Altered Dynamics of the fMRI Response to Faces in Individuals with Autism / Natalia M. KLEINHANS in Journal of Autism and Developmental Disorders, 46-1 (January 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.232-241 Titre : Altered Dynamics of the fMRI Response to Faces in Individuals with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Natalia M. KLEINHANS, Auteur ; Todd RICHARDS, Auteur ; Jessica GREENSON, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur Année de publication : 2016 Article en page(s) : p.232-241 Langues : Anglais (eng) Mots-clés : Habituation  Faces  Houses  Amygdala  Fusiform  Adaptation Index. décimale : PER Périodiques Résumé : Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2565-8 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2784 [article] Altered Dynamics of the fMRI Response to Faces in Individuals with Autism [Texte imprimé et/ou numérique] / Natalia M. KLEINHANS, Auteur ; Todd RICHARDS, Auteur ; Jessica GREENSON, Auteur ; Geraldine DAWSON, Auteur ; Elizabeth H. AYLWARD, Auteur . - 2016 . - p.232-241. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-1 (January 2016) . - p.232-241 Mots-clés : Habituation  Faces  Houses  Amygdala  Fusiform  Adaptation Index. décimale : PER Périodiques Résumé : Abnormal fMRI habituation in autism spectrum disorders (ASDs) has been proposed as a critical component in social impairment. This study investigated habituation to fearful faces and houses in ASD and whether fMRI measures of brain activity discriminate between ASD and typically developing (TD) controls. Two identical fMRI runs presenting masked fearful faces, houses, and scrambled images were collected. We found significantly slower fMRI responses to fearful faces but not houses in ASD. In addition, the pattern of slow to emerge amygdala activation to faces had robust discriminability [ASD vs. TD; area under the curve (AUC) = .852, p < .001]. In contrast, habituation to houses had no predictive value (AUC = .573, p = .365). Amygdala habituation to emotional faces may be useful for quantifying risk in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2565-8 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2784

An Early Start for Your Child with Autism / Sally J ROGERS

Public ISBD Titre : An Early Start for Your Child with Autism : Using Everyday Activities to Help Kids Connect, Communicate, and Learn Type de document : Texte imprimé et/ou numérique Auteurs : Sally J ROGERS, Auteur ; Geraldine DAWSON, Auteur ; Laurie A. VISMARA, Auteur Editeur : New-York [Etats-Unis] : Guilford Press Année de publication : 2012 Importance : 342 p. Format : 18,5cm x 26cm x 3cm ISBN/ISSN/EAN : 978-1-4625-0389-6 Note générale : Bibliogr., webogr, Index Langues : Anglais (eng) Index. décimale : APP-B Modèle de Denver Résumé : Cutting-edge research reveals that parents can play a huge role in helping toddlers and preschoolers with autism spectrum disorders (ASD) connect with others and live up to their potential. This encouraging guide from the developers of a groundbreaking early intervention program provides doable, practical strategies you can use every day. Nearly all young kids—including those with ASD—have an amazing capacity to learn. Drs. Sally Rogers, Geraldine Dawson, and Laurie Vismara make it surprisingly simple to turn daily routines like breakfast or bath time into fun and rewarding learning experiences that target crucial developmental skills. Vivid examples illustrate proven techniques for promoting play, language, and engagement. Get an early start—and give your child the tools to explore and enjoy the world. [Résumé d'Auteur/Editeur] Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1907 An Early Start for Your Child with Autism : Using Everyday Activities to Help Kids Connect, Communicate, and Learn [Texte imprimé et/ou numérique] / Sally J ROGERS, Auteur ; Geraldine DAWSON, Auteur ; Laurie A. VISMARA, Auteur . - New-York [Etats-Unis] : Guilford Press, 2012 . - 342 p. ; 18,5cm x 26cm x 3cm. ISBN : 978-1-4625-0389-6 Bibliogr., webogr, Index Langues : Anglais (eng) Index. décimale : APP-B Modèle de Denver Résumé : Cutting-edge research reveals that parents can play a huge role in helping toddlers and preschoolers with autism spectrum disorders (ASD) connect with others and live up to their potential. This encouraging guide from the developers of a groundbreaking early intervention program provides doable, practical strategies you can use every day. Nearly all young kids—including those with ASD—have an amazing capacity to learn. Drs. Sally Rogers, Geraldine Dawson, and Laurie Vismara make it surprisingly simple to turn daily routines like breakfast or bath time into fun and rewarding learning experiences that target crucial developmental skills. Vivid examples illustrate proven techniques for promoting play, language, and engagement. Get an early start—and give your child the tools to explore and enjoy the world. [Résumé d'Auteur/Editeur] Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1907

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An Investigation of a Classroom-Based Specialized Music Therapy Model for Children With Autism Spectrum Disorder: Voices Together Using the VOICSS™ Method / Lorrie SCHMID in Focus on Autism and Other Developmental Disabilities, 35-3 (September 2020)  

Public ISBD [article]  inFocus on Autism and Other Developmental Disabilities > 35-3 (September 2020) . - p.176-185 Titre : An Investigation of a Classroom-Based Specialized Music Therapy Model for Children With Autism Spectrum Disorder: Voices Together Using the VOICSS™ Method Type de document : Texte imprimé et/ou numérique Auteurs : Lorrie SCHMID, Auteur ; Lauren DEMOSS, Auteur ; Paige SCARBROUGH, Auteur ; Carol RIPPLE, Auteur ; Yasmine WHITE, Auteur ; Geraldine DAWSON, Auteur Article en page(s) : p.176-185 Mots-clés : autism spectrum disorders  intervention  communication  socialization  music therapy Index. décimale : PER Périodiques Résumé : Students with autism spectrum disorder (ASD) have marked deficits in social communication skills, which can challenge their ability to participate in academic and social activities. Music therapy is a popular intervention for children with ASD, and although research evidence supporting its effectiveness is growing, methodological flaws limit interpretation. The present study proposes a new measure, the DUACS, to assess outcomes associated with a group music therapy program, Voices Together. Participants were 64 elementary students from nine self-contained autism classrooms who attended 16 weekly intervention sessions. Teacher-reported behavior questionnaires and direct student behavioral measures were administered at baseline, during, and after treatment. Increases in communication and social skills suggested program effectiveness, particularly among students with higher baseline skills. Further investigation of this program approach will help to better understand its mechanisms and for whom it works best. En ligne : https://doi.org/10.1177/1088357620902505 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4300 [article] An Investigation of a Classroom-Based Specialized Music Therapy Model for Children With Autism Spectrum Disorder: Voices Together Using the VOICSS™ Method [Texte imprimé et/ou numérique] / Lorrie SCHMID, Auteur ; Lauren DEMOSS, Auteur ; Paige SCARBROUGH, Auteur ; Carol RIPPLE, Auteur ; Yasmine WHITE, Auteur ; Geraldine DAWSON, Auteur . - p.176-185. in Focus on Autism and Other Developmental Disabilities > 35-3 (September 2020) . - p.176-185 Mots-clés : autism spectrum disorders  intervention  communication  socialization  music therapy Index. décimale : PER Périodiques Résumé : Students with autism spectrum disorder (ASD) have marked deficits in social communication skills, which can challenge their ability to participate in academic and social activities. Music therapy is a popular intervention for children with ASD, and although research evidence supporting its effectiveness is growing, methodological flaws limit interpretation. The present study proposes a new measure, the DUACS, to assess outcomes associated with a group music therapy program, Voices Together. Participants were 64 elementary students from nine self-contained autism classrooms who attended 16 weekly intervention sessions. Teacher-reported behavior questionnaires and direct student behavioral measures were administered at baseline, during, and after treatment. Increases in communication and social skills suggested program effectiveness, particularly among students with higher baseline skills. Further investigation of this program approach will help to better understand its mechanisms and for whom it works best. En ligne : https://doi.org/10.1177/1088357620902505 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4300

Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk / Jerome CARAYOL in Molecular Autism, (February 2010)  

Public ISBD [article]  inMolecular Autism > (February 2010) . - 11 p. Titre : Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk Type de document : Texte imprimé et/ou numérique Auteurs : Jerome CARAYOL, Auteur ; Geraldine DAWSON, Auteur ; Gerard SCHELLENBERG, Auteur ; Frederic TORES, Auteur ; Jörg HAGER, Auteur ; Andreas ZIEGLER, Auteur Année de publication : 2010 Article en page(s) : 11 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Autism is a complex disorder characterized by deficits involving communication, social interaction, and repetitive and restrictive patterns of behavior. Twin studies have shown that autism is strongly heritable, suggesting a strong genetic component. In other disease states with a complex etiology, such as type 2 diabetes, cancer and cardiovascular disease, combined analysis of multiple genetic variants in a genetic score has helped to identify individuals at high risk of disease. Genetic scores are designed to test for association of genetic markers with disease. Method The accumulation of multiple risk alleles markedly increases the risk of being affected, and compared with studying polymorphisms individually, it improves the identification of subgroups of individuals at greater risk. In the present study, we show that this approach can be applied to autism by specifically looking at a high-risk population of children who have siblings with autism. A two-sample study design and the generation of a genetic score using multiple independent genes were used to assess the risk of autism in a high-risk population. Results In both samples, odds ratios (ORs) increased significantly as a function of the number of risk alleles, with a genetic score of 8 being associated with an OR of 5.54 (95% confidence interval [CI] 2.45 to 12.49). The sensitivities and specificities for each genetic score were similar in both analyses, and the resultant area under the receiver operating characteristic curves were identical (0.59). Conclusions These results suggest that the accumulation of multiple risk alleles in a genetic score is a useful strategy for assessing the risk of autism in siblings of affected individuals, and may be better than studying single polymorphisms for identifying subgroups of individuals with significantly greater risk. En ligne : http://dx.doi.org/10.1186/2040-2392-1-4 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1029 [article] Assessing the impact of a combined analysis of four common low-risk genetic variants on autism risk [Texte imprimé et/ou numérique] / Jerome CARAYOL, Auteur ; Geraldine DAWSON, Auteur ; Gerard SCHELLENBERG, Auteur ; Frederic TORES, Auteur ; Jörg HAGER, Auteur ; Andreas ZIEGLER, Auteur . - 2010 . - 11 p. Langues : Anglais (eng) in Molecular Autism > (February 2010) . - 11 p. Index. décimale : PER Périodiques Résumé : Background Autism is a complex disorder characterized by deficits involving communication, social interaction, and repetitive and restrictive patterns of behavior. Twin studies have shown that autism is strongly heritable, suggesting a strong genetic component. In other disease states with a complex etiology, such as type 2 diabetes, cancer and cardiovascular disease, combined analysis of multiple genetic variants in a genetic score has helped to identify individuals at high risk of disease. Genetic scores are designed to test for association of genetic markers with disease. Method The accumulation of multiple risk alleles markedly increases the risk of being affected, and compared with studying polymorphisms individually, it improves the identification of subgroups of individuals at greater risk. In the present study, we show that this approach can be applied to autism by specifically looking at a high-risk population of children who have siblings with autism. A two-sample study design and the generation of a genetic score using multiple independent genes were used to assess the risk of autism in a high-risk population. Results In both samples, odds ratios (ORs) increased significantly as a function of the number of risk alleles, with a genetic score of 8 being associated with an OR of 5.54 (95% confidence interval [CI] 2.45 to 12.49). The sensitivities and specificities for each genetic score were similar in both analyses, and the resultant area under the receiver operating characteristic curves were identical (0.59). Conclusions These results suggest that the accumulation of multiple risk alleles in a genetic score is a useful strategy for assessing the risk of autism in siblings of affected individuals, and may be better than studying single polymorphisms for identifying subgroups of individuals with significantly greater risk. En ligne : http://dx.doi.org/10.1186/2040-2392-1-4 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1029

Autism risk assessment in siblings of affected children using sex-specific genetic scores / Jerome CARAYOL in Molecular Autism, (October 2011)  

Public ISBD [article]  inMolecular Autism > (October 2011) . - 8 p. Titre : Autism risk assessment in siblings of affected children using sex-specific genetic scores Type de document : Texte imprimé et/ou numérique Auteurs : Jerome CARAYOL, Auteur ; Gerard SCHELLENBERG, Auteur ; Beth DOMBROSKI, Auteur ; Emmanuelle GENIN, Auteur ; Francis ROUSSEAU, Auteur ; Geraldine DAWSON, Auteur Année de publication : 2011 Article en page(s) : 8 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND:The inheritance pattern in most cases of autism is complex. The risk of autism is increased in siblings of children with autism and previous studies have indicated that the level of risk can be further identified by the accumulation of multiple susceptibility single nucleotide polymorphisms (SNPs) allowing for the identification of a higher-risk subgroup among siblings. As a result of the sex difference in the prevalence of autism, we explored the potential for identifying sex-specific autism susceptibility SNPs in siblings of children with autism and the ability to develop a sex-specific risk assessment genetic scoring system.METHODS:SNPs were chosen from genes known to be associated with autism. These markers were evaluated using an exploratory sample of 480 families from the Autism Genetic Resource Exchange (AGRE) repository. A reproducibility index (RI) was proposed and calculated in all children with autism and in males and females separately. Differing genetic scoring models were then constructed to develop a sex-specific genetic score model designed to identify individuals with a higher risk of autism. The ability of the genetic scores to identify high-risk children was then evaluated and replicated in an independent sample of 351 affected and 90 unaffected siblings from families with at least 1 child with autism.RESULTS:We identified three risk SNPs that had a high RI in males, two SNPs with a high RI in females, and three SNPs with a high RI in both sexes. Using these results, genetic scoring models for males and females were developed which demonstrated a significant association with autism (P = 2.2 x 10-6 and 1.9 x 10-5, respectively).CONCLUSIONS:Our results demonstrate that individual susceptibility associated SNPs for autism may have important differential sex effects. We also show that a sex-specific risk score based on the presence of multiple susceptibility associated SNPs allow for the identification of subgroups of siblings of children with autism who have a significantly higher risk of autism. En ligne : http://dx.doi.org/10.1186/2040-2392-2-17 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1494 [article] Autism risk assessment in siblings of affected children using sex-specific genetic scores [Texte imprimé et/ou numérique] / Jerome CARAYOL, Auteur ; Gerard SCHELLENBERG, Auteur ; Beth DOMBROSKI, Auteur ; Emmanuelle GENIN, Auteur ; Francis ROUSSEAU, Auteur ; Geraldine DAWSON, Auteur . - 2011 . - 8 p. Langues : Anglais (eng) in Molecular Autism > (October 2011) . - 8 p. Index. décimale : PER Périodiques Résumé : BACKGROUND:The inheritance pattern in most cases of autism is complex. The risk of autism is increased in siblings of children with autism and previous studies have indicated that the level of risk can be further identified by the accumulation of multiple susceptibility single nucleotide polymorphisms (SNPs) allowing for the identification of a higher-risk subgroup among siblings. As a result of the sex difference in the prevalence of autism, we explored the potential for identifying sex-specific autism susceptibility SNPs in siblings of children with autism and the ability to develop a sex-specific risk assessment genetic scoring system.METHODS:SNPs were chosen from genes known to be associated with autism. These markers were evaluated using an exploratory sample of 480 families from the Autism Genetic Resource Exchange (AGRE) repository. A reproducibility index (RI) was proposed and calculated in all children with autism and in males and females separately. Differing genetic scoring models were then constructed to develop a sex-specific genetic score model designed to identify individuals with a higher risk of autism. The ability of the genetic scores to identify high-risk children was then evaluated and replicated in an independent sample of 351 affected and 90 unaffected siblings from families with at least 1 child with autism.RESULTS:We identified three risk SNPs that had a high RI in males, two SNPs with a high RI in females, and three SNPs with a high RI in both sexes. Using these results, genetic scoring models for males and females were developed which demonstrated a significant association with autism (P = 2.2 x 10-6 and 1.9 x 10-5, respectively).CONCLUSIONS:Our results demonstrate that individual susceptibility associated SNPs for autism may have important differential sex effects. We also show that a sex-specific risk score based on the presence of multiple susceptibility associated SNPs allow for the identification of subgroups of siblings of children with autism who have a significantly higher risk of autism. En ligne : http://dx.doi.org/10.1186/2040-2392-2-17 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=1494

Autism Spectrum Disorders / David G. AMARAL

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Automated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability / Abigail BANGERTER in Molecular Autism, 11 (2020)  

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Les avancées dans le dépistage précoce et les interventions pour les nourrissons et jeunes enfants avec un trouble du spectre de l’autisme / Geraldine DAWSON in Bulletin Scientifique de l'arapi (Le), 32 (Automne 2013)

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Basal ganglia morphometry and repetitive behavior in young children with autism spectrum disorder / Annette ESTES in Autism Research, 4-3 (June 2011)  

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Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder / Natalia M. KLEINHANS in Journal of Autism and Developmental Disorders, 39-7 (July 2009)  

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Brief Report: Face Configuration Accuracy and Processing Speed Among Adults with High-Functioning Autism Spectrum Disorders / Susan FAJA in Journal of Autism and Developmental Disorders, 39-3 (March 2009)  

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Characteristics Associated with Presence of Depressive Symptoms in Adults with Autism Spectrum Disorder / Lindsey STERLING in Journal of Autism and Developmental Disorders, 38-6 (July 2008)  

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Clinical Validation of the Autism Behavior Inventory: Caregiver-Rated Assessment of Core and Associated Symptoms of Autism Spectrum Disorder / Abigail BANGERTER in Journal of Autism and Developmental Disorders, 50-6 (June 2020)  

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Complexity analysis of head movements in autistic toddlers / Pradeep Raj KRISHNAPPA BABU in Journal of Child Psychology and Psychiatry, 64-1 (January 2023)  

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Concomitant medication use in children with autism spectrum disorder: Data from the Autism Biomarkers Consortium for Clinical Trials / Logan SHURTZ in Autism, 27-4 (May 2023)  

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