Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system / Henriette ACOSTA in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1027-1042 Titre : Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system Type de document : Texte imprimé et/ou numérique Auteurs : Henriette ACOSTA, Auteur ; Katri KANTOJARVI, Auteur ; Jetro J. TUULARI, Auteur ; John D. LEWIS, Auteur ; Niloofar HASHEMPOUR, Auteur ; Noora M. SCHEININ, Auteur ; Satu J. LEHTOLA, Auteur ; Saara NOLVI, Auteur ; Vladimir S. FONOV, Auteur ; D. Louis COLLINS, Auteur ; Alan C. EVANS, Auteur ; Riitta PARKKOLA, Auteur ; Tuire LÄHDESMÄKI, Auteur ; Jani SAUNAVAARA, Auteur ; Harri MERISAARI, Auteur ; Linnea KARLSSON, Auteur ; Tiina PAUNIO, Auteur ; Hasse KARLSSON, Auteur Article en page(s) : p.1027-1042 Langues : Anglais (eng) Mots-clés : MRI  SDQ  amygdala  hyperactivity  prenatal stress Index. décimale : PER Périodiques Résumé : Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap. In Finnish mother-infant dyads, we investigated the association of a cumulative prenatal adversity sum score (PRE-AS) with (a) child emotional and behavioral problems assessed with the Strengths and Difficulties Questionnaire at 4 and 5 years (N = 1568, 45.3% female), (b) infant amygdalar and hippocampal volumes (subsample N = 122), and (c) its moderation by a hippocampal-specific coexpression polygenic risk score based on the serotonin transporter (SLC6A4) gene. We found that higher PRE-AS was linked to greater child emotional and behavioral problems at both time points, with partly stronger associations in boys than in girls. Higher PRE-AS was associated with larger bilateral infant amygdalar volumes in girls compared to boys, while no associations were found for hippocampal volumes. Further, hyperactivity/inattention in 4-year-old girls was related to both genotype and PRE-AS, the latter partially mediated by right amygdalar volumes as preliminary evidence suggests. Our study is the first to demonstrate a dose-dependent sexually dimorphic relationship between cumulative prenatal adversity and infant amygdalar volumes. En ligne : https://dx.doi.org/10.1017/S0954579423000275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Association of cumulative prenatal adversity with infant subcortical structure volumes and child problem behavior and its moderation by a coexpression polygenic risk score of the serotonin system [Texte imprimé et/ou numérique] / Henriette ACOSTA, Auteur ; Katri KANTOJARVI, Auteur ; Jetro J. TUULARI, Auteur ; John D. LEWIS, Auteur ; Niloofar HASHEMPOUR, Auteur ; Noora M. SCHEININ, Auteur ; Satu J. LEHTOLA, Auteur ; Saara NOLVI, Auteur ; Vladimir S. FONOV, Auteur ; D. Louis COLLINS, Auteur ; Alan C. EVANS, Auteur ; Riitta PARKKOLA, Auteur ; Tuire LÄHDESMÄKI, Auteur ; Jani SAUNAVAARA, Auteur ; Harri MERISAARI, Auteur ; Linnea KARLSSON, Auteur ; Tiina PAUNIO, Auteur ; Hasse KARLSSON, Auteur . - p.1027-1042. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1027-1042 Mots-clés : MRI  SDQ  amygdala  hyperactivity  prenatal stress Index. décimale : PER Périodiques Résumé : Prenatal adversity has been linked to later psychopathology. Yet, research on cumulative prenatal adversity, as well as its interaction with offspring genotype, on brain and behavioral development is scarce. With this study, we aimed to address this gap. In Finnish mother-infant dyads, we investigated the association of a cumulative prenatal adversity sum score (PRE-AS) with (a) child emotional and behavioral problems assessed with the Strengths and Difficulties Questionnaire at 4 and 5 years (N = 1568, 45.3% female), (b) infant amygdalar and hippocampal volumes (subsample N = 122), and (c) its moderation by a hippocampal-specific coexpression polygenic risk score based on the serotonin transporter (SLC6A4) gene. We found that higher PRE-AS was linked to greater child emotional and behavioral problems at both time points, with partly stronger associations in boys than in girls. Higher PRE-AS was associated with larger bilateral infant amygdalar volumes in girls compared to boys, while no associations were found for hippocampal volumes. Further, hyperactivity/inattention in 4-year-old girls was related to both genotype and PRE-AS, the latter partially mediated by right amygdalar volumes as preliminary evidence suggests. Our study is the first to demonstrate a dose-dependent sexually dimorphic relationship between cumulative prenatal adversity and infant amygdalar volumes. En ligne : https://dx.doi.org/10.1017/S0954579423000275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Course of child social-emotional and sleep symptoms, parental distress and pandemic-related stressors during COVID-19 / E. Juulia PAAVONEN ; Riikka KORJA ; Juho PELTO ; Max KARUKIVI ; Jetro J. TUULARI ; Hasse KARLSSON ; Linnea KARLSSON in Development and Psychopathology, 36-2 (May 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-2 (May 2024) . - p.518-532 Titre : Course of child social-emotional and sleep symptoms, parental distress and pandemic-related stressors during COVID-19 Type de document : Texte imprimé et/ou numérique Auteurs : E. Juulia PAAVONEN, Auteur ; Riikka KORJA, Auteur ; Juho PELTO, Auteur ; Max KARUKIVI, Auteur ; Jetro J. TUULARI, Auteur ; Hasse KARLSSON, Auteur ; Linnea KARLSSON, Auteur Article en page(s) : p.518-532 Langues : Anglais (eng) Mots-clés : COVID-19  children  parental distress  sleep  social-emotional symptoms Index. décimale : PER Périodiques Résumé : Research on the longitudinal courses of child social-emotional symptoms and sleep during the COVID-19 pandemic within societies would be of key value for promoting child well-being in global crises. We characterized the course of children?s social-emotional and sleep symptoms before and throughout the pandemic in a Finnish longitudinal cohort of 1825 5- to 9-year-old children (46% girls) with four follow-up points during the pandemic from up to 695 participants (spring 2020-summer 2021). Second, we examined the role of parental distress and COVID-related stressful events in child symptoms. Child total and behavioral symptoms increased in spring 2020 but decreased thereafter and remained stable throughout the rest of the follow-up. Sleep symptoms decreased in spring 2020 and remained stable thereafter. Parental distress was linked with higher child social-emotional and sleep symptoms. The cross-sectional associations between COVID-related stressors and child symptoms were partially mediated by parental distress. The findings propose that children can be protected from the long-term adverse influences of the pandemic, and parental well-being likely plays a mediating role between pandemic-related stressors and child well-being. Further research focusing on the societal and resilience factors underlying family and child responses to the pandemic is warranted. En ligne : https://dx.doi.org/10.1017/S0954579422001377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 [article] Course of child social-emotional and sleep symptoms, parental distress and pandemic-related stressors during COVID-19 [Texte imprimé et/ou numérique] / E. Juulia PAAVONEN, Auteur ; Riikka KORJA, Auteur ; Juho PELTO, Auteur ; Max KARUKIVI, Auteur ; Jetro J. TUULARI, Auteur ; Hasse KARLSSON, Auteur ; Linnea KARLSSON, Auteur . - p.518-532. Langues : Anglais (eng) in Development and Psychopathology > 36-2 (May 2024) . - p.518-532 Mots-clés : COVID-19  children  parental distress  sleep  social-emotional symptoms Index. décimale : PER Périodiques Résumé : Research on the longitudinal courses of child social-emotional symptoms and sleep during the COVID-19 pandemic within societies would be of key value for promoting child well-being in global crises. We characterized the course of children?s social-emotional and sleep symptoms before and throughout the pandemic in a Finnish longitudinal cohort of 1825 5- to 9-year-old children (46% girls) with four follow-up points during the pandemic from up to 695 participants (spring 2020-summer 2021). Second, we examined the role of parental distress and COVID-related stressful events in child symptoms. Child total and behavioral symptoms increased in spring 2020 but decreased thereafter and remained stable throughout the rest of the follow-up. Sleep symptoms decreased in spring 2020 and remained stable thereafter. Parental distress was linked with higher child social-emotional and sleep symptoms. The cross-sectional associations between COVID-related stressors and child symptoms were partially mediated by parental distress. The findings propose that children can be protected from the long-term adverse influences of the pandemic, and parental well-being likely plays a mediating role between pandemic-related stressors and child well-being. Further research focusing on the societal and resilience factors underlying family and child responses to the pandemic is warranted. En ligne : https://dx.doi.org/10.1017/S0954579422001377 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528

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