Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions / Cara R. DAMIANO in Journal of Neurodevelopmental Disorders, 4-1 (December 2012)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.13 Titre : Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions Type de document : Texte imprimé et/ou numérique Auteurs : Cara R. DAMIANO, Auteur ; Joseph ALOI, Auteur ; M. TREADWAY, Auteur ; James W. BODFISH, Auteur ; Gabriel S. DICHTER, Auteur Article en page(s) : p.13 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Efficient effort expenditure to obtain rewards is critical for optimal goal-directed behavior and learning. Clinical observation suggests that individuals with autism spectrum disorders (ASD) may show dysregulated reward-based effort expenditure, but no behavioral study to date has assessed effort-based decision-making in ASD. METHODS: The current study compared a group of adults with ASD to a group of typically developing adults on the Effort Expenditure for Rewards Task (EEfRT), a behavioral measure of effort-based decision-making. In this task, participants were provided with the probability of receiving a monetary reward on a particular trial and asked to choose between either an "easy task" (less motoric effort) for a small, stable reward or a "hard task" (greater motoric effort) for a variable but consistently larger reward. RESULTS: Participants with ASD chose the hard task more frequently than did the control group, yet were less influenced by differences in reward value and probability than the control group. Additionally, effort-based decision-making was related to repetitive behavior symptoms across both groups. CONCLUSIONS: These results suggest that individuals with ASD may be more willing to expend effort to obtain a monetary reward regardless of the reward contingencies. More broadly, results suggest that behavioral choices may be less influenced by information about reward contingencies in individuals with ASD. This atypical pattern of effort-based decision-making may be relevant for understanding the heightened reward motivation for circumscribed interests in ASD. En ligne : http://dx.doi.org/10.1186/1866-1955-4-13 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344 [article] Adults with autism spectrum disorders exhibit decreased sensitivity to reward parameters when making effort-based decisions [Texte imprimé et/ou numérique] / Cara R. DAMIANO, Auteur ; Joseph ALOI, Auteur ; M. TREADWAY, Auteur ; James W. BODFISH, Auteur ; Gabriel S. DICHTER, Auteur . - p.13. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 4-1 (December 2012) . - p.13 Index. décimale : PER Périodiques Résumé : BACKGROUND: Efficient effort expenditure to obtain rewards is critical for optimal goal-directed behavior and learning. Clinical observation suggests that individuals with autism spectrum disorders (ASD) may show dysregulated reward-based effort expenditure, but no behavioral study to date has assessed effort-based decision-making in ASD. METHODS: The current study compared a group of adults with ASD to a group of typically developing adults on the Effort Expenditure for Rewards Task (EEfRT), a behavioral measure of effort-based decision-making. In this task, participants were provided with the probability of receiving a monetary reward on a particular trial and asked to choose between either an "easy task" (less motoric effort) for a small, stable reward or a "hard task" (greater motoric effort) for a variable but consistently larger reward. RESULTS: Participants with ASD chose the hard task more frequently than did the control group, yet were less influenced by differences in reward value and probability than the control group. Additionally, effort-based decision-making was related to repetitive behavior symptoms across both groups. CONCLUSIONS: These results suggest that individuals with ASD may be more willing to expend effort to obtain a monetary reward regardless of the reward contingencies. More broadly, results suggest that behavioral choices may be less influenced by information about reward contingencies in individuals with ASD. This atypical pattern of effort-based decision-making may be relevant for understanding the heightened reward motivation for circumscribed interests in ASD. En ligne : http://dx.doi.org/10.1186/1866-1955-4-13 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=344

Affective Modulation of the Startle Eyeblink and Postauricular Reflexes in Autism Spectrum Disorder / Gabriel S. DICHTER in Journal of Autism and Developmental Disorders, 40-7 (July 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-7 (July 2010) . - p.858-869 Titre : Affective Modulation of the Startle Eyeblink and Postauricular Reflexes in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Gabriel S. DICHTER, Auteur ; Stephen D. BENNING, Auteur ; Tia N. HOLTZCLAW, Auteur ; James W. BODFISH, Auteur Année de publication : 2010 Article en page(s) : p.858-869 Langues : Anglais (eng) Mots-clés : Autism-spectrum-disorder Affective-startle-modulation Eyeblink Postauricular Index. décimale : PER Périodiques Résumé : Eyeblink and postauricular reflexes to standardized affective images were examined in individuals without (n = 37) and with (n = 20) autism spectrum disorders (ASDs). Affective reflex modulation in control participants replicated previous findings. The ASD group, however, showed anomalous reflex modulation patterns, despite similar self-report ratings of pictures. Specifically, the ASD group demonstrated exaggerated eyeblink responses to pleasant images and exaggerated postauricular responses to unpleasant images. Although ASD is often conceptualized in terms of specific deficits in affective responding in the social domain, the present results suggest a domain-general pattern of deficits in affective processing and that such deficits may arise at an early phase in the stream of information processing. En ligne : http://dx.doi.org/10.1007/s10803-009-0925-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=107 [article] Affective Modulation of the Startle Eyeblink and Postauricular Reflexes in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Gabriel S. DICHTER, Auteur ; Stephen D. BENNING, Auteur ; Tia N. HOLTZCLAW, Auteur ; James W. BODFISH, Auteur . - 2010 . - p.858-869. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-7 (July 2010) . - p.858-869 Mots-clés : Autism-spectrum-disorder Affective-startle-modulation Eyeblink Postauricular Index. décimale : PER Périodiques Résumé : Eyeblink and postauricular reflexes to standardized affective images were examined in individuals without (n = 37) and with (n = 20) autism spectrum disorders (ASDs). Affective reflex modulation in control participants replicated previous findings. The ASD group, however, showed anomalous reflex modulation patterns, despite similar self-report ratings of pictures. Specifically, the ASD group demonstrated exaggerated eyeblink responses to pleasant images and exaggerated postauricular responses to unpleasant images. Although ASD is often conceptualized in terms of specific deficits in affective responding in the social domain, the present results suggest a domain-general pattern of deficits in affective processing and that such deficits may arise at an early phase in the stream of information processing. En ligne : http://dx.doi.org/10.1007/s10803-009-0925-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=107

Age trends in visual exploration of social and nonsocial information in children with autism / Jed T. ELISON in Research in Autism Spectrum Disorders, 6-2 (April-June 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.842-851 Titre : Age trends in visual exploration of social and nonsocial information in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Jed T. ELISON, Auteur ; Noah J. SASSON, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Gabriel S. DICHTER, Auteur ; James W. BODFISH, Auteur Année de publication : 2012 Article en page(s) : p.842-851 Langues : Anglais (eng) Mots-clés : Autism  Attention  Visual exploration  Development  Eye tracking Index. décimale : PER Périodiques Résumé : Because previous studies of attention in autism spectrum disorders (ASD) have been restricted in age range examined, little is known about how these processes develop over the course of childhood. In this study we examined cross-sectional age effects on patterns of visual attention to social and nonsocial information in 43 typically developing children and 51 children with ASD ranging in age from 2 to 18. Results indicated a sharp increase in visual exploration with age and a decrease in perseverative and detail-focused attention for both groups of children. However, increased age was associated with greater increases in visual exploration for typically developing children than for those children with ASD. The developmental differences were most pronounced for attention to certain nonsocial stimuli as children with ASD demonstrated a disproportionate attentional bias for these stimuli from very early in life. Disproportionate visual attention to certain nonsocial objects relative to social stimuli in ASD spanned from early to late childhood, and thus may represent both an early and a persistent characteristic of the disorder. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.11.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150 [article] Age trends in visual exploration of social and nonsocial information in children with autism [Texte imprimé et/ou numérique] / Jed T. ELISON, Auteur ; Noah J. SASSON, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Gabriel S. DICHTER, Auteur ; James W. BODFISH, Auteur . - 2012 . - p.842-851. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-2 (April-June 2012) . - p.842-851 Mots-clés : Autism  Attention  Visual exploration  Development  Eye tracking Index. décimale : PER Périodiques Résumé : Because previous studies of attention in autism spectrum disorders (ASD) have been restricted in age range examined, little is known about how these processes develop over the course of childhood. In this study we examined cross-sectional age effects on patterns of visual attention to social and nonsocial information in 43 typically developing children and 51 children with ASD ranging in age from 2 to 18. Results indicated a sharp increase in visual exploration with age and a decrease in perseverative and detail-focused attention for both groups of children. However, increased age was associated with greater increases in visual exploration for typically developing children than for those children with ASD. The developmental differences were most pronounced for attention to certain nonsocial stimuli as children with ASD demonstrated a disproportionate attentional bias for these stimuli from very early in life. Disproportionate visual attention to certain nonsocial objects relative to social stimuli in ASD spanned from early to late childhood, and thus may represent both an early and a persistent characteristic of the disorder. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.11.005 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150

Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards / Cara R. DAMIANO in Molecular Autism, (January 2014)  

Public ISBD [article]  inMolecular Autism > (January 2014) Titre : Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards Type de document : Texte imprimé et/ou numérique Auteurs : Cara R. DAMIANO, Auteur ; Joseph ALOI, Auteur ; Kaitlyn DUNLAP, Auteur ; Caley BURRUS, Auteur ; Maya MOSNER, Auteur ; Rachel KOZINK, Auteur ; Ralph MCLAURIN, Auteur ; O'Dhaniel MULLETTE-GILLMAN, Auteur ; Ronald CARTER, Auteur ; Scott A. HUETTEL, Auteur ; Francis MCCLERNON, Auteur ; Allison ASHLEY-KOCH, Auteur ; Gabriel S. DICHTER, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : There has been significant progress in identifying genes that confer risk for autism spectrum disorders (ASDs). However, the heterogeneity of symptom presentation in ASDs impedes the detection of ASD risk genes. One approach to understanding genetic influences on ASD symptom expression is to evaluate relations between variants of ASD candidate genes and neural endophenotypes in unaffected samples. Allelic variations in the oxytocin receptor (OXTR) gene confer small but significant risk for ASDs for which the underlying mechanisms may involve associations between variability in oxytocin signaling pathways and neural response to rewards. The purpose of this preliminary study was to investigate the influence of allelic variability in the OXTR gene on neural responses to monetary rewards in healthy adults using functional magnetic resonance imaging (fMRI). The moderating effects of three single nucleotide polymorphisms (SNPs) (rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task. T homozygotes of the rs2268493 SNP demonstrated relatively decreased activation in mesolimbic reward circuitry (including the nucleus accumbens, amygdala, insula, thalamus and prefrontal cortical regions) during the anticipation of rewards but not during the outcome phase of the task. Allelic variation of the rs1042778 and rs237887 SNPs did not moderate mesolimbic activation during either reward anticipation or outcomes. This preliminary study suggests that the OXTR SNP rs2268493, which has been previously identified as an ASD risk gene, moderates mesolimbic responses during reward anticipation. Given previous findings of decreased mesolimbic activation during reward anticipation in ASD, the present results suggest that OXTR may confer ASD risk via influences on the neural systems that support reward anticipation. En ligne : http://dx.doi.org/10.1186/2040-2392-5-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards [Texte imprimé et/ou numérique] / Cara R. DAMIANO, Auteur ; Joseph ALOI, Auteur ; Kaitlyn DUNLAP, Auteur ; Caley BURRUS, Auteur ; Maya MOSNER, Auteur ; Rachel KOZINK, Auteur ; Ralph MCLAURIN, Auteur ; O'Dhaniel MULLETTE-GILLMAN, Auteur ; Ronald CARTER, Auteur ; Scott A. HUETTEL, Auteur ; Francis MCCLERNON, Auteur ; Allison ASHLEY-KOCH, Auteur ; Gabriel S. DICHTER, Auteur. Langues : Anglais (eng) in Molecular Autism > (January 2014) Index. décimale : PER Périodiques Résumé : There has been significant progress in identifying genes that confer risk for autism spectrum disorders (ASDs). However, the heterogeneity of symptom presentation in ASDs impedes the detection of ASD risk genes. One approach to understanding genetic influences on ASD symptom expression is to evaluate relations between variants of ASD candidate genes and neural endophenotypes in unaffected samples. Allelic variations in the oxytocin receptor (OXTR) gene confer small but significant risk for ASDs for which the underlying mechanisms may involve associations between variability in oxytocin signaling pathways and neural response to rewards. The purpose of this preliminary study was to investigate the influence of allelic variability in the OXTR gene on neural responses to monetary rewards in healthy adults using functional magnetic resonance imaging (fMRI). The moderating effects of three single nucleotide polymorphisms (SNPs) (rs1042778, rs2268493 and rs237887) of the OXTR gene on mesolimbic responses to rewards were evaluated using a monetary incentive delay fMRI task. T homozygotes of the rs2268493 SNP demonstrated relatively decreased activation in mesolimbic reward circuitry (including the nucleus accumbens, amygdala, insula, thalamus and prefrontal cortical regions) during the anticipation of rewards but not during the outcome phase of the task. Allelic variation of the rs1042778 and rs237887 SNPs did not moderate mesolimbic activation during either reward anticipation or outcomes. This preliminary study suggests that the OXTR SNP rs2268493, which has been previously identified as an ASD risk gene, moderates mesolimbic responses during reward anticipation. Given previous findings of decreased mesolimbic activation during reward anticipation in ASD, the present results suggest that OXTR may confer ASD risk via influences on the neural systems that support reward anticipation. En ligne : http://dx.doi.org/10.1186/2040-2392-5-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Brief Report: Circumscribed Attention in Young Children with Autism / Noah J. SASSON in Journal of Autism and Developmental Disorders, 41-2 (February 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-2 (February 2011) . - p.242-247 Titre : Brief Report: Circumscribed Attention in Young Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Noah J. SASSON, Auteur ; Jed T. ELISON, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Gabriel S. DICHTER, Auteur ; James W. BODFISH, Auteur Année de publication : 2011 Article en page(s) : p.242-247 Langues : Anglais (eng) Mots-clés : Autism  Attention  Visual exploration  Toddlers  Perseveration Index. décimale : PER Périodiques Résumé : School-aged children and adolescents with autism demonstrate circumscribed attentional patterns to nonsocial aspects of complex visual arrays (Sasson et al. 2008). The current study downward extended these findings to a sample of 2–5 year-olds with autism and 2–5 year-old typically developing children. Eye-tracking was used to quantify discrete aspects of visual attention to picture arrays containing combinations of social pictures, pictures of objects frequently involved in circumscribed interests in persons with autism (e.g., trains), and pictures of more commonplace objects (e.g., clothing). The children with autism exhibited greater exploration and perseverative attention on objects related to circumscribed interests than did typically developing children. Results suggest that circumscribed attention may be an early emerging characteristic of autism. En ligne : http://dx.doi.org/10.1007/s10803-010-1038-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117 [article] Brief Report: Circumscribed Attention in Young Children with Autism [Texte imprimé et/ou numérique] / Noah J. SASSON, Auteur ; Jed T. ELISON, Auteur ; Lauren M. TURNER-BROWN, Auteur ; Gabriel S. DICHTER, Auteur ; James W. BODFISH, Auteur . - 2011 . - p.242-247. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-2 (February 2011) . - p.242-247 Mots-clés : Autism  Attention  Visual exploration  Toddlers  Perseveration Index. décimale : PER Périodiques Résumé : School-aged children and adolescents with autism demonstrate circumscribed attentional patterns to nonsocial aspects of complex visual arrays (Sasson et al. 2008). The current study downward extended these findings to a sample of 2–5 year-olds with autism and 2–5 year-old typically developing children. Eye-tracking was used to quantify discrete aspects of visual attention to picture arrays containing combinations of social pictures, pictures of objects frequently involved in circumscribed interests in persons with autism (e.g., trains), and pictures of more commonplace objects (e.g., clothing). The children with autism exhibited greater exploration and perseverative attention on objects related to circumscribed interests than did typically developing children. Results suggest that circumscribed attention may be an early emerging characteristic of autism. En ligne : http://dx.doi.org/10.1007/s10803-010-1038-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=117

Brief Report: Cognitive Control of Social and Nonsocial Visual Attention in Autism / Antoinette SABATINO-DICRISCIO in Journal of Autism and Developmental Disorders, 46-8 (August 2016)  

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Brief Report: Feasibility of Social Cognition and Interaction Training for Adults with High Functioning Autism / Lauren M. TURNER-BROWN in Journal of Autism and Developmental Disorders, 38-9 (October 2008)  

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Dynamic Eye Tracking as a Predictor and Outcome Measure of Social Skills Intervention in Adolescents and Adults with Autism Spectrum Disorder / Rachel K. GREENE in Journal of Autism and Developmental Disorders, 51-4 (April 2021)  

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Experience sampling of positive affect in adolescents with autism: Feasibility and preliminary findings / Megan KOVAC in Research in Autism Spectrum Disorders, 29-30 (September–October 2016)  

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Functional Neuroimaging of Social and Nonsocial Cognitive Control in Autism / Antoinette SABATINO-DICRISCIO in Journal of Autism and Developmental Disorders, 43-12 (December 2013)  

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Generativity Abilities Predict Communication Deficits but not Repetitive Behaviors in Autism Spectrum Disorders / Gabriel S. DICHTER in Journal of Autism and Developmental Disorders, 39-9 (September 2009)  

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Intact hedonic responses to sweet tastes in autism spectrum disorder / Cara R. DAMIANO in Research in Autism Spectrum Disorders, 8-3 (March 2014)  

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Late Positive Potential ERP Responses to Social and Nonsocial Stimuli in Youth with Autism Spectrum Disorder / Stephen D. BENNING in Journal of Autism and Developmental Disorders, 46-9 (September 2016)  

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Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder / J. Anthony RICHEY in Journal of Autism and Developmental Disorders, 45-11 (November 2015)  

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Neural mechanisms of negative reinforcement in children and adolescents with autism spectrum disorders / Cara R. DAMIANO in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

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