Complex, low-intensity, individualised naturalistic developmental behavioural intervention in toddlers and pre-schoolers with autism spectrum disorder: The multicentre, observer-blind, parallel-group randomised-controlled A-FFIP trial / Christine M. FREITAG in Journal of Child Psychology and Psychiatry, 66-10 (October 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1500-1513 Titre : Complex, low-intensity, individualised naturalistic developmental behavioural intervention in toddlers and pre-schoolers with autism spectrum disorder: The multicentre, observer-blind, parallel-group randomised-controlled A-FFIP trial Type de document : texte imprimé Auteurs : Christine M. FREITAG, Auteur ; Marietta KIRCHNER, Auteur ; Lukas D. SAUER, Auteur ; Solvejg K. KLEBER, Auteur ; Leonie POLZER, Auteur ; Naisan RAJI, Auteur ; Christian LEMLER, Auteur ; Ulrike FRÖHLICH, Auteur ; Tomasz JARCZOK, Auteur ; Julia GEIßLER, Auteur ; Franziska RADTKE, Auteur ; Melanie RING, Auteur ; Veit ROESSNER, Auteur ; Regina TAURINES, Auteur ; Michelle NOTERDAEME, Auteur ; Karoline TEUFEL, Auteur ; Ziyon KIM, Auteur ; Janina KITZEROW-CLEVEN, Auteur Article en page(s) : p.1500-1513 Langues : Anglais (eng) Mots-clés : Naturalistic  developmental  behavioural  autism  social communication  repetitive behaviour  randomised-controlled Index. décimale : PER Périodiques Résumé : Background Naturalistic developmental behavioural interventions (NDBI) may improve social communication in toddlers/pre-school aged children with autism spectrum disorder (ASD). Here, we study efficacy of the low-intensity, complex NDBI ?Frankfurt Early Intervention Program for ASD? (A-FFIP) over 1 year by a confirmatory phase-III, prospective, randomised, controlled, parallel-group study with two treatment arms over four centres. Methods Main inclusion criteria: ASD (DSM-5), age 24 66 months, developmental quotient >30. Intervention: Manualised A-FFIP intervention. Control intervention: Early intervention as usual (EIAU). Primary outcome: Change in core ASD symptoms from baseline (T2) to immediate intervention endpoint at 12 months (T6) based on the blindly rated Brief Observation for Communication Change (BOSCC) total score. Statistical analysis: Mixed model for repeated measures with covariates baseline BOSCC-total, chronological age and centre. Results Between July 2018 and October 2021, N 134 children with ASD were randomly allocated to intervention (A-FFIP: n 68, EIAU: n 66). Groups did not differ at baseline, with a mean age of 49 (SD 10) months, a mean developmental age of 23.3 (SD 13.6) months and 26 (19.4%) females. The SARS-CoV-2 pandemic interfered severely with trial procedures. Intention-to-treat analysis in the primary analysis set, with at least one postbaseline BOSCC measure (A-FFIP n 64, EIAU n 60), did not find differences in the primary outcome by group (adjusted ES 0.06, 95% CI to 0.24 to 0.11). SARS-CoV2-related lockdown led to less improvement across groups. Secondary outcomes showed stronger improvements in parent-rated repetitive behaviour as well as parent- and teacher-rated executive functions for A-FFIP versus EIAU. Adverse events were comparable between groups. Conclusions The manualised NDBI program A-FFIP, which allows individually targeting six core basic abilities and five developmental domains related to longitudinal development in ASD, did not improve social communication, cognitive or behavioural outcomes beyond EIAU after 1 year, but may improve repetitive behaviour and executive function. En ligne : https://doi.org/10.1111/jcpp.14162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Complex, low-intensity, individualised naturalistic developmental behavioural intervention in toddlers and pre-schoolers with autism spectrum disorder: The multicentre, observer-blind, parallel-group randomised-controlled A-FFIP trial [texte imprimé] / Christine M. FREITAG, Auteur ; Marietta KIRCHNER, Auteur ; Lukas D. SAUER, Auteur ; Solvejg K. KLEBER, Auteur ; Leonie POLZER, Auteur ; Naisan RAJI, Auteur ; Christian LEMLER, Auteur ; Ulrike FRÖHLICH, Auteur ; Tomasz JARCZOK, Auteur ; Julia GEIßLER, Auteur ; Franziska RADTKE, Auteur ; Melanie RING, Auteur ; Veit ROESSNER, Auteur ; Regina TAURINES, Auteur ; Michelle NOTERDAEME, Auteur ; Karoline TEUFEL, Auteur ; Ziyon KIM, Auteur ; Janina KITZEROW-CLEVEN, Auteur . - p.1500-1513. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1500-1513 Mots-clés : Naturalistic  developmental  behavioural  autism  social communication  repetitive behaviour  randomised-controlled Index. décimale : PER Périodiques Résumé : Background Naturalistic developmental behavioural interventions (NDBI) may improve social communication in toddlers/pre-school aged children with autism spectrum disorder (ASD). Here, we study efficacy of the low-intensity, complex NDBI ?Frankfurt Early Intervention Program for ASD? (A-FFIP) over 1 year by a confirmatory phase-III, prospective, randomised, controlled, parallel-group study with two treatment arms over four centres. Methods Main inclusion criteria: ASD (DSM-5), age 24 66 months, developmental quotient >30. Intervention: Manualised A-FFIP intervention. Control intervention: Early intervention as usual (EIAU). Primary outcome: Change in core ASD symptoms from baseline (T2) to immediate intervention endpoint at 12 months (T6) based on the blindly rated Brief Observation for Communication Change (BOSCC) total score. Statistical analysis: Mixed model for repeated measures with covariates baseline BOSCC-total, chronological age and centre. Results Between July 2018 and October 2021, N 134 children with ASD were randomly allocated to intervention (A-FFIP: n 68, EIAU: n 66). Groups did not differ at baseline, with a mean age of 49 (SD 10) months, a mean developmental age of 23.3 (SD 13.6) months and 26 (19.4%) females. The SARS-CoV-2 pandemic interfered severely with trial procedures. Intention-to-treat analysis in the primary analysis set, with at least one postbaseline BOSCC measure (A-FFIP n 64, EIAU n 60), did not find differences in the primary outcome by group (adjusted ES 0.06, 95% CI to 0.24 to 0.11). SARS-CoV2-related lockdown led to less improvement across groups. Secondary outcomes showed stronger improvements in parent-rated repetitive behaviour as well as parent- and teacher-rated executive functions for A-FFIP versus EIAU. Adverse events were comparable between groups. Conclusions The manualised NDBI program A-FFIP, which allows individually targeting six core basic abilities and five developmental domains related to longitudinal development in ASD, did not improve social communication, cognitive or behavioural outcomes beyond EIAU after 1 year, but may improve repetitive behaviour and executive function. En ligne : https://doi.org/10.1111/jcpp.14162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder ? a randomized clinical trial / Christine M. FREITAG ; Arne POPMA ; Lucres NAUTA-JANSEN ; Kerstin KONRAD ; Eva UNTERNAEHRER ; Katharina ACKERMANN ; Anka BERNHARD ; Anne MARTINELLI ; Helena OLDENHOF ; Malou GUNDLACH ; Gregor KOHLS ; Martin PRÄTZLICH ; Meinhard KIESER ; Ronald LIMPRECHT ; Nora M. RASCHLE ; Noortje VRIENDS ; Robert L. TRESTMAN ; Marietta KIRCHNER ; Linda KERSTEN in Journal of Child Psychology and Psychiatry, 65-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-3 (March 2023) . - p.316-327 Titre : START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder ? a randomized clinical trial Type de document : texte imprimé Auteurs : Christine M. FREITAG, Auteur ; Arne POPMA, Auteur ; Lucres NAUTA-JANSEN, Auteur ; Kerstin KONRAD, Auteur ; Eva UNTERNAEHRER, Auteur ; Katharina ACKERMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Helena OLDENHOF, Auteur ; Malou GUNDLACH, Auteur ; Gregor KOHLS, Auteur ; Martin PRÄTZLICH, Auteur ; Meinhard KIESER, Auteur ; Ronald LIMPRECHT, Auteur ; Nora M. RASCHLE, Auteur ; Noortje VRIENDS, Auteur ; Robert L. TRESTMAN, Auteur ; Marietta KIRCHNER, Auteur ; Linda KERSTEN, Auteur Article en page(s) : p.316-327 Index. décimale : PER Périodiques Résumé : Background Conduct disorder (CD) and oppositional defiant disorder (ODD) both convey a high risk for maladjustment later in life and are understudied in girls. Here, we aimed at confirming the efficacy of START NOW, a cognitive-behavioral, dialectical behavior therapy-oriented skills training program aiming to enhance emotion regulation skills, interpersonal and psychosocial adjustment, adapted for female adolescents with CD or ODD. Methods A total of 127 girls were included in this prospective, cluster randomized, multi-center, parallel group, quasi-randomized, controlled phase III trial, which tested the efficacy of START NOW (n 72) compared with standard care (treatment as usual, TAU, n 55). All female adolescents had a clinical diagnosis of CD or ODD, were 15.6 (+1.5) years on average (range: 12 20 years), and were institutionalized in youth welfare institutions. The two primary endpoints were the change in number of CD/ODD symptoms between (1) baseline (T1) and post-treatment (T3), and (2) between T1 and 12-week follow-up (T4). Results Both treatment groups showed reduced CD/ODD symptoms at T3 compared with T1 (95% CI: START NOW 4.87, 2.49; TAU 4.94, 2.30). There was no significant mean difference in CD/ODD symptom reduction from T1 to T3 between START NOW and TAU ( 0.056; 95% CI 1.860, 1.749; Hedge's g 0.011). However, the START NOW group showed greater mean symptom reduction from T1 to T4 ( 2.326; 95% CI 4.274, 0.378; Hedge's g 0.563). Additionally, secondary endpoint results revealed a reduction in staff reported aggression and parent-reported irritability at post assessment. Conclusions Although START NOW did not result in greater symptom reduction from baseline to post-treatment compared with TAU, the START NOW group showed greater symptom reduction from baseline to follow-up with a medium effect size, which indicates a clinically meaningful delayed treatment effect. En ligne : https://doi.org/10.1111/jcpp.13896 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 [article] START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder ? a randomized clinical trial [texte imprimé] / Christine M. FREITAG, Auteur ; Arne POPMA, Auteur ; Lucres NAUTA-JANSEN, Auteur ; Kerstin KONRAD, Auteur ; Eva UNTERNAEHRER, Auteur ; Katharina ACKERMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Helena OLDENHOF, Auteur ; Malou GUNDLACH, Auteur ; Gregor KOHLS, Auteur ; Martin PRÄTZLICH, Auteur ; Meinhard KIESER, Auteur ; Ronald LIMPRECHT, Auteur ; Nora M. RASCHLE, Auteur ; Noortje VRIENDS, Auteur ; Robert L. TRESTMAN, Auteur ; Marietta KIRCHNER, Auteur ; Linda KERSTEN, Auteur . - p.316-327. in Journal of Child Psychology and Psychiatry > 65-3 (March 2023) . - p.316-327 Index. décimale : PER Périodiques Résumé : Background Conduct disorder (CD) and oppositional defiant disorder (ODD) both convey a high risk for maladjustment later in life and are understudied in girls. Here, we aimed at confirming the efficacy of START NOW, a cognitive-behavioral, dialectical behavior therapy-oriented skills training program aiming to enhance emotion regulation skills, interpersonal and psychosocial adjustment, adapted for female adolescents with CD or ODD. Methods A total of 127 girls were included in this prospective, cluster randomized, multi-center, parallel group, quasi-randomized, controlled phase III trial, which tested the efficacy of START NOW (n 72) compared with standard care (treatment as usual, TAU, n 55). All female adolescents had a clinical diagnosis of CD or ODD, were 15.6 (+1.5) years on average (range: 12 20 years), and were institutionalized in youth welfare institutions. The two primary endpoints were the change in number of CD/ODD symptoms between (1) baseline (T1) and post-treatment (T3), and (2) between T1 and 12-week follow-up (T4). Results Both treatment groups showed reduced CD/ODD symptoms at T3 compared with T1 (95% CI: START NOW 4.87, 2.49; TAU 4.94, 2.30). There was no significant mean difference in CD/ODD symptom reduction from T1 to T3 between START NOW and TAU ( 0.056; 95% CI 1.860, 1.749; Hedge's g 0.011). However, the START NOW group showed greater mean symptom reduction from T1 to T4 ( 2.326; 95% CI 4.274, 0.378; Hedge's g 0.563). Additionally, secondary endpoint results revealed a reduction in staff reported aggression and parent-reported irritability at post assessment. Conclusions Although START NOW did not result in greater symptom reduction from baseline to post-treatment compared with TAU, the START NOW group showed greater symptom reduction from baseline to follow-up with a medium effect size, which indicates a clinically meaningful delayed treatment effect. En ligne : https://doi.org/10.1111/jcpp.13896 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520

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