4 recherche sur le mot-clé 'behavioural'

Complex, low-intensity, individualised naturalistic developmental behavioural intervention in toddlers and pre-schoolers with autism spectrum disorder: The multicentre, observer-blind, parallel-group randomised-controlled A-FFIP trial / Christine M. FREITAG in Journal of Child Psychology and Psychiatry, 66-10 (October 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1500-1513 Titre : Complex, low-intensity, individualised naturalistic developmental behavioural intervention in toddlers and pre-schoolers with autism spectrum disorder: The multicentre, observer-blind, parallel-group randomised-controlled A-FFIP trial Type de document : texte imprimé Auteurs : Christine M. FREITAG, Auteur ; Marietta KIRCHNER, Auteur ; Lukas D. SAUER, Auteur ; Solvejg K. KLEBER, Auteur ; Leonie POLZER, Auteur ; Naisan RAJI, Auteur ; Christian LEMLER, Auteur ; Ulrike FRÖHLICH, Auteur ; Tomasz A. JARCZOK, Auteur ; Julia GEIßLER, Auteur ; Franziska RADTKE, Auteur ; Melanie RING, Auteur ; Veit ROESSNER, Auteur ; Regina TAURINES, Auteur ; Michelle NOTERDAEME, Auteur ; Karoline TEUFEL, Auteur ; Ziyon KIM, Auteur ; Janina KITZEROW-CLEVEN, Auteur Article en page(s) : p.1500-1513 Langues : Anglais (eng) Mots-clés : Naturalistic  developmental  behavioural  autism  social communication  repetitive behaviour  randomised-controlled Index. décimale : PER Périodiques Résumé : Background Naturalistic developmental behavioural interventions (NDBI) may improve social communication in toddlers/pre-school aged children with autism spectrum disorder (ASD). Here, we study efficacy of the low-intensity, complex NDBI ?Frankfurt Early Intervention Program for ASD? (A-FFIP) over 1 year by a confirmatory phase-III, prospective, randomised, controlled, parallel-group study with two treatment arms over four centres. Methods Main inclusion criteria: ASD (DSM-5), age 24 66 months, developmental quotient >30. Intervention: Manualised A-FFIP intervention. Control intervention: Early intervention as usual (EIAU). Primary outcome: Change in core ASD symptoms from baseline (T2) to immediate intervention endpoint at 12 months (T6) based on the blindly rated Brief Observation for Communication Change (BOSCC) total score. Statistical analysis: Mixed model for repeated measures with covariates baseline BOSCC-total, chronological age and centre. Results Between July 2018 and October 2021, N 134 children with ASD were randomly allocated to intervention (A-FFIP: n 68, EIAU: n 66). Groups did not differ at baseline, with a mean age of 49 (SD 10) months, a mean developmental age of 23.3 (SD 13.6) months and 26 (19.4%) females. The SARS-CoV-2 pandemic interfered severely with trial procedures. Intention-to-treat analysis in the primary analysis set, with at least one postbaseline BOSCC measure (A-FFIP n 64, EIAU n 60), did not find differences in the primary outcome by group (adjusted ES 0.06, 95% CI to 0.24 to 0.11). SARS-CoV2-related lockdown led to less improvement across groups. Secondary outcomes showed stronger improvements in parent-rated repetitive behaviour as well as parent- and teacher-rated executive functions for A-FFIP versus EIAU. Adverse events were comparable between groups. Conclusions The manualised NDBI program A-FFIP, which allows individually targeting six core basic abilities and five developmental domains related to longitudinal development in ASD, did not improve social communication, cognitive or behavioural outcomes beyond EIAU after 1 year, but may improve repetitive behaviour and executive function. En ligne : https://doi.org/10.1111/jcpp.14162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568 [article] Complex, low-intensity, individualised naturalistic developmental behavioural intervention in toddlers and pre-schoolers with autism spectrum disorder: The multicentre, observer-blind, parallel-group randomised-controlled A-FFIP trial [texte imprimé] / Christine M. FREITAG, Auteur ; Marietta KIRCHNER, Auteur ; Lukas D. SAUER, Auteur ; Solvejg K. KLEBER, Auteur ; Leonie POLZER, Auteur ; Naisan RAJI, Auteur ; Christian LEMLER, Auteur ; Ulrike FRÖHLICH, Auteur ; Tomasz A. JARCZOK, Auteur ; Julia GEIßLER, Auteur ; Franziska RADTKE, Auteur ; Melanie RING, Auteur ; Veit ROESSNER, Auteur ; Regina TAURINES, Auteur ; Michelle NOTERDAEME, Auteur ; Karoline TEUFEL, Auteur ; Ziyon KIM, Auteur ; Janina KITZEROW-CLEVEN, Auteur . - p.1500-1513. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-10 (October 2025) . - p.1500-1513 Mots-clés : Naturalistic  developmental  behavioural  autism  social communication  repetitive behaviour  randomised-controlled Index. décimale : PER Périodiques Résumé : Background Naturalistic developmental behavioural interventions (NDBI) may improve social communication in toddlers/pre-school aged children with autism spectrum disorder (ASD). Here, we study efficacy of the low-intensity, complex NDBI ?Frankfurt Early Intervention Program for ASD? (A-FFIP) over 1 year by a confirmatory phase-III, prospective, randomised, controlled, parallel-group study with two treatment arms over four centres. Methods Main inclusion criteria: ASD (DSM-5), age 24 66 months, developmental quotient >30. Intervention: Manualised A-FFIP intervention. Control intervention: Early intervention as usual (EIAU). Primary outcome: Change in core ASD symptoms from baseline (T2) to immediate intervention endpoint at 12 months (T6) based on the blindly rated Brief Observation for Communication Change (BOSCC) total score. Statistical analysis: Mixed model for repeated measures with covariates baseline BOSCC-total, chronological age and centre. Results Between July 2018 and October 2021, N 134 children with ASD were randomly allocated to intervention (A-FFIP: n 68, EIAU: n 66). Groups did not differ at baseline, with a mean age of 49 (SD 10) months, a mean developmental age of 23.3 (SD 13.6) months and 26 (19.4%) females. The SARS-CoV-2 pandemic interfered severely with trial procedures. Intention-to-treat analysis in the primary analysis set, with at least one postbaseline BOSCC measure (A-FFIP n 64, EIAU n 60), did not find differences in the primary outcome by group (adjusted ES 0.06, 95% CI to 0.24 to 0.11). SARS-CoV2-related lockdown led to less improvement across groups. Secondary outcomes showed stronger improvements in parent-rated repetitive behaviour as well as parent- and teacher-rated executive functions for A-FFIP versus EIAU. Adverse events were comparable between groups. Conclusions The manualised NDBI program A-FFIP, which allows individually targeting six core basic abilities and five developmental domains related to longitudinal development in ASD, did not improve social communication, cognitive or behavioural outcomes beyond EIAU after 1 year, but may improve repetitive behaviour and executive function. En ligne : https://doi.org/10.1111/jcpp.14162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=568

Commentary: Networks of peers, genes, and explanations – reflections on Szekely et al. (2016) / Thomas G. O'CONNOR in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.695-696 Titre : Commentary: Networks of peers, genes, and explanations – reflections on Szekely et al. (2016) Type de document : texte imprimé Auteurs : Thomas G. O'CONNOR, Auteur Article en page(s) : p.695-696 Langues : Anglais (eng) Mots-clés : Peer relationships  phenotype  genetics  behavioural Index. décimale : PER Périodiques Résumé : Much has been learned about the origins and effects of peer relationships on the health and well-being of children, adolescents, and adults. This commentary on Szekely et al. examines the role of genetics research on peer relationships, and the arising methodological and conceptual questions. Research findings on the genetics of peer networks illustrate how genetic influences may shape complex and dynamic phenotypes. Equally complex is the application of these findings for theory and practice. En ligne : http://dx.doi.org/10.1111/jcpp.12536 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Commentary: Networks of peers, genes, and explanations – reflections on Szekely et al. (2016) [texte imprimé] / Thomas G. O'CONNOR, Auteur . - p.695-696. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.695-696 Mots-clés : Peer relationships  phenotype  genetics  behavioural Index. décimale : PER Périodiques Résumé : Much has been learned about the origins and effects of peer relationships on the health and well-being of children, adolescents, and adults. This commentary on Szekely et al. examines the role of genetics research on peer relationships, and the arising methodological and conceptual questions. Research findings on the genetics of peer networks illustrate how genetic influences may shape complex and dynamic phenotypes. Equally complex is the application of these findings for theory and practice. En ligne : http://dx.doi.org/10.1111/jcpp.12536 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Editorial: Research Domain Criteria (RDoC): a new psychiatric nosology whose time has not yet come / Bradley S. PETERSON in Journal of Child Psychology and Psychiatry, 56-7 (July 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.719-722 Titre : Editorial: Research Domain Criteria (RDoC): a new psychiatric nosology whose time has not yet come Type de document : texte imprimé Auteurs : Bradley S. PETERSON, Auteur Article en page(s) : p.719-722 Langues : Anglais (eng) Mots-clés : Nosology  Research Domain Criteria (RDoC)  Diagnostic and Statistical Manual (DSM)  neural systems  behavioural  cognitive functions  developmental trajectories Index. décimale : PER Périodiques Résumé : In developing new ways of classifying mental disorders, RDoC is developing a new nosology, a new way of dividing nature at its seams. Given the NIMH influence on research agendas across the world, this scientific agenda will have important consequences for researchers and clinicians worldwide. Defining discrete neural systems and the behavioral and cognitive functions they subserve is scientifically important. Understanding how these systems relate to clinical problems, patient suffering, and improved treatments has immense potential practical value for clinical care worldwide. This Editorial places the RDoC framework in context and then sets out a series of conceptual, empirical, and developmental challenges for RDoC. Together these challenges suggest that RDoC is premature as a nosology and, as currently implemented, risks being reified and overly rigid in its application. En ligne : http://dx.doi.org/10.1111/jcpp.12439 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Editorial: Research Domain Criteria (RDoC): a new psychiatric nosology whose time has not yet come [texte imprimé] / Bradley S. PETERSON, Auteur . - p.719-722. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-7 (July 2015) . - p.719-722 Mots-clés : Nosology  Research Domain Criteria (RDoC)  Diagnostic and Statistical Manual (DSM)  neural systems  behavioural  cognitive functions  developmental trajectories Index. décimale : PER Périodiques Résumé : In developing new ways of classifying mental disorders, RDoC is developing a new nosology, a new way of dividing nature at its seams. Given the NIMH influence on research agendas across the world, this scientific agenda will have important consequences for researchers and clinicians worldwide. Defining discrete neural systems and the behavioral and cognitive functions they subserve is scientifically important. Understanding how these systems relate to clinical problems, patient suffering, and improved treatments has immense potential practical value for clinical care worldwide. This Editorial places the RDoC framework in context and then sets out a series of conceptual, empirical, and developmental challenges for RDoC. Together these challenges suggest that RDoC is premature as a nosology and, as currently implemented, risks being reified and overly rigid in its application. En ligne : http://dx.doi.org/10.1111/jcpp.12439 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Unique prediction of developmental psychopathology from genetic and familial risk / Robert J. LOUGHNAN in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1631-1643 Titre : Unique prediction of developmental psychopathology from genetic and familial risk Type de document : texte imprimé Auteurs : Robert J. LOUGHNAN, Auteur ; Clare E. PALMER, Auteur ; Carolina MAKOWSKI, Auteur ; Wesley K. THOMPSON, Auteur ; Deanna M. BARCH, Auteur ; Terry L. JERNIGAN, Auteur ; Anders M. DALE, Auteur ; Chun Chieh FAN, Auteur Article en page(s) : p.1631-1643 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Genetic Predisposition to Disease  Longitudinal Studies  Multifactorial Inheritance  Psychopathology  Attention Deficit Disorder with Hyperactivity/diagnosis  Risk Factors  Genetics  behavioural  family history Index. décimale : PER Périodiques Résumé : BACKGROUND: Early detection is critical for easing the rising burden of psychiatric disorders. However, the specificity of psychopathological measurements and genetic predictors is unclear among youth. METHODS: We measured associations between genetic risk for psychopathology (polygenic risk scores (PRS) and family history (FH) measures) and a wide range of behavioral measures in a large sample (n=5,204) of early adolescent participants (9-11 years) from the Adolescent Brain and Cognitive Development Study(SM) . Associations were measured both with and without accounting for shared variance across measures of genetic risk. RESULTS: When controlling for genetic risk for other psychiatric disorders, polygenic risk for problematic opioid use (POU) is uniquely associated with lower behavioral inhibition. Attention deficit hyperactivity disorder (ADHD), depression (DEP), and attempted suicide (SUIC) PRS shared many significant associations with externalizing, internalizing, and psychosis-related behaviors. However, when accounting for all measures of genetic and familial risk, these PRS also showed clear, unique patterns of association. Polygenic risk for ASD, BIP, and SCZ, and attempted suicide uniquely predicted variability in cognitive performance. FH accounted for unique variability in behavior above and beyond PRS and vice versa, with FH measures explaining a greater proportion of unique variability compared to the PRS. CONCLUSION: Our results indicate that, among youth, many behaviors show shared genetic influences; however, there is also specificity in the profile of emerging psychopathologies for individuals with high genetic risk for particular disorders. This may be useful for quantifying early, differential risk for psychopathology in development. En ligne : http://dx.doi.org/10.1111/jcpp.13649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490 [article] Unique prediction of developmental psychopathology from genetic and familial risk [texte imprimé] / Robert J. LOUGHNAN, Auteur ; Clare E. PALMER, Auteur ; Carolina MAKOWSKI, Auteur ; Wesley K. THOMPSON, Auteur ; Deanna M. BARCH, Auteur ; Terry L. JERNIGAN, Auteur ; Anders M. DALE, Auteur ; Chun Chieh FAN, Auteur . - p.1631-1643. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1631-1643 Mots-clés : Adolescent  Humans  Genetic Predisposition to Disease  Longitudinal Studies  Multifactorial Inheritance  Psychopathology  Attention Deficit Disorder with Hyperactivity/diagnosis  Risk Factors  Genetics  behavioural  family history Index. décimale : PER Périodiques Résumé : BACKGROUND: Early detection is critical for easing the rising burden of psychiatric disorders. However, the specificity of psychopathological measurements and genetic predictors is unclear among youth. METHODS: We measured associations between genetic risk for psychopathology (polygenic risk scores (PRS) and family history (FH) measures) and a wide range of behavioral measures in a large sample (n=5,204) of early adolescent participants (9-11 years) from the Adolescent Brain and Cognitive Development Study(SM) . Associations were measured both with and without accounting for shared variance across measures of genetic risk. RESULTS: When controlling for genetic risk for other psychiatric disorders, polygenic risk for problematic opioid use (POU) is uniquely associated with lower behavioral inhibition. Attention deficit hyperactivity disorder (ADHD), depression (DEP), and attempted suicide (SUIC) PRS shared many significant associations with externalizing, internalizing, and psychosis-related behaviors. However, when accounting for all measures of genetic and familial risk, these PRS also showed clear, unique patterns of association. Polygenic risk for ASD, BIP, and SCZ, and attempted suicide uniquely predicted variability in cognitive performance. FH accounted for unique variability in behavior above and beyond PRS and vice versa, with FH measures explaining a greater proportion of unique variability compared to the PRS. CONCLUSION: Our results indicate that, among youth, many behaviors show shared genetic influences; however, there is also specificity in the profile of emerging psychopathologies for individuals with high genetic risk for particular disorders. This may be useful for quantifying early, differential risk for psychopathology in development. En ligne : http://dx.doi.org/10.1111/jcpp.13649 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=490