Correction to: Early Second Trimester Maternal Serum SteroidRelated Biomarkers Associated with Autism Spectrum Disorder / Deborah A. BILDER in Journal of Autism and Developmental Disorders, 49-11 (November 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4584 Titre : Correction to: Early Second Trimester Maternal Serum SteroidRelated Biomarkers Associated with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Deborah A. BILDER, Auteur ; M. Sean ESPLIN, Auteur ; Hilary COON, Auteur ; Paul BURGHARDT, Auteur ; Erin A.S. CLARK, Auteur ; Alison FRASER, Auteur ; Ken R. SMITH, Auteur ; Whitney WORSHAM, Auteur ; Katlin CHAPPELLE, Auteur ; Thomas RAYNER, Auteur ; Amanda V. BAKIAN, Auteur Article en page(s) : p.4584 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The original version of the article has been published without funding source information. En ligne : http://dx.doi.org/10.1007/s10803-019-04206-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Correction to: Early Second Trimester Maternal Serum SteroidRelated Biomarkers Associated with Autism Spectrum Disorder [texte imprimé] / Deborah A. BILDER, Auteur ; M. Sean ESPLIN, Auteur ; Hilary COON, Auteur ; Paul BURGHARDT, Auteur ; Erin A.S. CLARK, Auteur ; Alison FRASER, Auteur ; Ken R. SMITH, Auteur ; Whitney WORSHAM, Auteur ; Katlin CHAPPELLE, Auteur ; Thomas RAYNER, Auteur ; Amanda V. BAKIAN, Auteur . - p.4584. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4584 Index. décimale : PER Périodiques Résumé : The original version of the article has been published without funding source information. En ligne : http://dx.doi.org/10.1007/s10803-019-04206-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder / Deborah A. BILDER in Journal of Autism and Developmental Disorders, 49-11 (November 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4572-4583 Titre : Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Deborah A. BILDER, Auteur ; M. Sean ESPLIN, Auteur ; Hilary COON, Auteur ; Paul BURGHARDT, Auteur ; Erin A.S. CLARK, Auteur ; Alison FRASER, Auteur ; Ken R. SMITH, Auteur ; Whitney WORSHAM, Auteur ; Katlin CHAPPELLE, Auteur ; Thomas RAYNER, Auteur ; Amanda V. BAKIAN, Auteur Article en page(s) : p.4572-4583 Langues : Anglais (eng) Mots-clés : Autism  Biomarkers  Metabolic syndrome  Prenatal risk factors Index. décimale : PER Périodiques Résumé : Epidemiologic studies link increased autism spectrum disorder (ASD) risk to obstetrical conditions associated with inflammation and steroid dysregulation, referred to as prenatal metabolic syndrome (PNMS). This pilot study measured steroid-related biomarkers in early second trimester maternal serum collected during the first and second trimester evaluation of risk study. ASD case and PNMS exposure status of index offspring were determined through linkage with autism registries and birth certificate records. ASD case (N = 53) and control (N = 19) groups were enriched for PNMS exposure. Higher estradiol and lower sex hormone binding globulin (SHBG) were significantly associated with increased ASD risk. Study findings provide preliminary evidence to link greater placental estradiol activity with ASD and support future investigations of the prenatal steroid environment in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04162-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Early Second Trimester Maternal Serum Steroid-Related Biomarkers Associated with Autism Spectrum Disorder [texte imprimé] / Deborah A. BILDER, Auteur ; M. Sean ESPLIN, Auteur ; Hilary COON, Auteur ; Paul BURGHARDT, Auteur ; Erin A.S. CLARK, Auteur ; Alison FRASER, Auteur ; Ken R. SMITH, Auteur ; Whitney WORSHAM, Auteur ; Katlin CHAPPELLE, Auteur ; Thomas RAYNER, Auteur ; Amanda V. BAKIAN, Auteur . - p.4572-4583. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4572-4583 Mots-clés : Autism  Biomarkers  Metabolic syndrome  Prenatal risk factors Index. décimale : PER Périodiques Résumé : Epidemiologic studies link increased autism spectrum disorder (ASD) risk to obstetrical conditions associated with inflammation and steroid dysregulation, referred to as prenatal metabolic syndrome (PNMS). This pilot study measured steroid-related biomarkers in early second trimester maternal serum collected during the first and second trimester evaluation of risk study. ASD case and PNMS exposure status of index offspring were determined through linkage with autism registries and birth certificate records. ASD case (N = 53) and control (N = 19) groups were enriched for PNMS exposure. Higher estradiol and lower sex hormone binding globulin (SHBG) were significantly associated with increased ASD risk. Study findings provide preliminary evidence to link greater placental estradiol activity with ASD and support future investigations of the prenatal steroid environment in ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-04162-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Sex-specific and sex-independent steroid-related biomarkers in early second trimester maternal serum associated with autism / Whitney WORSHAM ; Scott SULLIVAN ; M. Sean ESPLIN ; Paul BURGHARDT ; Alison FRASER ; Amanda V. BAKIAN in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 30 p. Titre : Sex-specific and sex-independent steroid-related biomarkers in early second trimester maternal serum associated with autism Type de document : texte imprimé Auteurs : Whitney WORSHAM, Auteur ; Scott SULLIVAN, Auteur ; M. Sean ESPLIN, Auteur ; Paul BURGHARDT, Auteur ; Alison FRASER, Auteur ; Amanda V. BAKIAN, Auteur Article en page(s) : 30 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to maternal metabolic conditions associated with inflammation and steroid dysregulation has previously been linked to increased autism risk. Steroid-related maternal serum biomarkers have also provided insight into the in utero steroid environment for offspring who develop autism. OBJECTIVE: This study examines the link between autism among offspring and early second trimester maternal steroid-related serum biomarkers from pregnancies enriched for prenatal metabolic syndrome (PNMS) exposure. STUDY DESIGN: Early second trimester maternal steroid-related serum biomarkers (i.e., estradiol, free testosterone, total testosterone, and sex hormone binding globulin) were compared between pregnancies corresponding to offspring with (N=68) and without (N=68) autism. Multiple logistic regression analyses were stratified by sex and gestational duration. One-way ANCOVA with post hoc tests was performed for groups defined by autism status and PNMS exposure. RESULTS: Increased estradiol was significantly associated with autism only in males (AOR=1.13 per 100 pg/ml, 95% CI 1.01-1.27, p=0.036) and only term pregnancies (AOR=1.17 per 100 pg/ml, 95% CI 1.04-1.32, p=0.010). Autism status was significantly associated with decreased sex hormone binding globulin (AOR=0.65 per 50 nmol/L, 95% CI 0.55-0.78, p<0.001) overall and when stratified by sex and term pregnancy status. The inverse association between sex hormone binding globulin and autism was independent of PNMS exposure. LIMITATIONS: The relative racial and ethnic homogeneity of Utah's population limits the generalizability of study results. Although significant differences by autism status were identified in concentrations of sex hormone binding globulin overall and of estradiol in participant subgroups, differences by PNMS exposure failed to reach statistical significance, which may reflect insufficient statistical power. CONCLUSION: Both elevated maternal serum estradiol in males only and low maternal serum sex hormone binding globulin in both sexes are associated with increased autism risk. Further investigation is merited to identify how steroid, metabolic, and inflammatory processes can interact to influence neurodevelopment in early second trimester. En ligne : http://dx.doi.org/10.1186/s13229-023-00562-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Sex-specific and sex-independent steroid-related biomarkers in early second trimester maternal serum associated with autism [texte imprimé] / Whitney WORSHAM, Auteur ; Scott SULLIVAN, Auteur ; M. Sean ESPLIN, Auteur ; Paul BURGHARDT, Auteur ; Alison FRASER, Auteur ; Amanda V. BAKIAN, Auteur . - 30 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 30 p. Index. décimale : PER Périodiques Résumé : BACKGROUND: Prenatal exposure to maternal metabolic conditions associated with inflammation and steroid dysregulation has previously been linked to increased autism risk. Steroid-related maternal serum biomarkers have also provided insight into the in utero steroid environment for offspring who develop autism. OBJECTIVE: This study examines the link between autism among offspring and early second trimester maternal steroid-related serum biomarkers from pregnancies enriched for prenatal metabolic syndrome (PNMS) exposure. STUDY DESIGN: Early second trimester maternal steroid-related serum biomarkers (i.e., estradiol, free testosterone, total testosterone, and sex hormone binding globulin) were compared between pregnancies corresponding to offspring with (N=68) and without (N=68) autism. Multiple logistic regression analyses were stratified by sex and gestational duration. One-way ANCOVA with post hoc tests was performed for groups defined by autism status and PNMS exposure. RESULTS: Increased estradiol was significantly associated with autism only in males (AOR=1.13 per 100 pg/ml, 95% CI 1.01-1.27, p=0.036) and only term pregnancies (AOR=1.17 per 100 pg/ml, 95% CI 1.04-1.32, p=0.010). Autism status was significantly associated with decreased sex hormone binding globulin (AOR=0.65 per 50 nmol/L, 95% CI 0.55-0.78, p<0.001) overall and when stratified by sex and term pregnancy status. The inverse association between sex hormone binding globulin and autism was independent of PNMS exposure. LIMITATIONS: The relative racial and ethnic homogeneity of Utah's population limits the generalizability of study results. Although significant differences by autism status were identified in concentrations of sex hormone binding globulin overall and of estradiol in participant subgroups, differences by PNMS exposure failed to reach statistical significance, which may reflect insufficient statistical power. CONCLUSION: Both elevated maternal serum estradiol in males only and low maternal serum sex hormone binding globulin in both sexes are associated with increased autism risk. Further investigation is merited to identify how steroid, metabolic, and inflammatory processes can interact to influence neurodevelopment in early second trimester. En ligne : http://dx.doi.org/10.1186/s13229-023-00562-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

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