais (eng) Mots-clés : longitudinal studies  mental health  early interventions  risk factors Index. décimale : PER Périodiques Résumé : Abstract In recent years, the use of longitudinal studies in mental health research has grown, particularly in the United Kingdom. These studies provide numerous benefits and improvements in mental health research, such as facilitating the early detection of risk factors for mental health problems. Nevertheless, they also come with drawbacks, including their high financial costs and the complexity involved in their implementation. Although significant efforts have been made in the United Kingdom to fund large longitudinal cohorts for mental health research, most existing longitudinal cohort studies tend to cover a broad range of factors across large sample sizes, often providing only limited information on each individual factor. To address this, future longitudinal studies should prioritise more focused and in-depth evaluations of key variables and mechanisms, rather than broad but less detailed assessments. In other words, it is essential that future longitudinal studies are specifically designed to test well-defined hypotheses. Overall, this could play a major role in guiding the design of more precise and effective early interventions for mental health. En ligne : https://doi.org/10.1111/jcpp.14176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=562 [article] Large-scale cohort studies in mental health research ? strengths and limitations [Texte imprimé et/ou numérique] / Isabel MORALES-MUÑOZ, Auteur . - p.929-931. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-7 (July 2025) . - p.929-931 Mots-clés : longitudinal studies  mental health  early interventions  risk factors Index. décimale : PER Périodiques Résumé : Abstract In recent years, the use of longitudinal studies in mental health research has grown, particularly in the United Kingdom. These studies provide numerous benefits and improvements in mental health research, such as facilitating the early detection of risk factors for mental health problems. Nevertheless, they also come with drawbacks, including their high financial costs and the complexity involved in their implementation. Although significant efforts have been made in the United Kingdom to fund large longitudinal cohorts for mental health research, most existing longitudinal cohort studies tend to cover a broad range of factors across large sample sizes, often providing only limited information on each individual factor. To address this, future longitudinal studies should prioritise more focused and in-depth evaluations of key variables and mechanisms, rather than broad but less detailed assessments. In other words, it is essential that future longitudinal studies are specifically designed to test well-defined hypotheses. Overall, this could play a major role in guiding the design of more precise and effective early interventions for mental health. En ligne : https://doi.org/10.1111/jcpp.14176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=562

Shorter night-time sleep duration and later sleep timing from infancy to adolescence / Ifigeneia MANITSA in Journal of Child Psychology and Psychiatry, 65-11 (November 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-11 (November 2024) . - p.1513-1525 Titre : Shorter night-time sleep duration and later sleep timing from infancy to adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Ifigeneia MANITSA, Auteur ; Alice M. GREGORY, Auteur ; Matthew R. BROOME, Auteur ; Andrew P. BAGSHAW, Auteur ; Steven MARWAHA, Auteur ; Isabel MORALES-MUÑOZ, Auteur Article en page(s) : p.1513-1525 Langues : Anglais (eng) Mots-clés : Sleep duration  chronotype  trajectories  perinatal risk factors  ALSPAC Index. décimale : PER Périodiques Résumé : Background Here, we (a) examined the trajectories of night-time sleep duration, bedtime and midpoint of night-time sleep (MPS) from infancy to adolescence, and (b) explored perinatal risk factors for persistent poor sleep health. Methods This study used data from 12,962 participants in the Avon Longitudinal Study of Parents and Children (ALSPAC). Parent or self-reported night-time sleep duration, bedtime and wake-up time were collected from questionnaires at 6, 18 and 30?months, and at 3.5, 4?5, 5?6, 6?7, 9, 11 and 15?16?years. Child's sex, birth weight, gestational age, health and temperament, together with mother's family adversity index (FAI), age at birth, prenatal socioeconomic status and postnatal anxiety and depression, were included as risk factors for persistent poor sleep health. Latent class growth analyses were applied first to detect trajectories of night-time sleep duration, bedtime and MPS, and we then applied logistic regressions for the longitudinal associations between risk factors and persistent poor sleep health domains. Results We obtained four trajectories for each of the three sleep domains. In particular, we identified a trajectory characterized by persistent shorter sleep, a trajectory of persistent later bedtime and a trajectory of persistent later MPS. Two risk factors were associated with the three poor sleep health domains: higher FAI with increased risk of persistent shorter sleep (OR?=?1.20, 95% CI?=?1.11?1.30, p? En ligne : https://doi.org/10.1111/jcpp.14004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] Shorter night-time sleep duration and later sleep timing from infancy to adolescence [Texte imprimé et/ou numérique] / Ifigeneia MANITSA, Auteur ; Alice M. GREGORY, Auteur ; Matthew R. BROOME, Auteur ; Andrew P. BAGSHAW, Auteur ; Steven MARWAHA, Auteur ; Isabel MORALES-MUÑOZ, Auteur . - p.1513-1525. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-11 (November 2024) . - p.1513-1525 Mots-clés : Sleep duration  chronotype  trajectories  perinatal risk factors  ALSPAC Index. décimale : PER Périodiques Résumé : Background Here, we (a) examined the trajectories of night-time sleep duration, bedtime and midpoint of night-time sleep (MPS) from infancy to adolescence, and (b) explored perinatal risk factors for persistent poor sleep health. Methods This study used data from 12,962 participants in the Avon Longitudinal Study of Parents and Children (ALSPAC). Parent or self-reported night-time sleep duration, bedtime and wake-up time were collected from questionnaires at 6, 18 and 30?months, and at 3.5, 4?5, 5?6, 6?7, 9, 11 and 15?16?years. Child's sex, birth weight, gestational age, health and temperament, together with mother's family adversity index (FAI), age at birth, prenatal socioeconomic status and postnatal anxiety and depression, were included as risk factors for persistent poor sleep health. Latent class growth analyses were applied first to detect trajectories of night-time sleep duration, bedtime and MPS, and we then applied logistic regressions for the longitudinal associations between risk factors and persistent poor sleep health domains. Results We obtained four trajectories for each of the three sleep domains. In particular, we identified a trajectory characterized by persistent shorter sleep, a trajectory of persistent later bedtime and a trajectory of persistent later MPS. Two risk factors were associated with the three poor sleep health domains: higher FAI with increased risk of persistent shorter sleep (OR?=?1.20, 95% CI?=?1.11?1.30, p? En ligne : https://doi.org/10.1111/jcpp.14004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

The role of inflammation in the prospective associations between early childhood sleep problems and ADHD at 10?years: findings from a UK birth cohort study / Isabel MORALES-MUÑOZ in Journal of Child Psychology and Psychiatry, 64-6 (June 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.930-940 Titre : The role of inflammation in the prospective associations between early childhood sleep problems and ADHD at 10?years: findings from a UK birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : Isabel MORALES-MUÑOZ, Auteur ; Rachel UPTHEGROVE, Auteur ; Kate LAWRENCE, Auteur ; Rasiah THAYAKARAN, Auteur ; Sandra KOOIJ, Auteur ; Alice M GREGORY, Auteur ; Steven MARWAHA, Auteur Article en page(s) : p.930-940 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Several underlying mechanisms potentially account for the link between sleep and attention deficit and hyperactivity disorder (ADHD), including inflammation. However, studies so far have been cross sectional. We investigate (a) the association between early childhood sleep and probable ADHD diagnosis in childhood and (b) whether childhood circulating inflammatory markers mediate these prospective associations. Methods Data from the Avon Longitudinal Study of Parents and Children were available for 7,658 10-year-old children. Parent-reported sleep duration, night awakening frequency and regular sleep routines were collected at 3.5?years. The Development and Wellbeing Assessment was administered to capture children with clinically relevant ADHD symptoms, or probable ADHD diagnosis. Blood samples were collected at 9?years, from which two inflammatory markers were obtained [interleukin-6 (IL-6) and C-reactive protein (CRP)]. Logistic regression analyses were applied to investigate the associations between sleep variables at 3.5?years and probable ADHD diagnosis at 10?years. Further, path analysis was applied to examine the potential mediating role of inflammation at 9?years (as measured by CRP and IL-6) in the associations between early sleep and ADHD at 10?years. Results Less regular sleep routines (OR = 0.51, 95% CI = 0.28-0.93, p = .029), shorter nighttime sleep (OR = 0.70, 95% CI = 0.56-0.89, p = .004) and higher night awakening frequency (OR = 1.27, 95% CI = 1.06-1.52, p = .009) at 3.5?years were associated with higher odds of ADHD at 10?years. Further, IL-6 at 9?years, but not CRP, mediated the association between irregular sleep routines and ADHD (bias-corrected estimate, ?0.002; p = .005) and between night awakening and ADHD (bias-corrected estimate, 0.002; p = .003). Conclusions Several sleep problems in early childhood constitute a risk factor for probable ADHD diagnosis at 10?years. Further, these associations are partially mediated by IL-6 at 9?years. These results open a new research vista to the pathophysiology of ADHD and highlight sleep and inflammation as potential preventative targets for ADHD. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13755 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] The role of inflammation in the prospective associations between early childhood sleep problems and ADHD at 10?years: findings from a UK birth cohort study [Texte imprimé et/ou numérique] / Isabel MORALES-MUÑOZ, Auteur ; Rachel UPTHEGROVE, Auteur ; Kate LAWRENCE, Auteur ; Rasiah THAYAKARAN, Auteur ; Sandra KOOIJ, Auteur ; Alice M GREGORY, Auteur ; Steven MARWAHA, Auteur . - p.930-940. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.930-940 Index. décimale : PER Périodiques Résumé : Background Several underlying mechanisms potentially account for the link between sleep and attention deficit and hyperactivity disorder (ADHD), including inflammation. However, studies so far have been cross sectional. We investigate (a) the association between early childhood sleep and probable ADHD diagnosis in childhood and (b) whether childhood circulating inflammatory markers mediate these prospective associations. Methods Data from the Avon Longitudinal Study of Parents and Children were available for 7,658 10-year-old children. Parent-reported sleep duration, night awakening frequency and regular sleep routines were collected at 3.5?years. The Development and Wellbeing Assessment was administered to capture children with clinically relevant ADHD symptoms, or probable ADHD diagnosis. Blood samples were collected at 9?years, from which two inflammatory markers were obtained [interleukin-6 (IL-6) and C-reactive protein (CRP)]. Logistic regression analyses were applied to investigate the associations between sleep variables at 3.5?years and probable ADHD diagnosis at 10?years. Further, path analysis was applied to examine the potential mediating role of inflammation at 9?years (as measured by CRP and IL-6) in the associations between early sleep and ADHD at 10?years. Results Less regular sleep routines (OR = 0.51, 95% CI = 0.28-0.93, p = .029), shorter nighttime sleep (OR = 0.70, 95% CI = 0.56-0.89, p = .004) and higher night awakening frequency (OR = 1.27, 95% CI = 1.06-1.52, p = .009) at 3.5?years were associated with higher odds of ADHD at 10?years. Further, IL-6 at 9?years, but not CRP, mediated the association between irregular sleep routines and ADHD (bias-corrected estimate, ?0.002; p = .005) and between night awakening and ADHD (bias-corrected estimate, 0.002; p = .003). Conclusions Several sleep problems in early childhood constitute a risk factor for probable ADHD diagnosis at 10?years. Further, these associations are partially mediated by IL-6 at 9?years. These results open a new research vista to the pathophysiology of ADHD and highlight sleep and inflammation as potential preventative targets for ADHD. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13755 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

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