Editorial Perspective: Bridging the translational neuroscience gap in autism - development of the 'shiftability' paradigm / Eileen DALY ; Nicolaas A. PUTS ; Ekaterina MALIEVSKAIA ; Declan G.M. MURPHY ; Gráinne M. MCALONAN in Journal of Child Psychology and Psychiatry, 65-6 (June 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-6 (June 2024) . - p.862-865 Titre : Editorial Perspective: Bridging the translational neuroscience gap in autism - development of the 'shiftability' paradigm Type de document : Texte imprimé et/ou numérique Auteurs : Eileen DALY, Auteur ; Nicolaas A. PUTS, Auteur ; Ekaterina MALIEVSKAIA, Auteur ; Declan G.M. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur Année de publication : 2024 Article en page(s) : p.862-865 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Clinical trials of pharmacological candidates targeting the core features of autism have largely failed. This is despite evidence linking differences in multiple neurochemical systems to brain function in autism. While this has in part been explained by the heterogeneity of the autistic population, the field has largely relied upon association studies to link brain chemistry to function. The only way to directly establish that a neurotransmitter or neuromodulator is involved in a candidate brain function is to change it and observe a shift in that function. This experimental approach dominates preclinical neuroscience, but not human studies. There is little direct experimental evidence describing how neurochemical systems modulate information processing in the living human brain. Thus, our understanding of how neurochemical differences contribute to neurodiversity is limited, impeding our ability to translate findings from animal studies into humans. Here, we introduce our 'shiftability' paradigm, an approach to bridge the translational gap in autism research. We provide an overview of the guiding principles and methodologies we use to directly test the hypothesis that neurochemical systems function differently in autistic and non-autistic individuals. En ligne : https://doi.org/10.1111/jcpp.13940 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529 [article] Editorial Perspective: Bridging the translational neuroscience gap in autism - development of the 'shiftability' paradigm [Texte imprimé et/ou numérique] / Eileen DALY, Auteur ; Nicolaas A. PUTS, Auteur ; Ekaterina MALIEVSKAIA, Auteur ; Declan G.M. MURPHY, Auteur ; Gráinne M. MCALONAN, Auteur . - 2024 . - p.862-865. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-6 (June 2024) . - p.862-865 Index. décimale : PER Périodiques Résumé : Clinical trials of pharmacological candidates targeting the core features of autism have largely failed. This is despite evidence linking differences in multiple neurochemical systems to brain function in autism. While this has in part been explained by the heterogeneity of the autistic population, the field has largely relied upon association studies to link brain chemistry to function. The only way to directly establish that a neurotransmitter or neuromodulator is involved in a candidate brain function is to change it and observe a shift in that function. This experimental approach dominates preclinical neuroscience, but not human studies. There is little direct experimental evidence describing how neurochemical systems modulate information processing in the living human brain. Thus, our understanding of how neurochemical differences contribute to neurodiversity is limited, impeding our ability to translate findings from animal studies into humans. Here, we introduce our 'shiftability' paradigm, an approach to bridge the translational gap in autism research. We provide an overview of the guiding principles and methodologies we use to directly test the hypothesis that neurochemical systems function differently in autistic and non-autistic individuals. En ligne : https://doi.org/10.1111/jcpp.13940 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529

Forwarding the Science of Sensory Features in Autism and Related Conditions / Nicolaas A. PUTS ; Zachary J. WILLIAMS ; Tiffany WOYNAROSKI in Journal of Autism and Developmental Disorders, 54-7 (July 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2663-2667 Titre : Forwarding the Science of Sensory Features in Autism and Related Conditions Type de document : Texte imprimé et/ou numérique Auteurs : Nicolaas A. PUTS, Auteur ; Zachary J. WILLIAMS, Auteur ; Tiffany WOYNAROSKI, Auteur Article en page(s) : p.2663-2667 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This editorial accompanies the JADD Special Issue on Sensory Features in Autism and Related Conditions: Developmental Approaches, Mechanisms and Targeted Interventions. The editorial is a commentary on the state of the science in sensory features in autism and related conditions and provides a synopsis of the information contained in the special issue including provocative thoughts about moving the field forward in this area. En ligne : https://doi.org/10.1007/s10803-023-05959-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Forwarding the Science of Sensory Features in Autism and Related Conditions [Texte imprimé et/ou numérique] / Nicolaas A. PUTS, Auteur ; Zachary J. WILLIAMS, Auteur ; Tiffany WOYNAROSKI, Auteur . - p.2663-2667. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2663-2667 Index. décimale : PER Périodiques Résumé : This editorial accompanies the JADD Special Issue on Sensory Features in Autism and Related Conditions: Developmental Approaches, Mechanisms and Targeted Interventions. The editorial is a commentary on the state of the science in sensory features in autism and related conditions and provides a synopsis of the information contained in the special issue including provocative thoughts about moving the field forward in this area. En ligne : https://doi.org/10.1007/s10803-023-05959-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Perceptual alterations in the relationship between sensory reactivity, intolerance of uncertainty, and anxiety in autistic children with and without ADHD / Helen J. Powell ; Jason L. HE ; Nermin Khalil ; Ericka L. WODKA ; Alyssa DeRonda ; Richard A. E. EDDEN ; Roma A. VASA ; Stewart H. MOSTOFSKY ; Nicolaas A. PUTS in Development and Psychopathology, 37-1 (February 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-1 (February 2025) . - p.16-28 Titre : Perceptual alterations in the relationship between sensory reactivity, intolerance of uncertainty, and anxiety in autistic children with and without ADHD : Development and Psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Helen J. Powell, Auteur ; Jason L. HE, Auteur ; Nermin Khalil, Auteur ; Ericka L. WODKA, Auteur ; Alyssa DeRonda, Auteur ; Richard A. E. EDDEN, Auteur ; Roma A. VASA, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nicolaas A. PUTS, Auteur Article en page(s) : p.16-28 Langues : Anglais (eng) Mots-clés : anxiety  autism  intolerance of uncertainty  perception  sensory Index. décimale : PER Périodiques Résumé : Sensory differences and anxiety disorders are highly prevalent in autistic individuals with and without ADHD. Studies have shown that sensory differences and anxiety are associated and that intolerance of uncertainty (IU) plays an important role in this relationship. However, it is unclear as to how different levels of the sensory processing pathway (i.e., perceptual, affective, or behavioral) contribute. Here, we used psychophysics to assess how alterations in tactile perception contribute to questionnaire measures of sensory reactivity, IU, and anxiety. Thirty-eight autistic children (aged 8-12 years; 27 with co-occurring ADHD) were included. Consistent with previous findings, mediation analyses showed that child-reported IU fully mediated an association between parent-reported sensory reactivity and parent-reported anxiety and that anxiety partially mediated an association between sensory reactivity and IU. Of the vibrotactile thresholds, only simultaneous frequency discrimination (SFD) thresholds correlated with sensory reactivity. Interestingly, we found that sensory reactivity fully mediated an association between SFD threshold and anxiety, and between SFD threshold and IU. Taken together, those findings suggest a mechanistic pathway whereby tactile perceptual alterations contribute to sensory reactivity at the affective level, leading in turn to increased IU and anxiety. This stepwise association can inform potential interventions for IU and anxiety in autism. En ligne : https://dx.doi.org/10.1017/S0954579423001360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546 [article] Perceptual alterations in the relationship between sensory reactivity, intolerance of uncertainty, and anxiety in autistic children with and without ADHD : Development and Psychopathology [Texte imprimé et/ou numérique] / Helen J. Powell, Auteur ; Jason L. HE, Auteur ; Nermin Khalil, Auteur ; Ericka L. WODKA, Auteur ; Alyssa DeRonda, Auteur ; Richard A. E. EDDEN, Auteur ; Roma A. VASA, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nicolaas A. PUTS, Auteur . - p.16-28. Langues : Anglais (eng) in Development and Psychopathology > 37-1 (February 2025) . - p.16-28 Mots-clés : anxiety  autism  intolerance of uncertainty  perception  sensory Index. décimale : PER Périodiques Résumé : Sensory differences and anxiety disorders are highly prevalent in autistic individuals with and without ADHD. Studies have shown that sensory differences and anxiety are associated and that intolerance of uncertainty (IU) plays an important role in this relationship. However, it is unclear as to how different levels of the sensory processing pathway (i.e., perceptual, affective, or behavioral) contribute. Here, we used psychophysics to assess how alterations in tactile perception contribute to questionnaire measures of sensory reactivity, IU, and anxiety. Thirty-eight autistic children (aged 8-12 years; 27 with co-occurring ADHD) were included. Consistent with previous findings, mediation analyses showed that child-reported IU fully mediated an association between parent-reported sensory reactivity and parent-reported anxiety and that anxiety partially mediated an association between sensory reactivity and IU. Of the vibrotactile thresholds, only simultaneous frequency discrimination (SFD) thresholds correlated with sensory reactivity. Interestingly, we found that sensory reactivity fully mediated an association between SFD threshold and anxiety, and between SFD threshold and IU. Taken together, those findings suggest a mechanistic pathway whereby tactile perceptual alterations contribute to sensory reactivity at the affective level, leading in turn to increased IU and anxiety. This stepwise association can inform potential interventions for IU and anxiety in autism. En ligne : https://dx.doi.org/10.1017/S0954579423001360 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=546

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