Correction: Understanding the relationship between cerebellar structure and social abilities / Dorothea L. FLORIS ; Pierrick COUPÉ ; Edouard DUCHESNAY ; Angeline MIHAILOV ; Antoine GRIGIS ; Indrit BÈGUE ; Julie VICTOR ; Vincent FROUIN ; Marion LEBOYER ; Josselin HOUENOU ; Charles LAIDI in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 24 p. Titre : Correction: Understanding the relationship between cerebellar structure and social abilities Type de document : Texte imprimé et/ou numérique Auteurs : Dorothea L. FLORIS, Auteur ; Pierrick COUPÉ, Auteur ; Edouard DUCHESNAY, Auteur ; Angeline MIHAILOV, Auteur ; Antoine GRIGIS, Auteur ; Indrit BÈGUE, Auteur ; Julie VICTOR, Auteur ; Vincent FROUIN, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur ; Charles LAIDI, Auteur Article en page(s) : 24 p. Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-023-00553-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Correction: Understanding the relationship between cerebellar structure and social abilities [Texte imprimé et/ou numérique] / Dorothea L. FLORIS, Auteur ; Pierrick COUPÉ, Auteur ; Edouard DUCHESNAY, Auteur ; Angeline MIHAILOV, Auteur ; Antoine GRIGIS, Auteur ; Indrit BÈGUE, Auteur ; Julie VICTOR, Auteur ; Vincent FROUIN, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur ; Charles LAIDI, Auteur . - 24 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 24 p. Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1186/s13229-023-00553-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach / Tochukwu NWEZE in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1159-1175 Titre : Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach Type de document : Texte imprimé et/ou numérique Auteurs : Tochukwu NWEZE, Auteur ; Tobias BANASCHEWSKI, Auteur ; Cyracius AJAELU, Auteur ; Chukwuemeka OKOYE, Auteur ; Michael EZENWA, Auteur ; Robert WHELAN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Arun L. W. BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Antoine GRIGIS, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Rüdiger BRÜHL, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure Paillère MARTINOT, Auteur ; Éric ARTIGES, Auteur ; Frauke NEES, Auteur ; Tomá? PAUS, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Sabina MILLENET, Auteur ; Juliane H. FRÖHNER, Auteur ; Michael N. SMOLKA, Auteur ; Henrik WALTER, Auteur ; Gunter SCHUMANN, Auteur ; Jamie L. HANSON, Auteur ; Imagen CONSORTIUM, Auteur Article en page(s) : p.1159-1175 Langues : Anglais (eng) Mots-clés : Stress  cortical development  cognitive functioning  longitudinal models  bivariate latent change score model  longitudinal mediation analysis Index. décimale : PER Périodiques Résumé : Background Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. Methods Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. Results Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. = .327, p = .042, 95% CI [ 0.643, 0.012]) and right anterior cingulate surface area (Std. = .274, p = .038, 95% CI [ 0.533, 0.015]) across ages 14 22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. Conclusion Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted. En ligne : https://doi.org/10.1111/jcpp.13793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach [Texte imprimé et/ou numérique] / Tochukwu NWEZE, Auteur ; Tobias BANASCHEWSKI, Auteur ; Cyracius AJAELU, Auteur ; Chukwuemeka OKOYE, Auteur ; Michael EZENWA, Auteur ; Robert WHELAN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Arun L. W. BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Antoine GRIGIS, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Rüdiger BRÜHL, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure Paillère MARTINOT, Auteur ; Éric ARTIGES, Auteur ; Frauke NEES, Auteur ; Tomá? PAUS, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Sabina MILLENET, Auteur ; Juliane H. FRÖHNER, Auteur ; Michael N. SMOLKA, Auteur ; Henrik WALTER, Auteur ; Gunter SCHUMANN, Auteur ; Jamie L. HANSON, Auteur ; Imagen CONSORTIUM, Auteur . - p.1159-1175. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1159-1175 Mots-clés : Stress  cortical development  cognitive functioning  longitudinal models  bivariate latent change score model  longitudinal mediation analysis Index. décimale : PER Périodiques Résumé : Background Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. Methods Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. Results Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. = .327, p = .042, 95% CI [ 0.643, 0.012]) and right anterior cingulate surface area (Std. = .274, p = .038, 95% CI [ 0.533, 0.015]) across ages 14 22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. Conclusion Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted. En ligne : https://doi.org/10.1111/jcpp.13793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Understanding the relationship between cerebellar structure and social abilities / Dorothea L. FLORIS ; Pierrick COUPÉ ; Edouard DUCHESNAY ; Angeline MIHAILOV ; Antoine GRIGIS ; Indrit BÈGUE ; Julie VICTOR ; Vincent FROUIN ; Marion LEBOYER ; Josselin HOUENOU ; Charles LAIDI in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 18 p. Titre : Understanding the relationship between cerebellar structure and social abilities Type de document : Texte imprimé et/ou numérique Auteurs : Dorothea L. FLORIS, Auteur ; Pierrick COUPÉ, Auteur ; Edouard DUCHESNAY, Auteur ; Angeline MIHAILOV, Auteur ; Antoine GRIGIS, Auteur ; Indrit BÈGUE, Auteur ; Julie VICTOR, Auteur ; Vincent FROUIN, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur ; Charles LAIDI, Auteur Article en page(s) : 18 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: The cerebellum contains more than 50% of all neurons in the brain and is involved in a broad range of cognitive functions, including social communication and social cognition. Inconsistent atypicalities in the cerebellum have been reported in individuals with autism compared to controls suggesting the limits of categorical case control comparisons. Alternatively, investigating how clinical dimensions are related to neuroanatomical features, in line with the Research Domain Criteria approach, might be more relevant. We hypothesized that the volume of the "cognitive" lobules of the cerebellum would be associated with social difficulties. METHODS: We analyzed structural MRI data from a large pediatric and transdiagnostic sample (Healthy Brain Network). We performed cerebellar parcellation with a well-validated automated segmentation pipeline (CERES). We studied how social communication abilities-assessed with the social component of the Social Responsiveness Scale (SRS)-were associated with the cerebellar structure, using linear mixed models and canonical correlation analysis. RESULTS: In 850 children and teenagers (mean age 10.8?+?3 years; range 5-18 years), we found a significant association between the cerebellum, IQ and social communication performance in our canonical correlation model. LIMITATIONS: Cerebellar parcellation relies on anatomical boundaries, which does not overlap with functional anatomy. The SRS was originally designed to identify social impairments associated with autism spectrum disorders. CONCLUSION: Our results unravel a complex relationship between cerebellar structure, social performance and IQ and provide support for the involvement of the cerebellum in social and cognitive processes. En ligne : http://dx.doi.org/10.1186/s13229-023-00551-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Understanding the relationship between cerebellar structure and social abilities [Texte imprimé et/ou numérique] / Dorothea L. FLORIS, Auteur ; Pierrick COUPÉ, Auteur ; Edouard DUCHESNAY, Auteur ; Angeline MIHAILOV, Auteur ; Antoine GRIGIS, Auteur ; Indrit BÈGUE, Auteur ; Julie VICTOR, Auteur ; Vincent FROUIN, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur ; Charles LAIDI, Auteur . - 18 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 18 p. Index. décimale : PER Périodiques Résumé : BACKGROUND: The cerebellum contains more than 50% of all neurons in the brain and is involved in a broad range of cognitive functions, including social communication and social cognition. Inconsistent atypicalities in the cerebellum have been reported in individuals with autism compared to controls suggesting the limits of categorical case control comparisons. Alternatively, investigating how clinical dimensions are related to neuroanatomical features, in line with the Research Domain Criteria approach, might be more relevant. We hypothesized that the volume of the "cognitive" lobules of the cerebellum would be associated with social difficulties. METHODS: We analyzed structural MRI data from a large pediatric and transdiagnostic sample (Healthy Brain Network). We performed cerebellar parcellation with a well-validated automated segmentation pipeline (CERES). We studied how social communication abilities-assessed with the social component of the Social Responsiveness Scale (SRS)-were associated with the cerebellar structure, using linear mixed models and canonical correlation analysis. RESULTS: In 850 children and teenagers (mean age 10.8?+?3 years; range 5-18 years), we found a significant association between the cerebellum, IQ and social communication performance in our canonical correlation model. LIMITATIONS: Cerebellar parcellation relies on anatomical boundaries, which does not overlap with functional anatomy. The SRS was originally designed to identify social impairments associated with autism spectrum disorders. CONCLUSION: Our results unravel a complex relationship between cerebellar structure, social performance and IQ and provide support for the involvement of the cerebellum in social and cognitive processes. En ligne : http://dx.doi.org/10.1186/s13229-023-00551-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

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