Emerging adulthood in autism: Striving for independence or interdependence? / Carly MOSER in Autism, 28-6 (June 2024)  

Public ISBD [article]  inAutism > 28-6 (June 2024) . - p.1325-1327 Titre : Emerging adulthood in autism: Striving for independence or interdependence? Type de document : texte imprimé Auteurs : Carly MOSER, Auteur ; Leann S. DAWALT, Auteur ; Meghan M. BURKE, Auteur ; Julie Lounds TAYLOR, Auteur Article en page(s) : p.1325-1327 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.1177/13623613241245647 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529 [article] Emerging adulthood in autism: Striving for independence or interdependence? [texte imprimé] / Carly MOSER, Auteur ; Leann S. DAWALT, Auteur ; Meghan M. BURKE, Auteur ; Julie Lounds TAYLOR, Auteur . - p.1325-1327. Langues : Anglais (eng) in Autism > 28-6 (June 2024) . - p.1325-1327 Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.1177/13623613241245647 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529

Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation / Jessica KLUSEK in Journal of Neurodevelopmental Disorders, 14 (2022)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 14 (2022) Titre : Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation Type de document : texte imprimé Auteurs : Jessica KLUSEK, Auteur ; Amanda FAIRCHILD, Auteur ; Carly MOSER, Auteur ; Marsha R. MAILICK, Auteur ; Angela John THURMAN, Auteur ; Leonard ABBEDUTO, Auteur Langues : Anglais (eng) Mots-clés : Adult  Alleles  Ataxia/genetics  Child  Cognitive Dysfunction/complications/genetics  Female  Fragile X Mental Retardation Protein/genetics  Fragile X Syndrome/complications/genetics  Humans  Language Disorders  Middle Aged  Mothers  Neurodegenerative Diseases/complications/genetics  Tremor/genetics  Aging  Fragile X premutation  Grammatical complexity  Language production  trials from F. Hoffman-LaRoche, Ltd., Roche TCRC, Inc., Neuren Pharmaceuticals  Limited, Inc, and the LuMind IDSC Foundation. AJT has received funding to develop  and implement outcome measures from Fulcrum Therapeutic. MM serves as the chair  of the Scientific Advisory Board of the John Merck Fund Developmental  Disabilities Program. The authors have no other relevant conflicts of interest to  disclose. Index. décimale : PER Périodiques Résumé : BACKGROUND: Women who carry a premutation allele of the FMR1 gene are at increased vulnerability to an array of age-related symptoms and disorders, including age-related decline in select cognitive skills. However, the risk factors for age-related decline are poorly understood, including the potential role of family history and genetic factors. In other forms of pathological aging, early decline in syntactic complexity is observed and predicts the later onset of neurodegenerative disease. To shed light on the earliest signs of degeneration, the present study characterized longitudinal changes in the syntactic complexity of women with the FMR1 premutation across midlife, and associations with family history of fragile X-associated tremor/ataxia syndrome (FXTAS) and CGG repeat length. METHODS: Forty-five women with the FMR1 premutation aged 35-64 years at study entry participated in 1-5 longitudinal assessments spaced approximately a year apart (130 observations total). All participants were mothers of children with confirmed fragile X syndrome. Language samples were analyzed for syntactic complexity and participants provided information on family history of FXTAS. CGG repeat length was determined via molecular genetic testing. RESULTS: Hierarchical linear models indicated that women who reported a family history of FXTAS exhibited faster age-related decline in syntactic complexity than those without a family history, with that difference emerging as the women reached their mid-50 s. CGG repeat length was not a significant predictor of age-related change. CONCLUSIONS: Results suggest that women with the FMR1 premutation who have a family history of FXTAS may be at increased risk for neurodegenerative disease, as indicated by age-related loss of syntactic complexity. Thus, family history of FXTAS may represent a personalized risk factor for age-related disease. Follow-up study is needed to determine whether syntactic decline is an early indicator of FXTAS specifically, as opposed to being a more general age-related cognitive decline associated with the FMR1 premutation. En ligne : https://dx.doi.org/10.1186/s11689-022-09415-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Family history of FXTAS is associated with age-related cognitive-linguistic decline among mothers with the FMR1 premutation [texte imprimé] / Jessica KLUSEK, Auteur ; Amanda FAIRCHILD, Auteur ; Carly MOSER, Auteur ; Marsha R. MAILICK, Auteur ; Angela John THURMAN, Auteur ; Leonard ABBEDUTO, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 14 (2022) Mots-clés : Adult  Alleles  Ataxia/genetics  Child  Cognitive Dysfunction/complications/genetics  Female  Fragile X Mental Retardation Protein/genetics  Fragile X Syndrome/complications/genetics  Humans  Language Disorders  Middle Aged  Mothers  Neurodegenerative Diseases/complications/genetics  Tremor/genetics  Aging  Fragile X premutation  Grammatical complexity  Language production  trials from F. Hoffman-LaRoche, Ltd., Roche TCRC, Inc., Neuren Pharmaceuticals  Limited, Inc, and the LuMind IDSC Foundation. AJT has received funding to develop  and implement outcome measures from Fulcrum Therapeutic. MM serves as the chair  of the Scientific Advisory Board of the John Merck Fund Developmental  Disabilities Program. The authors have no other relevant conflicts of interest to  disclose. Index. décimale : PER Périodiques Résumé : BACKGROUND: Women who carry a premutation allele of the FMR1 gene are at increased vulnerability to an array of age-related symptoms and disorders, including age-related decline in select cognitive skills. However, the risk factors for age-related decline are poorly understood, including the potential role of family history and genetic factors. In other forms of pathological aging, early decline in syntactic complexity is observed and predicts the later onset of neurodegenerative disease. To shed light on the earliest signs of degeneration, the present study characterized longitudinal changes in the syntactic complexity of women with the FMR1 premutation across midlife, and associations with family history of fragile X-associated tremor/ataxia syndrome (FXTAS) and CGG repeat length. METHODS: Forty-five women with the FMR1 premutation aged 35-64 years at study entry participated in 1-5 longitudinal assessments spaced approximately a year apart (130 observations total). All participants were mothers of children with confirmed fragile X syndrome. Language samples were analyzed for syntactic complexity and participants provided information on family history of FXTAS. CGG repeat length was determined via molecular genetic testing. RESULTS: Hierarchical linear models indicated that women who reported a family history of FXTAS exhibited faster age-related decline in syntactic complexity than those without a family history, with that difference emerging as the women reached their mid-50 s. CGG repeat length was not a significant predictor of age-related change. CONCLUSIONS: Results suggest that women with the FMR1 premutation who have a family history of FXTAS may be at increased risk for neurodegenerative disease, as indicated by age-related loss of syntactic complexity. Thus, family history of FXTAS may represent a personalized risk factor for age-related disease. Follow-up study is needed to determine whether syntactic decline is an early indicator of FXTAS specifically, as opposed to being a more general age-related cognitive decline associated with the FMR1 premutation. En ligne : https://dx.doi.org/10.1186/s11689-022-09415-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Mother–Child Biobehavioral Synchrony and Its Association With Social Functioning in Autistic School-Aged Children / Carly MOSER in Autism Research, 19-2 (February 2026)  

Public ISBD [article]  inAutism Research > 19-2 (February 2026) . - e70168 Titre : Mother–Child Biobehavioral Synchrony and Its Association With Social Functioning in Autistic School-Aged Children Type de document : texte imprimé Auteurs : Carly MOSER, Auteur ; Chih-Hsiang YANG, Auteur ; Abigail L. HOGAN, Auteur ; Amanda FAIRCHILD, Auteur ; Jane ROBERTS, Auteur ; Jessica KLUSEK, Auteur Article en page(s) : e70168 Langues : Anglais (eng) Mots-clés : autism  biobehavioral synchrony  heart activity  parent–child synchrony  respiratory sinus arrhythmia  social functioning Index. décimale : PER Périodiques Résumé : ABSTRACT Parent?child biobehavioral synchrony, or the concordance of behavior and physiological indicators between individuals, is theorized to support children's social development; however, this relationship has yet to be investigated in autistic children. This study examined whether moment-to-moment physiological synchrony?indexed via respiratory sinus arrhythmia (RSA)?and its interface with global levels of behavioral synchrony was associated with the pragmatic language skills and friendship quality of school-aged autistic children in 40 mother?child dyads. Mother?child dyads participated in a collaborative task, from which RSA synchrony and behavioral synchrony were assessed. Mothers and their autistic children demonstrated negative RSA synchrony, such that when one partner displayed an increase in RSA, the other partner showed a decrease in RSA. The extent of behavioral synchrony between mothers and their children did not moderate the strength of concordance between mother and child RSA. Negative RSA synchrony was associated with better pragmatic language skills in autistic children from mother?child dyads who displayed high levels of behavioral synchrony. These findings highlight the complexity of dyadic synchrony, suggesting that the coordination of mother?child RSA, in conjunction with behavioral synchrony, may aid in the development of social skills in autistic children that extend beyond the immediate caregiver context. However, larger longitudinal studies are needed to confirm this. En ligne : https://doi.org/10.1002/aur.70168 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582 [article] Mother–Child Biobehavioral Synchrony and Its Association With Social Functioning in Autistic School-Aged Children [texte imprimé] / Carly MOSER, Auteur ; Chih-Hsiang YANG, Auteur ; Abigail L. HOGAN, Auteur ; Amanda FAIRCHILD, Auteur ; Jane ROBERTS, Auteur ; Jessica KLUSEK, Auteur . - e70168. Langues : Anglais (eng) in Autism Research > 19-2 (February 2026) . - e70168 Mots-clés : autism  biobehavioral synchrony  heart activity  parent–child synchrony  respiratory sinus arrhythmia  social functioning Index. décimale : PER Périodiques Résumé : ABSTRACT Parent?child biobehavioral synchrony, or the concordance of behavior and physiological indicators between individuals, is theorized to support children's social development; however, this relationship has yet to be investigated in autistic children. This study examined whether moment-to-moment physiological synchrony?indexed via respiratory sinus arrhythmia (RSA)?and its interface with global levels of behavioral synchrony was associated with the pragmatic language skills and friendship quality of school-aged autistic children in 40 mother?child dyads. Mother?child dyads participated in a collaborative task, from which RSA synchrony and behavioral synchrony were assessed. Mothers and their autistic children demonstrated negative RSA synchrony, such that when one partner displayed an increase in RSA, the other partner showed a decrease in RSA. The extent of behavioral synchrony between mothers and their children did not moderate the strength of concordance between mother and child RSA. Negative RSA synchrony was associated with better pragmatic language skills in autistic children from mother?child dyads who displayed high levels of behavioral synchrony. These findings highlight the complexity of dyadic synchrony, suggesting that the coordination of mother?child RSA, in conjunction with behavioral synchrony, may aid in the development of social skills in autistic children that extend beyond the immediate caregiver context. However, larger longitudinal studies are needed to confirm this. En ligne : https://doi.org/10.1002/aur.70168 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=582

The Effect of a Parent Advocacy Intervention on Service Access for Autistic Youth: The Moderating Role of Baseline Advocacy Ability / Carly MOSER in Autism Research, 19-10 (October 2026)  

Public ISBD [article]  inAutism Research > 19-10 (October 2026) . - p.e70357 Titre : The Effect of a Parent Advocacy Intervention on Service Access for Autistic Youth: The Moderating Role of Baseline Advocacy Ability Type de document : texte imprimé Auteurs : Carly MOSER, Auteur ; Leann Smith DAWALT, Auteur ; Meghan M. BURKE, Auteur ; Julie Lounds TAYLOR, Auteur Année de publication : 2026 Article en page(s) : p.e70357 Langues : Anglais (eng) Mots-clés : adult disability services  autism  parent advocacy  transition to adulthood  treatment moderators Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic youth face significant challenges accessing adult disability services as they transition out of school-based services. Advocating for Supports to Improve Service Transitions (ASSIST), a group-based program, was developed to address this issue by teaching parents about the service system and how to advocate for services for their youth. Through a randomized controlled trial, previous findings showed that ASSIST improved parent advocacy ability and increased access to government programs for youth who had exited high school. To identify which families may benefit most from ASSIST, the current study used a baseline target moderation framework to examine whether parents' baseline levels of advocacy ability (i.e., knowledge of adult services, perceived advocacy skills, and empowerment) modified the effect of intervention modality (ASSIST vs. written materials) on the primary outcome. The primary outcome for this study was having one or more service needs met at the 6- or 12-month follow-up. Participants included 138 parents of transition-aged autistic youth who received the ASSIST program or comprehensive written materials on disability services. We found that parents taking ASSIST who reported high levels of perceived advocacy skills and empowerment at baseline were more likely to have a service need met compared to those who received written materials. These findings help clarify which families are most likely to benefit from a parent advocacy program and underscore the importance of parental empowerment and perceived advocacy skills in securing needed services for their autistic youth. En ligne : https://doi.org/10.1002/aur.70357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594 [article] The Effect of a Parent Advocacy Intervention on Service Access for Autistic Youth: The Moderating Role of Baseline Advocacy Ability [texte imprimé] / Carly MOSER, Auteur ; Leann Smith DAWALT, Auteur ; Meghan M. BURKE, Auteur ; Julie Lounds TAYLOR, Auteur . - 2026 . - p.e70357. Langues : Anglais (eng) in Autism Research > 19-10 (October 2026) . - p.e70357 Mots-clés : adult disability services  autism  parent advocacy  transition to adulthood  treatment moderators Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic youth face significant challenges accessing adult disability services as they transition out of school-based services. Advocating for Supports to Improve Service Transitions (ASSIST), a group-based program, was developed to address this issue by teaching parents about the service system and how to advocate for services for their youth. Through a randomized controlled trial, previous findings showed that ASSIST improved parent advocacy ability and increased access to government programs for youth who had exited high school. To identify which families may benefit most from ASSIST, the current study used a baseline target moderation framework to examine whether parents' baseline levels of advocacy ability (i.e., knowledge of adult services, perceived advocacy skills, and empowerment) modified the effect of intervention modality (ASSIST vs. written materials) on the primary outcome. The primary outcome for this study was having one or more service needs met at the 6- or 12-month follow-up. Participants included 138 parents of transition-aged autistic youth who received the ASSIST program or comprehensive written materials on disability services. We found that parents taking ASSIST who reported high levels of perceived advocacy skills and empowerment at baseline were more likely to have a service need met compared to those who received written materials. These findings help clarify which families are most likely to benefit from a parent advocacy program and underscore the importance of parental empowerment and perceived advocacy skills in securing needed services for their autistic youth. En ligne : https://doi.org/10.1002/aur.70357 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=594

---

1 (1 - 4 / 4) Par page : 25 50 100 200