Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls / Thayne L. SWEETEN in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.410-414 Titre : Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls Type de document : texte imprimé Auteurs : Thayne L. SWEETEN, Auteur ; Lisa A. CROEN, Auteur ; Gayle C. WINDHAM, Auteur ; J. Dennis ODELL, Auteur ; E. Gene STUBBS, Auteur ; Anthony R. TORRES, Auteur Article en page(s) : p.410-414 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  Hhv-6  Herpesvirus Index. décimale : PER Périodiques Résumé : Previous research indicates that infection, especially from viruses in the family Herpesviridae, may play a role in the etiology of some cases of autism spectrum disorder (ASD). Using a case-control design and the polymerase chain reaction with site-specific primers, we screened newborn and childhood blood samples for the presence of eight human herpesviruses. Herpesvirus DNA was detected in 4 of 225 ASD individuals and 2 of 235 controls, with the most frequently detected virus being HHV-6B. Although this study does not detect a significant ASD-Herpesviridae association, it is limited by the use of site-specific primers. We suggest that new techniques using bioinformatics to search next-generation sequencing databases will be more revealing of possible ASD-virus associations. En ligne : http://dx.doi.org/10.1007/s10803-018-3691-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Brief Report: Low Rates of Herpesvirus Detection in Blood of Individuals with Autism Spectrum Disorder and Controls [texte imprimé] / Thayne L. SWEETEN, Auteur ; Lisa A. CROEN, Auteur ; Gayle C. WINDHAM, Auteur ; J. Dennis ODELL, Auteur ; E. Gene STUBBS, Auteur ; Anthony R. TORRES, Auteur . - p.410-414. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.410-414 Mots-clés : Autism  Autism spectrum disorder  Hhv-6  Herpesvirus Index. décimale : PER Périodiques Résumé : Previous research indicates that infection, especially from viruses in the family Herpesviridae, may play a role in the etiology of some cases of autism spectrum disorder (ASD). Using a case-control design and the polymerase chain reaction with site-specific primers, we screened newborn and childhood blood samples for the presence of eight human herpesviruses. Herpesvirus DNA was detected in 4 of 225 ASD individuals and 2 of 235 controls, with the most frequently detected virus being HHV-6B. Although this study does not detect a significant ASD-Herpesviridae association, it is limited by the use of site-specific primers. We suggest that new techniques using bioinformatics to search next-generation sequencing databases will be more revealing of possible ASD-virus associations. En ligne : http://dx.doi.org/10.1007/s10803-018-3691-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

Effects of fenfluramine on eight outpatients with the syndrome of autism / E. Gene STUBBS in Developmental Medicine & Child Neurology, 28-2 (April 1986)

Public ISBD [article]  inDevelopmental Medicine & Child Neurology > 28-2 (April 1986) . - p.229-235 Titre : Effects of fenfluramine on eight outpatients with the syndrome of autism Type de document : texte imprimé Auteurs : E. Gene STUBBS, Auteur ; Edward R. RITVO, Auteur ; Sarojini S. BUDDEN, Auteur ; Russell H. JACKSON, Auteur ; Leif G. TERDAL, Auteur Année de publication : 1986 Article en page(s) : p.229-235 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Fenfluramine was administered to eight autistic outpatients in a double-blind study to determine its effects on symptomatic behavior, developmental scores, blood serotonin levels and platelet counts. Two children benefited substantially according to academic and cognitive tests, parental and teacher reports and the principal investigator's clinical impressions. They also manifested behavioral and mood swings. The remaining six children showed varying degrees of response; one was withdrawn during the study by his parents. The greatest improvement occurred in children with an IQ above 40; the more severely retarded improved little, and primarily in the motor sphere. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=612 [article] Effects of fenfluramine on eight outpatients with the syndrome of autism [texte imprimé] / E. Gene STUBBS, Auteur ; Edward R. RITVO, Auteur ; Sarojini S. BUDDEN, Auteur ; Russell H. JACKSON, Auteur ; Leif G. TERDAL, Auteur . - 1986 . - p.229-235. Langues : Anglais (eng) in Developmental Medicine & Child Neurology > 28-2 (April 1986) . - p.229-235 Index. décimale : PER Périodiques Résumé : Fenfluramine was administered to eight autistic outpatients in a double-blind study to determine its effects on symptomatic behavior, developmental scores, blood serotonin levels and platelet counts. Two children benefited substantially according to academic and cognitive tests, parental and teacher reports and the principal investigator's clinical impressions. They also manifested behavioral and mood swings. The remaining six children showed varying degrees of response; one was withdrawn during the study by his parents. The greatest improvement occurred in children with an IQ above 40; the more severely retarded improved little, and primarily in the motor sphere. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=612

---

1 (1 - 2 / 2) Par page : 25 50 100 200