Altered Dynamics of the fMRI Response to Faces in Individuals with Autism / Natalia M. KLEINHANS in Journal of Autism and Developmental Disorders, 46-1 (January 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.232-241 Titre : Altered Dynamics of the fMRI Response to Faces in Individuals with Autism Type de document : texte imprimé Auteurs : Natalia M. KLEINHANS, Auteur ; Todd RICHARDS, Auteur ; Jessica GREENSON, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur Année de publication : 2016 Article en page(s) : p.232-241 Langues : Anglais (eng) Mots-clés : Habituation  Faces  Houses  Amygdala  Fusiform  Adaptation Index. décimale : PER Périodiques Résumé : Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2565-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Altered Dynamics of the fMRI Response to Faces in Individuals with Autism [texte imprimé] / Natalia M. KLEINHANS, Auteur ; Todd RICHARDS, Auteur ; Jessica GREENSON, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur . - 2016 . - p.232-241. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.232-241 Mots-clés : Habituation  Faces  Houses  Amygdala  Fusiform  Adaptation Index. décimale : PER Périodiques Résumé : Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2565-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

An exploratory longitudinal study of social and language outcomes in children with autism in bilingual home environments / Vanessa ZHOU in Autism, 23-2 (February 2019)  

Public ISBD [article]  inAutism > 23-2 (February 2019) . - p.394-404 Titre : An exploratory longitudinal study of social and language outcomes in children with autism in bilingual home environments Type de document : texte imprimé Auteurs : Vanessa ZHOU, Auteur ; Jeffrey MUNSON, Auteur ; Jessica GREENSON, Auteur ; Yan HOU, Auteur ; Sally J. ROGERS, Auteur ; Annette M. ESTES, Auteur Article en page(s) : p.394-404 Langues : Anglais (eng) Mots-clés : Early Start Denver Model  autism  bilingualism  early intervention  home language environment  language exposure Index. décimale : PER Périodiques Résumé : Little is known about outcomes of early intervention for children with autism spectrum disorder reared in bilingual homes. There are concerns that social communication deficits among children with autism spectrum disorder may reduce the developmental benefits of early intervention for children with autism spectrum disorder raised in bilingual environments. We conducted an exploratory analysis of cross-sectional and longitudinal data from a larger study to explore associations between home language environment and language ability and social skills in response to early autism spectrum disorder intervention. Participants, aged 12-26 months when recruited, were a subset of a larger 2-year, randomized intervention trial (ClinicalTrials.gov identifier: NCT00698997). Children from bilingual homes ( n = 13) began intervention with lower gesture use but otherwise demonstrated equal baseline language and social abilities as compared with age and nonverbal IQ-matched children from monolingual homes ( n = 24). Significant language growth was exhibited by children from both language groups and there was no moderating effect of home language environment. The bilingual home group demonstrated increased gesture use over the course of intervention as compared with the monolingual home group. Preliminary data revealed no basis for concerns regarding negative impact of a bilingual home environment on language or social development in young children with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361317743251 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] An exploratory longitudinal study of social and language outcomes in children with autism in bilingual home environments [texte imprimé] / Vanessa ZHOU, Auteur ; Jeffrey MUNSON, Auteur ; Jessica GREENSON, Auteur ; Yan HOU, Auteur ; Sally J. ROGERS, Auteur ; Annette M. ESTES, Auteur . - p.394-404. Langues : Anglais (eng) in Autism > 23-2 (February 2019) . - p.394-404 Mots-clés : Early Start Denver Model  autism  bilingualism  early intervention  home language environment  language exposure Index. décimale : PER Périodiques Résumé : Little is known about outcomes of early intervention for children with autism spectrum disorder reared in bilingual homes. There are concerns that social communication deficits among children with autism spectrum disorder may reduce the developmental benefits of early intervention for children with autism spectrum disorder raised in bilingual environments. We conducted an exploratory analysis of cross-sectional and longitudinal data from a larger study to explore associations between home language environment and language ability and social skills in response to early autism spectrum disorder intervention. Participants, aged 12-26 months when recruited, were a subset of a larger 2-year, randomized intervention trial (ClinicalTrials.gov identifier: NCT00698997). Children from bilingual homes ( n = 13) began intervention with lower gesture use but otherwise demonstrated equal baseline language and social abilities as compared with age and nonverbal IQ-matched children from monolingual homes ( n = 24). Significant language growth was exhibited by children from both language groups and there was no moderating effect of home language environment. The bilingual home group demonstrated increased gesture use over the course of intervention as compared with the monolingual home group. Preliminary data revealed no basis for concerns regarding negative impact of a bilingual home environment on language or social development in young children with autism spectrum disorder. En ligne : http://dx.doi.org/10.1177/1362361317743251 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

Characteristics Associated with Presence of Depressive Symptoms in Adults with Autism Spectrum Disorder / Lindsey STERLING in Journal of Autism and Developmental Disorders, 38-6 (July 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1011-1018 Titre : Characteristics Associated with Presence of Depressive Symptoms in Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Lindsey STERLING, Auteur ; Geraldine DAWSON, Auteur ; Jessica GREENSON, Auteur ; Annette ESTES, Auteur Année de publication : 2008 Article en page(s) : p.1011-1018 Langues : Anglais (eng) Mots-clés : Autism Depression Anxiety Comorbidity Associated-psychopathology Cognitive-ability Index. décimale : PER Périodiques Résumé : Evidence suggests that individuals with autism spectrum disorders (ASD) often exhibit associated psychiatric symptoms, particularly related to depression. The current study investigated whether individual characteristics, specifically, severity of ASD symptoms, level of cognitive ability, and/or presence of other psychiatric disorders, are associated with occurrence of depressive symptoms in adults with ASD. Forty-six adults with ASD were administered a standardized psychiatric history interview. Twenty participants (43%) endorsed depressive symptoms. It was found that individuals with less social impairment, higher cognitive ability, and higher rates of other psychiatric symptoms, were more likely to report depressive symptoms. These characteristics may be vulnerability factors for the development of depression, and should be considered when screening and treating adults with ASD. En ligne : http://dx.doi.org/10.1007/s10803-007-0477-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Characteristics Associated with Presence of Depressive Symptoms in Adults with Autism Spectrum Disorder [texte imprimé] / Lindsey STERLING, Auteur ; Geraldine DAWSON, Auteur ; Jessica GREENSON, Auteur ; Annette ESTES, Auteur . - 2008 . - p.1011-1018. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-6 (July 2008) . - p.1011-1018 Mots-clés : Autism Depression Anxiety Comorbidity Associated-psychopathology Cognitive-ability Index. décimale : PER Périodiques Résumé : Evidence suggests that individuals with autism spectrum disorders (ASD) often exhibit associated psychiatric symptoms, particularly related to depression. The current study investigated whether individual characteristics, specifically, severity of ASD symptoms, level of cognitive ability, and/or presence of other psychiatric disorders, are associated with occurrence of depressive symptoms in adults with ASD. Forty-six adults with ASD were administered a standardized psychiatric history interview. Twenty participants (43%) endorsed depressive symptoms. It was found that individuals with less social impairment, higher cognitive ability, and higher rates of other psychiatric symptoms, were more likely to report depressive symptoms. These characteristics may be vulnerability factors for the development of depression, and should be considered when screening and treating adults with ASD. En ligne : http://dx.doi.org/10.1007/s10803-007-0477-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Early Social, Imitation, Play, and Language Abilities of Young Non-Autistic Siblings of Children with Autism / Karen TOTH in Journal of Autism and Developmental Disorders, 37-1 (January 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-1 (January 2007) . - p.145-157 Titre : Early Social, Imitation, Play, and Language Abilities of Young Non-Autistic Siblings of Children with Autism Type de document : texte imprimé Auteurs : Karen TOTH, Auteur ; Geraldine DAWSON, Auteur ; Andrew N. MELTZOFF, Auteur ; Jessica GREENSON, Auteur ; Deborah A. FEIN, Auteur Année de publication : 2007 Article en page(s) : p.145-157 Langues : Anglais (eng) Mots-clés : Autism Siblings Social Imitation Play Language Index. décimale : PER Périodiques Résumé : Studies are needed to better understand the broad autism phenotype in young siblings of children with autism. Cognitive, adaptive, social, imitation, play, and language abilities were examined in 42 non-autistic siblings and 20 toddlers with no family history of autism, ages 18–27 months. Siblings, as a group, were below average in expressive language and composite IQ, had lower mean receptive language, adaptive behavior, and social communication skills, and used fewer words, distal gestures, and responsive social smiles than comparison children. Additionally, parents reported social impairments in siblings by 13 months of age. These results suggest that the development of young non-autistic siblings is affected at an early age and, thus, should be closely monitored, with appropriate interventions implemented as needed. En ligne : http://dx.doi.org/10.1007/s10803-006-0336-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=621 [article] Early Social, Imitation, Play, and Language Abilities of Young Non-Autistic Siblings of Children with Autism [texte imprimé] / Karen TOTH, Auteur ; Geraldine DAWSON, Auteur ; Andrew N. MELTZOFF, Auteur ; Jessica GREENSON, Auteur ; Deborah A. FEIN, Auteur . - 2007 . - p.145-157. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-1 (January 2007) . - p.145-157 Mots-clés : Autism Siblings Social Imitation Play Language Index. décimale : PER Périodiques Résumé : Studies are needed to better understand the broad autism phenotype in young siblings of children with autism. Cognitive, adaptive, social, imitation, play, and language abilities were examined in 42 non-autistic siblings and 20 toddlers with no family history of autism, ages 18–27 months. Siblings, as a group, were below average in expressive language and composite IQ, had lower mean receptive language, adaptive behavior, and social communication skills, and used fewer words, distal gestures, and responsive social smiles than comparison children. Additionally, parents reported social impairments in siblings by 13 months of age. These results suggest that the development of young non-autistic siblings is affected at an early age and, thus, should be closely monitored, with appropriate interventions implemented as needed. En ligne : http://dx.doi.org/10.1007/s10803-006-0336-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=621

Enhancing Low-Intensity Coaching in Parent Implemented Early Start Denver Model Intervention for Early Autism: A Randomized Comparison Treatment Trial / Sally J. ROGERS in Journal of Autism and Developmental Disorders, 49-2 (February 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-2 (February 2019) . - p.632-646 Titre : Enhancing Low-Intensity Coaching in Parent Implemented Early Start Denver Model Intervention for Early Autism: A Randomized Comparison Treatment Trial Type de document : texte imprimé Auteurs : Sally J. ROGERS, Auteur ; Annette ESTES, Auteur ; Laura VISMARA, Auteur ; Jeffrey MUNSON, Auteur ; C. ZIERHUT, Auteur ; Jessica GREENSON, Auteur ; Geraldine DAWSON, Auteur ; Marie ROCHA, Auteur ; Catherine SUGAR, Auteur ; D. SENTURK, Auteur ; F. WHELAN, Auteur ; M. TALBOTT, Auteur Article en page(s) : p.632-646 Langues : Anglais (eng) Mots-clés : Autism  Esdm  Early intervention  Parent-implemented intervention  Toddlers Index. décimale : PER Périodiques Résumé : Short-term low intensity parent implemented intervention studies for toddlers with autism spectrum disorder (ASD) have found it difficult to demonstrate significantly improved developmental scores or autism severity compared to community treatment. We conducted a randomized comparative intent-to-treat study of a parent implemented intervention to (1) test the effects of an enhanced version on parent and child learning, and (2) evaluate the sensitivity to change of proximal versus distal measures of child behavior. We randomized 45 children with ASD, 12-30 months of age, into one of two versions of parent-implemented Early Start Denver Model (P-ESDM), the basic model, in which we delivered 1.5 h of clinic-based parent coaching weekly, and an enhanced version that contained three additions: motivational interviewing, multimodal learning tools, and a weekly 1.5-h home visit. We delivered the intervention for 12 weeks and measured child and parent change frequently in multiple settings. We found a time-by-group interaction: parents in the enhanced group demonstrated significantly greater gains in interaction skills than did parents in the non-enhanced group. Both interventions were associated with significant developmental acceleration; however, child outcomes did not differ by group. We found a significant relationship between degree of change in parental interaction skill and rate of children's improvement on our proximal measure. Parents in both groups reported satisfaction with the intervention. These findings suggest that parent skills improved more in the enhanced group than the comparison group. Children in the two groups showed similar improvements. Rate of individual parent learning was associated with greater individual child progress on a measure quite proximal to the treatment, though not on standardized assessments. En ligne : http://dx.doi.org/10.1007/s10803-018-3740-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382 [article] Enhancing Low-Intensity Coaching in Parent Implemented Early Start Denver Model Intervention for Early Autism: A Randomized Comparison Treatment Trial [texte imprimé] / Sally J. ROGERS, Auteur ; Annette ESTES, Auteur ; Laura VISMARA, Auteur ; Jeffrey MUNSON, Auteur ; C. ZIERHUT, Auteur ; Jessica GREENSON, Auteur ; Geraldine DAWSON, Auteur ; Marie ROCHA, Auteur ; Catherine SUGAR, Auteur ; D. SENTURK, Auteur ; F. WHELAN, Auteur ; M. TALBOTT, Auteur . - p.632-646. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-2 (February 2019) . - p.632-646 Mots-clés : Autism  Esdm  Early intervention  Parent-implemented intervention  Toddlers Index. décimale : PER Périodiques Résumé : Short-term low intensity parent implemented intervention studies for toddlers with autism spectrum disorder (ASD) have found it difficult to demonstrate significantly improved developmental scores or autism severity compared to community treatment. We conducted a randomized comparative intent-to-treat study of a parent implemented intervention to (1) test the effects of an enhanced version on parent and child learning, and (2) evaluate the sensitivity to change of proximal versus distal measures of child behavior. We randomized 45 children with ASD, 12-30 months of age, into one of two versions of parent-implemented Early Start Denver Model (P-ESDM), the basic model, in which we delivered 1.5 h of clinic-based parent coaching weekly, and an enhanced version that contained three additions: motivational interviewing, multimodal learning tools, and a weekly 1.5-h home visit. We delivered the intervention for 12 weeks and measured child and parent change frequently in multiple settings. We found a time-by-group interaction: parents in the enhanced group demonstrated significantly greater gains in interaction skills than did parents in the non-enhanced group. Both interventions were associated with significant developmental acceleration; however, child outcomes did not differ by group. We found a significant relationship between degree of change in parental interaction skill and rate of children's improvement on our proximal measure. Parents in both groups reported satisfaction with the intervention. These findings suggest that parent skills improved more in the enhanced group than the comparison group. Children in the two groups showed similar improvements. Rate of individual parent learning was associated with greater individual child progress on a measure quite proximal to the treatment, though not on standardized assessments. En ligne : http://dx.doi.org/10.1007/s10803-018-3740-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=382

Sleep Problems and Trajectories of Restricted and Repetitive Behaviors in Children with Neurodevelopmental Disabilities / Katherine E. MACDUFFIE in Journal of Autism and Developmental Disorders, 50-11 (November 2020)  

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The effect of early autism intervention on parental sense of efficacy in a randomized trial depends on the initial level of parent stress / Annette ESTES in Autism, 25-7 (October 2021)  

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The effect of early autism intervention on parental sense of efficacy in a randomized trial depends on the initial level of parent stress / Annette ESTES in Autism, 26-7 (October 2022)  

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The Impact of Parent-Delivered Intervention on Parents of Very Young Children with Autism / Annette ESTES in Journal of Autism and Developmental Disorders, 44-2 (February 2014)  

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