An RDoC-based approach to adolescent self-injurious thoughts and behaviors: The interactive role of social affiliation and cardiac arousal / Benjamin W. NELSON in Development and Psychopathology, 36-3 (August 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-3 (August 2024) . - p.1005-1015 Titre : An RDoC-based approach to adolescent self-injurious thoughts and behaviors: The interactive role of social affiliation and cardiac arousal Type de document : Texte imprimé et/ou numérique Auteurs : Benjamin W. NELSON, Auteur ; Olivia H. POLLAK, Auteur ; Matthew G. CLAYTON, Auteur ; Eva H. TELZER, Auteur ; Mitchell J. PRINSTEIN, Auteur Article en page(s) : p.1005-1015 Langues : Anglais (eng) Mots-clés : adolescence  cardiac arousal  self-injurious thoughts and behaviors  social stress Index. décimale : PER Périodiques Résumé : Recent theoretical models have posited that increases in self-injurious thoughts and behaviors (SITBs) during adolescence may be linked to failures in biological stress regulation in contexts of social stress. However, there is a lack of data examining this hypothesis during the transition to adolescence, a sensitive period of development characterized by changes across socioaffective and psychophysiological domains. Building on principles from developmental psychopathology and the RDoC framework, the present study used a longitudinal design in a sample of 147 adolescents to test whether interactions among experiences of social (i.e., parent and peer) conflict and cardiac arousal (i.e., resting heart rate) predicted adolescents' engagement in SITBs (i.e., nonsuicidal self-injury, NSSI; and suicidal ideation; SI) across 1-year follow-up. Prospective analyses revealed that adolescents experiencing a combination of greater peer, but not family, conflict and higher cardiac arousal at baseline showed significant longitudinal increases in NSSI. In contrast, social conflict did not interact with cardiac arousal to predict future SI. Findings indicate that greater peer-related interpersonal stress in adolescents may increase risk for future NSSI among youth with physiological vulnerabilities (i.e., higher resting heart rate) that may be markers of maladaptive stress responses. Future research should examine these processes at finer timescales to elucidate whether these factors are proximal predictors of within-day SITBs. En ligne : https://dx.doi.org/10.1017/S0954579423000251 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] An RDoC-based approach to adolescent self-injurious thoughts and behaviors: The interactive role of social affiliation and cardiac arousal [Texte imprimé et/ou numérique] / Benjamin W. NELSON, Auteur ; Olivia H. POLLAK, Auteur ; Matthew G. CLAYTON, Auteur ; Eva H. TELZER, Auteur ; Mitchell J. PRINSTEIN, Auteur . - p.1005-1015. Langues : Anglais (eng) in Development and Psychopathology > 36-3 (August 2024) . - p.1005-1015 Mots-clés : adolescence  cardiac arousal  self-injurious thoughts and behaviors  social stress Index. décimale : PER Périodiques Résumé : Recent theoretical models have posited that increases in self-injurious thoughts and behaviors (SITBs) during adolescence may be linked to failures in biological stress regulation in contexts of social stress. However, there is a lack of data examining this hypothesis during the transition to adolescence, a sensitive period of development characterized by changes across socioaffective and psychophysiological domains. Building on principles from developmental psychopathology and the RDoC framework, the present study used a longitudinal design in a sample of 147 adolescents to test whether interactions among experiences of social (i.e., parent and peer) conflict and cardiac arousal (i.e., resting heart rate) predicted adolescents' engagement in SITBs (i.e., nonsuicidal self-injury, NSSI; and suicidal ideation; SI) across 1-year follow-up. Prospective analyses revealed that adolescents experiencing a combination of greater peer, but not family, conflict and higher cardiac arousal at baseline showed significant longitudinal increases in NSSI. In contrast, social conflict did not interact with cardiac arousal to predict future SI. Findings indicate that greater peer-related interpersonal stress in adolescents may increase risk for future NSSI among youth with physiological vulnerabilities (i.e., higher resting heart rate) that may be markers of maladaptive stress responses. Future research should examine these processes at finer timescales to elucidate whether these factors are proximal predictors of within-day SITBs. En ligne : https://dx.doi.org/10.1017/S0954579423000251 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Proinflammatory gene expression is associated with prospective risk for adolescent suicidal thoughts and behaviors over twelve months / Matthew G. CLAYTON in Development and Psychopathology, 37-3 (August 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-3 (August 2025) . - p.1676-1684 Titre : Proinflammatory gene expression is associated with prospective risk for adolescent suicidal thoughts and behaviors over twelve months Type de document : Texte imprimé et/ou numérique Auteurs : Matthew G. CLAYTON, Auteur ; Steve W. COLE, Auteur ; Matteo GILETTA, Auteur ; Paul D. HASTINGS, Auteur ; Matthew K. NOCK, Auteur ; Karen D. RUDOLPH, Auteur ; George M. SLAVICH, Auteur ; Mitchell J. PRINSTEIN, Auteur Article en page(s) : p.1676-1684 Langues : Anglais (eng) Mots-clés : adolescence  biomarkers  childhood trauma  inflammation  suicide Index. décimale : PER Périodiques Résumé : Objective:Recent theories have implicated inflammatory biology in the development of psychopathology and maladaptive behaviors in adolescence, including suicidal thoughts and behaviors (STB). Examining specific biological markers related to inflammation is thus warranted to better understand risk for STB in adolescents, for whom suicide is a leading cause of death.Method:Participants were 211 adolescent females (ages 9-14 years; Mage = 11.8 years, SD = 1.8 years) at increased risk for STB. This study examined the prospective association between basal levels of inflammatory gene expression (average of 15 proinflammatory mRNA transcripts) and subsequent risk for suicidal ideation and suicidal behavior over a 12-month follow-up period.Results:Controlling for past levels of STB, greater proinflammatory gene expression was associated with prospective risk for STB in these youth. Similar effects were observed for CD14 mRNA level, a marker of monocyte abundance within the blood sample. Sensitivity analyses controlling for other relevant covariates, including history of trauma, depressive symptoms, and STB prior to data collection, yielded similar patterns of results.Conclusions:Upregulated inflammatory signaling in the immune system is prospectively associated with STB among at-risk adolescent females, even after controlling for history of trauma, depressive symptoms, and STB prior to data collection. Additional research is needed to identify the sources of inflammatory up-regulation in adolescents (e.g., stress psychobiology, physiological development, microbial exposures) and strategies for mitigating such effects to reduce STB. En ligne : https://www.cambridge.org/core/product/25AD4CF3A7BD16D263771246B7E45F56 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] Proinflammatory gene expression is associated with prospective risk for adolescent suicidal thoughts and behaviors over twelve months [Texte imprimé et/ou numérique] / Matthew G. CLAYTON, Auteur ; Steve W. COLE, Auteur ; Matteo GILETTA, Auteur ; Paul D. HASTINGS, Auteur ; Matthew K. NOCK, Auteur ; Karen D. RUDOLPH, Auteur ; George M. SLAVICH, Auteur ; Mitchell J. PRINSTEIN, Auteur . - p.1676-1684. Langues : Anglais (eng) in Development and Psychopathology > 37-3 (August 2025) . - p.1676-1684 Mots-clés : adolescence  biomarkers  childhood trauma  inflammation  suicide Index. décimale : PER Périodiques Résumé : Objective:Recent theories have implicated inflammatory biology in the development of psychopathology and maladaptive behaviors in adolescence, including suicidal thoughts and behaviors (STB). Examining specific biological markers related to inflammation is thus warranted to better understand risk for STB in adolescents, for whom suicide is a leading cause of death.Method:Participants were 211 adolescent females (ages 9-14 years; Mage = 11.8 years, SD = 1.8 years) at increased risk for STB. This study examined the prospective association between basal levels of inflammatory gene expression (average of 15 proinflammatory mRNA transcripts) and subsequent risk for suicidal ideation and suicidal behavior over a 12-month follow-up period.Results:Controlling for past levels of STB, greater proinflammatory gene expression was associated with prospective risk for STB in these youth. Similar effects were observed for CD14 mRNA level, a marker of monocyte abundance within the blood sample. Sensitivity analyses controlling for other relevant covariates, including history of trauma, depressive symptoms, and STB prior to data collection, yielded similar patterns of results.Conclusions:Upregulated inflammatory signaling in the immune system is prospectively associated with STB among at-risk adolescent females, even after controlling for history of trauma, depressive symptoms, and STB prior to data collection. Additional research is needed to identify the sources of inflammatory up-regulation in adolescents (e.g., stress psychobiology, physiological development, microbial exposures) and strategies for mitigating such effects to reduce STB. En ligne : https://www.cambridge.org/core/product/25AD4CF3A7BD16D263771246B7E45F56 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

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